EuRBPDB

Description

Ensembl ID: ENSG00000229117 (Gene tree)
Gene ID: 6171
Gene Symbol: RPL41
Alias: L41
Full Name: ribosomal protein L41
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 1,358 bases
Position: chr12:56,116,586-56,117,943
Accession: 10354
RBP type: canonical RBP
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000420821	Ribosomal_L41	PF05162.13	3.3e-11	1	1
ENSP00000449026	Ribosomal_L41	PF05162.13	3.3e-11	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000501597	RPL41-202	469	-	ENSP00000420821	25 (aa)	-	P62945
ENST00000552314	RPL41-206	595	-	-	- (aa)	-	-
ENST00000546485	RPL41-203	335	-	-	- (aa)	-	-
ENST00000546591	RPL41-204	699	-	ENSP00000449026	25 (aa)	-	P62945
ENST00000358888	RPL41-201	551	-	-	- (aa)	-	-
ENST00000546654	RPL41-205	238	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000229117	RPL41	100	100.000	ENSANAG00000038487	RPL41	100	100.000	Aotus_nancymaae
ENSG00000229117	RPL41	100	100.000	ENSCJAG00000046732	RPL41	100	100.000	Callithrix_jacchus
ENSG00000229117	RPL41	100	100.000	ENSTSYG00000033367	RPL41	100	100.000	Carlito_syrichta

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	Process
GO:0002181	cytoplasmic translation	25957688.	IDA	Process
GO:0003723	RNA binding	1326959.	TAS	Function
GO:0003730	mRNA 3'-UTR binding	16213212.	IDA	Function
GO:0003735	structural constituent of ribosome	12962325.	NAS	Function
GO:0005829	cytosol	-	TAS	Component
GO:0006412	translation	12962325.	NAS	Process
GO:0006413	translational initiation	-	TAS	Process
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	-	TAS	Process
GO:0019083	viral transcription	-	TAS	Process
GO:0022625	cytosolic large ribosomal subunit	12962325.	HDA	Component
GO:0022625	cytosolic large ribosomal subunit	25957688.	IDA	Component
GO:0042788	polysomal ribosome	25957688.	IDA	Component
GO:0048027	mRNA 5'-UTR binding	16213212.	IDA	Function