EuRBPDB

Description

Ensembl ID: ENSG00000234127 (Gene tree)
Gene ID: 7726
Gene Symbol: TRIM26
Alias: RNF95|ZNF173
Full Name: tripartite motif containing 26
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 29,042 bases
Position: chr6:30,184,453-30,213,494
Accession: 12962
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000454678	TRIM26-268	3478	XM_005249374	ENSP00000410446	539 (aa)	XP_005249431	Q12899
ENST00000434785	TRIM26-265	582	-	ENSP00000400920	122 (aa)	-	A2AE50
ENST00000487829	TRIM26-270	502	-	-	- (aa)	-	-
ENST00000480999	TRIM26-269	3114	-	-	- (aa)	-	-
ENST00000453195	TRIM26-267	3318	XM_005249377	ENSP00000391879	539 (aa)	XP_005249434	Q12899
ENST00000437089	TRIM26-266	3250	-	ENSP00000395491	539 (aa)	-	Q12899
ENST00000418026	TRIM26-264	603	-	ENSP00000387530	157 (aa)	-	Q5SPU2
ENST00000416596	TRIM26-263	1124	-	ENSP00000413673	248 (aa)	-	A2AE48

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000234127	Multiple Sclerosis	6.6E-7	19010793
ENSG00000234127	Behcet Syndrome	5.94211194496239E-05	20622878
ENSG00000234127	Behcet Syndrome	2.59967736699546E-06	20622878
ENSG00000234127	Platelet Function Tests	2.6098439E-009	-
ENSG00000234127	Platelet Function Tests	7.7483424E-009	-
ENSG00000234127	Warfarin	3.0600000E-005	-
ENSG00000234127	Warfarin	3.2690000E-005	-
ENSG00000234127	Warfarin	3.0600000E-005	-
ENSG00000234127	Warfarin	3.0600000E-005	-
ENSG00000234127	Attention Deficit Disorder with Hyperactivity	2E-12	23453885
ENSG00000234127	Bipolar Disorder	2E-12	23453885
ENSG00000234127	Child Development Disorders, Pervasive	2E-12	23453885
ENSG00000234127	Depressive Disorder	2E-12	23453885
ENSG00000234127	Schizophrenia	2E-12	23453885
ENSG00000234127	Aggression	8E-7	24489884
ENSG00000234127	Schizophrenia	1E-16	22883433
ENSG00000234127	Schizophrenia	2E-12	21926974

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000234127	rs116408368	6	30202733	T	Autism spectrum disorder or schizophrenia	28540026	[1.12-1.19]	1.15	EFO_0000692\|EFO_0003756
ENSG00000234127	rs116418332	6	30193759	A	Lung cancer	28604730	[1.142217593-1.234757521]	1.1875865	EFO_0001071
ENSG00000234127	rs116418332	6	30193759	A	Squamous cell lung carcinoma	28604730	[1.180581902-1.337700478]	1.2566881	EFO_0000708
ENSG00000234127	rs116418332	6	30193759	A	Lung cancer in ever smokers	28604730	[1.145408553-1.272672964]	1.2073652	EFO_0006527\|EFO_0001071
ENSG00000234127	rs2523722	6	30197496	G	Schizophrenia	22883433	[1.12-1.39]	1.25	EFO_0000692
ENSG00000234127	rs2844775	6	30211645	A	Anger	24489884	[NR] unit decrease	0.15	EFO_0003015
ENSG00000234127	rs2021722	6	30206354	C	Schizophrenia	21926974	[1.11-1.19]	1.15	EFO_0000692
ENSG00000234127	rs116408368	6	30202733	T	Schizophrenia	30285260	[1.17-1.24]	1.203	EFO_0000692

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	8530076.	NAS	Function
GO:0005515	protein binding	21516116.21750715.25416956.	IPI	Function
GO:0005575	cellular_component	-	ND	Component
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016740	transferase activity	-	IEA	Function
GO:0045087	innate immune response	18248090.	IDA	Process
GO:0046597	negative regulation of viral entry into host cell	18248090.	IDA	Process
GO:0046872	metal ion binding	8530076.	NAS	Function
GO:0051091	positive regulation of DNA-binding transcription factor activity	23077300.	IDA	Process
GO:0060333	interferon-gamma-mediated signaling pathway	-	TAS	Process
GO:1902187	negative regulation of viral release from host cell	18248090.	IDA	Process