EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000234414 (Gene tree)
Gene ID: 5940
Gene Symbol: RBMY1A1
Alias: YRRM1|YRRM2|RBM1|RBM2
Full Name: RNA binding motif protein, Y-linked, family 1, member A1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 49,643 bases
Position: chrY:21,511,372-21,561,014
Accession: 9912
RBP type: canonical RBP
Summary: This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein is thought to function as a splicing regulator during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000303712	RBM1CTR	PF08081.11	7.6e-22	1	1
ENSP00000372154	RBM1CTR	PF08081.11	8.4e-22	1	1
ENSP00000388006	RBM1CTR	PF08081.11	8.4e-22	1	1
ENSP00000303712	RRM_1	PF00076.22	8.4e-21	1	1
ENSP00000372154	RRM_1	PF00076.22	9.3e-21	1	1
ENSP00000388006	RRM_1	PF00076.22	9.3e-21	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9344660	Multiple functional copies of the RBM gene family, a spermatogenesis candidate on the human Y chromosome.	Genomics	1997 Oct 15	Chai NN	-
9297971	The molecular genetics of male infertility.	Bioessays	1997 Sep	Elliott DJ	-
9806824	A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males.	Genomics	1998 Nov 15	Yen PH	-
9598316	Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene.	Genomics	1998 Apr 15	Chai NN	-
9499427	Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities.	Hum Mol Genet	1998 Apr	Mahadevaiah SK	-
9108067	Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm.	Proc Natl Acad Sci U S A	1997 Apr 15	Elliott DJ	-
10439009	Microdeletions within the azoospermia factor subregions of the Y chromosome in patients with idiopathic azoospermia.	Fertil Steril	1999 Aug	Kim SW	-
8923005	Recurrent duplication and deletion polymorphisms on the long arm of the Y chromosome in normal males.	Hum Mol Genet	1996 Nov	Jobling MA	-
10402374	Screening for microdeletions of Y chromosome genes in patients undergoing intracytoplasmic sperm injection.	Hum Reprod	1999 Jul	Krausz C	-
11844312	Y chromosome microdeletions and male infertility.	Hum Fertil (Camb)	1998	Elliott DJ	-
11163833	Expression of CDY1 may identify complete spermatogenesis.	Fertil Steril	2001 Jan	Kleiman SE	-
11172293	The contribution of RNA-binding motif (RBM) antibody to the histopathologic evaluation of testicular biopsies from infertile men.	Hum Pathol	2001 Jan	Maymon BB	-
11062946	[Immunohistochemical identification of testicular germ cells--preliminary report].	Harefuah	2000 Sep	Maymon BB	-
11014580	Absence of RBM expression as a marker of intratubular (in situ) germ cell neoplasia of the testis.	Hum Pathol	2000 Sep	Lifschitz-Mercer B	-
10749975	RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.	Hum Mol Genet	2000 Mar 22	Venables JP	-
20016065	Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}.	J Cell Sci	2010 Jan 1	Dreumont N	doi: 10.1242/jcs.055889.
19893608	The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon.	PLoS Genet	2009 Nov	Liu Y	doi: 10.1371/journal.pgen.1000707
17050323	Natural transmission of AZFb Y-chromosomal microdeletion from father to his three sons.	Arch Androl	2006 Nov-Dec	Samli H	-
21422736	Identifying mRNAs bound by human RBMY protein in the testis.	J Reprod Dev	2011 Feb	Zeng M	-
28498920	Copy number variation of functional RBMY1 is associated with sperm motility: an azoospermia factor-linked candidate for asthenozoospermia.	Hum Reprod	2017 Jul 1	Yan Y	doi: 10.1093/humrep/dex100.
17318228	The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction.	EMBO Rep	2007 Apr	Skrisovska L	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000303902	RBMY1A1-201	1491	-	ENSP00000303712	459 (aa)	-	P0DJD3
ENST00000382707	RBMY1A1-203	1921	XM_011531437	ENSP00000372154	496 (aa)	XP_011529739	P0DJD3
ENST00000361046	RBMY1A1-202	1718	-	ENSP00000354329	81 (aa)	-	F2Z2U1
ENST00000439108	RBMY1A1-204	1879	-	ENSP00000388006	496 (aa)	-	P0DJD3

Gene Model

Click here to download ENSG00000234414's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000234414's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000234414	RBMY1A1	100	99.194	ENSG00000169800	RBMY1F	100	99.194
ENSG00000234414	RBMY1A1	90	75.676	ENSG00000170748	RBMXL2	84	53.435
ENSG00000234414	RBMY1A1	75	43.548	ENSG00000132819	RBM38	72	39.773
ENSG00000234414	RBMY1A1	69	39.286	ENSG00000152430	BOLL	51	38.636
ENSG00000234414	RBMY1A1	84	33.824	ENSG00000076053	RBM7	77	31.148
ENSG00000234414	RBMY1A1	79	36.923	ENSG00000151923	TIAL1	66	34.444
ENSG00000234414	RBMY1A1	75	34.426	ENSG00000163694	RBM47	51	34.286
ENSG00000234414	RBMY1A1	100	100.000	ENSG00000244395	RBMY1D	100	100.000
ENSG00000234414	RBMY1A1	90	78.378	ENSG00000213516	RBMXL1	100	68.750
ENSG00000234414	RBMY1A1	78	39.683	ENSG00000111786	SRSF9	78	34.343
ENSG00000234414	RBMY1A1	81	34.848	ENSG00000100650	SRSF5	85	35.484
ENSG00000234414	RBMY1A1	85	31.429	ENSG00000114503	NCBP2	51	31.429
ENSG00000234414	RBMY1A1	63	44.231	ENSG00000138668	HNRNPD	68	36.842
ENSG00000234414	RBMY1A1	90	30.137	ENSG00000112081	SRSF3	73	30.137
ENSG00000234414	RBMY1A1	75	41.071	ENSG00000197451	HNRNPAB	54	36.792
ENSG00000234414	RBMY1A1	84	41.071	ENSG00000071626	DAZAP1	79	41.071
ENSG00000234414	RBMY1A1	68	42.000	ENSG00000135486	HNRNPA1	54	30.952
ENSG00000234414	RBMY1A1	86	30.000	ENSG00000115128	SF3B6	54	30.000
ENSG00000234414	RBMY1A1	79	36.923	ENSG00000161547	SRSF2	78	38.235
ENSG00000234414	RBMY1A1	70	43.333	ENSG00000177733	HNRNPA0	52	43.333
ENSG00000234414	RBMY1A1	79	31.169	ENSG00000149187	CELF1	89	31.169
ENSG00000234414	RBMY1A1	81	55.224	ENSG00000102317	RBM3	52	54.321
ENSG00000234414	RBMY1A1	91	56.000	ENSG00000099622	CIRBP	99	56.962
ENSG00000234414	RBMY1A1	77	38.710	ENSG00000070756	PABPC1	84	36.508
ENSG00000234414	RBMY1A1	80	33.333	ENSG00000188529	SRSF10	50	31.818
ENSG00000234414	RBMY1A1	100	99.194	ENSG00000226941	RBMY1J	100	99.194
ENSG00000234414	RBMY1A1	85	34.286	ENSG00000104852	SNRNP70	55	36.538
ENSG00000234414	RBMY1A1	86	30.000	ENSG00000090621	PABPC4	66	32.941
ENSG00000234414	RBMY1A1	100	100.000	ENSG00000242389	RBMY1E	100	100.000
ENSG00000234414	RBMY1A1	79	38.462	ENSG00000116001	TIA1	86	36.667
ENSG00000234414	RBMY1A1	65	50.000	ENSG00000153944	MSI2	61	45.000
ENSG00000234414	RBMY1A1	93	80.263	ENSG00000147274	RBMX	97	80.556
ENSG00000234414	RBMY1A1	100	100.000	ENSG00000242875	RBMY1B	100	100.000

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000234414	RBMY1A1	90	76.712	ENSCSAG00000018310	-	100	55.354	Chlorocebus_sabaeus
ENSG00000234414	RBMY1A1	90	93.151	ENSCSAG00000018304	-	100	67.269	Chlorocebus_sabaeus
ENSG00000234414	RBMY1A1	80	65.152	ENSEBUG00000014816	-	70	66.154	Eptatretus_burgeri
ENSG00000234414	RBMY1A1	80	66.667	ENSEBUG00000007630	-	69	67.692	Eptatretus_burgeri
ENSG00000234414	RBMY1A1	88	65.278	ENSFDAG00000013847	-	96	65.278	Fukomys_damarensis
ENSG00000234414	RBMY1A1	88	65.278	ENSFDAG00000005725	-	96	65.278	Fukomys_damarensis
ENSG00000234414	RBMY1A1	90	94.521	ENSMMUG00000039261	-	79	90.659	Macaca_mulatta
ENSG00000234414	RBMY1A1	90	56.757	ENSMUSG00000094658	Rbmy	87	44.170	Mus_musculus
ENSG00000234414	RBMY1A1	90	56.757	ENSMUSG00000095948	Gm21708	87	44.170	Mus_musculus
ENSG00000234414	RBMY1A1	90	56.757	ENSMUSG00000101667	Gm29289	100	50.898	Mus_musculus
ENSG00000234414	RBMY1A1	90	59.459	ENSMUSG00000096520	Gm3376	87	45.230	Mus_musculus
ENSG00000234414	RBMY1A1	90	56.757	ENSMUSG00000093918	Gm21677	87	44.170	Mus_musculus
ENSG00000234414	RBMY1A1	90	58.108	ENSMUSG00000095852	Gm10256	87	44.523	Mus_musculus
ENSG00000234414	RBMY1A1	90	56.757	ENSMUSG00000094511	Gm21693	87	44.170	Mus_musculus
ENSG00000234414	RBMY1A1	90	56.757	ENSMUSG00000093987	Gm21704	87	44.170	Mus_musculus
ENSG00000234414	RBMY1A1	90	58.108	ENSMUSG00000102053	Gm4064	87	44.170	Mus_musculus
ENSG00000234414	RBMY1A1	90	58.108	ENSMUSG00000091987	Gm10352	87	44.523	Mus_musculus
ENSG00000234414	RBMY1A1	100	86.444	ENSPTRG00000050914	-	100	86.444	Pan_troglodytes
ENSG00000234414	RBMY1A1	100	93.561	ENSPTRG00000051022	-	100	93.561	Pan_troglodytes
ENSG00000234414	RBMY1A1	100	94.348	ENSPTRG00000046311	-	100	94.348	Pan_troglodytes
ENSG00000234414	RBMY1A1	100	75.949	ENSPTRG00000049088	-	100	75.949	Pan_troglodytes
ENSG00000234414	RBMY1A1	100	93.305	ENSPTRG00000047385	-	100	93.305	Pan_troglodytes
ENSG00000234414	RBMY1A1	100	86.000	ENSPTRG00000046270	-	100	89.417	Pan_troglodytes
ENSG00000234414	RBMY1A1	100	89.194	ENSPTRG00000047951	-	100	89.194	Pan_troglodytes
ENSG00000234414	RBMY1A1	100	91.957	ENSPTRG00000042791	-	100	91.957	Pan_troglodytes
ENSG00000234414	RBMY1A1	100	89.194	ENSPTRG00000043157	-	100	89.194	Pan_troglodytes
ENSG00000234414	RBMY1A1	100	89.391	ENSPTRG00000045105	-	100	89.391	Pan_troglodytes
ENSG00000234414	RBMY1A1	100	90.870	ENSPTRG00000051395	-	100	90.870	Pan_troglodytes
ENSG00000234414	RBMY1A1	86	61.972	ENSRNOG00000060963	Rbmy1j	81	48.000	Rattus_norvegicus
ENSG00000234414	RBMY1A1	97	63.670	ENSRBIG00000029066	-	100	63.670	Rhinopithecus_bieti
ENSG00000234414	RBMY1A1	90	91.781	ENSRBIG00000007617	-	99	78.840	Rhinopithecus_bieti
ENSG00000234414	RBMY1A1	90	91.781	ENSRROG00000029740	-	99	80.546	Rhinopithecus_roxellana

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	12165565.	IDA	Process
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	12165565.	IDA	Function
GO:0005515	protein binding	12165565.21044950.21516116.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0016607	nuclear speck	21873635.	IBA	Component
GO:0045292	mRNA cis splicing, via spliceosome	21873635.	IBA	Process