EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000239306 (Gene tree)
Gene ID: 10432
Gene Symbol: RBM14
Alias: SIP|SYTIP1|COAA|DKFZp779J0927
Full Name: RNA binding motif protein 14
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 13,353 bases
Position: chr11:66,616,582-66,629,934
Accession: 14219
RBP type: canonical RBP
Summary: This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000377548	RRM_5	PF13893.6	2.3e-09	1	2
ENSP00000377548	RRM_5	PF13893.6	2.3e-09	2	2
ENSP00000311747	RRM_5	PF13893.6	1.8e-07	1	2
ENSP00000311747	RRM_5	PF13893.6	1.8e-07	2	2
ENSP00000377548	RRM_1	PF00076.22	5.2e-30	1	2
ENSP00000377548	RRM_1	PF00076.22	5.2e-30	2	2
ENSP00000311747	RRM_1	PF00076.22	4.9e-28	1	2
ENSP00000311747	RRM_1	PF00076.22	4.9e-28	2	2
ENSP00000414650	RRM_1	PF00076.22	8e-19	1	2
ENSP00000414650	RRM_1	PF00076.22	8e-19	2	2
ENSP00000386995	RRM_1	PF00076.22	1e-18	1	2
ENSP00000386995	RRM_1	PF00076.22	1e-18	2	2
ENSP00000386518	RRM_1	PF00076.22	3.6e-18	1	2
ENSP00000386518	RRM_1	PF00076.22	3.6e-18	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15919756	Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator.	Endocrinology	2005 Sep	Iwasaki T	-
26951683	EBV noncoding RNA EBER2 interacts with host RNA-binding proteins to regulate viral gene expression.	Proc Natl Acad Sci U S A	2016 Mar 22	Lee N	doi: 10.1073/pnas.1601773113
28257890	A novel role of fragile X mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14.	Neuroscience	2017 May 4	Zhou LT	doi: 10.1016/j.neuroscience.2017.02.044
12810069	p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor.	Biochem Biophys Res Commun	2003 Jul 4	Ishitani K	-
18635665	The extracellular domain of the growth hormone receptor interacts with coactivator activator to promote cell proliferation.	Mol Endocrinol	2008 Sep	Conway-Campbell BL	doi: 10.1210/me.2008-0128
24811242	RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation.	Oncotarget	2014 May 15	Yuan M	-
26927092	Roles of RNA-Binding Proteins in DNA Damage Response.	Int J Mol Sci	2016 Feb 27	Kai M	doi: 10.3390/ijms17030310.
28426349	RNA-binding protein RBM14 regulates dissociation and association of non-homologous end joining proteins.	Cell Cycle	2017 Jun 18	Simon NE	doi: 10.1080/15384101.2017.1317419
28984199	Roles of alternative splicing in modulating transcriptional regulation.	BMC Syst Biol	2017 Oct 3	Li J	doi: 10.1186/s12918-017-0465-6.
29075020	The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ.	Sci Rep	2017 Oct 26	Firmin FF	doi: 10.1038/s41598-017-14570-y.
30429226	Nucleolar Relocalization of RBM14 by Influenza A Virus NS1 Protein.	mSphere	2018 Nov 14	Beyleveld G	doi: 10.1128/mSphereDirect.00549-18.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000460762	RBM14-206	459	-	-	- (aa)	-	-
ENST00000443702	RBM14-205	732	-	ENSP00000414650	129 (aa)	-	F8WDX3
ENST00000461478	RBM14-207	693	-	-	- (aa)	-	-
ENST00000310137	RBM14-201	2828	-	ENSP00000311747	669 (aa)	-	Q96PK6
ENST00000409372	RBM14-203	876	-	ENSP00000386518	159 (aa)	-	B8ZZ74
ENST00000409738	RBM14-204	372	-	ENSP00000386995	119 (aa)	-	Q96PK6
ENST00000496694	RBM14-208	562	-	-	- (aa)	-	-
ENST00000512283	RBM14-209	567	-	-	- (aa)	-	-
ENST00000393979	RBM14-202	1426	-	ENSP00000377548	156 (aa)	-	Q96PK6

Gene Model

Click here to download ENSG00000239306's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000239306's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000239306	RBM14	98	31.061	ENSG00000135486	HNRNPA1	57	32.090
ENSG00000239306	RBM14	94	48.529	ENSG00000173914	RBM4B	98	48.529
ENSG00000239306	RBM14	94	48.529	ENSG00000173933	RBM4	97	48.529
ENSG00000239306	RBM14	53	36.264	ENSG00000213516	RBMXL1	54	36.264
ENSG00000239306	RBM14	53	36.264	ENSG00000147274	RBMX	92	33.766
ENSG00000239306	RBM14	52	30.488	ENSG00000125970	RALY	90	30.864

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000239306	RBM14	96	61.842	ENSACAG00000012696	RBM14	99	46.011	Anolis_carolinensis
ENSG00000239306	RBM14	95	39.437	ENSACAG00000028084	-	86	40.141	Anolis_carolinensis
ENSG00000239306	RBM14	100	99.851	ENSANAG00000035377	RBM14	100	99.851	Aotus_nancymaae
ENSG00000239306	RBM14	100	99.253	ENSBTAG00000001225	RBM14	100	99.253	Bos_taurus
ENSG00000239306	RBM14	100	100.000	ENSCJAG00000001294	RBM14	100	100.000	Callithrix_jacchus
ENSG00000239306	RBM14	100	99.701	ENSCAFG00000012405	RBM14	100	99.701	Canis_familiaris
ENSG00000239306	RBM14	100	99.701	ENSCAFG00020015516	RBM14	100	99.701	Canis_lupus_dingo
ENSG00000239306	RBM14	100	99.253	ENSCHIG00000020952	RBM14	100	99.253	Capra_hircus
ENSG00000239306	RBM14	100	100.000	ENSTSYG00000000450	RBM14	100	100.000	Carlito_syrichta
ENSG00000239306	RBM14	85	96.041	ENSCAPG00000012991	RBM14	96	96.041	Cavia_aperea
ENSG00000239306	RBM14	100	100.000	ENSCPOG00000008019	RBM14	100	100.000	Cavia_porcellus
ENSG00000239306	RBM14	100	97.436	ENSCCAG00000034251	-	100	97.436	Cebus_capucinus
ENSG00000239306	RBM14	100	99.552	ENSCCAG00000019303	RBM14	100	99.552	Cebus_capucinus
ENSG00000239306	RBM14	100	100.000	ENSCATG00000036313	RBM14	100	100.000	Cercocebus_atys
ENSG00000239306	RBM14	100	100.000	ENSCLAG00000015277	RBM14	100	100.000	Chinchilla_lanigera
ENSG00000239306	RBM14	99	96.610	ENSCSAG00000008356	-	77	100.000	Chlorocebus_sabaeus
ENSG00000239306	RBM14	95	68.456	ENSCPBG00000023808	RBM14	99	53.163	Chrysemys_picta_bellii
ENSG00000239306	RBM14	100	100.000	ENSCANG00000028611	RBM14	100	100.000	Colobus_angolensis_palliatus
ENSG00000239306	RBM14	100	99.160	ENSCGRG00001024921	Rbm14	100	99.160	Cricetulus_griseus_chok1gshd
ENSG00000239306	RBM14	100	99.160	ENSCGRG00000010784	Rbm14	100	99.160	Cricetulus_griseus_crigri
ENSG00000239306	RBM14	100	98.954	ENSDNOG00000043225	RBM14	100	98.954	Dasypus_novemcinctus
ENSG00000239306	RBM14	100	100.000	ENSDORG00000002474	Rbm14	100	100.000	Dipodomys_ordii
ENSG00000239306	RBM14	99	42.857	ENSEBUG00000008661	-	61	43.226	Eptatretus_burgeri
ENSG00000239306	RBM14	100	99.701	ENSEASG00005005062	RBM14	100	99.701	Equus_asinus_asinus
ENSG00000239306	RBM14	100	99.701	ENSECAG00000022859	RBM14	100	99.701	Equus_caballus
ENSG00000239306	RBM14	100	100.000	ENSFCAG00000007392	RBM14	100	100.000	Felis_catus
ENSG00000239306	RBM14	95	65.541	ENSFALG00000002071	RBM14	100	41.134	Ficedula_albicollis
ENSG00000239306	RBM14	100	100.000	ENSFDAG00000002787	RBM14	100	100.000	Fukomys_damarensis
ENSG00000239306	RBM14	99	53.165	ENSGMOG00000009633	rbm14b	69	53.165	Gadus_morhua
ENSG00000239306	RBM14	100	65.854	ENSGALG00000035260	RBM14	96	53.226	Gallus_gallus
ENSG00000239306	RBM14	99	54.140	ENSGACG00000019028	rbm14b	69	54.140	Gasterosteus_aculeatus
ENSG00000239306	RBM14	87	51.592	ENSGAGG00000008555	-	99	50.929	Gopherus_agassizii
ENSG00000239306	RBM14	99	62.185	ENSGAGG00000001366	-	84	62.185	Gopherus_agassizii
ENSG00000239306	RBM14	100	100.000	ENSGGOG00000014455	RBM14	100	100.000	Gorilla_gorilla
ENSG00000239306	RBM14	100	99.253	ENSHGLG00000012589	RBM14	100	99.253	Heterocephalus_glaber_female
ENSG00000239306	RBM14	100	99.103	ENSHGLG00100011836	RBM14	100	99.103	Heterocephalus_glaber_male
ENSG00000239306	RBM14	99	53.797	ENSHCOG00000012571	rbm14b	97	57.018	Hippocampus_comes
ENSG00000239306	RBM14	100	100.000	ENSSTOG00000009796	RBM14	100	100.000	Ictidomys_tridecemlineatus
ENSG00000239306	RBM14	100	100.000	ENSJJAG00000020814	Rbm14	100	100.000	Jaculus_jaculus
ENSG00000239306	RBM14	99	53.548	ENSLACG00000017750	-	54	53.947	Latimeria_chalumnae
ENSG00000239306	RBM14	84	92.665	ENSLAFG00000009086	RBM14	100	92.665	Loxodonta_africana
ENSG00000239306	RBM14	100	100.000	ENSMFAG00000003827	RBM4	100	100.000	Macaca_fascicularis
ENSG00000239306	RBM14	100	100.000	ENSMMUG00000020363	RBM14	100	100.000	Macaca_mulatta
ENSG00000239306	RBM14	100	99.851	ENSMNEG00000014872	RBM14	100	99.851	Macaca_nemestrina
ENSG00000239306	RBM14	100	100.000	ENSMLEG00000024601	RBM14	100	100.000	Mandrillus_leucophaeus
ENSG00000239306	RBM14	97	63.248	ENSMGAG00000016129	-	97	63.248	Meleagris_gallopavo
ENSG00000239306	RBM14	100	99.160	ENSMAUG00000017509	Rbm14	100	99.160	Mesocricetus_auratus
ENSG00000239306	RBM14	100	99.552	ENSMICG00000031929	RBM14	100	99.552	Microcebus_murinus
ENSG00000239306	RBM14	100	99.160	ENSMOCG00000002491	Rbm14	100	99.160	Microtus_ochrogaster
ENSG00000239306	RBM14	90	94.366	ENSMODG00000007884	RBM14	100	84.628	Monodelphis_domestica
ENSG00000239306	RBM14	100	50.610	ENSMALG00000019079	-	96	50.610	Monopterus_albus
ENSG00000239306	RBM14	100	99.160	MGP_CAROLIEiJ_G0022517	Rbm14	100	99.160	Mus_caroli
ENSG00000239306	RBM14	100	99.160	ENSMUSG00000006456	Rbm14	100	99.160	Mus_musculus
ENSG00000239306	RBM14	100	99.160	MGP_PahariEiJ_G0014014	Rbm14	100	99.160	Mus_pahari
ENSG00000239306	RBM14	100	99.160	MGP_SPRETEiJ_G0023431	Rbm14	100	99.160	Mus_spretus
ENSG00000239306	RBM14	100	99.701	ENSMPUG00000003440	RBM14	100	99.701	Mustela_putorius_furo
ENSG00000239306	RBM14	100	94.359	ENSMLUG00000024395	-	100	74.141	Myotis_lucifugus
ENSG00000239306	RBM14	100	98.505	ENSMLUG00000015545	-	100	98.505	Myotis_lucifugus
ENSG00000239306	RBM14	100	100.000	ENSNGAG00000019304	Rbm14	100	100.000	Nannospalax_galili
ENSG00000239306	RBM14	100	99.676	ENSNLEG00000006197	RBM14	95	99.676	Nomascus_leucogenys
ENSG00000239306	RBM14	85	85.140	ENSMEUG00000005742	RBM14	100	85.664	Notamacropus_eugenii
ENSG00000239306	RBM14	100	98.057	ENSOPRG00000009139	RBM14	100	98.057	Ochotona_princeps
ENSG00000239306	RBM14	100	100.000	ENSODEG00000017717	RBM14	100	100.000	Octodon_degus
ENSG00000239306	RBM14	97	90.517	ENSOANG00000001240	-	97	90.517	Ornithorhynchus_anatinus
ENSG00000239306	RBM14	100	99.103	ENSOCUG00000022838	RBM14	100	99.103	Oryctolagus_cuniculus
ENSG00000239306	RBM14	100	47.899	ENSOMEG00000006508	-	93	48.980	Oryzias_melastigma
ENSG00000239306	RBM14	100	99.253	ENSOGAG00000032829	RBM14	100	99.253	Otolemur_garnettii
ENSG00000239306	RBM14	100	93.890	ENSOARG00000007565	RBM14	100	93.890	Ovis_aries
ENSG00000239306	RBM14	100	99.851	ENSPPAG00000033403	RBM14	100	99.851	Pan_paniscus
ENSG00000239306	RBM14	100	100.000	ENSPPRG00000003716	RBM14	100	100.000	Panthera_pardus
ENSG00000239306	RBM14	86	99.476	ENSPTIG00000016775	RBM14	86	99.476	Panthera_tigris_altaica
ENSG00000239306	RBM14	100	100.000	ENSPTRG00000003934	RBM14	100	100.000	Pan_troglodytes
ENSG00000239306	RBM14	100	100.000	ENSPANG00000004924	RBM14	100	100.000	Papio_anubis
ENSG00000239306	RBM14	81	80.000	ENSPSIG00000003436	RBM14	99	53.106	Pelodiscus_sinensis
ENSG00000239306	RBM14	100	47.899	ENSPMGG00000018869	-	91	48.966	Periophthalmus_magnuspinnatus
ENSG00000239306	RBM14	96	94.000	ENSPCIG00000008541	RBM14	92	94.000	Phascolarctos_cinereus
ENSG00000239306	RBM14	100	100.000	ENSPPYG00000003015	RBM14	100	100.000	Pongo_abelii
ENSG00000239306	RBM14	96	99.333	ENSPCAG00000003334	RBM14	90	98.492	Procavia_capensis
ENSG00000239306	RBM14	100	100.000	ENSPCOG00000016329	RBM14	100	100.000	Propithecus_coquereli
ENSG00000239306	RBM14	96	100.000	ENSPVAG00000010483	RBM14	74	97.872	Pteropus_vampyrus
ENSG00000239306	RBM14	100	98.655	ENSRNOG00000045568	Rbm14	100	98.655	Rattus_norvegicus
ENSG00000239306	RBM14	100	100.000	ENSRBIG00000043267	RBM14	100	100.000	Rhinopithecus_bieti
ENSG00000239306	RBM14	100	100.000	ENSRROG00000044302	RBM14	100	100.000	Rhinopithecus_roxellana
ENSG00000239306	RBM14	100	100.000	ENSSBOG00000031468	RBM14	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000239306	RBM14	84	80.836	ENSSHAG00000008478	RBM14	100	80.662	Sarcophilus_harrisii
ENSG00000239306	RBM14	94	100.000	ENSSARG00000006530	RBM14	100	92.526	Sorex_araneus
ENSG00000239306	RBM14	96	74.138	ENSSPUG00000005905	RBM14	100	53.754	Sphenodon_punctatus
ENSG00000239306	RBM14	100	99.552	ENSSSCG00000038008	RBM14	100	99.552	Sus_scrofa
ENSG00000239306	RBM14	96	96.000	ENSTBEG00000003641	RBM14	100	91.330	Tupaia_belangeri
ENSG00000239306	RBM14	96	100.000	ENSTTRG00000011156	RBM14	89	98.881	Tursiops_truncatus
ENSG00000239306	RBM14	96	99.333	ENSUAMG00000014883	RBM14	99	98.686	Ursus_americanus
ENSG00000239306	RBM14	80	90.467	ENSUMAG00000011736	RBM14	95	90.467	Ursus_maritimus
ENSG00000239306	RBM14	96	100.000	ENSVVUG00000010624	RBM14	100	99.672	Vulpes_vulpes
ENSG00000239306	RBM14	96	64.430	ENSXETG00000026650	rbm14	99	40.310	Xenopus_tropicalis
ENSG00000239306	RBM14	98	45.098	ENSXETG00000030260	-	56	45.614	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002218	activation of innate immune response	21873635.	IBA	Process
GO:0002218	activation of innate immune response	28712728.	IDA	Process
GO:0003712	transcription coregulator activity	11443112.	NAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	11443112.	NAS	Function
GO:0005515	protein binding	15919756.25385835.26871637.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	25385835.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005667	transcription factor complex	21873635.	IBA	Component
GO:0005667	transcription factor complex	11443112.	IPI	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	25385835.	IDA	Component
GO:0006260	DNA replication	11443112.	NAS	Process
GO:0006281	DNA repair	11443112.	NAS	Process
GO:0006310	DNA recombination	11443112.	NAS	Process
GO:0009725	response to hormone	11443112.	TAS	Process
GO:0016575	histone deacetylation	11443112.	IPI	Process
GO:0016592	mediator complex	11443112.	NAS	Component
GO:0016607	nuclear speck	21873635.	IBA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0030374	nuclear receptor transcription coactivator activity	21873635.	IBA	Function
GO:0030374	nuclear receptor transcription coactivator activity	11443112.	IPI	Function
GO:0030520	intracellular estrogen receptor signaling pathway	11443112.	NAS	Process
GO:0030674	protein binding, bridging	11443112.	NAS	Function
GO:0042921	glucocorticoid receptor signaling pathway	11443112.	NAS	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	11443112.15919756.	IDA	Process
GO:0046600	negative regulation of centriole replication	25385835.	IMP	Process
GO:0060395	SMAD protein signal transduction	-	IEA	Process
GO:0098534	centriole assembly	25385835.	IMP	Process
GO:1990904	ribonucleoprotein complex	11443112.	TAS	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18829545	Dual roles for coactivator activator and its counterbalancing isoform coactivator modulator in human kidney cell tumorigenesis.	Cancer Res	2008 Oct 1	Kang YK	doi: 10.1158/0008-5472.CAN-08-1734.
21736557	The coactivator activator CoAA regulates PEA3 group member transcriptional activity.	Biochem J	2011 Nov 1	Verreman K	doi: 10.1042/BJ20110728.
19416963	Functional pre- mRNA trans-splicing of coactivator CoAA and corepressor RBM4 during stem/progenitor cell differentiation.	J Biol Chem	2009 Jul 3	Brooks YS	doi: 10.1074/jbc.M109.006999

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr11	66625153	Missense_Mutation	novel	S426C	0.13
BLCA	chr11	66625555	Missense_Mutation	novel	S560F	0.33
BLCA	chr11	66616784	Missense_Mutation	NA	F22I	0.17
BLCA	chr11	66624951	Missense_Mutation	novel	R359C	0.35
BLCA	chr11	66617017	Missense_Mutation	novel	F99L	0.11	RRM_5
BLCA	chr11	66616980	Missense_Mutation	novel	S87L	0.33	RRM_5
BLCA	chr11	66617045	Missense_Mutation	NA	D109H	0.3	RRM_5
BLCA	chr11	66625252	Missense_Mutation	rs761053620	G459V	0.44
BLCA	chr11	66626591	Missense_Mutation	novel	Y645H	0.12
BRCA	chr11	66625630	Missense_Mutation	NA	R585Q	0.72
BRCA	chr11	66624468	Missense_Mutation	NA	F198L	0.2
BRCA	chr11	66625341	Nonsense_Mutation	NA	Q489*	0.27
BRCA	chr11	66624421	Missense_Mutation	NA	S182C	0.4
BRCA	chr11	66624550	Missense_Mutation	NA	S225C	0.38
BRCA	chr11	66625096	Missense_Mutation	rs764529837	S407L	0.25
CESC	chr11	66624288	In_Frame_Ins	novel	G139_E145dup	0.26
CESC	chr11	66616837	Silent	rs754533623	F39F	0.33
CESC	chr11	66625616	Silent	rs371074542	R580R	0.57
CESC	chr11	66624814	Missense_Mutation	rs773352601	S313L	0.68
CESC	chr11	66625312	Missense_Mutation	NA	S479L	0.6
CESC	chr11	66617000	Missense_Mutation	novel	E94K	0.3	RRM_5
CESC	chr11	66616837	Silent	rs754533623	F39F	0.33
CESC	chr11	66617017	Silent	NA	F99F	0.17
COAD	chr11	66624363	Missense_Mutation	NA	D163N	0.24
COAD	chr11	66616800	Missense_Mutation	rs776791555	T27M	0.12
COAD	chr11	66626551	Silent	NA	S631S	0.44
COAD	chr11	66625385	Silent	NA	A503A	0.16
COAD	chr11	66625653	Frame_Shift_Del	NA	*K594Rfs15**	0.67
COAD	chr11	66624338	Silent	rs534878980	G154G	0.19
COAD	chr11	66625564	Frame_Shift_Ins	NA	*A565Gfs13**	0.47
COAD	chr11	66624758	Silent	NA	S294S	0.17
COAD	chr11	66624484	Missense_Mutation	rs751672990	R203H	0.12
COAD	chr11	66626723	3'UTR	novel		0.4
COAD	chr11	66626661	Missense_Mutation	NA	R668H	0.44
ESCA	chr11	66616634	5'UTR	novel		0.1
ESCA	chr11	66616928	Missense_Mutation	novel	M70L	0.26
ESCA	chr11	66616837	Silent	rs754533623	F39F	0.16
GBM	chr11	66625638	Missense_Mutation	novel	Y588H	0.14
GBM	chr11	66624926	Silent	novel	A350A	0.25
GBM	chr11	66624696	Missense_Mutation	NA	R274C	0.26
GBM	chr11	66624599	Silent	rs149760892	P241P	0.25
GBM	chr11	66625665	Missense_Mutation	rs190230004	A597T	0.28
GBM	chr11	66625262	Silent	novel	G462G	0.14
HNSC	chr11	66626628	Missense_Mutation	rs748136584	R657Q	0.53
HNSC	chr11	66625508	Silent	novel	P544P	0.26
HNSC	chr11	66624482	Silent	novel	A202A	0.15
KIRC	chr11	66624307	Missense_Mutation	NA	V144G	0.3
KIRP	chr11	66616673	5'UTR	novel		0.53
KIRP	chr11	66617013	Missense_Mutation	NA	L98P	0.12	RRM_5
LAML	chr11	66626485	Silent	novel	A609A	0.56
LIHC	chr11	66617033	Missense_Mutation	NA	V105F	0.13	RRM_5
LIHC	chr11	66625390	Missense_Mutation	NA	G505E	0.16
LIHC	chr11	66624257	Silent	novel	A127A	0.26
LUAD	chr11	66625362	Missense_Mutation	novel	G496C	0.67
LUAD	chr11	66626564	Missense_Mutation	novel	R636C	0.29
LUAD	chr11	66624626	Missense_Mutation	NA	R250S	0.17
LUAD	chr11	66625096	Missense_Mutation	rs764529837	S407L	0.14
LUAD	chr11	66625369	Missense_Mutation	rs144272368	Y498C	0.25
LUAD	chr11	66625299	Missense_Mutation	novel	G475W	0.21
LUAD	chr11	66625175	Silent	novel	V433V	0.06
LUAD	chr11	66624406	Missense_Mutation	novel	G177E	0.39
LUAD	chr11	66624354	Nonsense_Mutation	novel	Q160*	0.34
LUSC	chr11	66625120	Frame_Shift_Del	novel	*P416Hfs56**	0.28
LUSC	chr11	66624351	Missense_Mutation	NA	V159L	0.1
LUSC	chr11	66624587	Silent	novel	Y237Y	0.23
LUSC	chr11	66624360	Frame_Shift_Del	novel	*D163Tfs68**	0.23
LUSC	chr11	66624883	Missense_Mutation	rs779415955	S336F	0.07
OV	chr11	66625467	Frame_Shift_Ins	novel	*Q531Pfs79**	0.28
PRAD	chr11	66625426	Missense_Mutation	novel	R517H	0.29
PRAD	chr11	66625615	Missense_Mutation	novel	R580H	0.52
READ	chr11	66625413	Missense_Mutation	NA	A513T	0.32
READ	chr11	66624298	Missense_Mutation	NA	R141H	0.21
READ	chr11	66624517	Missense_Mutation	rs758125063	R214H	0.35
READ	chr11	66624953	Silent	NA	R359R	0.27
SARC	chr11	66626477	Missense_Mutation	novel	R607S	0.22
SARC	chr11	66616883	Silent	novel	L55L	0.4
SKCM	chr11	66626526	Missense_Mutation	rs768721278	S623L	0.37
SKCM	chr11	66626672	3'UTR	novel		0.53
SKCM	chr11	66617017	Silent	NA	F99F	0.45
SKCM	chr11	66624893	Silent	NA	A339A	0.28
SKCM	chr11	66625375	Missense_Mutation	NA	A500V	0.14
SKCM	chr11	66625330	Missense_Mutation	NA	S485F	0.19
SKCM	chr11	66624826	Missense_Mutation	NA	S317F	0.52
SKCM	chr11	66624716	Silent	rs146815709	S280S	0.04
SKCM	chr11	66625648	Missense_Mutation	novel	P591L	0.11
SKCM	chr11	66626530	Silent	novel	F624F	0.48
SKCM	chr11	66626469	Missense_Mutation	NA	S604F	0.43
SKCM	chr11	66616877	Missense_Mutation	novel	E53K	0.44
SKCM	chr11	66625597	Missense_Mutation	NA	P574L	0.9
SKCM	chr11	66625503	Nonsense_Mutation	novel	Q543*	0.18
STAD	chr11	66624862	Missense_Mutation	NA	N329S	0.06
STAD	chr11	66625665	Missense_Mutation	rs190230004	A597T	0.47
STAD	chr11	66626622	Missense_Mutation	novel	Y655C	0.45
STAD	chr11	66624516	Missense_Mutation	rs747929881	R214C	0.11
STAD	chr11	66625597	Missense_Mutation	NA	P574L	0.3
STAD	chr11	66625429	Missense_Mutation	NA	T518S	0.05
STAD	chr11	66624628	Missense_Mutation	NA	A251V	0.08
STAD	chr11	66616737	Missense_Mutation	NA	G6D	0.2
STAD	chr11	66616737	Missense_Mutation	novel	G6A	0.25
STAD	chr11	66625339	Missense_Mutation	rs752831172	A488V	0.05
STAD	chr11	66625169	Silent	novel	A431A	0.34
STAD	chr11	66624970	Missense_Mutation	NA	Y365C	0.17
STAD	chr11	66625536	Missense_Mutation	NA	P554S	0.17
UCEC	chr11	66625325	Silent	novel	S483S	0.62
UCEC	chr11	66626535	Missense_Mutation	rs577465036	R626H	0.22
UCEC	chr11	66625318	Frame_Shift_Del	novel	*G481Vfs114**	0.33
UCEC	chr11	66624385	Missense_Mutation	novel	A170D	0.54
UCEC	chr11	66626657	Missense_Mutation	novel	R667C	0.62
UCEC	chr11	66626855	3'UTR	rs561763639		0.39
UCEC	chr11	66626623	Nonsense_Mutation	NA	Y655*	0.31
UCEC	chr11	66616656	5'UTR	novel		0.42
UCEC	chr11	66624219	Missense_Mutation	novel	A115T	0.31
UCEC	chr11	66625673	Silent	rs368354797	S599S	0.44
UCEC	chr11	66625630	Missense_Mutation	NA	R585Q	0.11
UCEC	chr11	66624853	Missense_Mutation	novel	S326Y	0.43
UCEC	chr11	66624236	Missense_Mutation	novel	E120D	0.41
UCEC	chr11	66625376	Silent	rs778362886	A500A	0.12
UCEC	chr11	66626805	3'UTR	novel		0.22
UCEC	chr11	66624298	Missense_Mutation	NA	R141H	0.3
UCEC	chr11	66626478	Missense_Mutation	novel	R607H	0.38
UCEC	chr11	66624775	Missense_Mutation	novel	S300Y	0.53
UCEC	chr11	66624424	Missense_Mutation	novel	A183D	0.48
UCEC	chr11	66624866	Silent	NA	S330S	0.38
UCEC	chr11	66625609	Missense_Mutation	NA	R578H	0.38
UCEC	chr11	66616822	Missense_Mutation	novel	M34I	0.2
UCEC	chr11	66625673	Silent	rs368354797	S599S	0.31
UCEC	chr11	66625673	Silent	rs368354797	S599S	0.37
UCEC	chr11	66626567	Missense_Mutation	novel	R637C	0.17
UCEC	chr11	66625595	Silent	rs376787377	P573P	0.29
UCEC	chr11	66626759	3'UTR	novel		0.32
UCEC	chr11	66626593	Silent	novel	Y645Y	0.18
UCEC	chr11	66626952	3'UTR	novel		0.63
UCEC	chr11	66625367	Silent	novel	S497S	0.51
UCEC	chr11	66626658	Missense_Mutation	NA	R667H	0.42
UCEC	chr11	66624816	Missense_Mutation	NA	A314T	0.39
UCEC	chr11	66625665	Missense_Mutation	rs190230004	A597T	0.45
UCEC	chr11	66626598	Missense_Mutation	NA	R647H	0.28
UCEC	chr11	66624951	Missense_Mutation	NA	R359S	0.39
UCEC	chr11	66625160	Silent	novel	Q428Q	0.06
UCEC	chr11	66626604	Missense_Mutation	novel	S649L	0.35
UCEC	chr11	66624298	Missense_Mutation	NA	R141H	0.33
UCEC	chr11	66625567	Missense_Mutation	NA	G564E	0.5
UCEC	chr11	66625001	Silent	novel	G375G	0.22
UCEC	chr11	66626657	Missense_Mutation	novel	R667C	0.22
UCEC	chr11	66625416	Missense_Mutation	NA	A514T	0.41
UCEC	chr11	66616736	Missense_Mutation	novel	G6S	0.43
UCEC	chr11	66624298	Missense_Mutation	NA	R141H	0.42
UCEC	chr11	66626518	Silent	NA	S620S	0.49

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.2554	0.018342
TGCT	DEL	0.7	0.21504

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0014	Kaplan-Meier Survival Analysis
KIRC	0.043	Kaplan-Meier Survival Analysis
STAD	0.00041	Kaplan-Meier Survival Analysis
MESO	0.027	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
UCS	0.036	Kaplan-Meier Survival Analysis
HNSC	0.015	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
PRAD	0.022	Kaplan-Meier Survival Analysis
KIRP	0.039	Kaplan-Meier Survival Analysis
PAAD	0.0001	Kaplan-Meier Survival Analysis
BLCA	0.028	Kaplan-Meier Survival Analysis
READ	0.0092	Kaplan-Meier Survival Analysis
LAML	0.011	Kaplan-Meier Survival Analysis
UCEC	0.041	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.05	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742