EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000240682 (Gene tree)
Gene ID: 57461
Gene Symbol: ISY1
Alias: KIAA1160|fSAP33
Full Name: ISY1 splicing factor homolog
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 33,879 bases
Position: chr3:129,127,415-129,161,293
Accession: 29201
RBP type: canonical RBP
Summary: (ISY1 Splicing Factor Homolog) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Transcription-Coupled Nucleotide Excision Repair (TC-NER). An important paralog of this gene is ISY1-RAB43.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000376973	Isy1	PF06246.12	4.2e-98	1	1
ENSP00000273541	Isy1	PF06246.12	7e-97	1	1
ENSP00000376970	Isy1	PF06246.12	3.7e-88	1	1
ENSP00000426416	Isy1	PF06246.12	3.3e-54	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000471497	ISY1-205	1211	-	-	- (aa)	-	-
ENST00000393292	ISY1-202	988	-	ENSP00000376970	252 (aa)	-	A8MVI5
ENST00000485703	ISY1-206	837	-	ENSP00000422403	124 (aa)	-	D6RC18
ENST00000471306	ISY1-204	552	-	-	- (aa)	-	-
ENST00000496163	ISY1-207	752	-	ENSP00000426416	148 (aa)	-	H0YA89
ENST00000393295	ISY1-203	3842	-	ENSP00000376973	285 (aa)	-	Q9ULR0
ENST00000273541	ISY1-201	1704	-	ENSP00000273541	307 (aa)	-	Q9ULR0

Gene Model

Click here to download ENSG00000240682's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000240682's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000240682	ISY1	99	98.587	ENSAMEG00000015341	-	86	98.587	Ailuropoda_melanoleuca
ENSG00000240682	ISY1	79	96.939	ENSACIG00000014723	isy1	74	88.587	Amphilophus_citrinellus
ENSG00000240682	ISY1	81	97.000	ENSAOCG00000007147	isy1	99	77.193	Amphiprion_ocellaris
ENSG00000240682	ISY1	81	97.000	ENSAPEG00000021883	isy1	99	68.987	Amphiprion_percula
ENSG00000240682	ISY1	80	77.966	ENSATEG00000009521	isy1	84	74.510	Anabas_testudineus
ENSG00000240682	ISY1	99	75.874	ENSAPLG00000014136	-	99	75.874	Anas_platyrhynchos
ENSG00000240682	ISY1	91	87.984	ENSACAG00000013166	-	99	87.597	Anolis_carolinensis
ENSG00000240682	ISY1	100	98.947	ENSANAG00000027120	-	100	98.947	Aotus_nancymaae
ENSG00000240682	ISY1	81	90.000	ENSACLG00000014430	isy1	99	71.831	Astatotilapia_calliptera
ENSG00000240682	ISY1	99	83.509	ENSAMXG00000005423	isy1	99	83.509	Astyanax_mexicanus
ENSG00000240682	ISY1	99	94.366	ENSBTAG00000030915	ISY1	99	94.718	Bos_taurus
ENSG00000240682	ISY1	94	49.632	WBGene00009966	isy-1	99	49.632	Caenorhabditis_elegans
ENSG00000240682	ISY1	100	98.947	ENSCJAG00000017419	-	100	98.947	Callithrix_jacchus
ENSG00000240682	ISY1	100	98.246	ENSCAFG00000004333	ISY1	100	98.246	Canis_familiaris
ENSG00000240682	ISY1	100	98.246	ENSCAFG00020004867	-	100	98.246	Canis_lupus_dingo
ENSG00000240682	ISY1	99	94.366	ENSCHIG00000008237	-	99	94.718	Capra_hircus
ENSG00000240682	ISY1	100	98.947	ENSTSYG00000013897	-	100	98.947	Carlito_syrichta
ENSG00000240682	ISY1	90	87.500	ENSCAPG00000016359	-	100	72.760	Cavia_aperea
ENSG00000240682	ISY1	100	98.596	ENSCPOG00000014735	-	100	98.596	Cavia_porcellus
ENSG00000240682	ISY1	100	99.298	ENSCCAG00000028517	-	100	99.298	Cebus_capucinus
ENSG00000240682	ISY1	100	99.649	ENSCATG00000030672	-	100	99.649	Cercocebus_atys
ENSG00000240682	ISY1	100	98.252	ENSCLAG00000007518	-	100	98.252	Chinchilla_lanigera
ENSG00000240682	ISY1	100	99.649	ENSCSAG00000008798	-	100	99.649	Chlorocebus_sabaeus
ENSG00000240682	ISY1	55	98.765	ENSCHOG00000001401	-	55	97.521	Choloepus_hoffmanni
ENSG00000240682	ISY1	99	89.437	ENSCPBG00000026346	-	99	89.085	Chrysemys_picta_bellii
ENSG00000240682	ISY1	99	65.263	ENSCING00000000716	-	99	63.860	Ciona_intestinalis
ENSG00000240682	ISY1	99	65.141	ENSCSAVG00000008992	-	99	64.014	Ciona_savignyi
ENSG00000240682	ISY1	100	99.649	ENSCANG00000037761	-	100	99.649	Colobus_angolensis_palliatus
ENSG00000240682	ISY1	100	97.544	ENSCGRG00001003415	Isy1	100	97.544	Cricetulus_griseus_chok1gshd
ENSG00000240682	ISY1	100	97.544	ENSCGRG00000011641	Isy1	100	97.544	Cricetulus_griseus_crigri
ENSG00000240682	ISY1	80	95.960	ENSCSEG00000020382	isy1	95	71.713	Cynoglossus_semilaevis
ENSG00000240682	ISY1	99	77.895	ENSCVAG00000000650	isy1	99	77.895	Cyprinodon_variegatus
ENSG00000240682	ISY1	99	82.105	ENSDARG00000063466	isy1	99	82.105	Danio_rerio
ENSG00000240682	ISY1	100	96.503	ENSDNOG00000002763	-	100	96.503	Dasypus_novemcinctus
ENSG00000240682	ISY1	97	97.834	ENSDORG00000006886	Isy1	100	97.834	Dipodomys_ordii
ENSG00000240682	ISY1	79	76.923	FBgn0037550	CG9667	99	60.727	Drosophila_melanogaster
ENSG00000240682	ISY1	96	96.350	ENSETEG00000017009	-	100	96.350	Echinops_telfairi
ENSG00000240682	ISY1	61	65.789	ENSEBUG00000002888	isy1	70	67.188	Eptatretus_burgeri
ENSG00000240682	ISY1	97	94.585	ENSEASG00005015810	-	97	94.585	Equus_asinus_asinus
ENSG00000240682	ISY1	94	98.881	ENSECAG00000013768	-	88	98.881	Equus_caballus
ENSG00000240682	ISY1	99	84.615	ENSELUG00000000489	isy1	99	84.615	Esox_lucius
ENSG00000240682	ISY1	100	98.246	ENSFCAG00000008664	-	100	98.246	Felis_catus
ENSG00000240682	ISY1	99	88.028	ENSFALG00000000023	-	99	88.028	Ficedula_albicollis
ENSG00000240682	ISY1	100	81.754	ENSFALG00000014998	-	100	81.754	Ficedula_albicollis
ENSG00000240682	ISY1	97	97.842	ENSFDAG00000012661	-	95	97.842	Fukomys_damarensis
ENSG00000240682	ISY1	80	95.960	ENSFHEG00000006776	isy1	99	77.895	Fundulus_heteroclitus
ENSG00000240682	ISY1	80	83.051	ENSGMOG00000005635	isy1	73	82.353	Gadus_morhua
ENSG00000240682	ISY1	99	88.732	ENSGALG00000005012	-	99	88.732	Gallus_gallus
ENSG00000240682	ISY1	79	95.918	ENSGAFG00000019550	isy1	99	75.177	Gambusia_affinis
ENSG00000240682	ISY1	80	95.960	ENSGACG00000003342	isy1	99	77.817	Gasterosteus_aculeatus
ENSG00000240682	ISY1	96	87.636	ENSGAGG00000021274	-	97	87.209	Gopherus_agassizii
ENSG00000240682	ISY1	100	100.000	ENSGGOG00000038733	ISY1	100	100.000	Gorilla_gorilla
ENSG00000240682	ISY1	71	65.909	ENSHBUG00000008922	-	92	65.909	Haplochromis_burtoni
ENSG00000240682	ISY1	98	78.648	ENSHGLG00000017889	-	79	78.648	Heterocephalus_glaber_female
ENSG00000240682	ISY1	100	97.895	ENSHGLG00000002576	-	100	97.895	Heterocephalus_glaber_female
ENSG00000240682	ISY1	99	95.804	ENSHGLG00100004254	-	99	95.804	Heterocephalus_glaber_male
ENSG00000240682	ISY1	98	78.648	ENSHGLG00100005531	-	79	78.648	Heterocephalus_glaber_male
ENSG00000240682	ISY1	99	73.145	ENSHCOG00000014775	isy1	99	73.145	Hippocampus_comes
ENSG00000240682	ISY1	99	83.451	ENSIPUG00000011379	Isy1	99	83.451	Ictalurus_punctatus
ENSG00000240682	ISY1	99	97.544	ENSSTOG00000024769	-	100	97.544	Ictidomys_tridecemlineatus
ENSG00000240682	ISY1	80	99.160	ENSJJAG00000009635	Isy1	96	97.309	Jaculus_jaculus
ENSG00000240682	ISY1	99	87.324	ENSLACG00000004490	isy1	99	86.972	Latimeria_chalumnae
ENSG00000240682	ISY1	99	84.912	ENSLOCG00000013988	isy1	99	84.912	Lepisosteus_oculatus
ENSG00000240682	ISY1	99	87.324	ENSLAFG00000004015	-	100	87.324	Loxodonta_africana
ENSG00000240682	ISY1	100	99.649	ENSMFAG00000037074	-	100	99.649	Macaca_fascicularis
ENSG00000240682	ISY1	100	99.649	ENSMMUG00000011580	ISY1-RAB43	100	99.649	Macaca_mulatta
ENSG00000240682	ISY1	99	92.254	ENSMNEG00000043206	ISY1	99	92.254	Macaca_nemestrina
ENSG00000240682	ISY1	100	99.649	ENSMLEG00000033836	-	100	99.649	Mandrillus_leucophaeus
ENSG00000240682	ISY1	99	79.577	ENSMAMG00000009501	isy1	99	78.873	Mastacembelus_armatus
ENSG00000240682	ISY1	81	97.000	ENSMZEG00005012021	isy1	99	78.873	Maylandia_zebra
ENSG00000240682	ISY1	99	87.676	ENSMGAG00000005181	-	99	88.028	Meleagris_gallopavo
ENSG00000240682	ISY1	100	97.544	ENSMAUG00000008793	Isy1	100	97.544	Mesocricetus_auratus
ENSG00000240682	ISY1	97	94.928	ENSMICG00000037547	-	100	94.928	Microcebus_murinus
ENSG00000240682	ISY1	100	98.246	ENSMOCG00000000472	Isy1	100	98.246	Microtus_ochrogaster
ENSG00000240682	ISY1	99	71.034	ENSMMOG00000017810	isy1	99	71.034	Mola_mola
ENSG00000240682	ISY1	100	90.526	ENSMODG00000008387	-	100	90.175	Monodelphis_domestica
ENSG00000240682	ISY1	99	79.298	ENSMALG00000020650	isy1	99	78.596	Monopterus_albus
ENSG00000240682	ISY1	100	98.246	MGP_CAROLIEiJ_G0028619	Isy1	100	98.246	Mus_caroli
ENSG00000240682	ISY1	100	98.246	ENSMUSG00000030056	Isy1	100	98.246	Mus_musculus
ENSG00000240682	ISY1	100	85.664	MGP_PahariEiJ_G0022357	Isy1	100	85.664	Mus_pahari
ENSG00000240682	ISY1	100	98.246	MGP_SPRETEiJ_G0029631	Isy1	100	98.246	Mus_spretus
ENSG00000240682	ISY1	99	88.380	ENSMPUG00000017307	-	95	88.380	Mustela_putorius_furo
ENSG00000240682	ISY1	99	92.958	ENSMLUG00000011804	-	100	92.958	Myotis_lucifugus
ENSG00000240682	ISY1	100	98.596	ENSNGAG00000015207	Isy1	100	98.596	Nannospalax_galili
ENSG00000240682	ISY1	80	90.909	ENSNBRG00000006974	isy1	75	85.556	Neolamprologus_brichardi
ENSG00000240682	ISY1	100	99.649	ENSNLEG00000028747	ISY1	100	99.649	Nomascus_leucogenys
ENSG00000240682	ISY1	82	87.692	ENSMEUG00000008434	-	78	87.692	Notamacropus_eugenii
ENSG00000240682	ISY1	99	96.820	ENSOPRG00000005468	-	85	96.820	Ochotona_princeps
ENSG00000240682	ISY1	97	84.892	ENSODEG00000002067	-	96	85.252	Octodon_degus
ENSG00000240682	ISY1	81	90.000	ENSONIG00000000267	isy1	100	74.603	Oreochromis_niloticus
ENSG00000240682	ISY1	99	79.715	ENSOANG00000013141	-	99	79.004	Ornithorhynchus_anatinus
ENSG00000240682	ISY1	100	98.246	ENSOCUG00000003923	-	100	98.246	Oryctolagus_cuniculus
ENSG00000240682	ISY1	99	77.163	ENSORLG00000013250	isy1	99	76.842	Oryzias_latipes
ENSG00000240682	ISY1	80	95.960	ENSORLG00020020966	isy1	99	76.491	Oryzias_latipes_hni
ENSG00000240682	ISY1	99	77.163	ENSORLG00015017316	isy1	99	76.125	Oryzias_latipes_hsok
ENSG00000240682	ISY1	99	76.207	ENSOMEG00000023905	isy1	99	75.874	Oryzias_melastigma
ENSG00000240682	ISY1	99	99.296	ENSOGAG00000005142	-	99	99.296	Otolemur_garnettii
ENSG00000240682	ISY1	99	90.845	ENSOARG00000003231	-	94	91.197	Ovis_aries
ENSG00000240682	ISY1	100	99.649	ENSPPAG00000042141	-	100	99.649	Pan_paniscus
ENSG00000240682	ISY1	100	98.246	ENSPPRG00000003480	-	100	98.246	Panthera_pardus
ENSG00000240682	ISY1	100	98.246	ENSPTIG00000017919	-	100	98.246	Panthera_tigris_altaica
ENSG00000240682	ISY1	100	100.000	ENSPTRG00000015367	ISY1	100	100.000	Pan_troglodytes
ENSG00000240682	ISY1	100	99.298	ENSPANG00000004750	-	100	99.298	Papio_anubis
ENSG00000240682	ISY1	99	84.507	ENSPKIG00000024592	isy1	99	84.507	Paramormyrops_kingsleyae
ENSG00000240682	ISY1	99	88.028	ENSPSIG00000009384	-	99	87.676	Pelodiscus_sinensis
ENSG00000240682	ISY1	96	66.909	ENSPMGG00000016328	isy1	88	65.091	Periophthalmus_magnuspinnatus
ENSG00000240682	ISY1	100	97.895	ENSPEMG00000005390	Isy1	100	97.895	Peromyscus_maniculatus_bairdii
ENSG00000240682	ISY1	80	91.000	ENSPMAG00000005010	-	99	85.475	Petromyzon_marinus
ENSG00000240682	ISY1	100	90.526	ENSPCIG00000000466	-	74	90.175	Phascolarctos_cinereus
ENSG00000240682	ISY1	51	80.000	ENSPFOG00000010228	isy1	99	66.480	Poecilia_formosa
ENSG00000240682	ISY1	79	94.898	ENSPREG00000015121	isy1	99	70.357	Poecilia_reticulata
ENSG00000240682	ISY1	100	99.649	ENSPPYG00000013424	-	100	99.649	Pongo_abelii
ENSG00000240682	ISY1	99	87.582	ENSPCAG00000009535	-	100	87.582	Procavia_capensis
ENSG00000240682	ISY1	74	100.000	ENSPCOG00000025242	-	100	100.000	Propithecus_coquereli
ENSG00000240682	ISY1	99	83.509	ENSPNAG00000000703	isy1	99	83.509	Pygocentrus_nattereri
ENSG00000240682	ISY1	100	97.895	ENSRNOG00000010021	Isy1	100	97.895	Rattus_norvegicus
ENSG00000240682	ISY1	100	85.614	ENSRBIG00000028747	ISY1	100	85.614	Rhinopithecus_bieti
ENSG00000240682	ISY1	100	99.649	ENSRROG00000032314	ISY1	100	99.649	Rhinopithecus_roxellana
ENSG00000240682	ISY1	73	36.458	YJR050W	ISY1	63	34.437	Saccharomyces_cerevisiae
ENSG00000240682	ISY1	100	99.298	ENSSBOG00000029301	-	100	99.298	Saimiri_boliviensis_boliviensis
ENSG00000240682	ISY1	100	90.526	ENSSHAG00000017192	-	100	90.175	Sarcophilus_harrisii
ENSG00000240682	ISY1	99	83.860	ENSSFOG00015001127	isy1	99	83.860	Scleropages_formosus
ENSG00000240682	ISY1	99	78.947	ENSSMAG00000006601	isy1	99	77.895	Scophthalmus_maximus
ENSG00000240682	ISY1	99	78.947	ENSSDUG00000018291	isy1	99	79.298	Seriola_dumerili
ENSG00000240682	ISY1	99	78.596	ENSSLDG00000022252	isy1	99	78.947	Seriola_lalandi_dorsalis
ENSG00000240682	ISY1	54	98.750	ENSSARG00000007648	-	67	72.678	Sorex_araneus
ENSG00000240682	ISY1	99	89.085	ENSSPUG00000018050	-	99	88.732	Sphenodon_punctatus
ENSG00000240682	ISY1	73	97.778	ENSSPAG00000021900	isy1	63	89.474	Stegastes_partitus
ENSG00000240682	ISY1	100	97.895	ENSSSCG00000038900	-	100	97.895	Sus_scrofa
ENSG00000240682	ISY1	80	87.288	ENSTGUG00000003998	-	99	83.710	Taeniopygia_guttata
ENSG00000240682	ISY1	80	96.970	ENSTGUG00000007076	-	100	85.593	Taeniopygia_guttata
ENSG00000240682	ISY1	80	94.949	ENSTRUG00000002546	isy1	96	87.778	Takifugu_rubripes
ENSG00000240682	ISY1	96	78.333	ENSTNIG00000005224	isy1	99	72.318	Tetraodon_nigroviridis
ENSG00000240682	ISY1	79	95.726	ENSTBEG00000006938	-	100	76.364	Tupaia_belangeri
ENSG00000240682	ISY1	99	92.606	ENSTTRG00000015267	-	100	92.606	Tursiops_truncatus
ENSG00000240682	ISY1	79	93.878	ENSUAMG00000018980	-	81	100.000	Ursus_americanus
ENSG00000240682	ISY1	64	100.000	ENSVPAG00000015390	-	63	100.000	Vicugna_pacos
ENSG00000240682	ISY1	100	98.246	ENSVVUG00000018261	-	100	98.246	Vulpes_vulpes
ENSG00000240682	ISY1	76	94.681	ENSXETG00000018921	isy1	100	96.923	Xenopus_tropicalis
ENSG00000240682	ISY1	79	97.959	ENSXCOG00000017248	isy1	99	88.596	Xiphophorus_couchianus
ENSG00000240682	ISY1	80	97.980	ENSXMAG00000012452	isy1	99	76.761	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000350	generation of catalytic spliceosome for second transesterification step	21873635.	IBA	Process
GO:0000384	first spliceosomal transesterification activity	21873635.	IBA	Function
GO:0000389	mRNA 3'-splice site recognition	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000974	Prp19 complex	21873635.	IBA	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	22365833.25599396.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0071013	catalytic step 2 spliceosome	21873635.	IBA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component
GO:0071014	post-mRNA release spliceosomal complex	21873635.	IBA	Component
GO:0071020	post-spliceosomal complex	21873635.	IBA	Component