EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000241058 (Gene tree)
Gene ID: 221078
Gene Symbol: NSUN6
Alias: FLJ23743|NOPD1|ARL5B-AS1
Full Name: NOP2/Sun RNA methyltransferase 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 114,103 bases
Position: chr10:18,545,207-18,659,309
Accession: 23529
RBP type: canonical RBP
Summary: (NOP2/Sun RNA Methyltransferase 6) is a Protein Coding gene. Diseases associated with NSUN6 include Brugada Syndrome 4 and Brugada Syndrome. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is NSUN5.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000366519	Methyltr_RsmB-F	PF01189.17	9.2e-45	1	1
ENSP00000366519	Methyltransf_31	PF13847.6	5.4e-07	1	1
ENSP00000366519	FtsJ	PF01728.19	2.1e-06	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28531330	Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6.	Nucleic Acids Res	2017 Jun 20	Liu RJ	doi: 10.1093/nar/gkx473.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000449529	NSUN6-204	689	-	-	- (aa)	-	-
ENST00000444660	NSUN6-203	524	-	-	- (aa)	-	-
ENST00000606425	NSUN6-207	578	-	ENSP00000476221	149 (aa)	-	U3KQU2
ENST00000456217	NSUN6-205	392	-	-	- (aa)	-	-
ENST00000607346	NSUN6-208	553	-	ENSP00000486203	35 (aa)	-	A0A0D9SF14
ENST00000377304	NSUN6-201	2201	XM_011519383	ENSP00000366519	469 (aa)	XP_011517685	Q8TEA1
ENST00000414939	NSUN6-202	637	-	-	- (aa)	-	-
ENST00000493816	NSUN6-206	315	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000241058's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000241058	rs11015020	10	18588058	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000241058	rs4445544	10	18587155	C	Schizophrenia	30285260	[1.05-1.1]	1.074	EFO_0000692

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000241058's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000241058	NSUN6	99	59.574	ENSAPOG00000016126	nsun6	99	59.574	Acanthochromis_polyacanthus
ENSG00000241058	NSUN6	100	88.273	ENSAMEG00000012963	NSUN6	100	88.273	Ailuropoda_melanoleuca
ENSG00000241058	NSUN6	99	60.645	ENSACIG00000016632	nsun6	99	60.645	Amphilophus_citrinellus
ENSG00000241058	NSUN6	99	60.381	ENSAOCG00000020920	nsun6	99	60.381	Amphiprion_ocellaris
ENSG00000241058	NSUN6	99	60.169	ENSAPEG00000015212	nsun6	95	60.169	Amphiprion_percula
ENSG00000241058	NSUN6	99	61.064	ENSATEG00000004585	nsun6	99	61.064	Anabas_testudineus
ENSG00000241058	NSUN6	99	71.828	ENSAPLG00000013473	NSUN6	99	71.828	Anas_platyrhynchos
ENSG00000241058	NSUN6	91	71.852	ENSACAG00000005626	NSUN6	98	66.964	Anolis_carolinensis
ENSG00000241058	NSUN6	100	95.522	ENSANAG00000027899	NSUN6	100	95.522	Aotus_nancymaae
ENSG00000241058	NSUN6	99	60.722	ENSACLG00000000803	nsun6	99	60.722	Astatotilapia_calliptera
ENSG00000241058	NSUN6	99	58.511	ENSAMXG00000010451	nsun6	99	58.511	Astyanax_mexicanus
ENSG00000241058	NSUN6	91	86.765	ENSBTAG00000022003	NSUN6	98	88.722	Bos_taurus
ENSG00000241058	NSUN6	100	94.670	ENSCJAG00000008427	NSUN6	100	94.670	Callithrix_jacchus
ENSG00000241058	NSUN6	100	88.273	ENSCAFG00000004422	NSUN6	100	88.273	Canis_familiaris
ENSG00000241058	NSUN6	100	88.273	ENSCAFG00020012116	NSUN6	100	88.273	Canis_lupus_dingo
ENSG00000241058	NSUN6	100	85.501	ENSCHIG00000012618	NSUN6	99	85.501	Capra_hircus
ENSG00000241058	NSUN6	100	90.618	ENSTSYG00000010744	NSUN6	100	90.618	Carlito_syrichta
ENSG00000241058	NSUN6	89	80.815	ENSCPOG00000005850	-	98	80.815	Cavia_porcellus
ENSG00000241058	NSUN6	93	74.945	ENSCPOG00000022824	-	98	74.945	Cavia_porcellus
ENSG00000241058	NSUN6	100	94.883	ENSCCAG00000036696	NSUN6	100	94.883	Cebus_capucinus
ENSG00000241058	NSUN6	100	97.868	ENSCATG00000038294	NSUN6	100	97.868	Cercocebus_atys
ENSG00000241058	NSUN6	100	85.075	ENSCLAG00000008092	NSUN6	99	85.075	Chinchilla_lanigera
ENSG00000241058	NSUN6	100	97.655	ENSCSAG00000012571	NSUN6	100	97.655	Chlorocebus_sabaeus
ENSG00000241058	NSUN6	91	61.765	ENSCHOG00000006503	-	69	77.679	Choloepus_hoffmanni
ENSG00000241058	NSUN6	99	73.932	ENSCPBG00000015063	NSUN6	98	75.439	Chrysemys_picta_bellii
ENSG00000241058	NSUN6	79	38.843	ENSCING00000017577	-	98	44.958	Ciona_intestinalis
ENSG00000241058	NSUN6	100	98.294	ENSCANG00000033916	NSUN6	100	98.294	Colobus_angolensis_palliatus
ENSG00000241058	NSUN6	100	82.303	ENSCGRG00001023166	Nsun6	99	82.303	Cricetulus_griseus_chok1gshd
ENSG00000241058	NSUN6	100	82.303	ENSCGRG00000016549	Nsun6	99	82.303	Cricetulus_griseus_crigri
ENSG00000241058	NSUN6	99	61.505	ENSCSEG00000000514	nsun6	99	61.505	Cynoglossus_semilaevis
ENSG00000241058	NSUN6	99	59.408	ENSCVAG00000006888	nsun6	99	59.408	Cyprinodon_variegatus
ENSG00000241058	NSUN6	99	57.419	ENSDARG00000103478	nsun6	99	57.419	Danio_rerio
ENSG00000241058	NSUN6	100	78.891	ENSDNOG00000014162	NSUN6	100	78.891	Dasypus_novemcinctus
ENSG00000241058	NSUN6	100	85.288	ENSDORG00000001962	Nsun6	99	85.288	Dipodomys_ordii
ENSG00000241058	NSUN6	90	41.149	FBgn0037200	CG11109	94	43.767	Drosophila_melanogaster
ENSG00000241058	NSUN6	79	83.929	ENSETEG00000020201	NSUN6	79	83.929	Echinops_telfairi
ENSG00000241058	NSUN6	75	55.372	ENSEBUG00000002845	nsun6	92	55.372	Eptatretus_burgeri
ENSG00000241058	NSUN6	100	90.618	ENSEASG00005019939	NSUN6	100	90.618	Equus_asinus_asinus
ENSG00000241058	NSUN6	100	90.405	ENSECAG00000009221	NSUN6	100	90.405	Equus_caballus
ENSG00000241058	NSUN6	100	65.672	ENSEEUG00000008356	NSUN6	100	65.672	Erinaceus_europaeus
ENSG00000241058	NSUN6	99	59.958	ENSELUG00000021983	nsun6	92	59.958	Esox_lucius
ENSG00000241058	NSUN6	98	89.083	ENSFCAG00000015494	NSUN6	84	88.915	Felis_catus
ENSG00000241058	NSUN6	99	73.932	ENSFALG00000007398	NSUN6	99	73.932	Ficedula_albicollis
ENSG00000241058	NSUN6	89	86.842	ENSFDAG00000021538	NSUN6	99	86.842	Fukomys_damarensis
ENSG00000241058	NSUN6	99	60.510	ENSFHEG00000014522	nsun6	99	60.510	Fundulus_heteroclitus
ENSG00000241058	NSUN6	99	58.030	ENSGMOG00000011167	nsun6	100	58.030	Gadus_morhua
ENSG00000241058	NSUN6	99	73.662	ENSGALG00000008564	NSUN6	99	73.662	Gallus_gallus
ENSG00000241058	NSUN6	99	60.213	ENSGAFG00000002703	nsun6	99	60.213	Gambusia_affinis
ENSG00000241058	NSUN6	99	58.577	ENSGACG00000004059	nsun6	99	58.577	Gasterosteus_aculeatus
ENSG00000241058	NSUN6	95	74.099	ENSGAGG00000011440	NSUN6	94	74.773	Gopherus_agassizii
ENSG00000241058	NSUN6	100	99.360	ENSGGOG00000009321	NSUN6	100	99.360	Gorilla_gorilla
ENSG00000241058	NSUN6	99	60.722	ENSHBUG00000009093	nsun6	99	60.722	Haplochromis_burtoni
ENSG00000241058	NSUN6	100	86.567	ENSHGLG00000008085	NSUN6	99	86.567	Heterocephalus_glaber_female
ENSG00000241058	NSUN6	100	86.567	ENSHGLG00100016673	NSUN6	99	86.567	Heterocephalus_glaber_male
ENSG00000241058	NSUN6	99	59.529	ENSHCOG00000015758	nsun6	99	59.529	Hippocampus_comes
ENSG00000241058	NSUN6	99	58.475	ENSIPUG00000006281	nsun6	98	58.475	Ictalurus_punctatus
ENSG00000241058	NSUN6	100	86.354	ENSSTOG00000004317	NSUN6	99	86.354	Ictidomys_tridecemlineatus
ENSG00000241058	NSUN6	100	77.612	ENSJJAG00000001860	Nsun6	99	78.038	Jaculus_jaculus
ENSG00000241058	NSUN6	99	60.000	ENSKMAG00000013611	nsun6	99	60.000	Kryptolebias_marmoratus
ENSG00000241058	NSUN6	99	59.414	ENSLBEG00000017133	nsun6	99	59.414	Labrus_bergylta
ENSG00000241058	NSUN6	99	68.817	ENSLACG00000015374	NSUN6	99	68.817	Latimeria_chalumnae
ENSG00000241058	NSUN6	99	64.346	ENSLOCG00000010862	nsun6	98	64.346	Lepisosteus_oculatus
ENSG00000241058	NSUN6	100	89.979	ENSLAFG00000001485	NSUN6	100	89.979	Loxodonta_africana
ENSG00000241058	NSUN6	100	97.441	ENSMFAG00000045602	NSUN6	100	97.441	Macaca_fascicularis
ENSG00000241058	NSUN6	100	97.228	ENSMMUG00000007451	NSUN6	100	97.228	Macaca_mulatta
ENSG00000241058	NSUN6	100	97.228	ENSMNEG00000045340	NSUN6	100	97.228	Macaca_nemestrina
ENSG00000241058	NSUN6	100	97.441	ENSMLEG00000032035	NSUN6	100	97.441	Mandrillus_leucophaeus
ENSG00000241058	NSUN6	99	60.638	ENSMAMG00000004915	nsun6	99	60.638	Mastacembelus_armatus
ENSG00000241058	NSUN6	99	60.722	ENSMZEG00005000999	nsun6	99	60.722	Maylandia_zebra
ENSG00000241058	NSUN6	100	73.348	ENSMGAG00000007427	NSUN6	99	73.348	Meleagris_gallopavo
ENSG00000241058	NSUN6	100	84.222	ENSMAUG00000016025	Nsun6	99	84.222	Mesocricetus_auratus
ENSG00000241058	NSUN6	100	91.684	ENSMICG00000029435	NSUN6	100	91.684	Microcebus_murinus
ENSG00000241058	NSUN6	100	84.009	ENSMOCG00000009814	Nsun6	99	84.009	Microtus_ochrogaster
ENSG00000241058	NSUN6	99	58.562	ENSMMOG00000004263	nsun6	99	58.562	Mola_mola
ENSG00000241058	NSUN6	99	80.983	ENSMODG00000009471	NSUN6	99	80.983	Monodelphis_domestica
ENSG00000241058	NSUN6	99	60.213	ENSMALG00000020340	nsun6	99	60.213	Monopterus_albus
ENSG00000241058	NSUN6	100	81.663	MGP_CAROLIEiJ_G0023196	Nsun6	99	81.663	Mus_caroli
ENSG00000241058	NSUN6	100	81.237	ENSMUSG00000026707	Nsun6	99	81.237	Mus_musculus
ENSG00000241058	NSUN6	100	88.486	ENSMPUG00000011900	NSUN6	100	88.486	Mustela_putorius_furo
ENSG00000241058	NSUN6	99	88.248	ENSMLUG00000001824	NSUN6	98	88.248	Myotis_lucifugus
ENSG00000241058	NSUN6	100	85.288	ENSNGAG00000004582	Nsun6	99	85.288	Nannospalax_galili
ENSG00000241058	NSUN6	100	98.507	ENSNLEG00000012680	NSUN6	100	98.507	Nomascus_leucogenys
ENSG00000241058	NSUN6	94	57.111	ENSMEUG00000005251	NSUN6	99	57.111	Notamacropus_eugenii
ENSG00000241058	NSUN6	100	57.143	ENSOPRG00000006008	-	100	57.143	Ochotona_princeps
ENSG00000241058	NSUN6	91	87.150	ENSODEG00000010093	NSUN6	99	87.150	Octodon_degus
ENSG00000241058	NSUN6	99	60.549	ENSONIG00000006038	nsun6	99	60.549	Oreochromis_niloticus
ENSG00000241058	NSUN6	100	70.789	ENSOANG00000005705	NSUN6	96	70.789	Ornithorhynchus_anatinus
ENSG00000241058	NSUN6	100	86.892	ENSOCUG00000014870	NSUN6	79	86.892	Oryctolagus_cuniculus
ENSG00000241058	NSUN6	99	60.684	ENSORLG00000010870	nsun6	99	60.684	Oryzias_latipes
ENSG00000241058	NSUN6	99	60.470	ENSORLG00020009913	nsun6	99	60.470	Oryzias_latipes_hni
ENSG00000241058	NSUN6	99	60.684	ENSORLG00015009893	nsun6	99	60.684	Oryzias_latipes_hsok
ENSG00000241058	NSUN6	99	59.708	ENSOMEG00000003613	nsun6	99	59.708	Oryzias_melastigma
ENSG00000241058	NSUN6	99	87.500	ENSOGAG00000003925	NSUN6	100	87.500	Otolemur_garnettii
ENSG00000241058	NSUN6	100	86.780	ENSOARG00000013212	NSUN6	99	86.780	Ovis_aries
ENSG00000241058	NSUN6	100	98.934	ENSPPAG00000042405	NSUN6	100	98.934	Pan_paniscus
ENSG00000241058	NSUN6	100	89.126	ENSPPRG00000007015	NSUN6	100	89.126	Panthera_pardus
ENSG00000241058	NSUN6	100	89.126	ENSPTIG00000010890	NSUN6	100	89.126	Panthera_tigris_altaica
ENSG00000241058	NSUN6	100	94.670	ENSPTRG00000002340	NSUN6	100	94.670	Pan_troglodytes
ENSG00000241058	NSUN6	100	97.655	ENSPANG00000023143	NSUN6	100	97.655	Papio_anubis
ENSG00000241058	NSUN6	99	60.722	ENSPKIG00000011356	nsun6	97	60.722	Paramormyrops_kingsleyae
ENSG00000241058	NSUN6	99	72.222	ENSPSIG00000014756	NSUN6	99	72.222	Pelodiscus_sinensis
ENSG00000241058	NSUN6	99	60.385	ENSPMGG00000002869	nsun6	99	60.385	Periophthalmus_magnuspinnatus
ENSG00000241058	NSUN6	100	84.222	ENSPEMG00000023389	Nsun6	99	84.222	Peromyscus_maniculatus_bairdii
ENSG00000241058	NSUN6	99	47.257	ENSPMAG00000003159	nsun6	99	47.257	Petromyzon_marinus
ENSG00000241058	NSUN6	99	80.720	ENSPCIG00000008953	NSUN6	99	80.720	Phascolarctos_cinereus
ENSG00000241058	NSUN6	99	60.213	ENSPFOG00000016647	nsun6	99	60.213	Poecilia_formosa
ENSG00000241058	NSUN6	99	60.000	ENSPLAG00000021785	nsun6	99	60.000	Poecilia_latipinna
ENSG00000241058	NSUN6	99	60.213	ENSPMEG00000022256	nsun6	99	60.213	Poecilia_mexicana
ENSG00000241058	NSUN6	99	60.000	ENSPREG00000008237	nsun6	99	60.000	Poecilia_reticulata
ENSG00000241058	NSUN6	100	94.456	ENSPPYG00000002131	NSUN6	100	94.456	Pongo_abelii
ENSG00000241058	NSUN6	60	95.833	ENSPCAG00000014335	-	71	95.833	Procavia_capensis
ENSG00000241058	NSUN6	100	73.830	ENSPCOG00000004346	NSUN6	100	73.830	Propithecus_coquereli
ENSG00000241058	NSUN6	91	92.647	ENSPVAG00000006329	NSUN6	81	92.237	Pteropus_vampyrus
ENSG00000241058	NSUN6	99	61.456	ENSPNYG00000000646	nsun6	99	61.456	Pundamilia_nyererei
ENSG00000241058	NSUN6	99	59.831	ENSPNAG00000000807	nsun6	99	59.831	Pygocentrus_nattereri
ENSG00000241058	NSUN6	100	80.171	ENSRNOG00000018520	Nsun6	99	80.171	Rattus_norvegicus
ENSG00000241058	NSUN6	100	98.081	ENSRBIG00000033358	NSUN6	100	98.081	Rhinopithecus_bieti
ENSG00000241058	NSUN6	100	98.081	ENSRROG00000033711	NSUN6	100	98.081	Rhinopithecus_roxellana
ENSG00000241058	NSUN6	91	94.118	ENSSBOG00000036167	NSUN6	100	84.861	Saimiri_boliviensis_boliviensis
ENSG00000241058	NSUN6	100	80.679	ENSSHAG00000008315	NSUN6	100	80.679	Sarcophilus_harrisii
ENSG00000241058	NSUN6	99	59.751	ENSSFOG00015001941	nsun6	99	59.751	Scleropages_formosus
ENSG00000241058	NSUN6	99	60.510	ENSSMAG00000011608	nsun6	99	60.510	Scophthalmus_maximus
ENSG00000241058	NSUN6	99	62.340	ENSSDUG00000007541	nsun6	99	62.340	Seriola_dumerili
ENSG00000241058	NSUN6	99	62.128	ENSSLDG00000021347	nsun6	99	62.128	Seriola_lalandi_dorsalis
ENSG00000241058	NSUN6	83	79.394	ENSSARG00000013595	NSUN6	83	79.394	Sorex_araneus
ENSG00000241058	NSUN6	97	71.272	ENSSPUG00000014085	NSUN6	98	71.272	Sphenodon_punctatus
ENSG00000241058	NSUN6	99	59.110	ENSSPAG00000012441	nsun6	99	59.110	Stegastes_partitus
ENSG00000241058	NSUN6	100	85.928	ENSSSCG00000011041	NSUN6	99	85.928	Sus_scrofa
ENSG00000241058	NSUN6	99	74.786	ENSTGUG00000001241	NSUN6	99	74.786	Taeniopygia_guttata
ENSG00000241058	NSUN6	99	52.917	ENSTRUG00000008314	nsun6	99	52.917	Takifugu_rubripes
ENSG00000241058	NSUN6	84	68.878	ENSTBEG00000010815	NSUN6	99	68.878	Tupaia_belangeri
ENSG00000241058	NSUN6	99	85.684	ENSTTRG00000007423	NSUN6	100	85.684	Tursiops_truncatus
ENSG00000241058	NSUN6	100	88.913	ENSUMAG00000013383	NSUN6	100	88.913	Ursus_maritimus
ENSG00000241058	NSUN6	74	82.051	ENSVPAG00000010144	NSUN6	79	82.051	Vicugna_pacos
ENSG00000241058	NSUN6	100	88.273	ENSVVUG00000003814	NSUN6	100	88.273	Vulpes_vulpes
ENSG00000241058	NSUN6	100	68.298	ENSXETG00000022762	nsun6	100	68.590	Xenopus_tropicalis
ENSG00000241058	NSUN6	99	60.256	ENSXCOG00000011542	nsun6	99	60.256	Xiphophorus_couchianus
ENSG00000241058	NSUN6	99	60.213	ENSXMAG00000002289	nsun6	99	60.213	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	26160102.	IDA	Function
GO:0005737	cytoplasm	26160102.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006400	tRNA modification	-	TAS	Process
GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	26160102.	EXP	Function
GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	26160102.	IDA	Function
GO:0030488	tRNA methylation	-	IEA	Process