EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000241370 (Gene tree)
Gene ID: 79897
Gene Symbol: RPP21
Alias: FLJ22638|Em:AB014085.3|C6orf135
Full Name: ribonuclease P/MRP subunit p21
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 1,756 bases
Position: chr6:30,345,129-30,346,884
Accession: 21300
RBP type: canonical RBP
Summary: RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000397778	Rpr2	PF04032.16	3.4e-19	1	1
ENSP00000403833	Rpr2	PF04032.16	3.7e-19	1	1
ENSP00000394320	Rpr2	PF04032.16	4.8e-17	1	1
ENSP00000409799	Rpr2	PF04032.16	1.3e-16	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25361963	The L7Ae protein binds to two kink-turns in the Pyrococcus furiosus RNase P RNA.	Nucleic Acids Res	2014 Dec 1	Lai SM	doi: 10.1093/nar/gku994

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000436442	RPP21-223	522	-	ENSP00000397778	144 (aa)	-	Q9H633
ENST00000466327	RPP21-225	697	-	-	- (aa)	-	-
ENST00000489124	RPP21-227	450	-	-	- (aa)	-	-
ENST00000473266	RPP21-226	621	-	-	- (aa)	-	-
ENST00000433076	RPP21-222	577	-	ENSP00000409799	162 (aa)	-	Q9H633
ENST00000428040	RPP21-221	594	-	ENSP00000394320	177 (aa)	-	Q9H633
ENST00000491477	RPP21-228	457	-	-	- (aa)	-	-
ENST00000442966	RPP21-224	525	-	ENSP00000403833	154 (aa)	-	Q9H633
ENST00000498414	RPP21-229	1492	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000241370's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000241370	Body Height	8.0750000E-007	-
ENSG00000241370	Body Height	3.9380000E-005	-
ENSG00000241370	Trans Fatty Acids	5E-6	25646338

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000241370	rs6986	6	30345563	C	Neuroticism	29255261	z score increase	5.76	EFO_0007660
ENSG00000241370	rs6986	6	30345563	C	Trans fatty acid levels	25646338	[0.0046-0.0112] unit decrease	0.0079	EFO_0006821\|EFO_0006822
ENSG00000241370	rs6986	6	30345563	C	Feeling guilty	29500382	z score increase	7.25	EFO_0009595
ENSG00000241370	rs6986	6	30345563	C	Neurociticism	29500382	z score increase	6.16	EFO_0007660

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000241370's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000241370	RPP21	100	55.484	ENSAPOG00000008135	rpp21	97	53.548	Acanthochromis_polyacanthus
ENSG00000241370	RPP21	95	59.854	ENSACIG00000013344	rpp21	92	59.028	Amphilophus_citrinellus
ENSG00000241370	RPP21	84	63.934	ENSAOCG00000004192	rpp21	90	54.483	Amphiprion_ocellaris
ENSG00000241370	RPP21	84	63.115	ENSAPEG00000013689	-	92	53.793	Amphiprion_percula
ENSG00000241370	RPP21	84	63.115	ENSATEG00000016264	rpp21	81	61.417	Anabas_testudineus
ENSG00000241370	RPP21	83	63.866	ENSACAG00000011124	RPP21	98	63.866	Anolis_carolinensis
ENSG00000241370	RPP21	95	58.696	ENSACLG00000014185	rpp21	86	57.246	Astatotilapia_calliptera
ENSG00000241370	RPP21	84	68.595	ENSAMXG00000030709	rpp21	85	64.122	Astyanax_mexicanus
ENSG00000241370	RPP21	99	88.889	ENSBTAG00000050907	RPP21	80	88.889	Bos_taurus
ENSG00000241370	RPP21	100	87.662	ENSCAFG00000000394	RPP21	64	87.662	Canis_familiaris
ENSG00000241370	RPP21	100	88.312	ENSCHIG00000015983	RPP21	100	88.312	Capra_hircus
ENSG00000241370	RPP21	96	72.368	ENSTSYG00000034484	-	100	72.368	Carlito_syrichta
ENSG00000241370	RPP21	94	66.897	ENSTSYG00000010569	-	96	66.897	Carlito_syrichta
ENSG00000241370	RPP21	96	72.368	ENSTSYG00000034615	-	100	72.368	Carlito_syrichta
ENSG00000241370	RPP21	99	70.988	ENSTSYG00000013429	-	100	70.988	Carlito_syrichta
ENSG00000241370	RPP21	100	89.610	ENSTSYG00000033346	-	100	89.610	Carlito_syrichta
ENSG00000241370	RPP21	97	88.000	ENSCPOG00000006048	RPP21	93	88.000	Cavia_porcellus
ENSG00000241370	RPP21	99	86.275	ENSCLAG00000010598	RPP21	99	86.275	Chinchilla_lanigera
ENSG00000241370	RPP21	100	96.753	ENSCSAG00000008160	RPP21	100	96.753	Chlorocebus_sabaeus
ENSG00000241370	RPP21	72	62.136	ENSCPBG00000018817	RPP21	66	61.207	Chrysemys_picta_bellii
ENSG00000241370	RPP21	77	41.964	ENSCING00000019032	-	83	42.342	Ciona_intestinalis
ENSG00000241370	RPP21	79	40.870	ENSCSAVG00000010664	-	86	40.351	Ciona_savignyi
ENSG00000241370	RPP21	100	96.104	ENSCANG00000011612	-	100	96.104	Colobus_angolensis_palliatus
ENSG00000241370	RPP21	88	87.407	ENSCGRG00001011454	Rpp21	99	87.407	Cricetulus_griseus_chok1gshd
ENSG00000241370	RPP21	56	91.358	ENSCGRG00000013849	Rpp21	92	90.789	Cricetulus_griseus_crigri
ENSG00000241370	RPP21	100	54.140	ENSCSEG00000004131	rpp21	97	53.503	Cynoglossus_semilaevis
ENSG00000241370	RPP21	84	66.393	ENSCVAG00000015508	rpp21	74	66.393	Cyprinodon_variegatus
ENSG00000241370	RPP21	86	65.600	ENSDARG00000043404	rpp21	76	64.800	Danio_rerio
ENSG00000241370	RPP21	99	62.712	ENSETEG00000019458	-	100	59.887	Echinops_telfairi
ENSG00000241370	RPP21	100	84.358	ENSEASG00005018608	RPP21	100	84.358	Equus_asinus_asinus
ENSG00000241370	RPP21	82	83.673	ENSEEUG00000009996	RPP21	100	83.673	Erinaceus_europaeus
ENSG00000241370	RPP21	98	57.042	ENSELUG00000012638	rpp21	98	54.930	Esox_lucius
ENSG00000241370	RPP21	100	87.013	ENSFCAG00000034409	RPP21	100	87.013	Felis_catus
ENSG00000241370	RPP21	98	87.417	ENSFDAG00000012690	RPP21	98	87.417	Fukomys_damarensis
ENSG00000241370	RPP21	86	63.780	ENSFHEG00000001048	-	70	58.209	Fundulus_heteroclitus
ENSG00000241370	RPP21	94	58.088	ENSGAFG00000007229	rpp21	100	55.882	Gambusia_affinis
ENSG00000241370	RPP21	84	64.463	ENSGAGG00000014525	RPP21	74	62.595	Gopherus_agassizii
ENSG00000241370	RPP21	78	63.717	ENSHBUG00000015712	rpp21	100	61.062	Haplochromis_burtoni
ENSG00000241370	RPP21	97	87.919	ENSHGLG00000017208	RPP21	97	87.919	Heterocephalus_glaber_female
ENSG00000241370	RPP21	97	87.919	ENSHGLG00100009543	RPP21	97	87.919	Heterocephalus_glaber_male
ENSG00000241370	RPP21	81	62.185	ENSHCOG00000016770	rpp21	74	61.017	Hippocampus_comes
ENSG00000241370	RPP21	84	64.463	ENSIPUG00000024910	rpp21	79	64.463	Ictalurus_punctatus
ENSG00000241370	RPP21	97	85.906	ENSSTOG00000001680	RPP21	92	85.906	Ictidomys_tridecemlineatus
ENSG00000241370	RPP21	99	83.660	ENSJJAG00000011176	-	97	83.660	Jaculus_jaculus
ENSG00000241370	RPP21	99	55.944	ENSKMAG00000004174	rpp21	89	53.846	Kryptolebias_marmoratus
ENSG00000241370	RPP21	84	64.754	ENSLBEG00000010436	rpp21	77	60.630	Labrus_bergylta
ENSG00000241370	RPP21	85	60.976	ENSLACG00000001685	rpp21	80	57.600	Latimeria_chalumnae
ENSG00000241370	RPP21	100	57.419	ENSLOCG00000005595	rpp21	94	59.355	Lepisosteus_oculatus
ENSG00000241370	RPP21	99	84.314	ENSLAFG00000010777	-	99	84.314	Loxodonta_africana
ENSG00000241370	RPP21	94	55.479	ENSMAMG00000016016	rpp21	88	54.795	Mastacembelus_armatus
ENSG00000241370	RPP21	95	58.696	ENSMZEG00005019901	rpp21	86	57.246	Maylandia_zebra
ENSG00000241370	RPP21	97	81.333	ENSMAUG00000018282	Rpp21	92	81.333	Mesocricetus_auratus
ENSG00000241370	RPP21	98	81.457	ENSMOCG00000021357	Rpp21	91	81.457	Microtus_ochrogaster
ENSG00000241370	RPP21	82	60.504	ENSMMOG00000003373	rpp21	79	60.504	Mola_mola
ENSG00000241370	RPP21	99	76.761	ENSMODG00000015967	RPP21	90	81.159	Monodelphis_domestica
ENSG00000241370	RPP21	97	58.451	ENSMALG00000008960	rpp21	93	57.241	Monopterus_albus
ENSG00000241370	RPP21	97	80.667	MGP_CAROLIEiJ_G0021549	Rpp21	97	80.667	Mus_caroli
ENSG00000241370	RPP21	97	81.333	ENSMUSG00000024446	Rpp21	97	81.333	Mus_musculus
ENSG00000241370	RPP21	97	80.667	MGP_PahariEiJ_G0020546	Rpp21	97	80.667	Mus_pahari
ENSG00000241370	RPP21	97	82.000	MGP_SPRETEiJ_G0022458	Rpp21	97	82.000	Mus_spretus
ENSG00000241370	RPP21	85	96.721	ENSMPUG00000011835	RPP21	61	96.721	Mustela_putorius_furo
ENSG00000241370	RPP21	97	83.893	ENSNGAG00000001765	Rpp21	97	83.893	Nannospalax_galili
ENSG00000241370	RPP21	95	58.696	ENSNBRG00000000289	rpp21	86	57.246	Neolamprologus_brichardi
ENSG00000241370	RPP21	100	80.899	ENSOPRG00000006566	-	100	80.899	Ochotona_princeps
ENSG00000241370	RPP21	100	80.899	ENSOPRG00000005181	-	100	80.899	Ochotona_princeps
ENSG00000241370	RPP21	97	89.933	ENSODEG00000018027	RPP21	92	89.933	Octodon_degus
ENSG00000241370	RPP21	95	58.696	ENSONIG00000002839	rpp21	86	57.246	Oreochromis_niloticus
ENSG00000241370	RPP21	84	62.810	ENSORLG00000001568	rpp21	87	60.630	Oryzias_latipes
ENSG00000241370	RPP21	96	58.273	ENSORLG00020009421	rpp21	92	54.861	Oryzias_latipes_hni
ENSG00000241370	RPP21	84	63.115	ENSORLG00015005836	rpp21	81	59.055	Oryzias_latipes_hsok
ENSG00000241370	RPP21	79	63.478	ENSOMEG00000012626	rpp21	90	62.295	Oryzias_melastigma
ENSG00000241370	RPP21	100	88.961	ENSOARG00000012840	RPP21	86	88.961	Ovis_aries
ENSG00000241370	RPP21	100	88.312	ENSPPRG00000007503	RPP21	100	88.312	Panthera_pardus
ENSG00000241370	RPP21	99	92.308	ENSPTIG00000012252	RPP21	99	92.308	Panthera_tigris_altaica
ENSG00000241370	RPP21	100	60.000	ENSPKIG00000002378	rpp21	90	60.000	Paramormyrops_kingsleyae
ENSG00000241370	RPP21	97	58.451	ENSPMGG00000009953	rpp21	94	58.865	Periophthalmus_magnuspinnatus
ENSG00000241370	RPP21	99	80.921	ENSPEMG00000014367	Rpp21	91	80.921	Peromyscus_maniculatus_bairdii
ENSG00000241370	RPP21	52	66.667	ENSPMAG00000002639	rpp21	82	67.606	Petromyzon_marinus
ENSG00000241370	RPP21	82	63.866	ENSPLAG00000005510	rpp21	81	59.055	Poecilia_latipinna
ENSG00000241370	RPP21	82	63.559	ENSPMEG00000016927	rpp21	85	58.915	Poecilia_mexicana
ENSG00000241370	RPP21	87	57.037	ENSPREG00000020887	rpp21	86	57.037	Poecilia_reticulata
ENSG00000241370	RPP21	99	98.039	ENSPPYG00000016405	RPP21	99	98.039	Pongo_abelii
ENSG00000241370	RPP21	100	79.213	ENSPCAG00000001248	RPP21	100	79.213	Procavia_capensis
ENSG00000241370	RPP21	100	85.065	ENSPCOG00000024263	RPP21	100	85.065	Propithecus_coquereli
ENSG00000241370	RPP21	100	77.966	ENSPVAG00000007739	RPP21	100	77.966	Pteropus_vampyrus
ENSG00000241370	RPP21	95	57.971	ENSPNYG00000009022	rpp21	86	56.522	Pundamilia_nyererei
ENSG00000241370	RPP21	97	63.309	ENSPNAG00000022186	rpp21	97	57.516	Pygocentrus_nattereri
ENSG00000241370	RPP21	97	81.333	ENSRNOG00000000786	Rpp21	97	81.333	Rattus_norvegicus
ENSG00000241370	RPP21	100	93.506	ENSSBOG00000024099	RPP21	100	93.506	Saimiri_boliviensis_boliviensis
ENSG00000241370	RPP21	95	61.594	ENSSFOG00015008742	rpp21	92	55.056	Scleropages_formosus
ENSG00000241370	RPP21	99	54.545	ENSSMAG00000016466	rpp21	98	52.597	Scophthalmus_maximus
ENSG00000241370	RPP21	87	59.259	ENSSDUG00000022502	-	80	59.259	Seriola_dumerili
ENSG00000241370	RPP21	99	57.241	ENSSLDG00000007478	-	92	57.241	Seriola_lalandi_dorsalis
ENSG00000241370	RPP21	52	77.174	ENSSARG00000004968	-	99	78.495	Sorex_araneus
ENSG00000241370	RPP21	86	67.460	ENSSPUG00000015130	-	100	67.460	Sphenodon_punctatus
ENSG00000241370	RPP21	84	65.289	ENSSPUG00000014260	-	85	62.879	Sphenodon_punctatus
ENSG00000241370	RPP21	98	56.579	ENSSPAG00000014089	rpp21	84	54.605	Stegastes_partitus
ENSG00000241370	RPP21	100	87.013	ENSSSCG00000021130	RPP21	100	87.013	Sus_scrofa
ENSG00000241370	RPP21	91	58.042	ENSTRUG00000023935	rpp21	71	57.343	Takifugu_rubripes
ENSG00000241370	RPP21	95	88.356	ENSUAMG00000007674	RPP21	100	88.356	Ursus_americanus
ENSG00000241370	RPP21	98	80.682	ENSVPAG00000008066	RPP21	99	80.682	Vicugna_pacos
ENSG00000241370	RPP21	84	66.116	ENSXETG00000026230	rpp21	79	66.116	Xenopus_tropicalis
ENSG00000241370	RPP21	82	63.866	ENSXCOG00000013033	rpp21	81	59.055	Xiphophorus_couchianus
ENSG00000241370	RPP21	82	63.866	ENSXMAG00000026619	rpp21	81	59.055	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001682	tRNA 5'-leader removal	16723659.30454648.	IDA	Process
GO:0001682	tRNA 5'-leader removal	-	TAS	Process
GO:0004526	ribonuclease P activity	21873635.	IBA	Function
GO:0004526	ribonuclease P activity	16723659.30454648.	IDA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005655	nucleolar ribonuclease P complex	21873635.	IBA	Component
GO:0008033	tRNA processing	21873635.	IBA	Process
GO:0030681	multimeric ribonuclease P complex	16723659.30454648.	IDA	Component
GO:0042493	response to drug	18291362.	IEP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process