EuRBPDB

Description

Ensembl ID: ENSG00000241553 (Gene tree)
Gene ID: 10093
Gene Symbol: ARPC4
Alias: p20-Arc|ARC20
Full Name: actin related protein 2/3 complex subunit 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 15,232 bases
Position: chr3:9,792,495-9,807,726
Accession: 707
RBP type: non-canonical RBP
Summary: This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000498623	ARPC4-208	942	-	ENSP00000432235	78 (aa)	-	P59998
ENST00000397261	ARPC4-201	2582	-	ENSP00000380431	168 (aa)	-	P59998
ENST00000467289	ARPC4-205	729	-	-	- (aa)	-	-
ENST00000417500	ARPC4-202	957	-	ENSP00000414751	44 (aa)	-	F8WDW3
ENST00000479956	ARPC4-206	506	-	-	- (aa)	-	-
ENST00000433034	ARPC4-203	926	-	ENSP00000388169	187 (aa)	-	P59998
ENST00000485273	ARPC4-207	577	-	ENSP00000473435	77 (aa)	-	R4GN08
ENST00000440787	ARPC4-204	910	-	ENSP00000395085	113 (aa)	-	F8WDD7

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG
hsa04666	Fc gamma R-mediated phagocytosis	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05100	Bacterial invasion of epithelial cells	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG
hsa05131	Shigellosis	KEGG
hsa05132	Salmonella infection	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000241553	ARPC4	100	100.000	ENSMUSG00000079426	Arpc4	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005200	structural constituent of cytoskeleton	11741539.	IDA	Function
GO:0005515	protein binding	11162547.16169070.25416956.26655834.30021884.	IPI	Function
GO:0005634	nucleus	-	ISS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005885	Arp2/3 protein complex	11162547.11741539.	IDA	Component
GO:0005885	Arp2/3 protein complex	9230079.	TAS	Component
GO:0019899	enzyme binding	23921388.	IPI	Function
GO:0030041	actin filament polymerization	-	IEA	Process
GO:0030674	protein binding, bridging	11162547.	IPI	Function
GO:0034314	Arp2/3 complex-mediated actin nucleation	11741539.	IDA	Process
GO:0035861	site of double-strand break	-	ISS	Component
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	Process
GO:0042995	cell projection	-	IEA	Component
GO:0045010	actin nucleation	11162547.	NAS	Process
GO:0048013	ephrin receptor signaling pathway	-	TAS	Process
GO:0051015	actin filament binding	11741539.	IDA	Function
GO:0051015	actin filament binding	11162547.	NAS	Function
GO:0061024	membrane organization	-	TAS	Process
GO:0070062	extracellular exosome	19056867.20458337.	HDA	Component