EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000241945 (Gene tree)
Gene ID: 5822
Gene Symbol: PWP2
Alias: EHOC-17|UTP1|PWP2H
Full Name: PWP2 small subunit processome component
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 23,892 bases
Position: chr21:44,107,290-44,131,181
Accession: 9711
RBP type: canonical RBP
Summary: (PWP2 Small Subunit Processome Component) is a Protein Coding gene. Diseases associated with PWP2 include Holoprosencephaly 1. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include snoRNA binding. An important paralog of this gene is LOC102724159.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000291576	Utp12	PF04003.12	1e-21	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000486126	PWP2-205	583	-	-	- (aa)	-	-
ENST00000456705	PWP2-202	604	-	ENSP00000411749	186 (aa)	-	C9J544
ENST00000476948	PWP2-204	603	-	-	- (aa)	-	-
ENST00000494310	PWP2-206	712	-	-	- (aa)	-	-
ENST00000291576	PWP2-201	3297	XM_011529667	ENSP00000291576	919 (aa)	XP_011527969	Q15269
ENST00000471490	PWP2-203	4564	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000241945's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000241945	Child Development Disorders, Pervasive	7.0838300E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000241945's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000241945	PWP2	96	73.363	ENSAPOG00000021522	pwp2h	97	73.363	Acanthochromis_polyacanthus
ENSG00000241945	PWP2	98	88.053	ENSAMEG00000010907	-	99	87.541	Ailuropoda_melanoleuca
ENSG00000241945	PWP2	96	73.236	ENSACIG00000024109	pwp2h	97	72.433	Amphilophus_citrinellus
ENSG00000241945	PWP2	96	73.025	ENSAOCG00000014853	pwp2h	96	76.852	Amphiprion_ocellaris
ENSG00000241945	PWP2	96	72.799	ENSAPEG00000008152	pwp2h	97	72.635	Amphiprion_percula
ENSG00000241945	PWP2	96	72.379	ENSATEG00000015493	pwp2h	100	72.780	Anabas_testudineus
ENSG00000241945	PWP2	96	77.211	ENSAPLG00000010371	-	96	77.211	Anas_platyrhynchos
ENSG00000241945	PWP2	98	74.890	ENSACAG00000017861	-	97	75.819	Anolis_carolinensis
ENSG00000241945	PWP2	100	96.087	ENSANAG00000034845	-	100	96.087	Aotus_nancymaae
ENSG00000241945	PWP2	96	72.584	ENSACLG00000011425	pwp2h	97	72.422	Astatotilapia_calliptera
ENSG00000241945	PWP2	97	69.637	ENSAMXG00000007988	pwp2h	96	69.324	Astyanax_mexicanus
ENSG00000241945	PWP2	99	90.461	ENSBTAG00000007105	-	99	90.351	Bos_taurus
ENSG00000241945	PWP2	96	38.350	WBGene00018891	F55F8.3	96	38.122	Caenorhabditis_elegans
ENSG00000241945	PWP2	100	95.326	ENSCJAG00000005570	-	100	94.457	Callithrix_jacchus
ENSG00000241945	PWP2	98	88.827	ENSCAFG00000010687	-	99	88.596	Canis_familiaris
ENSG00000241945	PWP2	82	87.467	ENSCAFG00020019199	-	90	87.203	Canis_lupus_dingo
ENSG00000241945	PWP2	99	85.371	ENSCHIG00000026362	-	99	86.026	Capra_hircus
ENSG00000241945	PWP2	100	92.927	ENSTSYG00000009022	-	99	92.702	Carlito_syrichta
ENSG00000241945	PWP2	99	89.145	ENSCAPG00000017934	-	100	88.453	Cavia_aperea
ENSG00000241945	PWP2	99	88.745	ENSCPOG00000023616	-	99	88.420	Cavia_porcellus
ENSG00000241945	PWP2	100	95.435	ENSCCAG00000034616	-	100	94.565	Cebus_capucinus
ENSG00000241945	PWP2	100	98.912	ENSCATG00000032550	-	100	98.912	Cercocebus_atys
ENSG00000241945	PWP2	100	89.771	ENSCLAG00000009503	-	100	89.554	Chinchilla_lanigera
ENSG00000241945	PWP2	100	98.259	ENSCSAG00000007903	-	100	98.259	Chlorocebus_sabaeus
ENSG00000241945	PWP2	96	78.507	ENSCPBG00000018335	-	97	78.394	Chrysemys_picta_bellii
ENSG00000241945	PWP2	96	56.834	ENSCSAVG00000004186	-	97	56.492	Ciona_savignyi
ENSG00000241945	PWP2	100	98.477	ENSCANG00000028013	-	100	98.477	Colobus_angolensis_palliatus
ENSG00000241945	PWP2	99	90.000	ENSCGRG00001020074	Pwp2	99	89.565	Cricetulus_griseus_chok1gshd
ENSG00000241945	PWP2	99	90.000	ENSCGRG00000003750	Pwp2	99	89.565	Cricetulus_griseus_crigri
ENSG00000241945	PWP2	98	70.633	ENSCSEG00000000861	pwp2h	96	71.766	Cynoglossus_semilaevis
ENSG00000241945	PWP2	96	72.768	ENSCVAG00000000996	pwp2h	97	72.768	Cyprinodon_variegatus
ENSG00000241945	PWP2	98	67.398	ENSDARG00000037109	pwp2h	96	67.670	Danio_rerio
ENSG00000241945	PWP2	86	87.264	ENSDNOG00000012128	-	99	87.137	Dasypus_novemcinctus
ENSG00000241945	PWP2	95	84.325	ENSDORG00000003015	Pwp2	95	84.211	Dipodomys_ordii
ENSG00000241945	PWP2	97	47.014	FBgn0033557	CG12325	96	47.317	Drosophila_melanogaster
ENSG00000241945	PWP2	85	64.149	ENSEBUG00000003140	pwp2h	95	63.764	Eptatretus_burgeri
ENSG00000241945	PWP2	98	90.545	ENSEASG00005001651	-	100	89.320	Equus_asinus_asinus
ENSG00000241945	PWP2	98	90.768	ENSECAG00000006090	-	100	89.752	Equus_caballus
ENSG00000241945	PWP2	98	71.444	ENSELUG00000001878	pwp2h	97	72.022	Esox_lucius
ENSG00000241945	PWP2	99	87.677	ENSFCAG00000004487	-	99	87.895	Felis_catus
ENSG00000241945	PWP2	98	75.969	ENSFALG00000012300	-	97	77.036	Ficedula_albicollis
ENSG00000241945	PWP2	98	90.022	ENSFDAG00000016140	-	100	89.145	Fukomys_damarensis
ENSG00000241945	PWP2	94	72.654	ENSFHEG00000009078	pwp2h	100	72.654	Fundulus_heteroclitus
ENSG00000241945	PWP2	96	70.535	ENSGMOG00000016522	pwp2h	96	70.488	Gadus_morhua
ENSG00000241945	PWP2	98	76.222	ENSGALG00000045726	-	97	77.149	Gallus_gallus
ENSG00000241945	PWP2	99	71.288	ENSGAFG00000011340	pwp2h	97	72.360	Gambusia_affinis
ENSG00000241945	PWP2	96	70.852	ENSGACG00000014928	pwp2h	99	69.892	Gasterosteus_aculeatus
ENSG00000241945	PWP2	98	78.073	ENSGAGG00000005377	-	97	78.733	Gopherus_agassizii
ENSG00000241945	PWP2	100	99.239	ENSGGOG00000041875	-	100	99.239	Gorilla_gorilla
ENSG00000241945	PWP2	96	72.809	ENSHBUG00000005530	pwp2h	97	72.646	Haplochromis_burtoni
ENSG00000241945	PWP2	100	88.030	ENSHGLG00000017401	-	100	87.922	Heterocephalus_glaber_female
ENSG00000241945	PWP2	99	87.350	ENSHGLG00100013888	-	99	87.241	Heterocephalus_glaber_male
ENSG00000241945	PWP2	97	69.609	ENSHCOG00000018121	pwp2h	95	69.786	Hippocampus_comes
ENSG00000241945	PWP2	98	68.818	ENSIPUG00000014074	pwp2h	97	69.222	Ictalurus_punctatus
ENSG00000241945	PWP2	99	90.330	ENSSTOG00000014194	-	99	90.330	Ictidomys_tridecemlineatus
ENSG00000241945	PWP2	99	90.849	ENSJJAG00000013039	Pwp2	99	90.849	Jaculus_jaculus
ENSG00000241945	PWP2	96	72.316	ENSKMAG00000003143	pwp2h	97	72.316	Kryptolebias_marmoratus
ENSG00000241945	PWP2	96	71.670	ENSLBEG00000006388	pwp2h	97	71.109	Labrus_bergylta
ENSG00000241945	PWP2	93	71.611	ENSLACG00000006084	pwp2h	97	71.948	Latimeria_chalumnae
ENSG00000241945	PWP2	98	71.239	ENSLOCG00000003663	pwp2h	96	71.139	Lepisosteus_oculatus
ENSG00000241945	PWP2	94	90.487	ENSLAFG00000003871	-	100	90.371	Loxodonta_africana
ENSG00000241945	PWP2	100	98.694	ENSMFAG00000044448	-	100	98.694	Macaca_fascicularis
ENSG00000241945	PWP2	100	98.694	ENSMMUG00000005271	PWP2	100	98.694	Macaca_mulatta
ENSG00000241945	PWP2	100	98.694	ENSMNEG00000030782	-	100	98.694	Macaca_nemestrina
ENSG00000241945	PWP2	100	98.803	ENSMLEG00000039860	-	100	98.803	Mandrillus_leucophaeus
ENSG00000241945	PWP2	96	73.025	ENSMAMG00000022327	pwp2h	97	72.860	Mastacembelus_armatus
ENSG00000241945	PWP2	96	72.472	ENSMZEG00005015448	pwp2h	97	72.309	Maylandia_zebra
ENSG00000241945	PWP2	99	68.271	ENSMGAG00000014596	-	96	69.291	Meleagris_gallopavo
ENSG00000241945	PWP2	92	64.019	ENSMAUG00000020265	Pwp2	93	65.187	Mesocricetus_auratus
ENSG00000241945	PWP2	99	91.921	ENSMICG00000001002	-	99	91.812	Microcebus_murinus
ENSG00000241945	PWP2	99	89.651	ENSMOCG00000003844	Pwp2	99	89.760	Microtus_ochrogaster
ENSG00000241945	PWP2	95	69.741	ENSMMOG00000000882	pwp2h	99	71.298	Mola_mola
ENSG00000241945	PWP2	99	82.009	ENSMODG00000021081	-	99	81.570	Monodelphis_domestica
ENSG00000241945	PWP2	98	72.444	ENSMALG00000000821	pwp2h	97	73.333	Monopterus_albus
ENSG00000241945	PWP2	99	88.998	MGP_CAROLIEiJ_G0015505	Pwp2	99	88.671	Mus_caroli
ENSG00000241945	PWP2	99	89.434	ENSMUSG00000032834	Pwp2	99	89.434	Mus_musculus
ENSG00000241945	PWP2	99	89.216	MGP_PahariEiJ_G0030918	Pwp2	99	89.216	Mus_pahari
ENSG00000241945	PWP2	99	89.325	MGP_SPRETEiJ_G0016318	Pwp2	99	89.325	Mus_spretus
ENSG00000241945	PWP2	86	86.658	ENSMPUG00000009936	-	98	86.531	Mustela_putorius_furo
ENSG00000241945	PWP2	98	84.496	ENSMLUG00000004823	-	99	84.061	Myotis_lucifugus
ENSG00000241945	PWP2	99	90.076	ENSNGAG00000021106	Pwp2	99	89.858	Nannospalax_galili
ENSG00000241945	PWP2	99	69.979	ENSNBRG00000016527	pwp2h	97	71.334	Neolamprologus_brichardi
ENSG00000241945	PWP2	97	98.423	ENSNLEG00000001928	-	100	98.423	Nomascus_leucogenys
ENSG00000241945	PWP2	99	88.986	ENSODEG00000013073	-	100	88.877	Octodon_degus
ENSG00000241945	PWP2	96	72.472	ENSONIG00000007136	pwp2h	97	72.309	Oreochromis_niloticus
ENSG00000241945	PWP2	97	79.012	ENSOANG00000006477	-	97	79.012	Ornithorhynchus_anatinus
ENSG00000241945	PWP2	98	71.476	ENSORLG00000000066	pwp2h	97	72.429	Oryzias_latipes
ENSG00000241945	PWP2	98	71.696	ENSORLG00020000321	pwp2h	97	72.655	Oryzias_latipes_hni
ENSG00000241945	PWP2	98	67.731	ENSORLG00015014731	pwp2h	97	68.588	Oryzias_latipes_hsok
ENSG00000241945	PWP2	97	56.376	ENSOMEG00000020671	pwp2h	99	56.852	Oryzias_melastigma
ENSG00000241945	PWP2	99	92.873	ENSOGAG00000012473	-	100	92.544	Otolemur_garnettii
ENSG00000241945	PWP2	99	87.199	ENSOARG00000011672	-	99	89.633	Ovis_aries
ENSG00000241945	PWP2	100	99.674	ENSPPAG00000037874	-	100	99.674	Pan_paniscus
ENSG00000241945	PWP2	99	87.486	ENSPPRG00000011088	-	100	87.813	Panthera_pardus
ENSG00000241945	PWP2	99	79.847	ENSPTIG00000020872	-	99	79.956	Panthera_tigris_altaica
ENSG00000241945	PWP2	100	99.782	ENSPTRG00000013969	-	100	99.782	Pan_troglodytes
ENSG00000241945	PWP2	100	98.694	ENSPANG00000006267	-	100	98.694	Papio_anubis
ENSG00000241945	PWP2	98	69.367	ENSPKIG00000002693	pwp2h	100	72.673	Paramormyrops_kingsleyae
ENSG00000241945	PWP2	96	77.715	ENSPSIG00000009783	-	97	77.749	Pelodiscus_sinensis
ENSG00000241945	PWP2	96	72.523	ENSPMGG00000022349	pwp2h	96	72.316	Periophthalmus_magnuspinnatus
ENSG00000241945	PWP2	99	90.749	ENSPEMG00000009968	Pwp2	100	89.913	Peromyscus_maniculatus_bairdii
ENSG00000241945	PWP2	99	80.807	ENSPCIG00000014548	-	97	82.022	Phascolarctos_cinereus
ENSG00000241945	PWP2	96	72.391	ENSPFOG00000014764	pwp2h	97	72.615	Poecilia_formosa
ENSG00000241945	PWP2	96	72.391	ENSPLAG00000011559	pwp2h	97	72.615	Poecilia_latipinna
ENSG00000241945	PWP2	96	72.391	ENSPMEG00000021347	pwp2h	97	72.615	Poecilia_mexicana
ENSG00000241945	PWP2	96	72.860	ENSPREG00000015887	pwp2h	97	72.840	Poecilia_reticulata
ENSG00000241945	PWP2	100	98.259	ENSPPYG00000011478	-	99	98.259	Pongo_abelii
ENSG00000241945	PWP2	99	83.804	ENSPCAG00000004676	-	99	83.370	Procavia_capensis
ENSG00000241945	PWP2	99	92.519	ENSPCOG00000012856	-	99	92.519	Propithecus_coquereli
ENSG00000241945	PWP2	99	81.619	ENSPVAG00000002312	-	99	81.619	Pteropus_vampyrus
ENSG00000241945	PWP2	74	70.930	ENSPNYG00000008379	pwp2h	95	70.725	Pundamilia_nyererei
ENSG00000241945	PWP2	96	69.721	ENSPNAG00000017876	pwp2h	99	68.099	Pygocentrus_nattereri
ENSG00000241945	PWP2	99	89.648	ENSRNOG00000001210	Pwp2	99	89.130	Rattus_norvegicus
ENSG00000241945	PWP2	100	98.259	ENSRBIG00000034365	-	100	98.259	Rhinopithecus_bieti
ENSG00000241945	PWP2	100	98.368	ENSRROG00000031946	-	100	98.368	Rhinopithecus_roxellana
ENSG00000241945	PWP2	98	42.998	YCR057C	PWP2	92	43.679	Saccharomyces_cerevisiae
ENSG00000241945	PWP2	99	96.405	ENSSBOG00000034554	-	99	96.397	Saimiri_boliviensis_boliviensis
ENSG00000241945	PWP2	99	71.506	ENSSFOG00015003316	pwp2	97	72.687	Scleropages_formosus
ENSG00000241945	PWP2	96	72.964	ENSSMAG00000011839	pwp2h	96	72.964	Scophthalmus_maximus
ENSG00000241945	PWP2	96	72.135	ENSSDUG00000011462	pwp2h	96	72.309	Seriola_dumerili
ENSG00000241945	PWP2	96	72.768	ENSSLDG00000008651	pwp2h	96	72.604	Seriola_lalandi_dorsalis
ENSG00000241945	PWP2	98	77.753	ENSSPUG00000002980	-	98	77.941	Sphenodon_punctatus
ENSG00000241945	PWP2	96	72.054	ENSSPAG00000023368	pwp2h	97	72.697	Stegastes_partitus
ENSG00000241945	PWP2	99	87.009	ENSSSCG00000029627	-	99	86.900	Sus_scrofa
ENSG00000241945	PWP2	61	72.143	ENSTGUG00000018216	-	100	72.143	Taeniopygia_guttata
ENSG00000241945	PWP2	96	76.471	ENSTGUG00000005996	-	100	76.471	Taeniopygia_guttata
ENSG00000241945	PWP2	98	70.399	ENSTRUG00000013258	pwp2h	97	70.960	Takifugu_rubripes
ENSG00000241945	PWP2	98	69.556	ENSTNIG00000010613	pwp2h	97	70.056	Tetraodon_nigroviridis
ENSG00000241945	PWP2	82	93.006	ENSTBEG00000015597	-	90	92.817	Tupaia_belangeri
ENSG00000241945	PWP2	94	88.618	ENSTTRG00000006728	-	100	88.502	Tursiops_truncatus
ENSG00000241945	PWP2	99	87.622	ENSUAMG00000019031	-	100	87.622	Ursus_americanus
ENSG00000241945	PWP2	99	84.934	ENSUMAG00000025481	-	99	84.934	Ursus_maritimus
ENSG00000241945	PWP2	98	88.778	ENSVVUG00000024125	-	99	88.255	Vulpes_vulpes
ENSG00000241945	PWP2	80	51.214	ENSXETG00000018002	pwp2	87	60.000	Xenopus_tropicalis
ENSG00000241945	PWP2	96	68.849	ENSXCOG00000020474	pwp2h	97	68.268	Xiphophorus_couchianus
ENSG00000241945	PWP2	99	71.663	ENSXMAG00000008124	pwp2h	97	72.452	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000028	ribosomal small subunit assembly	21873635.	IBA	Process
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006364	rRNA processing	-	TAS	Process
GO:0032040	small-subunit processome	21873635.	IBA	Component
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	21873635.	IBA	Component