EuRBPDB

Description

Ensembl ID: ENSG00000241973 (Gene tree)
Gene ID: 5297
Gene Symbol: PI4KA
Alias: PI4K-ALPHA|pi4K230|PIK4CA
Full Name: phosphatidylinositol 4-kinase alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 151,727 bases
Position: chr22:20,707,691-20,859,417
Accession: 8983
RBP type: non-canonical RBP
Summary: This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2018]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000489966	PI4KA-216	290	-	-	- (aa)	-	-
ENST00000485950	PI4KA-214	479	-	-	- (aa)	-	-
ENST00000494113	PI4KA-218	515	-	-	- (aa)	-	-
ENST00000482030	PI4KA-211	655	-	-	- (aa)	-	-
ENST00000399213	PI4KA-202	1636	-	ENSP00000382162	435 (aa)	-	A8MTF1
ENST00000466394	PI4KA-206	782	-	-	- (aa)	-	-
ENST00000485963	PI4KA-215	2301	-	-	- (aa)	-	-
ENST00000477368	PI4KA-210	535	-	-	- (aa)	-	-
ENST00000449120	PI4KA-203	574	-	ENSP00000402437	87 (aa)	-	C9JLI1
ENST00000475414	PI4KA-208	400	-	-	- (aa)	-	-
ENST00000255882	PI4KA-201	6752	XM_005261634	ENSP00000255882	2102 (aa)	XP_005261692	P42356
ENST00000466162	PI4KA-205	589	-	-	- (aa)	-	-
ENST00000477245	PI4KA-209	3026	-	-	- (aa)	-	-
ENST00000492581	PI4KA-217	3925	-	-	- (aa)	-	-
ENST00000462210	PI4KA-204	560	-	-	- (aa)	-	-
ENST00000484220	PI4KA-212	646	-	-	- (aa)	-	-
ENST00000485123	PI4KA-213	455	-	-	- (aa)	-	-
ENST00000466772	PI4KA-207	3109	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00562	Inositol phosphate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04070	Phosphatidylinositol signaling system	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000241973	rs178050	22	20814301	A	Fulminant type 1 diabetes	30552108	[1.33-2.07]	1.66	EFO_0001359

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004430	1-phosphatidylinositol 4-kinase activity	21873635.	IBA	Function
GO:0004430	1-phosphatidylinositol 4-kinase activity	-	ISS	Function
GO:0005515	protein binding	14676841.15607035.21238945.21297162.23675303.23935497.25608530.26571211.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	23229899.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	23229899.	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006661	phosphatidylinositol biosynthetic process	-	TAS	Process
GO:0007165	signal transduction	7961848.	NAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016020	membrane	21873635.	IBA	Component
GO:0016301	kinase activity	25327288.	IDA	Function
GO:0016310	phosphorylation	25327288.	IDA	Process
GO:0019034	viral replication complex	19376974.	IMP	Component
GO:0030660	Golgi-associated vesicle membrane	-	ISS	Component
GO:0039694	viral RNA genome replication	19376974.	IMP	Process
GO:0044803	multi-organism membrane organization	19376974.	IMP	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046786	viral replication complex formation and maintenance	19376974.	IMP	Process
GO:0046854	phosphatidylinositol phosphorylation	21873635.	IBA	Process
GO:0046854	phosphatidylinositol phosphorylation	-	ISS	Process
GO:0048015	phosphatidylinositol-mediated signaling	21873635.	IBA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component