EuRBPDB

Description

Ensembl ID: ENSG00000242247 (Gene tree)
Gene ID: 26286
Gene Symbol: ARFGAP3
Alias: ARFGAP1
Full Name: ADP ribosylation factor GTPase activating protein 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 61,605 bases
Position: chr22:42,796,502-42,858,106
Accession: 661
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000435208	ARFGAP3-202	501	-	ENSP00000407734	92 (aa)	-	B0QYV9
ENST00000493606	ARFGAP3-206	580	-	-	- (aa)	-	-
ENST00000454099	ARFGAP3-205	542	-	ENSP00000403520	152 (aa)	-	B0QYV8
ENST00000263245	ARFGAP3-201	2857	XM_005261525	ENSP00000263245	516 (aa)	XP_005261582	Q9NP61
ENST00000437119	ARFGAP3-203	1650	-	ENSP00000388791	472 (aa)	-	Q9NP61
ENST00000453516	ARFGAP3-204	817	-	ENSP00000403995	273 (aa)	-	H0Y6A0

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0005096	GTPase activator activity	21873635.	IBA	Function
GO:0005096	GTPase activator activity	11172815.	IDA	Function
GO:0005515	protein binding	24705354.	IPI	Function
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0005802	trans-Golgi network	21873635.	IBA	Component
GO:0005829	cytosol	11172815.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	11172815.	NAS	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	21873635.	IBA	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	Process
GO:0008565	protein transporter activity	11172815.	NAS	Function
GO:0009306	protein secretion	11172815.	IEP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016192	vesicle-mediated transport	11172815.	NAS	Process
GO:0030126	COPI vesicle coat	21873635.	IBA	Component
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048205	COPI coating of Golgi vesicle	21873635.	IBA	Process