EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000242485 (Gene tree)
Gene ID: 55052
Gene Symbol: MRPL20
Alias: FLJ10024
Full Name: mitochondrial ribosomal protein L20
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 5,939 bases
Position: chr1:1,401,896-1,407,834
Accession: 14478
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000341082	Ribosomal_L20	PF00453.18	7.6e-34	1	1
ENSP00000460924	Ribosomal_L20	PF00453.18	2.2e-20	1	1
ENSP00000459994	Ribosomal_L20	PF00453.18	5.1e-15	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000492508	MRPL20-205	588	-	ENSP00000459994	66 (aa)	-	I3L2X1
ENST00000487659	MRPL20-204	1693	-	-	- (aa)	-	-
ENST00000477686	MRPL20-202	314	-	-	- (aa)	-	-
ENST00000344843	MRPL20-201	721	-	ENSP00000341082	149 (aa)	-	Q9BYC9
ENST00000493287	MRPL20-206	504	-	-	- (aa)	-	-
ENST00000482352	MRPL20-203	1049	-	ENSP00000460924	155 (aa)	-	Q9BYC9

Gene Model

Click here to download ENSG00000242485's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000242485	rs1171	1	1401954	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000242485's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000242485	MRPL20	98	69.178	ENSAPOG00000011835	mrpl20	97	71.739	Acanthochromis_polyacanthus
ENSG00000242485	MRPL20	99	83.784	ENSAMEG00000013932	MRPL20	99	83.784	Ailuropoda_melanoleuca
ENSG00000242485	MRPL20	98	69.863	ENSACIG00000019179	mrpl20	98	69.863	Amphilophus_citrinellus
ENSG00000242485	MRPL20	98	69.178	ENSAOCG00000007734	mrpl20	98	69.178	Amphiprion_ocellaris
ENSG00000242485	MRPL20	98	68.493	ENSAPEG00000014049	mrpl20	98	68.493	Amphiprion_percula
ENSG00000242485	MRPL20	98	69.178	ENSATEG00000007369	mrpl20	98	69.178	Anabas_testudineus
ENSG00000242485	MRPL20	99	69.595	ENSACAG00000009143	MRPL20	99	69.595	Anolis_carolinensis
ENSG00000242485	MRPL20	100	79.605	ENSANAG00000021078	-	100	79.605	Aotus_nancymaae
ENSG00000242485	MRPL20	91	68.889	ENSACLG00000021726	mrpl20	87	68.889	Astatotilapia_calliptera
ENSG00000242485	MRPL20	86	75.439	ENSAMXG00000035403	mrpl20	84	70.588	Astyanax_mexicanus
ENSG00000242485	MRPL20	100	85.235	ENSBTAG00000004872	MRPL20	75	85.235	Bos_taurus
ENSG00000242485	MRPL20	100	91.946	ENSCJAG00000039231	-	100	91.946	Callithrix_jacchus
ENSG00000242485	MRPL20	100	88.591	ENSCAFG00000019259	MRPL20	100	88.591	Canis_familiaris
ENSG00000242485	MRPL20	82	79.630	ENSCAFG00020025880	-	65	83.784	Canis_lupus_dingo
ENSG00000242485	MRPL20	100	85.235	ENSCHIG00000010545	MRPL20	100	85.235	Capra_hircus
ENSG00000242485	MRPL20	100	92.617	ENSTSYG00000033620	MRPL20	100	92.617	Carlito_syrichta
ENSG00000242485	MRPL20	100	89.933	ENSCPOG00000023001	MRPL20	100	89.933	Cavia_porcellus
ENSG00000242485	MRPL20	100	89.933	ENSCCAG00000032768	-	100	89.933	Cebus_capucinus
ENSG00000242485	MRPL20	100	97.315	ENSCATG00000033927	MRPL20	100	97.315	Cercocebus_atys
ENSG00000242485	MRPL20	86	74.219	ENSCATG00000040437	-	67	74.219	Cercocebus_atys
ENSG00000242485	MRPL20	100	87.919	ENSCLAG00000009757	-	100	87.919	Chinchilla_lanigera
ENSG00000242485	MRPL20	91	68.333	ENSCLAG00000011866	-	100	59.060	Chinchilla_lanigera
ENSG00000242485	MRPL20	100	97.315	ENSCSAG00000000688	-	100	97.315	Chlorocebus_sabaeus
ENSG00000242485	MRPL20	100	96.644	ENSCSAG00000019479	-	100	96.644	Chlorocebus_sabaeus
ENSG00000242485	MRPL20	100	79.195	ENSCPBG00000022905	MRPL20	100	79.195	Chrysemys_picta_bellii
ENSG00000242485	MRPL20	100	75.168	ENSCANG00000039625	MRPL20	100	75.168	Colobus_angolensis_palliatus
ENSG00000242485	MRPL20	100	85.906	ENSCGRG00001024028	Mrpl20	100	85.906	Cricetulus_griseus_chok1gshd
ENSG00000242485	MRPL20	100	85.906	ENSCGRG00000007447	Mrpl20	100	85.906	Cricetulus_griseus_crigri
ENSG00000242485	MRPL20	98	67.123	ENSCSEG00000002016	mrpl20	85	67.123	Cynoglossus_semilaevis
ENSG00000242485	MRPL20	98	66.438	ENSCVAG00000022768	mrpl20	99	66.438	Cyprinodon_variegatus
ENSG00000242485	MRPL20	100	61.745	ENSDARG00000090462	mrpl20	100	61.745	Danio_rerio
ENSG00000242485	MRPL20	99	87.838	ENSDNOG00000044958	MRPL20	99	87.838	Dasypus_novemcinctus
ENSG00000242485	MRPL20	56	93.976	ENSDORG00000028591	Mrpl20	100	93.976	Dipodomys_ordii
ENSG00000242485	MRPL20	83	39.024	FBgn0036335	mRpL20	82	39.024	Drosophila_melanogaster
ENSG00000242485	MRPL20	99	72.973	ENSETEG00000012315	MRPL20	99	72.973	Echinops_telfairi
ENSG00000242485	MRPL20	99	68.027	ENSEBUG00000002214	mrpl20	99	68.027	Eptatretus_burgeri
ENSG00000242485	MRPL20	100	85.906	ENSEASG00005014515	MRPL20	100	85.906	Equus_asinus_asinus
ENSG00000242485	MRPL20	100	85.906	ENSECAG00000018364	MRPL20	100	85.906	Equus_caballus
ENSG00000242485	MRPL20	81	65.000	ENSEEUG00000004596	-	100	65.000	Erinaceus_europaeus
ENSG00000242485	MRPL20	98	69.863	ENSELUG00000013398	mrpl20	98	69.863	Esox_lucius
ENSG00000242485	MRPL20	99	87.075	ENSFCAG00000033203	MRPL20	99	87.075	Felis_catus
ENSG00000242485	MRPL20	100	69.128	ENSFALG00000009334	MRPL20	100	69.128	Ficedula_albicollis
ENSG00000242485	MRPL20	100	87.919	ENSFDAG00000013320	MRPL20	100	87.919	Fukomys_damarensis
ENSG00000242485	MRPL20	98	65.753	ENSFHEG00000004769	mrpl20	99	65.753	Fundulus_heteroclitus
ENSG00000242485	MRPL20	97	67.361	ENSGMOG00000008125	mrpl20	100	67.361	Gadus_morhua
ENSG00000242485	MRPL20	100	74.497	ENSGALG00000001542	MRPL20	100	74.497	Gallus_gallus
ENSG00000242485	MRPL20	98	67.808	ENSGAFG00000021580	mrpl20	99	67.808	Gambusia_affinis
ENSG00000242485	MRPL20	98	68.493	ENSGACG00000001134	mrpl20	98	68.493	Gasterosteus_aculeatus
ENSG00000242485	MRPL20	100	78.523	ENSGAGG00000001945	MRPL20	100	78.523	Gopherus_agassizii
ENSG00000242485	MRPL20	100	100.000	ENSGGOG00000027251	-	100	100.000	Gorilla_gorilla
ENSG00000242485	MRPL20	98	68.493	ENSHBUG00000023626	mrpl20	98	68.493	Haplochromis_burtoni
ENSG00000242485	MRPL20	100	86.577	ENSHGLG00000017538	MRPL20	100	86.577	Heterocephalus_glaber_female
ENSG00000242485	MRPL20	100	87.248	ENSHGLG00100012816	MRPL20	100	87.248	Heterocephalus_glaber_male
ENSG00000242485	MRPL20	98	63.014	ENSHCOG00000005830	mrpl20	98	63.014	Hippocampus_comes
ENSG00000242485	MRPL20	99	65.306	ENSIPUG00000018055	mrpl20	99	65.306	Ictalurus_punctatus
ENSG00000242485	MRPL20	100	86.577	ENSJJAG00000020728	Mrpl20	100	86.577	Jaculus_jaculus
ENSG00000242485	MRPL20	98	67.808	ENSKMAG00000021650	mrpl20	98	67.808	Kryptolebias_marmoratus
ENSG00000242485	MRPL20	98	67.808	ENSLBEG00000021562	mrpl20	98	67.808	Labrus_bergylta
ENSG00000242485	MRPL20	100	81.208	ENSLACG00000019149	MRPL20	100	81.208	Latimeria_chalumnae
ENSG00000242485	MRPL20	99	88.514	ENSLAFG00000010706	MRPL20	99	88.514	Loxodonta_africana
ENSG00000242485	MRPL20	100	97.315	ENSMFAG00000043214	MRPL20	100	97.315	Macaca_fascicularis
ENSG00000242485	MRPL20	94	73.571	ENSMFAG00000046195	-	83	73.571	Macaca_fascicularis
ENSG00000242485	MRPL20	100	84.516	ENSMMUG00000038877	MRPL20	100	84.516	Macaca_mulatta
ENSG00000242485	MRPL20	89	75.188	ENSMNEG00000000027	-	68	75.188	Macaca_nemestrina
ENSG00000242485	MRPL20	100	97.315	ENSMNEG00000041891	MRPL20	100	97.315	Macaca_nemestrina
ENSG00000242485	MRPL20	91	72.593	ENSMLEG00000037605	-	83	72.593	Mandrillus_leucophaeus
ENSG00000242485	MRPL20	85	94.643	ENSMLEG00000037086	MRPL20	100	96.667	Mandrillus_leucophaeus
ENSG00000242485	MRPL20	98	69.863	ENSMAMG00000023884	mrpl20	98	69.863	Mastacembelus_armatus
ENSG00000242485	MRPL20	98	68.493	ENSMZEG00005011376	mrpl20	98	68.493	Maylandia_zebra
ENSG00000242485	MRPL20	81	75.207	ENSMGAG00000002774	MRPL20	82	75.207	Meleagris_gallopavo
ENSG00000242485	MRPL20	100	86.577	ENSMAUG00000013299	Mrpl20	100	86.577	Mesocricetus_auratus
ENSG00000242485	MRPL20	100	92.617	ENSMICG00000041892	MRPL20	100	92.617	Microcebus_murinus
ENSG00000242485	MRPL20	100	84.564	ENSMOCG00000000404	-	100	84.564	Microtus_ochrogaster
ENSG00000242485	MRPL20	100	78.523	ENSMOCG00000009545	-	100	78.523	Microtus_ochrogaster
ENSG00000242485	MRPL20	98	50.000	ENSMMOG00000021753	mrpl20	97	50.000	Mola_mola
ENSG00000242485	MRPL20	100	81.208	ENSMODG00000006562	MRPL20	100	81.208	Monodelphis_domestica
ENSG00000242485	MRPL20	98	67.123	ENSMALG00000018593	mrpl20	98	67.123	Monopterus_albus
ENSG00000242485	MRPL20	100	87.248	MGP_CAROLIEiJ_G0026904	Mrpl20	100	87.248	Mus_caroli
ENSG00000242485	MRPL20	100	87.919	ENSMUSG00000029066	Mrpl20	100	87.919	Mus_musculus
ENSG00000242485	MRPL20	100	83.893	MGP_PahariEiJ_G0029252	Mrpl20	100	83.893	Mus_pahari
ENSG00000242485	MRPL20	100	87.919	MGP_SPRETEiJ_G0027898	Mrpl20	100	87.919	Mus_spretus
ENSG00000242485	MRPL20	100	89.262	ENSMLUG00000011857	MRPL20	100	89.262	Myotis_lucifugus
ENSG00000242485	MRPL20	100	84.564	ENSNGAG00000021688	Mrpl20	100	84.564	Nannospalax_galili
ENSG00000242485	MRPL20	98	68.493	ENSNBRG00000006018	mrpl20	98	68.493	Neolamprologus_brichardi
ENSG00000242485	MRPL20	56	98.795	ENSNLEG00000013868	-	81	98.795	Nomascus_leucogenys
ENSG00000242485	MRPL20	100	88.591	ENSODEG00000010734	MRPL20	100	88.591	Octodon_degus
ENSG00000242485	MRPL20	98	69.178	ENSONIG00000018914	mrpl20	98	69.178	Oreochromis_niloticus
ENSG00000242485	MRPL20	98	67.123	ENSORLG00000018304	mrpl20	98	67.123	Oryzias_latipes
ENSG00000242485	MRPL20	98	67.123	ENSORLG00020009128	mrpl20	98	67.123	Oryzias_latipes_hni
ENSG00000242485	MRPL20	98	67.123	ENSORLG00015005156	mrpl20	98	67.123	Oryzias_latipes_hsok
ENSG00000242485	MRPL20	98	68.493	ENSOMEG00000015654	mrpl20	98	68.493	Oryzias_melastigma
ENSG00000242485	MRPL20	100	91.275	ENSOGAG00000005968	MRPL20	100	91.275	Otolemur_garnettii
ENSG00000242485	MRPL20	100	85.235	ENSOARG00000003529	MRPL20	100	85.235	Ovis_aries
ENSG00000242485	MRPL20	100	100.000	ENSPPAG00000042350	-	100	100.000	Pan_paniscus
ENSG00000242485	MRPL20	99	87.755	ENSPPRG00000009188	MRPL20	99	87.755	Panthera_pardus
ENSG00000242485	MRPL20	54	92.593	ENSPTIG00000020769	MRPL20	89	92.593	Panthera_tigris_altaica
ENSG00000242485	MRPL20	100	100.000	ENSPTRG00000000029	MRPL20	100	100.000	Pan_troglodytes
ENSG00000242485	MRPL20	94	72.857	ENSPANG00000036197	-	100	72.857	Papio_anubis
ENSG00000242485	MRPL20	100	97.315	ENSPANG00000015802	MRPL20	100	97.315	Papio_anubis
ENSG00000242485	MRPL20	100	66.443	ENSPKIG00000002248	mrpl20	100	66.443	Paramormyrops_kingsleyae
ENSG00000242485	MRPL20	95	71.831	ENSPSIG00000003939	MRPL20	100	71.831	Pelodiscus_sinensis
ENSG00000242485	MRPL20	97	70.345	ENSPMGG00000003966	mrpl20	97	70.345	Periophthalmus_magnuspinnatus
ENSG00000242485	MRPL20	50	38.961	ENSPMGG00000022271	-	73	32.692	Periophthalmus_magnuspinnatus
ENSG00000242485	MRPL20	100	67.785	ENSPEMG00000009458	-	85	67.785	Peromyscus_maniculatus_bairdii
ENSG00000242485	MRPL20	66	37.755	ENSPMAG00000009990	-	78	37.755	Petromyzon_marinus
ENSG00000242485	MRPL20	100	79.195	ENSPCIG00000007747	MRPL20	100	79.195	Phascolarctos_cinereus
ENSG00000242485	MRPL20	98	66.438	ENSPFOG00000018163	mrpl20	99	66.438	Poecilia_formosa
ENSG00000242485	MRPL20	98	66.438	ENSPLAG00000016451	mrpl20	99	66.438	Poecilia_latipinna
ENSG00000242485	MRPL20	98	66.438	ENSPMEG00000002561	mrpl20	99	66.438	Poecilia_mexicana
ENSG00000242485	MRPL20	98	60.544	ENSPREG00000004925	mrpl20	99	61.486	Poecilia_reticulata
ENSG00000242485	MRPL20	99	90.541	ENSPCAG00000001425	MRPL20	99	90.541	Procavia_capensis
ENSG00000242485	MRPL20	99	81.757	ENSPCOG00000004450	-	99	81.757	Propithecus_coquereli
ENSG00000242485	MRPL20	100	90.604	ENSPCOG00000025653	-	100	90.604	Propithecus_coquereli
ENSG00000242485	MRPL20	98	68.493	ENSPNYG00000008626	mrpl20	98	68.493	Pundamilia_nyererei
ENSG00000242485	MRPL20	100	64.430	ENSPNAG00000016694	mrpl20	100	64.430	Pygocentrus_nattereri
ENSG00000242485	MRPL20	100	86.577	ENSRNOG00000018647	Mrpl20	100	86.577	Rattus_norvegicus
ENSG00000242485	MRPL20	100	97.987	ENSRBIG00000042278	MRPL20	100	97.987	Rhinopithecus_bieti
ENSG00000242485	MRPL20	100	97.987	ENSRROG00000003574	MRPL20	100	97.987	Rhinopithecus_roxellana
ENSG00000242485	MRPL20	56	92.771	ENSSBOG00000035454	-	100	92.771	Saimiri_boliviensis_boliviensis
ENSG00000242485	MRPL20	95	77.778	ENSSHAG00000008197	MRPL20	100	68.387	Sarcophilus_harrisii
ENSG00000242485	MRPL20	100	66.443	ENSSFOG00015016009	mrpl20	100	66.443	Scleropages_formosus
ENSG00000242485	MRPL20	98	69.178	ENSSMAG00000000214	mrpl20	98	69.178	Scophthalmus_maximus
ENSG00000242485	MRPL20	98	70.548	ENSSDUG00000008646	mrpl20	98	70.548	Seriola_dumerili
ENSG00000242485	MRPL20	98	70.548	ENSSLDG00000023171	mrpl20	98	70.548	Seriola_lalandi_dorsalis
ENSG00000242485	MRPL20	100	71.141	ENSSPUG00000016911	MRPL20	100	71.141	Sphenodon_punctatus
ENSG00000242485	MRPL20	98	69.178	ENSSPAG00000012887	mrpl20	98	69.178	Stegastes_partitus
ENSG00000242485	MRPL20	99	87.162	ENSSSCG00000033374	MRPL20	99	87.162	Sus_scrofa
ENSG00000242485	MRPL20	81	74.380	ENSTGUG00000003113	MRPL20	98	74.380	Taeniopygia_guttata
ENSG00000242485	MRPL20	97	68.966	ENSTRUG00000021410	mrpl20	97	68.966	Takifugu_rubripes
ENSG00000242485	MRPL20	100	69.799	ENSTNIG00000014657	mrpl20	100	69.799	Tetraodon_nigroviridis
ENSG00000242485	MRPL20	100	89.933	ENSTBEG00000008735	MRPL20	100	89.933	Tupaia_belangeri
ENSG00000242485	MRPL20	80	85.714	ENSTTRG00000017046	MRPL20	99	85.714	Tursiops_truncatus
ENSG00000242485	MRPL20	85	76.786	ENSUAMG00000028406	-	76	69.748	Ursus_americanus
ENSG00000242485	MRPL20	100	89.262	ENSUAMG00000012829	-	100	89.262	Ursus_americanus
ENSG00000242485	MRPL20	85	75.000	ENSUMAG00000003240	-	76	69.748	Ursus_maritimus
ENSG00000242485	MRPL20	73	71.930	ENSUMAG00000001917	-	100	71.930	Ursus_maritimus
ENSG00000242485	MRPL20	56	87.952	ENSVPAG00000001846	-	100	87.952	Vicugna_pacos
ENSG00000242485	MRPL20	100	89.262	ENSVVUG00000004455	MRPL20	100	89.262	Vulpes_vulpes
ENSG00000242485	MRPL20	100	73.154	ENSXETG00000011118	mrpl20	100	73.154	Xenopus_tropicalis
ENSG00000242485	MRPL20	98	65.753	ENSXCOG00000004220	mrpl20	99	65.753	Xiphophorus_couchianus
ENSG00000242485	MRPL20	98	65.753	ENSXMAG00000016652	mrpl20	99	65.753	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000027	ribosomal large subunit assembly	21873635.	IBA	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0005515	protein binding	20601428.	IPI	Function
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005761	mitochondrial ribosome	21873635.	IBA	Component
GO:0005761	mitochondrial ribosome	20601428.	IDA	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0019843	rRNA binding	-	IEA	Function
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process