EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000243147 (Gene tree)
Gene ID: 9553
Gene Symbol: MRPL33
Alias: RPL33L|C2orf1
Full Name: mitochondrial ribosomal protein L33
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 216,371 bases
Position: chr2:27,771,717-27,988,087
Accession: 14487
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000296102	Ribosomal_L33	PF00471.20	1.6e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000476552	MRPL33-205	587	-	-	- (aa)	-	-
ENST00000472192	MRPL33-204	238	-	-	- (aa)	-	-
ENST00000448427	MRPL33-203	527	-	ENSP00000407385	69 (aa)	-	F8WF37
ENST00000296102	MRPL33-201	518	-	ENSP00000296102	65 (aa)	-	O75394
ENST00000379666	MRPL33-202	404	-	ENSP00000368988	54 (aa)	-	O75394
ENST00000483992	MRPL33-206	729	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000243147's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000243147	Glucose	1E-15	22581228
ENSG00000243147	Body Mass Index	1E-15	22581228

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000243147	rs12474906	2	27810671	A	Schizophrenia	26198764	[NR]	1.07	EFO_0000692
ENSG00000243147	rs3736594	2	27772914	A	Fasting blood glucose	22581228	[0.017-0.027] unit increase	0.0222	EFO_0004465
ENSG00000243147	rs3736594	2	27772914	A	Fasting blood glucose (BMI interaction)	22581228	[-0.00028-0.00212] unit increase	9.18E-04	EFO_0004340\|EFO_0004465
ENSG00000243147	rs12623170	2	27797290	C	Schizophrenia	28991256	[1.04-1.08]	1.0604454	EFO_0000692
ENSG00000243147	rs4630723	2	27801464	?	Blood urea nitrogen levels	29403010	[0.014-0.03] unit decrease novel	0.02186	EFO_0004741
ENSG00000243147	rs4666014	2	27796308	?	Hematocrit	29403010	[0.016-0.033] unit increase novel	0.02427	EFO_0004348
ENSG00000243147	rs148298182	2	27936042	?	General cognitive ability	29844566	z-score decrease	4.556	EFO_0004337
ENSG00000243147	rs11686001	2	27800195	?	Reaction time	29844566	[0.0046-0.0113] unit decrease	0.0079224	EFO_0008393
ENSG00000243147	rs72810550	2	27860513	?	DNA methylation variation (age effect)	30348214			GO_0006306
ENSG00000243147	rs68118529	2	27895896	T	Male-pattern baldness	30573740	[0.035-0.067] unit increase	0.050711	EFO_0007825
ENSG00000243147	rs10173848	2	27920150	?	Lung function (FEV1/FVC)	30595370			EFO_0004713
ENSG00000243147	rs12623170	2	27797290	C	Schizophrenia	30285260	[1.04-1.08]	1.0604454	EFO_0000692
ENSG00000243147	rs12623170	2	27797290	C	Schizophrenia	30285260	[1.04-1.09]	1.0670081	EFO_0000692

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000243147's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000243147	MRPL33	98	65.625	ENSAPOG00000013668	mrpl33	98	65.625	Acanthochromis_polyacanthus
ENSG00000243147	MRPL33	80	76.923	ENSAMEG00000001164	MRPL33	100	76.923	Ailuropoda_melanoleuca
ENSG00000243147	MRPL33	100	56.923	ENSACIG00000011015	mrpl33	100	56.923	Amphilophus_citrinellus
ENSG00000243147	MRPL33	100	60.000	ENSAOCG00000015330	mrpl33	100	60.000	Amphiprion_ocellaris
ENSG00000243147	MRPL33	100	60.000	ENSAPEG00000023310	mrpl33	100	60.000	Amphiprion_percula
ENSG00000243147	MRPL33	100	55.882	ENSATEG00000011035	mrpl33	100	55.882	Anabas_testudineus
ENSG00000243147	MRPL33	100	89.231	ENSANAG00000030770	MRPL33	100	89.231	Aotus_nancymaae
ENSG00000243147	MRPL33	100	60.000	ENSACLG00000025855	mrpl33	100	60.000	Astatotilapia_calliptera
ENSG00000243147	MRPL33	100	84.615	ENSBTAG00000032831	MRPL33	100	84.615	Bos_taurus
ENSG00000243147	MRPL33	100	84.615	ENSBTAG00000055077	MRPL33	100	84.615	Bos_taurus
ENSG00000243147	MRPL33	88	82.456	ENSBTAG00000054835	-	92	82.456	Bos_taurus
ENSG00000243147	MRPL33	100	84.615	ENSBTAG00000035199	MRPL33	100	84.615	Bos_taurus
ENSG00000243147	MRPL33	100	89.231	ENSCJAG00000046753	MRPL33	100	89.231	Callithrix_jacchus
ENSG00000243147	MRPL33	100	80.000	ENSCAFG00000005186	-	100	80.000	Canis_familiaris
ENSG00000243147	MRPL33	100	78.462	ENSCAFG00020013937	-	100	78.462	Canis_lupus_dingo
ENSG00000243147	MRPL33	88	84.211	ENSTSYG00000003123	-	100	84.211	Carlito_syrichta
ENSG00000243147	MRPL33	100	73.846	ENSTSYG00000037426	-	100	73.846	Carlito_syrichta
ENSG00000243147	MRPL33	78	74.510	ENSCAPG00000007076	MRPL33	100	74.510	Cavia_aperea
ENSG00000243147	MRPL33	100	75.385	ENSCPOG00000030574	MRPL33	100	75.385	Cavia_porcellus
ENSG00000243147	MRPL33	100	93.846	ENSCCAG00000019922	MRPL33	100	93.846	Cebus_capucinus
ENSG00000243147	MRPL33	100	93.846	ENSCATG00000038280	MRPL33	100	93.846	Cercocebus_atys
ENSG00000243147	MRPL33	100	76.923	ENSCLAG00000007340	MRPL33	100	76.923	Chinchilla_lanigera
ENSG00000243147	MRPL33	88	75.439	ENSCPBG00000025396	MRPL33	88	75.439	Chrysemys_picta_bellii
ENSG00000243147	MRPL33	100	95.385	ENSCANG00000031675	MRPL33	100	95.385	Colobus_angolensis_palliatus
ENSG00000243147	MRPL33	100	72.308	ENSCGRG00001009851	-	100	72.308	Cricetulus_griseus_chok1gshd
ENSG00000243147	MRPL33	100	80.000	ENSCGRG00001023932	-	100	80.000	Cricetulus_griseus_chok1gshd
ENSG00000243147	MRPL33	100	80.000	ENSCGRG00000002802	Mrpl33	100	80.000	Cricetulus_griseus_crigri
ENSG00000243147	MRPL33	100	63.077	ENSCSEG00000002845	mrpl33	100	63.077	Cynoglossus_semilaevis
ENSG00000243147	MRPL33	100	67.692	ENSDARG00000104031	mrpl33	100	67.692	Danio_rerio
ENSG00000243147	MRPL33	100	78.462	ENSDORG00000025964	Mrpl33	100	78.462	Dipodomys_ordii
ENSG00000243147	MRPL33	100	76.923	ENSETEG00000003239	MRPL33	100	76.923	Echinops_telfairi
ENSG00000243147	MRPL33	100	69.231	ENSELUG00000015148	RM33	100	69.231	Esox_lucius
ENSG00000243147	MRPL33	100	81.538	ENSFCAG00000034471	-	100	81.538	Felis_catus
ENSG00000243147	MRPL33	100	81.538	ENSFDAG00000008924	MRPL33	100	81.538	Fukomys_damarensis
ENSG00000243147	MRPL33	100	60.000	ENSFHEG00000009336	mrpl33	100	60.000	Fundulus_heteroclitus
ENSG00000243147	MRPL33	88	66.667	ENSGMOG00000001965	mrpl33	100	66.667	Gadus_morhua
ENSG00000243147	MRPL33	80	69.231	ENSGAFG00000019516	mrpl33	85	69.231	Gambusia_affinis
ENSG00000243147	MRPL33	100	61.538	ENSGACG00000012910	mrpl33	100	61.538	Gasterosteus_aculeatus
ENSG00000243147	MRPL33	77	74.000	ENSGAGG00000007777	MRPL33	79	68.182	Gopherus_agassizii
ENSG00000243147	MRPL33	100	100.000	ENSGGOG00000039421	MRPL33	100	100.000	Gorilla_gorilla
ENSG00000243147	MRPL33	100	81.538	ENSHGLG00000008938	MRPL33	100	81.538	Heterocephalus_glaber_female
ENSG00000243147	MRPL33	100	81.538	ENSHGLG00100007051	MRPL33	100	81.538	Heterocephalus_glaber_male
ENSG00000243147	MRPL33	100	72.308	ENSIPUG00000010286	mrpl33	100	72.308	Ictalurus_punctatus
ENSG00000243147	MRPL33	100	78.462	ENSSTOG00000032505	MRPL33	100	78.462	Ictidomys_tridecemlineatus
ENSG00000243147	MRPL33	100	78.462	ENSJJAG00000020354	Mrpl33	100	78.462	Jaculus_jaculus
ENSG00000243147	MRPL33	85	63.636	ENSKMAG00000003900	mrpl33	90	63.636	Kryptolebias_marmoratus
ENSG00000243147	MRPL33	88	70.175	ENSLBEG00000023093	mrpl33	80	70.175	Labrus_bergylta
ENSG00000243147	MRPL33	100	67.692	ENSLACG00000022672	MRPL33	100	67.692	Latimeria_chalumnae
ENSG00000243147	MRPL33	100	93.846	ENSMFAG00000002856	-	100	93.846	Macaca_fascicularis
ENSG00000243147	MRPL33	100	90.769	ENSMFAG00000005696	-	100	90.769	Macaca_fascicularis
ENSG00000243147	MRPL33	100	93.846	ENSMMUG00000045024	MRPL33	100	93.846	Macaca_mulatta
ENSG00000243147	MRPL33	100	93.846	ENSMMUG00000022650	-	100	93.846	Macaca_mulatta
ENSG00000243147	MRPL33	100	93.846	ENSMNEG00000037034	MRPL33	100	93.846	Macaca_nemestrina
ENSG00000243147	MRPL33	100	93.846	ENSMLEG00000029710	MRPL33	100	93.846	Mandrillus_leucophaeus
ENSG00000243147	MRPL33	100	55.385	ENSMAMG00000014373	mrpl33	100	55.385	Mastacembelus_armatus
ENSG00000243147	MRPL33	100	60.000	ENSMZEG00005009499	mrpl33	100	60.000	Maylandia_zebra
ENSG00000243147	MRPL33	100	81.538	ENSMAUG00000008426	Mrpl33	100	81.538	Mesocricetus_auratus
ENSG00000243147	MRPL33	100	90.769	ENSMICG00000043272	MRPL33	100	90.769	Microcebus_murinus
ENSG00000243147	MRPL33	100	78.462	ENSMOCG00000013281	Mrpl33	100	78.462	Microtus_ochrogaster
ENSG00000243147	MRPL33	100	58.462	ENSMMOG00000004915	mrpl33	100	58.462	Mola_mola
ENSG00000243147	MRPL33	88	75.439	ENSMODG00000015587	MRPL33	100	75.439	Monodelphis_domestica
ENSG00000243147	MRPL33	100	61.538	ENSMALG00000004698	mrpl33	100	61.538	Monopterus_albus
ENSG00000243147	MRPL33	100	76.923	ENSMUSG00000106918	Mrpl33	100	76.923	Mus_musculus
ENSG00000243147	MRPL33	100	86.154	ENSMLUG00000000185	MRPL33	100	86.154	Myotis_lucifugus
ENSG00000243147	MRPL33	100	78.462	ENSNGAG00000010413	Mrpl33	100	78.462	Nannospalax_galili
ENSG00000243147	MRPL33	100	64.615	ENSNBRG00000011414	mrpl33	100	64.615	Neolamprologus_brichardi
ENSG00000243147	MRPL33	100	96.923	ENSNLEG00000015281	MRPL33	100	96.923	Nomascus_leucogenys
ENSG00000243147	MRPL33	100	70.769	ENSOPRG00000011891	MRPL33	100	70.769	Ochotona_princeps
ENSG00000243147	MRPL33	88	75.439	ENSOANG00000021528	MRPL33	100	75.439	Ornithorhynchus_anatinus
ENSG00000243147	MRPL33	100	63.077	ENSORLG00000028315	mrpl33	100	63.077	Oryzias_latipes
ENSG00000243147	MRPL33	100	70.769	ENSORLG00015005523	mrpl33	100	70.769	Oryzias_latipes_hsok
ENSG00000243147	MRPL33	100	69.231	ENSOMEG00000009622	mrpl33	100	69.231	Oryzias_melastigma
ENSG00000243147	MRPL33	100	100.000	ENSPPAG00000032496	MRPL33	100	100.000	Pan_paniscus
ENSG00000243147	MRPL33	100	81.538	ENSPPRG00000001558	-	100	81.538	Panthera_pardus
ENSG00000243147	MRPL33	100	81.538	ENSPTIG00000001562	-	100	81.538	Panthera_tigris_altaica
ENSG00000243147	MRPL33	100	100.000	ENSPTRG00000011779	MRPL33	100	100.000	Pan_troglodytes
ENSG00000243147	MRPL33	100	93.846	ENSPANG00000006930	MRPL33	100	93.846	Papio_anubis
ENSG00000243147	MRPL33	100	60.000	ENSPKIG00000022674	mrpl33	100	60.000	Paramormyrops_kingsleyae
ENSG00000243147	MRPL33	100	55.385	ENSPMGG00000005859	mrpl33	100	55.385	Periophthalmus_magnuspinnatus
ENSG00000243147	MRPL33	100	75.385	ENSPEMG00000009497	-	100	75.385	Peromyscus_maniculatus_bairdii
ENSG00000243147	MRPL33	100	76.923	ENSPCIG00000029130	MRPL33	100	76.923	Phascolarctos_cinereus
ENSG00000243147	MRPL33	100	70.769	ENSPFOG00000011120	mrpl33	100	70.769	Poecilia_formosa
ENSG00000243147	MRPL33	100	63.077	ENSPLAG00000010635	mrpl33	100	63.077	Poecilia_latipinna
ENSG00000243147	MRPL33	100	70.769	ENSPMEG00000008536	mrpl33	100	70.769	Poecilia_mexicana
ENSG00000243147	MRPL33	100	61.538	ENSPREG00000004811	mrpl33	100	61.538	Poecilia_reticulata
ENSG00000243147	MRPL33	100	96.923	ENSPPYG00000012536	MRPL33	100	96.923	Pongo_abelii
ENSG00000243147	MRPL33	100	86.154	ENSPCOG00000020451	MRPL33	100	86.154	Propithecus_coquereli
ENSG00000243147	MRPL33	100	81.538	ENSPVAG00000006159	MRPL33	100	81.538	Pteropus_vampyrus
ENSG00000243147	MRPL33	100	58.462	ENSPNAG00000011437	mrpl33	100	58.462	Pygocentrus_nattereri
ENSG00000243147	MRPL33	100	78.462	ENSRNOG00000025388	Mrpl33	100	78.462	Rattus_norvegicus
ENSG00000243147	MRPL33	100	95.385	ENSRBIG00000037274	MRPL33	100	95.385	Rhinopithecus_bieti
ENSG00000243147	MRPL33	100	95.385	ENSRROG00000034607	MRPL33	100	95.385	Rhinopithecus_roxellana
ENSG00000243147	MRPL33	100	89.231	ENSSBOG00000002398	MRPL33	100	89.231	Saimiri_boliviensis_boliviensis
ENSG00000243147	MRPL33	100	56.164	ENSSFOG00015004529	mrpl33	100	56.164	Scleropages_formosus
ENSG00000243147	MRPL33	100	50.769	ENSSMAG00000015166	mrpl33	100	50.769	Scophthalmus_maximus
ENSG00000243147	MRPL33	100	60.000	ENSSLDG00000015845	mrpl33	100	60.000	Seriola_lalandi_dorsalis
ENSG00000243147	MRPL33	100	64.615	ENSSPAG00000013797	mrpl33	100	64.615	Stegastes_partitus
ENSG00000243147	MRPL33	100	58.462	ENSSPAG00000013784	mrpl33	100	58.462	Stegastes_partitus
ENSG00000243147	MRPL33	100	84.615	ENSSSCG00000034129	-	100	84.615	Sus_scrofa
ENSG00000243147	MRPL33	100	68.182	ENSSSCG00000025479	-	100	68.182	Sus_scrofa
ENSG00000243147	MRPL33	98	64.062	ENSTRUG00000023587	mrpl33	88	64.062	Takifugu_rubripes
ENSG00000243147	MRPL33	100	67.692	ENSTNIG00000018771	mrpl33	100	67.692	Tetraodon_nigroviridis
ENSG00000243147	MRPL33	100	83.077	ENSTTRG00000012541	MRPL33	100	83.077	Tursiops_truncatus
ENSG00000243147	MRPL33	100	81.538	ENSUAMG00000009281	-	100	81.538	Ursus_americanus
ENSG00000243147	MRPL33	88	82.456	ENSVPAG00000003380	MRPL33	100	82.456	Vicugna_pacos
ENSG00000243147	MRPL33	80	69.231	ENSXMAG00000018439	mrpl33	85	69.231	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	-	IEA	Function
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28869607	MRPL33 and its splicing regulator hnRNPK are required for mitochondria function and implicated in tumor progression.	Oncogene	2018 Jan 4	Liu L	doi: 10.1038/onc.2017.314

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr2	27774449	Missense_Mutation	rs750428922	E23K	0.13	Ribosomal_L33
BRCA	chr2	27779669	3'UTR	novel		0.33
COAD	chr2	27774504	Missense_Mutation	novel	L41P	0.32	Ribosomal_L33
COAD	chr2	27779530	3'UTR	NA		0.3
COAD	chr2	27779471	Missense_Mutation	rs763582483	R63C	0.15
GBM	chr2	27779442	Missense_Mutation	novel	R53I	0.53	Ribosomal_L33
HNSC	chr2	27779434	Splice_Region	novel	V50V	0.09
HNSC	chr2	27779515	3'UTR	novel		0.31
LAML	chr2	27779527	3'UTR	novel		0.04
LUAD	chr2	27774508	Silent	rs770493267	T42T	0.22
LUSC	chr2	27779608	3'UTR	novel		0.31
LUSC	chr2	27779485	3'UTR	novel		0.08
PAAD	chr2	27771740	5'UTR	novel		0.07
SKCM	chr2	27774446	Frame_Shift_Del	novel	*S22Afs20**	0.23	Ribosomal_L33
SKCM	chr2	27774488	Nonsense_Mutation	novel	R36*	0.36	Ribosomal_L33
STAD	chr2	27779590	3'UTR	novel		0.11
STAD	chr2	27774478	Silent	novel	T32T	0.29
STAD	chr2	27771781	Missense_Mutation	NA	F2L	0.2
THCA	chr2	27779706	3'UTR	novel		0.2
THCA	chr2	27779708	3'UTR	novel		0.2
UCEC	chr2	27771733	5'UTR	novel		0.37
UCEC	chr2	27771727	5'UTR	novel		0.1
UCEC	chr2	27774465	Missense_Mutation	novel	F28S	0.36	Ribosomal_L33
UCEC	chr2	27779519	3'UTR	novel		0.22
UCEC	chr2	27774473	Missense_Mutation	novel	N31D	0.38	Ribosomal_L33
UCEC	chr2	27779447	Missense_Mutation	novel	L55I	0.34	Ribosomal_L33
UCEC	chr2	27779649	3'UTR	novel		0.58
UCEC	chr2	27771738	5'UTR	rs777775364		0.12
UCEC	chr2	27771763	5'UTR	rs764934798		0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2271	0.099937
KIRP	AMP	0.1354	0.13274
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0978	0.2014
TGCT	AMP	0.2667	0.0050216

Survival Analysis

Cancer	P-value	Q-value
MESO	0.013	Kaplan-Meier Survival Analysis
HNSC	0.00011	Kaplan-Meier Survival Analysis
LUSC	0.048	Kaplan-Meier Survival Analysis
TGCT	0.031	Kaplan-Meier Survival Analysis
KICH	0.01	Kaplan-Meier Survival Analysis
UCEC	0.011	Kaplan-Meier Survival Analysis
LIHC	0.00024	Kaplan-Meier Survival Analysis
OV	0.033	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742