EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000243927 (Gene tree)
Gene ID: 64968
Gene Symbol: MRPS6
Alias: MRP-S6|RPMS6|C21orf101
Full Name: mitochondrial ribosomal protein S6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 69,811 bases
Position: chr21:34,073,224-34,143,034
Accession: 14051
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000382250	Ribosomal_S6	PF01250.17	1.7e-16	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000483977	MRPS6-204	3934	-	-	- (aa)	-	-
ENST00000488492	MRPS6-205	909	-	-	- (aa)	-	-
ENST00000482679	MRPS6-203	1956	-	-	- (aa)	-	-
ENST00000399312	MRPS6-201	990	-	ENSP00000382250	125 (aa)	-	P82932
ENST00000477091	MRPS6-202	1061	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000243927's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000243927	Platelet Function Tests	1.1920200E-005	-
ENSG00000243927	Platelet Function Tests	1.8956100E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000243927	rs147050753	21	34092388	?	Red blood cell count	30595370			EFO_0004305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000243927's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000243927	MRPS6	76	69.474	ENSAPOG00000001860	mrps6	82	69.474	Acanthochromis_polyacanthus
ENSG00000243927	MRPS6	97	79.339	ENSAMEG00000014707	MRPS6	100	79.339	Ailuropoda_melanoleuca
ENSG00000243927	MRPS6	86	59.813	ENSACIG00000009753	mrps6	86	59.813	Amphilophus_citrinellus
ENSG00000243927	MRPS6	76	66.316	ENSAOCG00000003466	mrps6	79	66.316	Amphiprion_ocellaris
ENSG00000243927	MRPS6	86	60.748	ENSAPEG00000015740	mrps6	97	60.748	Amphiprion_percula
ENSG00000243927	MRPS6	86	59.813	ENSATEG00000017579	mrps6	97	59.813	Anabas_testudineus
ENSG00000243927	MRPS6	98	66.667	ENSACAG00000005071	MRPS6	100	66.667	Anolis_carolinensis
ENSG00000243927	MRPS6	100	90.400	ENSANAG00000022450	MRPS6	100	90.400	Aotus_nancymaae
ENSG00000243927	MRPS6	86	60.748	ENSACLG00000026010	mrps6	88	60.748	Astatotilapia_calliptera
ENSG00000243927	MRPS6	76	64.211	ENSAMXG00000026285	mrps6	83	64.211	Astyanax_mexicanus
ENSG00000243927	MRPS6	99	85.484	ENSBTAG00000012594	MRPS6	100	85.484	Bos_taurus
ENSG00000243927	MRPS6	100	90.400	ENSCJAG00000043803	MRPS6	100	90.400	Callithrix_jacchus
ENSG00000243927	MRPS6	99	85.484	ENSCAFG00000028779	MRPS6	100	85.484	Canis_familiaris
ENSG00000243927	MRPS6	99	85.484	ENSCAFG00020024603	MRPS6	100	85.484	Canis_lupus_dingo
ENSG00000243927	MRPS6	99	87.097	ENSCHIG00000020464	MRPS6	100	87.097	Capra_hircus
ENSG00000243927	MRPS6	100	85.600	ENSTSYG00000004217	MRPS6	100	85.600	Carlito_syrichta
ENSG00000243927	MRPS6	87	83.486	ENSCAPG00000003067	MRPS6	100	83.486	Cavia_aperea
ENSG00000243927	MRPS6	87	83.486	ENSCPOG00000036980	MRPS6	100	83.486	Cavia_porcellus
ENSG00000243927	MRPS6	100	89.600	ENSCCAG00000024506	MRPS6	100	89.600	Cebus_capucinus
ENSG00000243927	MRPS6	100	92.000	ENSCATG00000005273	MRPS6	100	92.000	Cercocebus_atys
ENSG00000243927	MRPS6	87	85.321	ENSCLAG00000004549	MRPS6	100	85.321	Chinchilla_lanigera
ENSG00000243927	MRPS6	100	93.600	ENSCSAG00000009933	MRPS6	100	93.600	Chlorocebus_sabaeus
ENSG00000243927	MRPS6	87	83.486	ENSCHOG00000003863	MRPS6	100	83.486	Choloepus_hoffmanni
ENSG00000243927	MRPS6	88	90.909	ENSCANG00000041718	MRPS6	100	90.909	Colobus_angolensis_palliatus
ENSG00000243927	MRPS6	100	80.000	ENSCGRG00001004615	Mrps6	100	80.000	Cricetulus_griseus_chok1gshd
ENSG00000243927	MRPS6	88	78.182	ENSCGRG00000018105	Mrps6	100	78.182	Cricetulus_griseus_crigri
ENSG00000243927	MRPS6	86	57.009	ENSCSEG00000011973	mrps6	97	57.009	Cynoglossus_semilaevis
ENSG00000243927	MRPS6	76	66.316	ENSCVAG00000004108	mrps6	83	66.316	Cyprinodon_variegatus
ENSG00000243927	MRPS6	86	54.630	ENSDARG00000039543	mrps6	92	54.630	Danio_rerio
ENSG00000243927	MRPS6	99	83.871	ENSDNOG00000041980	MRPS6	100	83.871	Dasypus_novemcinctus
ENSG00000243927	MRPS6	100	82.400	ENSDORG00000028219	Mrps6	100	82.400	Dipodomys_ordii
ENSG00000243927	MRPS6	92	46.957	ENSEBUG00000001150	mrps6	100	47.581	Eptatretus_burgeri
ENSG00000243927	MRPS6	99	78.226	ENSEASG00005006162	MRPS6	100	78.226	Equus_asinus_asinus
ENSG00000243927	MRPS6	86	60.185	ENSELUG00000015914	mrps6	93	60.185	Esox_lucius
ENSG00000243927	MRPS6	99	87.903	ENSFCAG00000035307	MRPS6	100	87.903	Felis_catus
ENSG00000243927	MRPS6	97	66.116	ENSFALG00000005093	MRPS6	99	66.116	Ficedula_albicollis
ENSG00000243927	MRPS6	87	82.569	ENSFDAG00000014986	MRPS6	100	82.569	Fukomys_damarensis
ENSG00000243927	MRPS6	88	57.273	ENSFHEG00000005395	mrps6	90	57.273	Fundulus_heteroclitus
ENSG00000243927	MRPS6	76	64.211	ENSGMOG00000019810	mrps6	81	64.211	Gadus_morhua
ENSG00000243927	MRPS6	93	54.310	ENSGAFG00000006521	mrps6	100	54.310	Gambusia_affinis
ENSG00000243927	MRPS6	98	64.754	ENSGAGG00000017604	MRPS6	100	64.754	Gopherus_agassizii
ENSG00000243927	MRPS6	88	100.000	ENSGGOG00000043405	MRPS6	100	100.000	Gorilla_gorilla
ENSG00000243927	MRPS6	86	60.748	ENSHBUG00000010529	mrps6	84	60.748	Haplochromis_burtoni
ENSG00000243927	MRPS6	99	84.677	ENSHGLG00000011207	MRPS6	100	84.677	Heterocephalus_glaber_female
ENSG00000243927	MRPS6	87	82.569	ENSHGLG00100016976	MRPS6	100	82.569	Heterocephalus_glaber_male
ENSG00000243927	MRPS6	92	56.522	ENSHCOG00000012233	mrps6	99	56.522	Hippocampus_comes
ENSG00000243927	MRPS6	87	83.486	ENSSTOG00000028147	MRPS6	100	83.486	Ictidomys_tridecemlineatus
ENSG00000243927	MRPS6	100	77.600	ENSJJAG00000019018	Mrps6	100	77.600	Jaculus_jaculus
ENSG00000243927	MRPS6	76	63.158	ENSKMAG00000015801	mrps6	80	63.158	Kryptolebias_marmoratus
ENSG00000243927	MRPS6	76	61.053	ENSLBEG00000012963	mrps6	78	61.053	Labrus_bergylta
ENSG00000243927	MRPS6	98	59.350	ENSLACG00000011712	MRPS6	100	59.350	Latimeria_chalumnae
ENSG00000243927	MRPS6	86	56.481	ENSLOCG00000018238	mrps6	90	56.481	Lepisosteus_oculatus
ENSG00000243927	MRPS6	91	73.684	ENSLAFG00000020645	MRPS6	92	73.684	Loxodonta_africana
ENSG00000243927	MRPS6	90	90.179	ENSMFAG00000032733	MRPS6	97	90.179	Macaca_fascicularis
ENSG00000243927	MRPS6	90	90.179	ENSMMUG00000023156	MRPS6	97	90.179	Macaca_mulatta
ENSG00000243927	MRPS6	90	88.393	ENSMNEG00000004266	MRPS6	97	88.393	Macaca_nemestrina
ENSG00000243927	MRPS6	88	91.818	ENSMLEG00000042372	MRPS6	100	91.818	Mandrillus_leucophaeus
ENSG00000243927	MRPS6	86	60.748	ENSMAMG00000019881	mrps6	93	60.748	Mastacembelus_armatus
ENSG00000243927	MRPS6	86	60.748	ENSMZEG00005008327	mrps6	88	60.748	Maylandia_zebra
ENSG00000243927	MRPS6	86	62.037	ENSMGAG00000016139	MRPS6	100	62.037	Meleagris_gallopavo
ENSG00000243927	MRPS6	100	88.000	ENSMICG00000027621	MRPS6	100	88.000	Microcebus_murinus
ENSG00000243927	MRPS6	100	81.600	ENSMOCG00000006588	Mrps6	100	81.600	Microtus_ochrogaster
ENSG00000243927	MRPS6	86	62.617	ENSMMOG00000003410	mrps6	80	62.617	Mola_mola
ENSG00000243927	MRPS6	87	76.147	ENSMODG00000021054	MRPS6	92	76.147	Monodelphis_domestica
ENSG00000243927	MRPS6	76	67.368	ENSMALG00000002531	mrps6	86	67.368	Monopterus_albus
ENSG00000243927	MRPS6	100	85.600	MGP_CAROLIEiJ_G0020970	Mrps6	100	85.600	Mus_caroli
ENSG00000243927	MRPS6	100	85.600	ENSMUSG00000039680	Mrps6	100	85.600	Mus_musculus
ENSG00000243927	MRPS6	100	84.800	MGP_PahariEiJ_G0016675	Mrps6	100	84.800	Mus_pahari
ENSG00000243927	MRPS6	100	85.600	MGP_SPRETEiJ_G0021876	Mrps6	100	85.600	Mus_spretus
ENSG00000243927	MRPS6	99	87.097	ENSMPUG00000001330	MRPS6	100	87.097	Mustela_putorius_furo
ENSG00000243927	MRPS6	89	86.486	ENSMLUG00000027328	MRPS6	100	86.486	Myotis_lucifugus
ENSG00000243927	MRPS6	100	82.400	ENSNGAG00000004525	Mrps6	100	82.400	Nannospalax_galili
ENSG00000243927	MRPS6	86	61.682	ENSNBRG00000015785	mrps6	88	61.682	Neolamprologus_brichardi
ENSG00000243927	MRPS6	99	95.161	ENSNLEG00000033707	MRPS6	100	95.161	Nomascus_leucogenys
ENSG00000243927	MRPS6	98	77.049	ENSMEUG00000006954	MRPS6	71	77.049	Notamacropus_eugenii
ENSG00000243927	MRPS6	88	80.000	ENSOPRG00000018417	-	61	80.000	Ochotona_princeps
ENSG00000243927	MRPS6	99	84.677	ENSODEG00000003176	-	100	84.677	Octodon_degus
ENSG00000243927	MRPS6	99	83.065	ENSODEG00000019042	-	100	83.065	Octodon_degus
ENSG00000243927	MRPS6	99	83.871	ENSODEG00000019820	-	100	83.871	Octodon_degus
ENSG00000243927	MRPS6	86	60.748	ENSONIG00000009920	mrps6	91	60.748	Oreochromis_niloticus
ENSG00000243927	MRPS6	88	79.091	ENSOCUG00000025692	MRPS6	99	79.091	Oryctolagus_cuniculus
ENSG00000243927	MRPS6	76	66.316	ENSORLG00000011435	mrps6	79	66.316	Oryzias_latipes
ENSG00000243927	MRPS6	76	65.263	ENSORLG00020016619	mrps6	83	65.263	Oryzias_latipes_hni
ENSG00000243927	MRPS6	76	65.263	ENSORLG00015001426	mrps6	87	65.263	Oryzias_latipes_hsok
ENSG00000243927	MRPS6	76	66.316	ENSOMEG00000022340	mrps6	81	66.316	Oryzias_melastigma
ENSG00000243927	MRPS6	99	85.484	ENSOGAG00000031219	MRPS6	100	85.484	Otolemur_garnettii
ENSG00000243927	MRPS6	88	84.545	ENSOARG00000012707	MRPS6	97	78.049	Ovis_aries
ENSG00000243927	MRPS6	88	100.000	ENSPPAG00000033507	MRPS6	100	100.000	Pan_paniscus
ENSG00000243927	MRPS6	87	86.239	ENSPPRG00000011728	MRPS6	88	86.239	Panthera_pardus
ENSG00000243927	MRPS6	87	86.239	ENSPTIG00000000875	MRPS6	88	86.239	Panthera_tigris_altaica
ENSG00000243927	MRPS6	100	100.000	ENSPTRG00000013877	MRPS6	100	100.000	Pan_troglodytes
ENSG00000243927	MRPS6	100	91.200	ENSPANG00000033815	MRPS6	100	91.200	Papio_anubis
ENSG00000243927	MRPS6	100	53.600	ENSPKIG00000006507	mrps6	100	53.600	Paramormyrops_kingsleyae
ENSG00000243927	MRPS6	91	54.386	ENSPSIG00000017909	MRPS6	99	56.731	Pelodiscus_sinensis
ENSG00000243927	MRPS6	93	78.448	ENSPEMG00000023075	Mrps6	100	80.909	Peromyscus_maniculatus_bairdii
ENSG00000243927	MRPS6	98	77.049	ENSPCIG00000008946	MRPS6	100	77.049	Phascolarctos_cinereus
ENSG00000243927	MRPS6	76	62.105	ENSPFOG00000016295	mrps6	87	62.105	Poecilia_formosa
ENSG00000243927	MRPS6	76	62.105	ENSPLAG00000003859	mrps6	79	62.105	Poecilia_latipinna
ENSG00000243927	MRPS6	76	61.053	ENSPMEG00000019989	mrps6	82	61.053	Poecilia_mexicana
ENSG00000243927	MRPS6	76	60.000	ENSPREG00000023188	mrps6	86	60.000	Poecilia_reticulata
ENSG00000243927	MRPS6	86	93.519	ENSPPYG00000011386	MRPS6	88	92.920	Pongo_abelii
ENSG00000243927	MRPS6	88	80.909	ENSPCAG00000002299	MRPS6	100	80.909	Procavia_capensis
ENSG00000243927	MRPS6	96	88.333	ENSPCOG00000013816	MRPS6	100	88.000	Propithecus_coquereli
ENSG00000243927	MRPS6	99	87.097	ENSPVAG00000013059	MRPS6	67	87.097	Pteropus_vampyrus
ENSG00000243927	MRPS6	86	60.748	ENSPNYG00000017777	mrps6	88	60.748	Pundamilia_nyererei
ENSG00000243927	MRPS6	76	64.211	ENSPNAG00000027225	mrps6	76	64.211	Pygocentrus_nattereri
ENSG00000243927	MRPS6	100	87.200	ENSRNOG00000059381	Mrps6	100	87.200	Rattus_norvegicus
ENSG00000243927	MRPS6	88	91.818	ENSRBIG00000003438	MRPS6	100	91.818	Rhinopithecus_bieti
ENSG00000243927	MRPS6	88	90.909	ENSRROG00000040127	MRPS6	88	90.909	Rhinopithecus_roxellana
ENSG00000243927	MRPS6	89	87.387	ENSSBOG00000034972	MRPS6	99	87.387	Saimiri_boliviensis_boliviensis
ENSG00000243927	MRPS6	77	65.625	ENSSFOG00015003890	mrps6	75	65.625	Scleropages_formosus
ENSG00000243927	MRPS6	76	63.158	ENSSMAG00000008876	mrps6	82	63.158	Scophthalmus_maximus
ENSG00000243927	MRPS6	76	64.211	ENSSDUG00000005175	mrps6	88	64.211	Seriola_dumerili
ENSG00000243927	MRPS6	86	58.879	ENSSLDG00000023246	mrps6	97	58.879	Seriola_lalandi_dorsalis
ENSG00000243927	MRPS6	80	55.000	ENSSPUG00000013319	MRPS6	100	55.000	Sphenodon_punctatus
ENSG00000243927	MRPS6	76	66.316	ENSSPAG00000010499	mrps6	86	66.316	Stegastes_partitus
ENSG00000243927	MRPS6	99	87.097	ENSSSCG00000026981	MRPS6	100	87.097	Sus_scrofa
ENSG00000243927	MRPS6	97	65.289	ENSTGUG00000000454	MRPS6	99	65.289	Taeniopygia_guttata
ENSG00000243927	MRPS6	86	61.111	ENSTRUG00000021829	mrps6	95	61.111	Takifugu_rubripes
ENSG00000243927	MRPS6	87	87.156	ENSTTRG00000004878	MRPS6	100	87.156	Tursiops_truncatus
ENSG00000243927	MRPS6	92	80.870	ENSUAMG00000028318	MRPS6	100	80.870	Ursus_americanus
ENSG00000243927	MRPS6	97	77.686	ENSUMAG00000020133	MRPS6	98	77.686	Ursus_maritimus
ENSG00000243927	MRPS6	87	68.807	ENSVPAG00000009160	MRPS6	100	68.807	Vicugna_pacos
ENSG00000243927	MRPS6	92	81.739	ENSVVUG00000022921	MRPS6	100	81.739	Vulpes_vulpes
ENSG00000243927	MRPS6	98	57.377	ENSXETG00000032139	MRPS6	100	64.545	Xenopus_tropicalis
ENSG00000243927	MRPS6	76	63.158	ENSXMAG00000019807	mrps6	86	63.158	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	11402041.	ISS	Function
GO:0003735	structural constituent of ribosome	11279123.	NAS	Function
GO:0005515	protein binding	22458338.25416956.	IPI	Function
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005763	mitochondrial small ribosomal subunit	21873635.	IBA	Component
GO:0005763	mitochondrial small ribosomal subunit	25838379.	IDA	Component
GO:0005763	mitochondrial small ribosomal subunit	11402041.	ISS	Component
GO:0006412	translation	11279123.	NAS	Process
GO:0015935	small ribosomal subunit	11279123.	NAS	Component
GO:0032543	mitochondrial translation	11402041.	ISS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process
GO:0070181	small ribosomal subunit rRNA binding	21873635.	IBA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr21	34142565	Missense_Mutation	novel	E115K	0.48
BLCA	chr21	34142491	Missense_Mutation	novel	R90T	0.1	Ribosomal_S6
BLCA	chr21	34125370	Silent	NA	T25T	0.5
COAD	chr21	34125478	Splice_Region	rs779997227	G61G	0.41
COAD	chr21	34125366	Missense_Mutation	rs753096820	R24H	0.2	Ribosomal_S6
COAD	chr21	34125385	Missense_Mutation	NA	M30I	0.15	Ribosomal_S6
KIRC	chr21	34142423	Frame_Shift_Del	novel	*Y69Mfs18**	0.27	Ribosomal_S6
LUAD	chr21	34142457	Missense_Mutation	NA	V79L	0.4	Ribosomal_S6
LUAD	chr21	34142459	Silent	novel	V79V	0.14
LUAD	chr21	34142460	Nonsense_Mutation	novel	E80*	0.14	Ribosomal_S6
LUAD	chr21	34142433	Missense_Mutation	novel	P71S	0.1	Ribosomal_S6
LUAD	chr21	34125479	Missense_Mutation	NA	G62W	0.2	Ribosomal_S6
LUAD	chr21	34125466	Missense_Mutation	NA	Q57H	0.2	Ribosomal_S6
LUAD	chr21	34142556	Missense_Mutation	rs764160661	P112S	0.06
LUSC	chr21	34142421	Missense_Mutation	rs773705009	D67Y	0.53	Ribosomal_S6
READ	chr21	34142627	3'UTR	novel		0.22
STAD	chr21	34125369	Missense_Mutation	rs555801788	T25M	0.15	Ribosomal_S6
UCEC	chr21	34125376	Silent	novel	E27E	0.08
UCEC	chr21	34142813	3'UTR	novel		0.5
UCEC	chr21	34142473	Missense_Mutation	rs777690532	R84Q	0.28	Ribosomal_S6
UCEC	chr21	34142405	Splice_Region	novel		0.51
UCEC	chr21	34142473	Missense_Mutation	rs777690532	R84Q	0.36	Ribosomal_S6
UCEC	chr21	34142676	3'UTR	novel		0.17
UCEC	chr21	34125376	Missense_Mutation	NA	E27D	0.36	Ribosomal_S6
UCEC	chr21	34142635	3'UTR	novel		0.58
UCEC	chr21	34142414	Missense_Mutation	NA	F64L	0.31	Ribosomal_S6
UCEC	chr21	34142552	Silent	novel	P110P	0.19
UCEC	chr21	34125406	Silent	novel	R37R	0.24

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00029	Kaplan-Meier Survival Analysis
ACC	0.036	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.038	Kaplan-Meier Survival Analysis
BLCA	0.0001	Kaplan-Meier Survival Analysis
GBM	0.021	Kaplan-Meier Survival Analysis
LIHC	0.016	Kaplan-Meier Survival Analysis
LGG	0.00071	Kaplan-Meier Survival Analysis
UVM	0.00016	Kaplan-Meier Survival Analysis
OV	0.016	Kaplan-Meier Survival Analysis