EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000244462 (Gene tree)
Gene ID: 10137
Gene Symbol: RBM12
Alias: HRIHFB2091|KIAA0765|SWAN
Full Name: RNA binding motif protein 12
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 16,032 bases
Position: chr20:35,648,925-35,664,956
Accession: 9898
RBP type: canonical RBP
Summary: This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in four transcript variants. All variants encode the same protein. [provided by RefSeq, Nov 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000352668	RRM_1	PF00076.22	4.4e-30	1	3
ENSP00000352668	RRM_1	PF00076.22	4.4e-30	2	3
ENSP00000352668	RRM_1	PF00076.22	4.4e-30	3	3
ENSP00000363217	RRM_1	PF00076.22	4.4e-30	1	3
ENSP00000363217	RRM_1	PF00076.22	4.4e-30	2	3
ENSP00000363217	RRM_1	PF00076.22	4.4e-30	3	3
ENSP00000363228	RRM_1	PF00076.22	4.4e-30	1	3
ENSP00000363228	RRM_1	PF00076.22	4.4e-30	2	3
ENSP00000363228	RRM_1	PF00076.22	4.4e-30	3	3

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28628109	Truncating mutations in RBM12 are associated with psychosis.	Nat Genet	2017 Aug	Steinberg S	doi: 10.1038/ng.3894
18831769	Promoter-sharing by different genes in human genome--CPNE1 and RBM12 gene pair as an example.	BMC Genomics	2008 Oct 3	Yang W	doi: 10.1186/1471-2164-9-456.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000435161	RBM12-206	565	-	ENSP00000411692	134 (aa)	-	A6PVI1
ENST00000359646	RBM12-201	5332	-	ENSP00000352668	932 (aa)	-	Q9NTZ6
ENST00000374104	RBM12-202	5213	-	ENSP00000363217	932 (aa)	-	Q9NTZ6
ENST00000374114	RBM12-203	6662	-	ENSP00000363228	932 (aa)	-	Q9NTZ6
ENST00000431148	RBM12-205	583	-	ENSP00000392642	143 (aa)	-	A6PVI0
ENST00000424458	RBM12-204	1068	-	ENSP00000411036	291 (aa)	-	Q5JX62

Gene Model

Click here to download ENSG00000244462's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000244462	Arterial Pressure	1.8695450E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000244462's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000244462	RBM12	65	72.414	ENSG00000183808	RBM12B	99	74.074
ENSG00000244462	RBM12	63	31.818	ENSG00000169045	HNRNPH1	94	33.333

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000244462	RBM12	100	98.507	ENSAMEG00000019189	RBM12	100	95.815	Ailuropoda_melanoleuca
ENSG00000244462	RBM12	100	94.776	ENSACAG00000006330	RBM12	98	78.610	Anolis_carolinensis
ENSG00000244462	RBM12	100	98.969	ENSANAG00000032596	RBM12	98	98.391	Aotus_nancymaae
ENSG00000244462	RBM12	100	98.601	ENSBTAG00000044015	RBM12	100	91.432	Bos_taurus
ENSG00000244462	RBM12	100	98.507	ENSCAFG00000008256	RBM12	98	94.206	Canis_familiaris
ENSG00000244462	RBM12	100	98.507	ENSCAFG00020005650	RBM12	100	94.206	Canis_lupus_dingo
ENSG00000244462	RBM12	100	98.601	ENSCHIG00000024592	RBM12	100	93.562	Capra_hircus
ENSG00000244462	RBM12	100	98.601	ENSTSYG00000030563	RBM12	98	94.742	Carlito_syrichta
ENSG00000244462	RBM12	100	98.507	ENSCAPG00000006176	RBM12	80	93.866	Cavia_aperea
ENSG00000244462	RBM12	100	98.507	ENSCPOG00000035170	RBM12	100	93.909	Cavia_porcellus
ENSG00000244462	RBM12	100	97.203	ENSCCAG00000035899	-	100	76.288	Cebus_capucinus
ENSG00000244462	RBM12	96	94.731	ENSCCAG00000036056	-	98	94.731	Cebus_capucinus
ENSG00000244462	RBM12	100	99.464	ENSCATG00000030934	RBM12	98	99.464	Cercocebus_atys
ENSG00000244462	RBM12	100	97.761	ENSCLAG00000017230	RBM12	100	93.240	Chinchilla_lanigera
ENSG00000244462	RBM12	100	99.356	ENSCANG00000030552	RBM12	98	99.356	Colobus_angolensis_palliatus
ENSG00000244462	RBM12	100	97.902	ENSCGRG00001021144	Rbm12	100	86.231	Cricetulus_griseus_chok1gshd
ENSG00000244462	RBM12	100	97.902	ENSCGRG00000012719	Rbm12	100	86.231	Cricetulus_griseus_crigri
ENSG00000244462	RBM12	100	97.902	ENSDORG00000028509	-	100	93.269	Dipodomys_ordii
ENSG00000244462	RBM12	100	96.503	ENSDORG00000000606	-	100	81.571	Dipodomys_ordii
ENSG00000244462	RBM12	84	66.667	ENSEBUG00000016806	rbm12	89	65.649	Eptatretus_burgeri
ENSG00000244462	RBM12	100	98.507	ENSECAG00000021997	RBM12	100	93.884	Equus_caballus
ENSG00000244462	RBM12	100	97.203	ENSEEUG00000008858	-	56	95.699	Erinaceus_europaeus
ENSG00000244462	RBM12	100	97.761	ENSFDAG00000014663	RBM12	100	93.562	Fukomys_damarensis
ENSG00000244462	RBM12	100	97.761	ENSGALG00000030253	RBM12	100	79.636	Gallus_gallus
ENSG00000244462	RBM12	100	100.000	ENSGGOG00000028500	RBM12	98	99.785	Gorilla_gorilla
ENSG00000244462	RBM12	100	97.902	ENSHGLG00000013208	RBM12	100	93.670	Heterocephalus_glaber_female
ENSG00000244462	RBM12	100	97.902	ENSHGLG00100019158	RBM12	90	97.022	Heterocephalus_glaber_male
ENSG00000244462	RBM12	100	98.601	ENSSTOG00000019739	RBM12	100	90.126	Ictidomys_tridecemlineatus
ENSG00000244462	RBM12	100	97.203	ENSLAFG00000010341	RBM12	100	93.240	Loxodonta_africana
ENSG00000244462	RBM12	100	99.464	ENSMFAG00000032583	RBM12	98	99.464	Macaca_fascicularis
ENSG00000244462	RBM12	100	99.571	ENSMMUG00000020960	CPNE1	100	99.571	Macaca_mulatta
ENSG00000244462	RBM12	100	99.571	ENSMNEG00000045365	RBM12	98	99.571	Macaca_nemestrina
ENSG00000244462	RBM12	100	99.571	ENSMLEG00000032492	RBM12	98	99.571	Mandrillus_leucophaeus
ENSG00000244462	RBM12	69	94.624	ENSMAMG00000001497	rbm12	72	86.408	Mastacembelus_armatus
ENSG00000244462	RBM12	100	97.761	ENSMGAG00000001502	RBM12	100	79.479	Meleagris_gallopavo
ENSG00000244462	RBM12	100	97.902	ENSMAUG00000012800	Rbm12	100	87.437	Mesocricetus_auratus
ENSG00000244462	RBM12	100	98.601	ENSMICG00000032761	-	98	93.670	Microcebus_murinus
ENSG00000244462	RBM12	100	88.811	ENSMICG00000029540	-	72	84.748	Microcebus_murinus
ENSG00000244462	RBM12	100	97.203	ENSMOCG00000012950	Rbm12	100	92.776	Microtus_ochrogaster
ENSG00000244462	RBM12	100	97.761	ENSMODG00000001591	RBM12	98	84.979	Monodelphis_domestica
ENSG00000244462	RBM12	100	98.601	MGP_CAROLIEiJ_G0024551	Rbm12	98	93.295	Mus_caroli
ENSG00000244462	RBM12	100	97.902	ENSMUSG00000089824	Rbm12	100	92.867	Mus_musculus
ENSG00000244462	RBM12	100	98.601	MGP_PahariEiJ_G0025996	Rbm12	100	93.295	Mus_pahari
ENSG00000244462	RBM12	100	98.601	MGP_SPRETEiJ_G0025473	Rbm12	99	93.010	Mus_spretus
ENSG00000244462	RBM12	100	98.507	ENSMPUG00000017789	-	100	93.777	Mustela_putorius_furo
ENSG00000244462	RBM12	100	97.902	ENSMLUG00000011217	RBM12	98	93.133	Myotis_lucifugus
ENSG00000244462	RBM12	100	99.301	ENSNGAG00000015846	Rbm12	100	86.861	Nannospalax_galili
ENSG00000244462	RBM12	100	100.000	ENSNLEG00000010268	RBM12	98	99.678	Nomascus_leucogenys
ENSG00000244462	RBM12	100	97.761	ENSMEUG00000007621	RBM12	100	84.657	Notamacropus_eugenii
ENSG00000244462	RBM12	100	95.804	ENSOPRG00000005687	RBM12	100	91.720	Ochotona_princeps
ENSG00000244462	RBM12	100	96.269	ENSODEG00000013870	RBM12	100	86.442	Octodon_degus
ENSG00000244462	RBM12	100	100.000	ENSPPAG00000040719	RBM12	98	100.000	Pan_paniscus
ENSG00000244462	RBM12	100	100.000	ENSPTRG00000040708	-	98	100.000	Pan_troglodytes
ENSG00000244462	RBM12	100	100.000	ENSPTRG00000013446	RBM12	98	100.000	Pan_troglodytes
ENSG00000244462	RBM12	100	99.571	ENSPANG00000020003	CPNE1	98	99.571	Papio_anubis
ENSG00000244462	RBM12	100	96.269	ENSPSIG00000007369	RBM12	90	93.103	Pelodiscus_sinensis
ENSG00000244462	RBM12	78	83.810	ENSPMGG00000018816	rbm12	96	83.810	Periophthalmus_magnuspinnatus
ENSG00000244462	RBM12	100	98.601	ENSPEMG00000017769	Rbm12	100	81.845	Peromyscus_maniculatus_bairdii
ENSG00000244462	RBM12	82	82.609	ENSPFOG00000023551	rbm12	98	78.873	Poecilia_formosa
ENSG00000244462	RBM12	100	99.679	ENSPPYG00000010960	RBM12	100	99.679	Pongo_abelii
ENSG00000244462	RBM12	100	96.269	ENSPCAG00000008653	RBM12	100	91.416	Procavia_capensis
ENSG00000244462	RBM12	100	98.601	ENSPCOG00000023724	RBM12	98	96.137	Propithecus_coquereli
ENSG00000244462	RBM12	100	97.015	ENSPVAG00000014937	RBM12	100	93.670	Pteropus_vampyrus
ENSG00000244462	RBM12	100	97.902	ENSRNOG00000049913	LOC100910990	97	92.725	Rattus_norvegicus
ENSG00000244462	RBM12	100	97.902	ENSRNOG00000019723	Rbm12	97	92.725	Rattus_norvegicus
ENSG00000244462	RBM12	100	99.571	ENSRBIG00000042965	RBM12	98	99.571	Rhinopithecus_bieti
ENSG00000244462	RBM12	100	99.571	ENSRROG00000037485	RBM12	98	99.571	Rhinopithecus_roxellana
ENSG00000244462	RBM12	100	98.969	ENSSBOG00000027633	RBM12	98	98.283	Saimiri_boliviensis_boliviensis
ENSG00000244462	RBM12	100	97.761	ENSSHAG00000018585	RBM12	100	85.193	Sarcophilus_harrisii
ENSG00000244462	RBM12	100	98.507	ENSSSCG00000036156	RBM12	100	94.023	Sus_scrofa
ENSG00000244462	RBM12	100	97.761	ENSTGUG00000003002	RBM12	100	79.077	Taeniopygia_guttata
ENSG00000244462	RBM12	100	98.507	ENSTTRG00000017035	RBM12	100	93.562	Tursiops_truncatus
ENSG00000244462	RBM12	100	98.507	ENSUAMG00000010430	RBM12	100	94.099	Ursus_americanus
ENSG00000244462	RBM12	100	98.507	ENSVPAG00000003812	RBM12	87	100.000	Vicugna_pacos
ENSG00000244462	RBM12	100	84.173	ENSXETG00000033541	RBM12	74	65.919	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	25910212.26871637.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component