EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000247596 (Gene tree)
Gene ID: 11344
Gene Symbol: TWF2
Alias: A6RP|A6r|PTK9L
Full Name: twinfilin actin binding protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 10,651 bases
Position: chr3:52,228,610-52,239,260
Accession: 9621
RBP type: non-canonical RBP
Summary: The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000305533	TWF2-201	1718	-	ENSP00000303908	349 (aa)	-	Q6IBS0
ENST00000472755	TWF2-202	584	-	-	- (aa)	-	-
ENST00000499914	TWF2-203	1440	-	ENSP00000426464	254 (aa)	-	D6RG15

Gene Model

Click here to download ENSG00000247596's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000247596	rs353547	3	52234850	?	Autism spectrum disorder or schizophrenia	28540026	[1.03-1.08]	1.0526316	EFO_0000692\|EFO_0003756
ENSG00000247596	rs353547	3	52234850	T	Feeling nervous	29500382	z score decrease	6	EFO_0009597
ENSG00000247596	rs353547	3	52234850	T	Feeling worry	29500382	unit decrease	6.015	EFO_0009589
ENSG00000247596	rs353547	3	52234850	T	Worry	29942085	[0.012-0.022] unit decrease	0.01697	EFO_0005230

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000247596's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000247596	TWF2	99	65.217	ENSG00000151239	TWF1	99	65.217	Homo_sapiens
ENSG00000247596	TWF2	100	96.562	ENSMUSG00000023277	Twf2	100	96.562	Mus_musculus
ENSG00000247596	TWF2	99	66.570	ENSMUSG00000022451	Twf1	98	66.570	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003785	actin monomer binding	21873635.	IBA	Function
GO:0003785	actin monomer binding	12807912.18837697.	ISS	Function
GO:0005080	protein kinase C binding	10406962.	IPI	Function
GO:0005515	protein binding	21044950.	IPI	Function
GO:0005524	ATP binding	10406962.	IDA	Function
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	12807912.	ISS	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	25468996.	IDA	Component
GO:0005737	cytoplasm	10406962.	NAS	Component
GO:0005884	actin filament	21873635.	IBA	Component
GO:0010591	regulation of lamellipodium assembly	21873635.	IBA	Process
GO:0010592	positive regulation of lamellipodium assembly	17910947.	IMP	Process
GO:0010976	positive regulation of neuron projection development	21873635.	IBA	Process
GO:0010976	positive regulation of neuron projection development	17910947.	IMP	Process
GO:0030016	myofibril	21873635.	IBA	Component
GO:0030016	myofibril	18837697.	ISS	Component
GO:0030027	lamellipodium	12807912.	ISS	Component
GO:0030030	cell projection organization	-	IEA	Process
GO:0030042	actin filament depolymerization	21873635.	IBA	Process
GO:0030175	filopodium	12807912.	ISS	Component
GO:0030426	growth cone	17910947.	IDA	Component
GO:0030837	negative regulation of actin filament polymerization	12807912.	ISS	Process
GO:0032420	stereocilium	19955359.	ISS	Component
GO:0032532	regulation of microvillus length	19955359.	IC	Process
GO:0032956	regulation of actin cytoskeleton organization	17910947.	IMP	Process
GO:0042989	sequestering of actin monomers	21873635.	IBA	Process
GO:0042989	sequestering of actin monomers	18837697.	ISS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045773	positive regulation of axon extension	17910947.	IMP	Process
GO:0048471	perinuclear region of cytoplasm	12807912.	ISS	Component
GO:0051015	actin filament binding	21873635.	IBA	Function
GO:0051016	barbed-end actin filament capping	21873635.	IBA	Process
GO:0051016	barbed-end actin filament capping	18837697.	ISS	Process
GO:0070062	extracellular exosome	19199708.	HDA	Component
GO:0071300	cellular response to retinoic acid	17910947.	IMP	Process
GO:0071363	cellular response to growth factor stimulus	17910947.	IMP	Process