EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000247626 (Gene tree)
Gene ID: 92935
Gene Symbol: MARS2
Alias: mtMetRS|SPAX3
Full Name: methionyl-tRNA synthetase 2, mitochondrial
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 3,087 bases
Position: chr2:197,705,304-197,708,390
Accession: 25133
RBP type: canonical RBP
Summary: This gene produces a mitochondrial methionyl-tRNA synthetase protein that is encoded by the nuclear genome and imported to the mitochondrion. This protein likely functions as a monomer and is predicted to localize to the mitochondrial matrix. Mutations in this gene are associated with the autosomal recessive neurodegenerative disease spastic ataxia-3 (SPAX3). [provided by RefSeq, Apr 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000282276	tRNA-synt_1g	PF09334.11	3e-107	1	1
ENSP00000282276	tRNA-synt_1	PF00133.22	2.9e-19	1	2
ENSP00000282276	tRNA-synt_1	PF00133.22	2.9e-19	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000282276	MARS2-201	3019	-	ENSP00000282276	593 (aa)	-	Q96GW9

Gene Model

Click here to download ENSG00000247626's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00450	Selenocompound metabolism	KEGG
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000247626's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000247626	MARS2	98	59.316	ENSAPOG00000013656	mars2	95	59.316	Acanthochromis_polyacanthus
ENSG00000247626	MARS2	100	90.556	ENSAMEG00000019748	MARS2	100	90.556	Ailuropoda_melanoleuca
ENSG00000247626	MARS2	93	61.413	ENSACIG00000014134	mars2	93	61.413	Amphilophus_citrinellus
ENSG00000247626	MARS2	92	61.326	ENSAOCG00000018305	mars2	91	61.326	Amphiprion_ocellaris
ENSG00000247626	MARS2	92	61.510	ENSAPEG00000004704	mars2	91	61.510	Amphiprion_percula
ENSG00000247626	MARS2	90	62.127	ENSATEG00000000690	mars2	89	62.127	Anabas_testudineus
ENSG00000247626	MARS2	89	65.028	ENSACAG00000008856	MARS2	99	65.028	Anolis_carolinensis
ENSG00000247626	MARS2	100	96.796	ENSANAG00000001001	MARS2	100	96.796	Aotus_nancymaae
ENSG00000247626	MARS2	93	61.232	ENSACLG00000002370	mars2	91	61.232	Astatotilapia_calliptera
ENSG00000247626	MARS2	91	60.111	ENSAMXG00000011610	mars2	88	60.111	Astyanax_mexicanus
ENSG00000247626	MARS2	100	89.882	ENSBTAG00000002056	MARS2	100	89.882	Bos_taurus
ENSG00000247626	MARS2	100	95.784	ENSCJAG00000022885	MARS2	100	95.784	Callithrix_jacchus
ENSG00000247626	MARS2	98	87.737	ENSCAFG00000024359	MARS2	100	87.184	Canis_familiaris
ENSG00000247626	MARS2	98	87.737	ENSCAFG00020004676	MARS2	71	87.184	Canis_lupus_dingo
ENSG00000247626	MARS2	97	90.138	ENSCHIG00000016548	MARS2	99	90.138	Capra_hircus
ENSG00000247626	MARS2	100	81.619	ENSCPOG00000025973	MARS2	100	81.619	Cavia_porcellus
ENSG00000247626	MARS2	100	96.965	ENSCCAG00000019937	MARS2	100	96.965	Cebus_capucinus
ENSG00000247626	MARS2	100	96.796	ENSCATG00000001827	MARS2	97	96.796	Cercocebus_atys
ENSG00000247626	MARS2	100	78.246	ENSCLAG00000010386	MARS2	100	78.246	Chinchilla_lanigera
ENSG00000247626	MARS2	100	97.470	ENSCSAG00000018765	MARS2	100	97.470	Chlorocebus_sabaeus
ENSG00000247626	MARS2	100	79.089	ENSCHOG00000012068	MARS2	100	79.089	Choloepus_hoffmanni
ENSG00000247626	MARS2	91	66.483	ENSCPBG00000012041	MARS2	93	66.483	Chrysemys_picta_bellii
ENSG00000247626	MARS2	85	47.316	ENSCING00000005183	-	89	47.316	Ciona_intestinalis
ENSG00000247626	MARS2	90	46.097	ENSCSAVG00000011619	-	99	46.097	Ciona_savignyi
ENSG00000247626	MARS2	100	96.965	ENSCANG00000038503	MARS2	100	96.965	Colobus_angolensis_palliatus
ENSG00000247626	MARS2	100	85.497	ENSCGRG00001010364	Mars2	100	85.497	Cricetulus_griseus_chok1gshd
ENSG00000247626	MARS2	100	85.497	ENSCGRG00000019118	Mars2	100	85.497	Cricetulus_griseus_crigri
ENSG00000247626	MARS2	94	56.738	ENSCSEG00000002875	mars2	94	57.455	Cynoglossus_semilaevis
ENSG00000247626	MARS2	96	60.633	ENSCVAG00000004559	mars2	98	60.633	Cyprinodon_variegatus
ENSG00000247626	MARS2	94	59.286	ENSDARG00000009218	mars2	93	59.286	Danio_rerio
ENSG00000247626	MARS2	100	88.702	ENSDNOG00000041522	MARS2	100	88.702	Dasypus_novemcinctus
ENSG00000247626	MARS2	81	85.239	ENSDORG00000010789	Mars2	95	85.093	Dipodomys_ordii
ENSG00000247626	MARS2	95	45.201	FBgn0027083	MetRS-m	94	45.201	Drosophila_melanogaster
ENSG00000247626	MARS2	78	85.714	ENSETEG00000004697	MARS2	78	85.714	Echinops_telfairi
ENSG00000247626	MARS2	100	91.062	ENSEASG00005020133	MARS2	100	91.062	Equus_asinus_asinus
ENSG00000247626	MARS2	100	91.062	ENSECAG00000004931	MARS2	83	91.062	Equus_caballus
ENSG00000247626	MARS2	55	82.927	ENSEEUG00000011835	-	54	82.927	Erinaceus_europaeus
ENSG00000247626	MARS2	91	61.738	ENSELUG00000016227	mars2	88	61.738	Esox_lucius
ENSG00000247626	MARS2	100	89.545	ENSFCAG00000009491	MARS2	100	89.545	Felis_catus
ENSG00000247626	MARS2	84	66.135	ENSFALG00000011592	MARS2	98	66.135	Ficedula_albicollis
ENSG00000247626	MARS2	76	86.830	ENSFDAG00000012635	MARS2	99	86.830	Fukomys_damarensis
ENSG00000247626	MARS2	90	61.940	ENSFHEG00000014055	mars2	88	61.940	Fundulus_heteroclitus
ENSG00000247626	MARS2	91	59.259	ENSGMOG00000011494	mars2	97	59.259	Gadus_morhua
ENSG00000247626	MARS2	93	64.079	ENSGALG00000004019	MARS2	96	64.079	Gallus_gallus
ENSG00000247626	MARS2	90	61.567	ENSGAFG00000001691	mars2	89	61.394	Gambusia_affinis
ENSG00000247626	MARS2	93	61.051	ENSGACG00000017489	mars2	90	61.051	Gasterosteus_aculeatus
ENSG00000247626	MARS2	91	76.316	ENSGAGG00000009486	MARS2	93	65.930	Gopherus_agassizii
ENSG00000247626	MARS2	100	98.820	ENSGGOG00000034895	MARS2	100	98.820	Gorilla_gorilla
ENSG00000247626	MARS2	93	61.051	ENSHBUG00000018278	mars2	91	61.051	Haplochromis_burtoni
ENSG00000247626	MARS2	100	83.980	ENSHGLG00000017624	MARS2	100	83.980	Heterocephalus_glaber_female
ENSG00000247626	MARS2	100	81.450	ENSHGLG00100009649	MARS2	100	81.450	Heterocephalus_glaber_male
ENSG00000247626	MARS2	92	61.835	ENSHCOG00000007757	mars2	90	61.835	Hippocampus_comes
ENSG00000247626	MARS2	91	61.296	ENSIPUG00000009852	mars2	89	61.296	Ictalurus_punctatus
ENSG00000247626	MARS2	100	89.545	ENSSTOG00000015451	MARS2	100	89.545	Ictidomys_tridecemlineatus
ENSG00000247626	MARS2	96	86.865	ENSJJAG00000023940	Mars2	97	86.865	Jaculus_jaculus
ENSG00000247626	MARS2	96	60.175	ENSKMAG00000019760	mars2	94	60.175	Kryptolebias_marmoratus
ENSG00000247626	MARS2	91	61.667	ENSLBEG00000003607	mars2	89	61.667	Labrus_bergylta
ENSG00000247626	MARS2	91	62.407	ENSLACG00000007705	MARS2	90	62.407	Latimeria_chalumnae
ENSG00000247626	MARS2	64	65.435	ENSLOCG00000015357	mars2	86	65.435	Lepisosteus_oculatus
ENSG00000247626	MARS2	100	87.352	ENSLAFG00000030667	MARS2	100	87.352	Loxodonta_africana
ENSG00000247626	MARS2	100	96.965	ENSMFAG00000012275	MARS2	100	96.965	Macaca_fascicularis
ENSG00000247626	MARS2	100	97.133	ENSMMUG00000023810	MARS2	100	97.133	Macaca_mulatta
ENSG00000247626	MARS2	100	97.133	ENSMNEG00000019593	MARS2	97	97.133	Macaca_nemestrina
ENSG00000247626	MARS2	100	97.133	ENSMLEG00000023045	MARS2	100	97.133	Mandrillus_leucophaeus
ENSG00000247626	MARS2	92	62.364	ENSMAMG00000019576	mars2	92	62.364	Mastacembelus_armatus
ENSG00000247626	MARS2	93	61.232	ENSMZEG00005008469	mars2	91	61.232	Maylandia_zebra
ENSG00000247626	MARS2	92	65.146	ENSMGAG00000001828	MARS2	99	65.146	Meleagris_gallopavo
ENSG00000247626	MARS2	100	85.497	ENSMAUG00000017224	Mars2	100	85.497	Mesocricetus_auratus
ENSG00000247626	MARS2	99	85.544	ENSMOCG00000006676	Mars2	100	85.544	Microtus_ochrogaster
ENSG00000247626	MARS2	93	59.273	ENSMMOG00000004128	mars2	94	59.273	Mola_mola
ENSG00000247626	MARS2	93	74.147	ENSMODG00000024604	MARS2	99	74.147	Monodelphis_domestica
ENSG00000247626	MARS2	96	60.000	ENSMALG00000007538	mars2	93	60.000	Monopterus_albus
ENSG00000247626	MARS2	100	85.666	MGP_CAROLIEiJ_G0014147	Mars2	100	85.666	Mus_caroli
ENSG00000247626	MARS2	100	85.835	ENSMUSG00000046994	Mars2	100	85.835	Mus_musculus
ENSG00000247626	MARS2	100	86.341	MGP_PahariEiJ_G0027386	Mars2	100	86.341	Mus_pahari
ENSG00000247626	MARS2	100	85.666	MGP_SPRETEiJ_G0014953	Mars2	100	85.666	Mus_spretus
ENSG00000247626	MARS2	100	89.226	ENSMPUG00000019823	MARS2	100	89.226	Mustela_putorius_furo
ENSG00000247626	MARS2	96	88.536	ENSNGAG00000018031	Mars2	99	88.536	Nannospalax_galili
ENSG00000247626	MARS2	93	61.413	ENSNBRG00000012114	mars2	93	61.413	Neolamprologus_brichardi
ENSG00000247626	MARS2	100	97.976	ENSNLEG00000018752	MARS2	100	97.976	Nomascus_leucogenys
ENSG00000247626	MARS2	99	72.315	ENSMEUG00000000590	MARS2	99	72.315	Notamacropus_eugenii
ENSG00000247626	MARS2	94	60.901	ENSONIG00000002473	mars2	92	60.901	Oreochromis_niloticus
ENSG00000247626	MARS2	100	88.702	ENSOCUG00000017798	MARS2	100	88.702	Oryctolagus_cuniculus
ENSG00000247626	MARS2	91	62.037	ENSORLG00000000799	mars2	91	62.037	Oryzias_latipes
ENSG00000247626	MARS2	92	61.355	ENSORLG00020004562	mars2	92	61.355	Oryzias_latipes_hni
ENSG00000247626	MARS2	92	62.088	ENSORLG00015013596	mars2	92	62.088	Oryzias_latipes_hsok
ENSG00000247626	MARS2	90	62.500	ENSOMEG00000013859	mars2	90	62.500	Oryzias_melastigma
ENSG00000247626	MARS2	100	90.219	ENSOGAG00000007205	MARS2	100	90.219	Otolemur_garnettii
ENSG00000247626	MARS2	100	89.899	ENSOARG00000015634	MARS2	100	89.899	Ovis_aries
ENSG00000247626	MARS2	100	99.157	ENSPPAG00000007220	MARS2	100	99.157	Pan_paniscus
ENSG00000247626	MARS2	100	90.051	ENSPPRG00000018464	MARS2	100	90.051	Panthera_pardus
ENSG00000247626	MARS2	100	99.157	ENSPTRG00000047853	MARS2	100	99.157	Pan_troglodytes
ENSG00000247626	MARS2	100	96.627	ENSPANG00000016544	MARS2	100	96.627	Papio_anubis
ENSG00000247626	MARS2	91	62.338	ENSPKIG00000021425	mars2	89	62.338	Paramormyrops_kingsleyae
ENSG00000247626	MARS2	83	65.996	ENSPSIG00000009657	MARS2	97	65.996	Pelodiscus_sinensis
ENSG00000247626	MARS2	90	62.243	ENSPMGG00000020811	mars2	97	62.243	Periophthalmus_magnuspinnatus
ENSG00000247626	MARS2	100	85.497	ENSPEMG00000008377	Mars2	100	85.497	Peromyscus_maniculatus_bairdii
ENSG00000247626	MARS2	92	54.741	ENSPMAG00000004222	mars2	99	54.741	Petromyzon_marinus
ENSG00000247626	MARS2	93	74.688	ENSPCIG00000010610	MARS2	89	75.045	Phascolarctos_cinereus
ENSG00000247626	MARS2	90	61.940	ENSPFOG00000000782	mars2	89	61.940	Poecilia_formosa
ENSG00000247626	MARS2	90	61.940	ENSPLAG00000003992	mars2	89	61.940	Poecilia_latipinna
ENSG00000247626	MARS2	90	62.127	ENSPMEG00000016916	mars2	89	62.127	Poecilia_mexicana
ENSG00000247626	MARS2	90	61.940	ENSPREG00000012744	mars2	89	61.940	Poecilia_reticulata
ENSG00000247626	MARS2	100	98.651	ENSPPYG00000013049	MARS2	100	98.651	Pongo_abelii
ENSG00000247626	MARS2	100	78.415	ENSPVAG00000015267	MARS2	100	78.415	Pteropus_vampyrus
ENSG00000247626	MARS2	93	61.232	ENSPNYG00000009085	mars2	91	61.232	Pundamilia_nyererei
ENSG00000247626	MARS2	92	60.766	ENSPNAG00000017691	mars2	93	60.766	Pygocentrus_nattereri
ENSG00000247626	MARS2	100	86.847	ENSRNOG00000050002	Mars2	100	86.847	Rattus_norvegicus
ENSG00000247626	MARS2	100	86.847	ENSRNOG00000048668	LOC100911305	100	86.847	Rattus_norvegicus
ENSG00000247626	MARS2	100	97.133	ENSRBIG00000018803	MARS2	100	97.133	Rhinopithecus_bieti
ENSG00000247626	MARS2	100	97.133	ENSRROG00000012594	MARS2	100	97.133	Rhinopithecus_roxellana
ENSG00000247626	MARS2	85	36.881	YGR171C	MSM1	91	36.881	Saccharomyces_cerevisiae
ENSG00000247626	MARS2	100	95.953	ENSSBOG00000016226	MARS2	100	95.953	Saimiri_boliviensis_boliviensis
ENSG00000247626	MARS2	93	73.084	ENSSHAG00000017980	MARS2	100	73.084	Sarcophilus_harrisii
ENSG00000247626	MARS2	91	62.477	ENSSFOG00015004532	mars2	91	62.477	Scleropages_formosus
ENSG00000247626	MARS2	90	61.682	ENSSMAG00000012289	mars2	88	61.682	Scophthalmus_maximus
ENSG00000247626	MARS2	91	60.628	ENSSDUG00000004847	mars2	90	60.628	Seriola_dumerili
ENSG00000247626	MARS2	91	61.183	ENSSLDG00000004117	mars2	90	61.183	Seriola_lalandi_dorsalis
ENSG00000247626	MARS2	100	85.160	ENSSARG00000004616	MARS2	100	85.160	Sorex_araneus
ENSG00000247626	MARS2	92	66.055	ENSSPUG00000005569	MARS2	93	66.055	Sphenodon_punctatus
ENSG00000247626	MARS2	92	62.431	ENSSPAG00000001547	mars2	89	62.431	Stegastes_partitus
ENSG00000247626	MARS2	99	89.779	ENSSSCG00000034494	MARS2	100	90.138	Sus_scrofa
ENSG00000247626	MARS2	83	65.051	ENSTGUG00000005225	MARS2	98	65.051	Taeniopygia_guttata
ENSG00000247626	MARS2	91	64.378	ENSTRUG00000012627	mars2	89	64.378	Takifugu_rubripes
ENSG00000247626	MARS2	92	61.679	ENSTNIG00000015747	mars2	93	61.679	Tetraodon_nigroviridis
ENSG00000247626	MARS2	100	91.231	ENSTTRG00000003421	MARS2	100	91.231	Tursiops_truncatus
ENSG00000247626	MARS2	96	90.861	ENSUAMG00000009131	MARS2	97	90.861	Ursus_americanus
ENSG00000247626	MARS2	97	82.872	ENSUMAG00000020961	MARS2	98	82.872	Ursus_maritimus
ENSG00000247626	MARS2	98	88.083	ENSVVUG00000025921	MARS2	100	87.521	Vulpes_vulpes
ENSG00000247626	MARS2	99	50.254	ENSXETG00000018187	mars2	98	50.254	Xenopus_tropicalis
ENSG00000247626	MARS2	90	61.940	ENSXCOG00000016798	mars2	91	61.940	Xiphophorus_couchianus
ENSG00000247626	MARS2	90	61.567	ENSXMAG00000000296	mars2	89	61.567	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004825	methionine-tRNA ligase activity	21873635.	IBA	Function
GO:0004825	methionine-tRNA ligase activity	15274629.	IDA	Function
GO:0004825	methionine-tRNA ligase activity	-	TAS	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	15274629.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	Process
GO:0006431	methionyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0006431	methionyl-tRNA aminoacylation	15274629.	IDA	Process