EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000248333 (Gene tree)
Gene ID: 984
Gene Symbol: CDK11B
Alias: CDK11-p110|CDK11-p58|CDK11-p46|CDC2L1
Full Name: cyclin dependent kinase 11B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 24,614 bases
Position: chr1:1,635,226-1,659,839
Accession: 1729
RBP type: non-canonical RBP
Summary: This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21044963	The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2α complex on splicing.	J Biol Chem	2011 Jan 7	Loyer P	doi: 10.1074/jbc.M110.192518

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000626918	CDK11B-207	2457	-	ENSP00000485705	772 (aa)	-	A0A0D9SEI3
ENST00000341832	CDK11B-203	2998	XM_017002925	ENSP00000463048	782 (aa)	XP_016858414	P21127
ENST00000611150	CDK11B-205	2350	-	ENSP00000484222	244 (aa)	-	A0A087X1I0
ENST00000629312	CDK11B-209	2496	-	ENSP00000485849	785 (aa)	-	A0A0D9SEN2
ENST00000615951	CDK11B-206	2227	-	ENSP00000481846	203 (aa)	-	A0A087WYI9
ENST00000407249	CDK11B-204	2677	XM_006711065	ENSP00000464036	795 (aa)	XP_006711128	P21127
ENST00000340677	CDK11B-201	2534	XM_011542494	ENSP00000464016	748 (aa)	XP_011540796	P21127
ENST00000341028	CDK11B-202	881	-	-	- (aa)	-	-
ENST00000629289	CDK11B-208	2490	-	ENSP00000485937	783 (aa)	-	A0A0D9SER5

Gene Model

Click here to download ENSG00000248333's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000248333	rs3765908	1	1641275	A	Pulse pressure	28135244	[0.13-0.32] unit increase	0.2281	EFO_0005763

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000248333's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000248333	CDK11B	100	96.811	ENSMUSG00000029062	Cdk11b	100	96.811	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000278	mitotic cell cycle	1639388.	NAS	Process
GO:0001558	regulation of cell growth	10882096.	IEP	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004672	protein kinase activity	1639388.8195233.	TAS	Function
GO:0004674	protein serine/threonine kinase activity	12501247.	IDA	Function
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0005515	protein binding	12624090.16413544.19245811.25965346.	IPI	Function
GO:0005524	ATP binding	12501247.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	8195233.	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006355	regulation of transcription, DNA-templated	9750192.	NAS	Process
GO:0006468	protein phosphorylation	21873635.	IBA	Process
GO:0006468	protein phosphorylation	12501247.	IDA	Process
GO:0006915	apoptotic process	9750192.	NAS	Process
GO:0008283	cell proliferation	8195233.	TAS	Process
GO:0050684	regulation of mRNA processing	12501247.	IDA	Process
GO:0051726	regulation of cell cycle	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25106495	CDK11p58 inhibits ERα-positive breast cancer invasion by targeting integrin β3 via the repression of ERα signaling.	BMC Cancer	2014 Aug 8	Chi Y	doi: 10.1186/1471-2407-14-577.
27207777	Cyclin-Dependent Kinase 11 (CDK11) Is Required for Ovarian Cancer Cell Growth In Vitro and In Vivo, and Its Inhibition Causes Apoptosis and Sensitizes Cells to Paclitaxel.	Mol Cancer Ther	2016 Jul	Liu X	doi: 10.1158/1535-7163.MCT-16-0032
25576733	Hepsin inhibits CDK11p58 IRES activity by suppressing unr expression and eIF-2α phosphorylation in prostate cancer.	Cell Signal	2015 Apr	Zhang C	doi: 10.1016/j.cellsig.2014.12.020
25837326	Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy.	Breast Cancer Res	2015	Kren BT	doi: 10.1186/s13058-015-0524-0

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	1637812	Missense_Mutation	NA	E485K	0.27
BLCA	chr1	1640450	Missense_Mutation	rs769701760	P373S	0.23
BRCA	chr1	1638532	Missense_Mutation	NA	G450A	0.22
BRCA	chr1	1636957	Silent	NA	A593A	0.31
BRCA	chr1	1637884	Splice_Site	NA	X461_splice	0.19
BRCA	chr1	1636374	Silent	rs375553551	F688F	0.14
BRCA	chr1	1655433	Missense_Mutation	NA	D55N	0.26
BRCA	chr1	1655385	Missense_Mutation	novel	D71H	0.06
BRCA	chr1	1637474	Missense_Mutation	rs753220778	V515M	0.11
BRCA	chr1	1637812	Missense_Mutation	NA	E485K	0.17
CESC	chr1	1636742	Silent	rs767271491	L632L	0.09
CESC	chr1	1637866	Missense_Mutation	novel	K467E	0.42
CESC	chr1	1636952	Missense_Mutation	NA	T595N	0.34
CESC	chr1	1636426	Missense_Mutation	novel	V671A	0.29
CESC	chr1	1636949	Frame_Shift_Del	novel	*P596Rfs4**	0.45
CESC	chr1	1657407	Missense_Mutation	NA	E27Q	0.34
CHOL	chr1	1636897	Missense_Mutation	novel	K613N	0.26
COAD	chr1	1637843	In_Frame_Del	NA	E474del	0.22
COAD	chr1	1637130	Missense_Mutation	rs778552932	R561H	0.15
COAD	chr1	1641945	Missense_Mutation	novel	D284N	0.15
COAD	chr1	1636785	Missense_Mutation	NA	A618V	0.11
COAD	chr1	1637175	Missense_Mutation	NA	L546Q	0.29
COAD	chr1	1637846	In_Frame_Del	novel	K473del	0.29
COAD	chr1	1638542	Missense_Mutation	novel	G447C	0.37
COAD	chr1	1637783	Silent	novel	H494H	0.46
COAD	chr1	1636951	Silent	NA	T595T	0.19
COAD	chr1	1640439	Silent	novel	R376R	0.08
COAD	chr1	1637148	Frame_Shift_Del	novel	*K551Qfs7**	0.06
COAD	chr1	1636714	Missense_Mutation	novel	S642A	0.56
COAD	chr1	1640297	Missense_Mutation	novel	K424E	0.37
COAD	chr1	1636982	Missense_Mutation	NA	R585Q	0.2
COAD	chr1	1641991	Missense_Mutation	novel	E268D	0.33
DLBC	chr1	1655446	Silent	novel	E50E	0.09
DLBC	chr1	1638584	Missense_Mutation	rs765357030	R433W	0.43
ESCA	chr1	1641683	Nonsense_Mutation	novel	E343*	0.87
ESCA	chr1	1640386	Missense_Mutation	novel	G394A	0.09
ESCA	chr1	1657386	Missense_Mutation	NA	R34C	0.36
HNSC	chr1	1637781	Missense_Mutation	NA	P495H	0.08
HNSC	chr1	1636965	Silent	novel	L591L	0.12
HNSC	chr1	1637797	Missense_Mutation	novel	L490F	0.18
HNSC	chr1	1636984	Silent	rs368832250	A584A	0.41
HNSC	chr1	1655462	Missense_Mutation	novel	R45L	0.42
HNSC	chr1	1655455	Silent	novel	S47S	0.58
HNSC	chr1	1636715	Missense_Mutation	rs1059815	K641N	0.26
KIRC	chr1	1638569	Missense_Mutation	novel	F438L	0.08
KIRC	chr1	1638570	Missense_Mutation	novel	E437D	0.08
LGG	chr1	1657402	Missense_Mutation	NA	E28D	0.36
LGG	chr1	1640291	Missense_Mutation	novel	L426M	0.48
LIHC	chr1	1636405	Missense_Mutation	novel	E678V	0.45
LIHC	chr1	1640431	Missense_Mutation	novel	R379L	0.13
LUAD	chr1	1637474	Missense_Mutation	rs753220778	V515L	0.2
LUAD	chr1	1637845	Nonsense_Mutation	NA	E474*	0.4
LUSC	chr1	1636422	Missense_Mutation	novel	K672N	0.42
MESO	chr1	1637177	In_Frame_Del	novel	I544_Q545del	0.33
OV	chr1	1636784	Silent	novel	A618A	0.3
READ	chr1	1645213	Missense_Mutation	novel	R182W	0.3
SARC	chr1	1641084	Missense_Mutation	rs747942866	D360N	0.3
SKCM	chr1	1655456	Missense_Mutation	novel	S47F	0.51
SKCM	chr1	1645199	Silent	novel	K186K	0.51
SKCM	chr1	1636967	Missense_Mutation	novel	P590L	0.33
SKCM	chr1	1636968	Missense_Mutation	NA	P590S	0.31
SKCM	chr1	1636724	Silent	rs373048979	F638F	0.23
SKCM	chr1	1640381	Missense_Mutation	NA	P396S	0.2
SKCM	chr1	1655381	Missense_Mutation	NA	S72F	0.45
SKCM	chr1	1637831	Silent	NA	F478F	0.3
SKCM	chr1	1636970	Missense_Mutation	NA	S589F	0.21
SKCM	chr1	1636970	Missense_Mutation	NA	S589F	0.61
STAD	chr1	1645167	Missense_Mutation	novel	R197Q	0.47
STAD	chr1	1655369	Missense_Mutation	novel	R76I	0.14
STAD	chr1	1638549	Silent	rs551456893	I444I	0.19
STAD	chr1	1636768	Missense_Mutation	novel	V624M	0.39
STAD	chr1	1640342	Missense_Mutation	rs375622928	D409N	0.15
STAD	chr1	1636995	Missense_Mutation	novel	F581V	0.07
STAD	chr1	1637781	Missense_Mutation	NA	P495H	0.06
STAD	chr1	1640356	Missense_Mutation	NA	G404V	0.22
STAD	chr1	1657376	Frame_Shift_Del	novel	*N37Ifs17**	0.18
STAD	chr1	1636683	Missense_Mutation	novel	K652R	0.25
UCEC	chr1	1657375	Missense_Mutation	novel	N37K	0.21
UCEC	chr1	1636385	Missense_Mutation	NA	R685C	0.1
UCEC	chr1	1657456	Silent	novel	V10V	0.05
UCEC	chr1	1657376	Frame_Shift_Del	novel	*N37Ifs17**	0.09
UCEC	chr1	1636724	Silent	rs373048979	F638F	0.18
UCEC	chr1	1640368	Missense_Mutation	NA	A400V	0.13
UCEC	chr1	1637474	Missense_Mutation	rs753220778	V515M	0.35
UCEC	chr1	1640285	Missense_Mutation	novel	A428S	0.37
UCEC	chr1	1657376	Frame_Shift_Del	novel	*N37Ifs17**	0.27
UCEC	chr1	1636992	Missense_Mutation	novel	G582R	0.33
UCEC	chr1	1636793	Silent	rs776784906	Y615Y	0.44
UCEC	chr1	1636901	Missense_Mutation	novel	A612V	0.47
UCEC	chr1	1638549	Silent	rs551456893	I444I	0.21
UCEC	chr1	1645192	Missense_Mutation	rs752682015	R189W	0.1
UCEC	chr1	1637169	Missense_Mutation	rs770250152	R548H	0.43
UCEC	chr1	1657473	Missense_Mutation	novel	K5Q	0.32
UCEC	chr1	1657422	Nonsense_Mutation	novel	R22*	0.18
UCEC	chr1	1640355	Silent	rs749587191	G404G	0.38
UCEC	chr1	1657421	Missense_Mutation	novel	R22Q	0.06
UCEC	chr1	1637794	Missense_Mutation	NA	K491E	0.27
UCEC	chr1	1637170	Missense_Mutation	novel	R548C	0.49
UCEC	chr1	1657376	Frame_Shift_Del	novel	*N37Ifs17**	0.08
UCEC	chr1	1657386	Missense_Mutation	NA	R34C	0.24
UCEC	chr1	1640422	Missense_Mutation	novel	G382E	0.07
UCEC	chr1	1657376	Frame_Shift_Del	novel	*N37Ifs17**	0.44
UCEC	chr1	1640435	Missense_Mutation	rs748349947	D378N	0.12
UCEC	chr1	1646112	Intron	novel		0.24
UCEC	chr1	1640432	Nonsense_Mutation	novel	R379*	0.36
UCEC	chr1	1638549	Silent	rs551456893	I444I	0.19
UCEC	chr1	1637131	Missense_Mutation	novel	R561C	0.4
UCS	chr1	1645242	Missense_Mutation	novel	E172G	0.11

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1153	0.00029523
DLBC	DEL	0.1875	0.011841
HNSC	DEL	0.1418	7.0766e-07
KIRC	DEL	0.1439	2.3538e-09
KIRP	DEL	0.184	1.462e-09
LIHC	DEL	0.4027	1.1606e-33
LUAD	DEL	0.1357	0.0024765
LUSC	DEL	0.3473	2.5882e-07
MESO	DEL	0.3448	2.434e-07
SARC	DEL	0.2412	8.425e-11
SKCM	DEL	0.1689	5.1876e-09
TGCT	DEL	0.1867	0.00046313
UCS	DEL	0.3036	0.0051125

Survival Analysis

Cancer	P-value	Q-value
THYM	0.014	Kaplan-Meier Survival Analysis
KIRC	0.0081	Kaplan-Meier Survival Analysis
STAD	0.028	Kaplan-Meier Survival Analysis
MESO	0.012	Kaplan-Meier Survival Analysis
ACC	0.011	Kaplan-Meier Survival Analysis
HNSC	0.0047	Kaplan-Meier Survival Analysis
BRCA	0.032	Kaplan-Meier Survival Analysis
KIRP	0.0061	Kaplan-Meier Survival Analysis
PCPG	0.029	Kaplan-Meier Survival Analysis
LAML	0.00056	Kaplan-Meier Survival Analysis
UCEC	0.038	Kaplan-Meier Survival Analysis
LIHC	0.019	Kaplan-Meier Survival Analysis
LGG	0.00012	Kaplan-Meier Survival Analysis
UVM	0.0016	Kaplan-Meier Survival Analysis