EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000254093 (Gene tree)
Gene ID: 54984
Gene Symbol: PINX1
Alias: PinX1|LPTL|LPTS|FLJ20565|MGC8850|Gno1|Pxr1
Full Name: PIN2 (TERF1) interacting telomerase inhibitor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 74,939 bases
Position: chr8:10,764,961-10,839,899
Accession: 30046
RBP type: canonical RBP
Summary: PINX1 (PIN2 (TERF1) Interacting Telomerase Inhibitor 1) is a Protein Coding gene. Diseases associated with PINX1 include Bladder Urothelial Carcinoma and Hepatocellular Carcinoma. Among its related pathways are Regulation of Telomerase. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and telomerase RNA binding. An important paralog of this gene is GPATCH4.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000428853	G-patch	PF01585.23	2.6e-15	1	1
ENSP00000428728	G-patch	PF01585.23	3.6e-15	1	1
ENSP00000318966	G-patch	PF01585.23	6.1e-15	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000523559	PINX1-205	778	-	ENSP00000428242	134 (aa)	-	E5RJG9
ENST00000524114	PINX1-208	610	-	ENSP00000428728	198 (aa)	-	E5RGR1
ENST00000524026	PINX1-206	571	-	-	- (aa)	-	-
ENST00000517607	PINX1-202	530	-	-	- (aa)	-	-
ENST00000314787	PINX1-201	1545	-	ENSP00000318966	328 (aa)	-	Q96BK5
ENST00000520018	PINX1-204	601	-	-	- (aa)	-	-
ENST00000519088	PINX1-203	1272	-	ENSP00000428853	174 (aa)	-	Q96BK5
ENST00000524061	PINX1-207	440	-	ENSP00000429346	19 (aa)	-	H0YBF0

Gene Model

Click here to download ENSG00000254093's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000254093	Lipids	1.1567959773163E-5	17903299
ENSG00000254093	Muscle, Skeletal	8.7160000E-005	-
ENSG00000254093	Rotator Cuff	1.6650000E-005	-
ENSG00000254093	Urine	3.7911063E-005	-
ENSG00000254093	Asthma	5.0684310E-005	-
ENSG00000254093	Platelet Function Tests	4.4400000E-016	-
ENSG00000254093	Platelet Function Tests	4.4400000E-016	-
ENSG00000254093	S-(3-hydroxypropyl)cysteine N-acetate	5E-6	26053186
ENSG00000254093	Smoking	5E-6	26053186
ENSG00000254093	Atherosclerosis	2E-8	21909108
ENSG00000254093	Triglycerides	3E-11	24097068
ENSG00000254093	3-hydroxy-1-methylpropylmercapturic acid	3E-9	26053186
ENSG00000254093	Smoking	3E-9	26053186
ENSG00000254093	Gastrointestinal Microbiome	5E-8	27723756
ENSG00000254093	Triglycerides	1E-8	20686565

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000254093	rs11986935	8	10834039	?	Gut microbiota (beta diversity)	27723756	NR percent increase	0.97	EFO_0007874
ENSG00000254093	rs35660623	8	10829027	?	3-hydroxypropylmercapturic acid levels in smokers	26053186	[NR] unit decrease	0.5385	EFO_0004318\|EFO_0007014
ENSG00000254093	rs13271456	8	10767736	?	3-hydroxy-1-methylpropylmercapturic acid levels in smokers	26053186	[NR] unit decrease	1.3337	EFO_0004318\|EFO_0007015
ENSG00000254093	rs11776767	8	10826419	C	Triglycerides	24097068	[NR] mg/dL increase	0.022	EFO_0004530
ENSG00000254093	rs9650657	8	10749890	T	Neuroticism	29255261	z score increase	9.986	EFO_0007660
ENSG00000254093	rs2116093	8	10755789	C	Spherical equivalent or myopia (age of diagnosis)	29808027	[NR] z score increase	5.527	EFO_0004847\|HP_0000545\|EFO_0007814
ENSG00000254093	rs2898245	8	10808664	G	Self-reported math ability	30038396	[0.012-0.023] unit increase	0.0176	EFO_0004875
ENSG00000254093	rs11250079	8	10815498	C	Lymphocyte counts	27863252	[0.016-0.031] unit increase	0.02327049	EFO_0004587
ENSG00000254093	rs79674288	8	10731290	T	Facial morphology (factor 22)	28441456	[0.42-0.91] unit decrease	0.6657	EFO_0007841
ENSG00000254093	rs7814757	8	10817678	T	Systolic blood pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006335\|EFO_0004329
ENSG00000254093	rs13276026	8	10752445	A	Systolic blood pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006335\|EFO_0004329
ENSG00000254093	rs4551304	8	10807559	A	Diastolic blood pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006336\|EFO_0004329
ENSG00000254093	rs4551304	8	10807559	A	Diastolic blood pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006336\|EFO_0004329
ENSG00000254093	rs4551304	8	10807559	A	Mean arterial pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006340\|EFO_0004329
ENSG00000254093	rs13276026	8	10752445	A	Mean arterial pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006340\|EFO_0004329
ENSG00000254093	rs6601530	8	10813762	G	Carotid intima media thickness	21909108	[0.01-0.01] unit increase	0.0078	EFO_0003914
ENSG00000254093	rs11776767	8	10826419	C	Triglycerides	20686565	[1.25-2.77] mg/dL increase	2.01	EFO_0004530
ENSG00000254093	rs1821002	8	10782555	G	Systolic blood pressure	28135244	[0.33-0.52] unit decrease	0.4223	EFO_0006335
ENSG00000254093	rs6995541	8	10813750	A	Triglyceride levels	28334899	[0.019-0.034] unit decrease (EA Beta values)	0.0265	EFO_0004530
ENSG00000254093	rs10100265	8	10775649	A	Type 2 diabetes	30054458	[0.034-0.065] unit increase	0.0491	EFO_0001360
ENSG00000254093	rs6995692	8	10729498	?	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test)	29455858			EFO_0006527\|EFO_0006336
ENSG00000254093	rs6995692	8	10729498	?	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test)	29455858			EFO_0006527\|EFO_0006336
ENSG00000254093	rs6995692	8	10729498	?	Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)	29455858			EFO_0006527\|EFO_0006335
ENSG00000254093	rs6995692	8	10729498	?	Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)	29455858			EFO_0006527\|EFO_0006335
ENSG00000254093	rs6995692	8	10729498	?	Systolic blood pressure x smoking status (ever vs never) interaction (2df test)	29455858			EFO_0006527\|EFO_0006335
ENSG00000254093	rs6995692	8	10729498	?	Systolic blood pressure x smoking status (ever vs never) interaction (2df test)	29455858			EFO_0006527\|EFO_0006335
ENSG00000254093	rs6995692	8	10729498	?	Diastolic blood pressure x smoking status (ever vs never) interaction (2df test)	29455858			EFO_0006527\|EFO_0006336
ENSG00000254093	rs6995692	8	10729498	?	Diastolic blood pressure x smoking status (ever vs never) interaction (2df test)	29455858			EFO_0006527\|EFO_0006336
ENSG00000254093	rs28570522	8	10773058	A	Acne (severe)	30542056	[1.10-1.20]	1.14	EFO_0003894
ENSG00000254093	rs200482500	8	10748714	?	Carotid intima media thickness	30510157	[0.004-0.0072] unit increase	0.0056	EFO_0004860
ENSG00000254093	rs6995692	8	10729498	C	Number of sexual partners	30643258	[0.0095-0.0188] unit decrease	0.01412887	EFO_0007877
ENSG00000254093	rs4841436	8	10736964	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000254093	rs2409652	8	10821577	T	Adventurousness	30643258	[0.009-0.0177] unit decrease	0.013383289	EFO_0008579
ENSG00000254093	rs75946928	8	10811954	A	General risk tolerance (MTAG)	30643258	[0.0055-0.0117] unit decrease	0.0086	EFO_0008579

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000254093's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000254093	PINX1	60	32.231	ENSG00000160818	GPATCH4	79	32.231

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000254093	PINX1	72	74.227	ENSAPOG00000019162	pinx1	65	49.583	Acanthochromis_polyacanthus
ENSG00000254093	PINX1	98	74.046	ENSACIG00000002565	pinx1	93	66.834	Amphilophus_citrinellus
ENSG00000254093	PINX1	98	70.992	ENSAOCG00000007968	-	51	74.219	Amphiprion_ocellaris
ENSG00000254093	PINX1	93	70.400	ENSAPEG00000008823	pinx1	94	62.312	Amphiprion_percula
ENSG00000254093	PINX1	93	71.774	ENSATEG00000005291	pinx1	51	63.682	Anabas_testudineus
ENSG00000254093	PINX1	73	78.571	ENSAPLG00000011359	-	100	78.571	Anas_platyrhynchos
ENSG00000254093	PINX1	98	77.863	ENSACAG00000028950	PINX1	61	66.986	Anolis_carolinensis
ENSG00000254093	PINX1	98	92.366	ENSANAG00000029168	-	100	77.134	Aotus_nancymaae
ENSG00000254093	PINX1	98	73.282	ENSACLG00000011764	pinx1	55	62.500	Astatotilapia_calliptera
ENSG00000254093	PINX1	98	74.809	ENSAMXG00000019248	pinx1	75	50.000	Astyanax_mexicanus
ENSG00000254093	PINX1	98	96.183	ENSBTAG00000000500	PINX1	98	70.405	Bos_taurus
ENSG00000254093	PINX1	99	44.853	WBGene00011966	T23G7.3	81	34.420	Caenorhabditis_elegans
ENSG00000254093	PINX1	100	97.015	ENSCJAG00000047277	PINX1	100	94.253	Callithrix_jacchus
ENSG00000254093	PINX1	97	93.077	ENSCAFG00000008087	PINX1	98	72.981	Canis_familiaris
ENSG00000254093	PINX1	84	97.345	ENSCAFG00020012022	PINX1	96	73.927	Canis_lupus_dingo
ENSG00000254093	PINX1	98	95.420	ENSCHIG00000026485	PINX1	97	68.847	Capra_hircus
ENSG00000254093	PINX1	93	71.774	ENSCAPG00000017262	PINX1	95	57.778	Cavia_aperea
ENSG00000254093	PINX1	98	94.656	ENSCPOG00000038127	PINX1	96	67.391	Cavia_porcellus
ENSG00000254093	PINX1	98	96.992	ENSCCAG00000025092	-	96	85.981	Cebus_capucinus
ENSG00000254093	PINX1	98	93.130	ENSCCAG00000035196	-	96	73.418	Cebus_capucinus
ENSG00000254093	PINX1	100	97.761	ENSCCAG00000031868	-	100	94.253	Cebus_capucinus
ENSG00000254093	PINX1	98	99.237	ENSCATG00000043703	PINX1	96	91.850	Cercocebus_atys
ENSG00000254093	PINX1	98	94.656	ENSCLAG00000015490	PINX1	94	68.471	Chinchilla_lanigera
ENSG00000254093	PINX1	96	76.744	ENSCSAG00000015668	-	96	71.924	Chlorocebus_sabaeus
ENSG00000254093	PINX1	98	99.237	ENSCSAG00000016897	PINX1	97	94.357	Chlorocebus_sabaeus
ENSG00000254093	PINX1	96	75.969	ENSCHOG00000006874	PINX1	97	55.836	Choloepus_hoffmanni
ENSG00000254093	PINX1	93	76.613	ENSCPBG00000020140	PINX1	70	58.730	Chrysemys_picta_bellii
ENSG00000254093	PINX1	95	55.906	ENSCING00000019756	-	70	47.917	Ciona_intestinalis
ENSG00000254093	PINX1	98	98.473	ENSCANG00000042110	PINX1	96	92.790	Colobus_angolensis_palliatus
ENSG00000254093	PINX1	98	90.840	ENSCGRG00001022710	Pinx1	98	67.802	Cricetulus_griseus_chok1gshd
ENSG00000254093	PINX1	98	90.840	ENSCGRG00000013834	Pinx1	98	67.802	Cricetulus_griseus_crigri
ENSG00000254093	PINX1	93	70.161	ENSCVAG00000023335	pinx1	68	50.562	Cyprinodon_variegatus
ENSG00000254093	PINX1	98	75.573	ENSDARG00000023532	pinx1	72	55.814	Danio_rerio
ENSG00000254093	PINX1	98	92.366	ENSDORG00000004065	Pinx1	96	73.041	Dipodomys_ordii
ENSG00000254093	PINX1	98	54.412	ENSEBUG00000007099	PINX1	95	55.090	Eptatretus_burgeri
ENSG00000254093	PINX1	98	96.183	ENSEASG00005016402	PINX1	96	73.209	Equus_asinus_asinus
ENSG00000254093	PINX1	98	96.947	ENSECAG00000013778	PINX1	96	72.897	Equus_caballus
ENSG00000254093	PINX1	98	73.134	ENSELUG00000005680	pinx1	73	73.016	Esox_lucius
ENSG00000254093	PINX1	98	96.947	ENSFCAG00000004537	PINX1	97	76.012	Felis_catus
ENSG00000254093	PINX1	98	81.679	ENSFALG00000010926	PINX1	56	71.144	Ficedula_albicollis
ENSG00000254093	PINX1	98	94.656	ENSFDAG00000021284	PINX1	86	73.759	Fukomys_damarensis
ENSG00000254093	PINX1	98	73.282	ENSFHEG00000019078	pinx1	55	63.462	Fundulus_heteroclitus
ENSG00000254093	PINX1	98	71.970	ENSGMOG00000010002	pinx1	95	43.137	Gadus_morhua
ENSG00000254093	PINX1	98	78.626	ENSGALG00000041139	PINX1	73	56.757	Gallus_gallus
ENSG00000254093	PINX1	98	73.282	ENSGAFG00000003523	pinx1	58	62.981	Gambusia_affinis
ENSG00000254093	PINX1	98	66.165	ENSGACG00000010809	pinx1	64	57.273	Gasterosteus_aculeatus
ENSG00000254093	PINX1	100	97.866	ENSGGOG00000008531	PINX1	99	97.866	Gorilla_gorilla
ENSG00000254093	PINX1	85	72.807	ENSHBUG00000017142	pinx1	83	75.188	Haplochromis_burtoni
ENSG00000254093	PINX1	98	94.656	ENSHGLG00000008063	PINX1	97	67.290	Heterocephalus_glaber_female
ENSG00000254093	PINX1	98	94.656	ENSHGLG00100015337	PINX1	97	67.290	Heterocephalus_glaber_male
ENSG00000254093	PINX1	98	74.809	ENSHCOG00000007428	pinx1	89	53.061	Hippocampus_comes
ENSG00000254093	PINX1	98	75.573	ENSIPUG00000016224	Pinx1	55	63.801	Ictalurus_punctatus
ENSG00000254093	PINX1	98	94.656	ENSSTOG00000010007	PINX1	90	74.528	Ictidomys_tridecemlineatus
ENSG00000254093	PINX1	98	93.130	ENSJJAG00000010795	Pinx1	85	74.296	Jaculus_jaculus
ENSG00000254093	PINX1	98	75.573	ENSKMAG00000012953	pinx1	56	64.251	Kryptolebias_marmoratus
ENSG00000254093	PINX1	98	72.180	ENSLBEG00000002014	pinx1	53	62.201	Labrus_bergylta
ENSG00000254093	PINX1	98	75.573	ENSLOCG00000016761	pinx1	60	64.623	Lepisosteus_oculatus
ENSG00000254093	PINX1	98	99.237	ENSMFAG00000030022	PINX1	97	94.357	Macaca_fascicularis
ENSG00000254093	PINX1	98	99.237	ENSMNEG00000034727	PINX1	97	95.298	Macaca_nemestrina
ENSG00000254093	PINX1	98	98.473	ENSMLEG00000041535	PINX1	97	94.357	Mandrillus_leucophaeus
ENSG00000254093	PINX1	98	76.336	ENSMAMG00000016984	pinx1	58	62.780	Mastacembelus_armatus
ENSG00000254093	PINX1	93	72.581	ENSMZEG00005016167	pinx1	54	61.692	Maylandia_zebra
ENSG00000254093	PINX1	96	75.556	ENSMGAG00000014194	PINX1	96	76.129	Meleagris_gallopavo
ENSG00000254093	PINX1	98	90.840	ENSMAUG00000008214	Pinx1	96	69.688	Mesocricetus_auratus
ENSG00000254093	PINX1	98	91.603	ENSMICG00000044679	PINX1	97	76.012	Microcebus_murinus
ENSG00000254093	PINX1	93	91.129	ENSMOCG00000015963	Pinx1	85	71.479	Microtus_ochrogaster
ENSG00000254093	PINX1	98	70.229	ENSMMOG00000015606	pinx1	78	72.000	Mola_mola
ENSG00000254093	PINX1	98	79.389	ENSMODG00000008908	-	98	71.921	Monodelphis_domestica
ENSG00000254093	PINX1	98	76.336	ENSMALG00000003416	pinx1	60	78.000	Monopterus_albus
ENSG00000254093	PINX1	98	92.366	MGP_CAROLIEiJ_G0019409	Pinx1	98	70.462	Mus_caroli
ENSG00000254093	PINX1	98	93.893	ENSMUSG00000021958	Pinx1	97	71.692	Mus_musculus
ENSG00000254093	PINX1	98	93.130	MGP_PahariEiJ_G0030427	Pinx1	96	71.028	Mus_pahari
ENSG00000254093	PINX1	98	93.130	MGP_SPRETEiJ_G0020301	Pinx1	97	61.442	Mus_spretus
ENSG00000254093	PINX1	93	91.129	ENSMLUG00000003309	PINX1	95	71.975	Myotis_lucifugus
ENSG00000254093	PINX1	98	93.893	ENSNGAG00000023442	Pinx1	96	71.963	Nannospalax_galili
ENSG00000254093	PINX1	74	69.697	ENSNBRG00000019635	pinx1	51	58.523	Neolamprologus_brichardi
ENSG00000254093	PINX1	98	100.000	ENSNLEG00000027321	PINX1	100	96.646	Nomascus_leucogenys
ENSG00000254093	PINX1	93	92.742	ENSODEG00000010312	PINX1	96	65.064	Octodon_degus
ENSG00000254093	PINX1	98	73.282	ENSONIG00000015338	pinx1	56	62.981	Oreochromis_niloticus
ENSG00000254093	PINX1	98	96.183	ENSOCUG00000029598	PINX1	96	72.360	Oryctolagus_cuniculus
ENSG00000254093	PINX1	98	71.756	ENSORLG00000027082	pinx1	59	62.019	Oryzias_latipes
ENSG00000254093	PINX1	98	71.756	ENSORLG00020004528	pinx1	59	62.500	Oryzias_latipes_hni
ENSG00000254093	PINX1	98	71.756	ENSORLG00015023021	pinx1	73	55.642	Oryzias_latipes_hsok
ENSG00000254093	PINX1	98	73.282	ENSOMEG00000015931	pinx1	57	63.462	Oryzias_melastigma
ENSG00000254093	PINX1	98	94.656	ENSOGAG00000001021	-	97	72.274	Otolemur_garnettii
ENSG00000254093	PINX1	91	80.328	ENSOGAG00000030473	-	84	63.704	Otolemur_garnettii
ENSG00000254093	PINX1	93	95.968	ENSOARG00000015141	PINX1	95	69.108	Ovis_aries
ENSG00000254093	PINX1	100	97.590	ENSPPAG00000030738	PINX1	100	97.590	Pan_paniscus
ENSG00000254093	PINX1	98	96.183	ENSPPRG00000011818	PINX1	97	75.701	Panthera_pardus
ENSG00000254093	PINX1	98	96.947	ENSPTIG00000004845	PINX1	97	76.012	Panthera_tigris_altaica
ENSG00000254093	PINX1	98	99.237	ENSPTRG00000019980	PINX1	100	96.697	Pan_troglodytes
ENSG00000254093	PINX1	98	98.473	ENSPANG00000011251	PINX1	97	93.730	Papio_anubis
ENSG00000254093	PINX1	98	73.282	ENSPKIG00000004453	pinx1	58	61.215	Paramormyrops_kingsleyae
ENSG00000254093	PINX1	95	69.291	ENSPSIG00000005928	PINX1	97	71.429	Pelodiscus_sinensis
ENSG00000254093	PINX1	98	71.429	ENSPMGG00000018147	pinx1	83	61.927	Periophthalmus_magnuspinnatus
ENSG00000254093	PINX1	98	89.313	ENSPEMG00000022225	Pinx1	98	69.659	Peromyscus_maniculatus_bairdii
ENSG00000254093	PINX1	98	71.756	ENSPMAG00000003859	pinx1	100	71.970	Petromyzon_marinus
ENSG00000254093	PINX1	98	81.679	ENSPCIG00000004800	PINX1	74	67.355	Phascolarctos_cinereus
ENSG00000254093	PINX1	98	74.046	ENSPFOG00000009972	pinx1	58	62.264	Poecilia_formosa
ENSG00000254093	PINX1	98	74.046	ENSPLAG00000015081	pinx1	58	62.264	Poecilia_latipinna
ENSG00000254093	PINX1	98	72.519	ENSPMEG00000020309	pinx1	57	61.538	Poecilia_mexicana
ENSG00000254093	PINX1	93	72.581	ENSPREG00000019021	pinx1	53	61.194	Poecilia_reticulata
ENSG00000254093	PINX1	98	77.099	ENSPPYG00000016935	-	96	71.160	Pongo_abelii
ENSG00000254093	PINX1	100	96.657	ENSPPYG00000018361	PINX1	100	96.657	Pongo_abelii
ENSG00000254093	PINX1	72	84.828	ENSPCAG00000002496	PINX1	84	64.493	Procavia_capensis
ENSG00000254093	PINX1	93	94.355	ENSPCOG00000028161	-	99	85.799	Propithecus_coquereli
ENSG00000254093	PINX1	96	76.744	ENSPVAG00000010440	PINX1	96	66.250	Pteropus_vampyrus
ENSG00000254093	PINX1	74	70.707	ENSPNYG00000006606	pinx1	50	60.116	Pundamilia_nyererei
ENSG00000254093	PINX1	98	72.519	ENSPNAG00000005570	pinx1	53	63.107	Pygocentrus_nattereri
ENSG00000254093	PINX1	98	93.893	ENSRNOG00000012012	Pinx1	88	72.449	Rattus_norvegicus
ENSG00000254093	PINX1	98	98.473	ENSRBIG00000041410	PINX1	100	92.988	Rhinopithecus_bieti
ENSG00000254093	PINX1	98	98.473	ENSRROG00000044493	PINX1	98	93.103	Rhinopithecus_roxellana
ENSG00000254093	PINX1	98	98.473	ENSSBOG00000026142	PINX1	97	85.893	Saimiri_boliviensis_boliviensis
ENSG00000254093	PINX1	73	74.658	ENSSHAG00000009238	-	56	57.384	Sarcophilus_harrisii
ENSG00000254093	PINX1	98	73.282	ENSSFOG00015009356	pinx1	53	63.158	Scleropages_formosus
ENSG00000254093	PINX1	98	74.046	ENSSMAG00000011442	pinx1	55	63.942	Scophthalmus_maximus
ENSG00000254093	PINX1	98	73.282	ENSSDUG00000013586	pinx1	53	62.981	Seriola_dumerili
ENSG00000254093	PINX1	90	75.207	ENSSPUG00000002809	PINX1	87	69.730	Sphenodon_punctatus
ENSG00000254093	PINX1	98	74.046	ENSSPAG00000018262	pinx1	75	54.478	Stegastes_partitus
ENSG00000254093	PINX1	98	87.786	ENSSSCG00000031622	-	99	66.565	Sus_scrofa
ENSG00000254093	PINX1	98	96.947	ENSSSCG00000009692	-	97	71.875	Sus_scrofa
ENSG00000254093	PINX1	98	77.863	ENSTGUG00000013313	PINX1	100	71.728	Taeniopygia_guttata
ENSG00000254093	PINX1	98	68.702	ENSTNIG00000016334	pinx1	57	60.804	Tetraodon_nigroviridis
ENSG00000254093	PINX1	96	96.899	ENSTTRG00000001679	PINX1	96	68.966	Tursiops_truncatus
ENSG00000254093	PINX1	93	95.968	ENSUAMG00000015238	PINX1	93	73.651	Ursus_americanus
ENSG00000254093	PINX1	98	96.183	ENSUMAG00000021812	PINX1	96	74.224	Ursus_maritimus
ENSG00000254093	PINX1	98	93.130	ENSVVUG00000024459	-	96	73.209	Vulpes_vulpes
ENSG00000254093	PINX1	93	96.774	ENSVVUG00000002273	-	68	74.522	Vulpes_vulpes
ENSG00000254093	PINX1	98	75.758	ENSXETG00000000688	pinx1	69	64.115	Xenopus_tropicalis
ENSG00000254093	PINX1	98	73.282	ENSXCOG00000005224	pinx1	58	62.500	Xiphophorus_couchianus
ENSG00000254093	PINX1	98	74.046	ENSXMAG00000027197	pinx1	62	64.423	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000228	nuclear chromosome	19393617.	IDA	Component
GO:0000776	kinetochore	19393617.	IDA	Component
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0000781	chromosome, telomeric region	11701125.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	11701125.19265708.21119197.24415760.	IDA	Component
GO:0005515	protein binding	11701125.15044100.15381700.17389648.18202258.19265708.19393617.21044950.21119197.24415760.27214791.	IPI	Function
GO:0005730	nucleolus	11701125.19265708.19393617.21119197.24415760.	IDA	Component
GO:0005730	nucleolus	26194824.	NAS	Component
GO:0005819	spindle	19393617.	IDA	Component
GO:0007004	telomere maintenance via telomerase	11701125.	IDA	Process
GO:0007080	mitotic metaphase plate congression	19393617.	IMP	Process
GO:0008285	negative regulation of cell proliferation	11003615.	NAS	Process
GO:0010521	telomerase inhibitor activity	11701125.	IDA	Function
GO:0010521	telomerase inhibitor activity	11701125.21119197.	IMP	Function
GO:0010521	telomerase inhibitor activity	26194824.	NAS	Function
GO:0010521	telomerase inhibitor activity	15381700.	TAS	Function
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	11701125.	IDA	Process
GO:0031397	negative regulation of protein ubiquitination	24415760.	IMP	Process
GO:0031647	regulation of protein stability	24415760.	IMP	Process
GO:0032211	negative regulation of telomere maintenance via telomerase	11701125.	IDA	Process
GO:0032211	negative regulation of telomere maintenance via telomerase	21119197.	IMP	Process
GO:0044877	protein-containing complex binding	18202258.	IPI	Function
GO:0051972	regulation of telomerase activity	15381700.	TAS	Process
GO:0051974	negative regulation of telomerase activity	11701125.	IDA	Process
GO:0051974	negative regulation of telomerase activity	11701125.21119197.	IMP	Process
GO:0051974	negative regulation of telomerase activity	26194824.	NAS	Process
GO:0070034	telomerase RNA binding	15381700.	IDA	Function
GO:0070198	protein localization to chromosome, telomeric region	22749911.	IMP	Process
GO:1902570	protein localization to nucleolus	24415760.	IDA	Process
GO:1904357	negative regulation of telomere maintenance via telomere lengthening	26194824.	NAS	Process
GO:1904744	positive regulation of telomeric DNA binding	19265708.24415760.	IDA	Process
GO:1904751	positive regulation of protein localization to nucleolus	19265708.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26187699	Novel role for PINX1 as a coregulator of nuclear hormone receptors.	Mol Cell Endocrinol	2015 Oct 15	Noriega-Reyes MY	doi: 10.1016/j.mce.2015.07.011
12508358	Mutation analysis of novel human liver-related putative tumor suppressor gene in hepatocellular carcinoma.	World J Gastroenterol	2003 Jan	Liao C	-
24672800	The role of PinX1 in growth control of breast cancer cells and its potential molecular mechanism by mRNA and lncRNA expression profiles screening.	Biomed Res Int	2014	Shi R	doi: 10.1155/2014/978984
22316341	PinX1 regulation of telomerase activity and apoptosis in nasopharyngeal carcinoma cells.	J Exp Clin Cancer Res	2012 Feb 8	Lai XF	doi: 10.1186/1756-9966-31-12.
29017500	NF-??B potentiates tumor growth by suppressing a novel target LPTS.	Cell Commun Signal	2017 Oct 10	Liu D	doi: 10.1186/s12964-017-0196-8.
18784941	The correlation of genetic instability of PINX1 gene to clinico-pathological features of gastric cancer in the Chinese population.	J Cancer Res Clin Oncol	2009 Mar	Ma Y	doi: 10.1007/s00432-008-0471-6
28815183	PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration.	Biomed Res Int	2017	Wang S	doi: 10.1155/2017/7956437
25888829	PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-??B/MMP-9 signaling pathway.	Mol Cancer	2015 Mar 26	Shi M	doi: 10.1186/s12943-015-0332-2.
15637589	Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma.	Oncogene	2005 Jan 6	Kondo T	-
19117989	Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells.	Cancer Res	2009 Jan 1	Zhang B	doi: 10.1158/0008-5472.CAN-08-1393.
24839934	PinX1 without the G-patch motif suppresses proliferation, induces senescence, but does not inhibit telomerase activity in colorectal cancer SW480 cells.	Oncol Rep	2014 Jul	Zhang R	doi: 10.3892/or.2014.3199
26211574	Decreased expression of PinX1 protein predicts poor prognosis of colorectal cancer patients receiving 5-FU adjuvant chemotherapy.	Biomed Pharmacother	2015 Jul	Deng W	doi: 10.1016/j.biopha.2015.04.011
28586040	Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer.	Oncol Rep	2017 Jul	Feng YZ	doi: 10.3892/or.2017.5696
30015978	Pin2/TRF1binding proteinX1 inhibits colorectal cancer cell migration and invasion invitro and metastasis invivo via the nuclear factor??B signaling pathway.	Oncol Rep	2018 Sep	Jiang T	doi: 10.3892/or.2018.6570

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr8	10765774	Missense_Mutation	rs374613074	T205M	0.54
BLCA	chr8	10765829	Missense_Mutation	NA	A187T	0.49
BLCA	chr8	10820234	Missense_Mutation	novel	D144H	0.11
BRCA	chr8	10765531	Missense_Mutation	NA	G286D	0.38
BRCA	chr8	10765913	Missense_Mutation	rs200616748	D159N	0.26
BRCA	chr8	10820222	Frame_Shift_Ins	novel	*G148Wfs6**	0.13
CESC	chr8	10765535	Missense_Mutation	NA	E285K	0.22
CESC	chr8	10765850	Missense_Mutation	NA	E180K	0.26
CHOL	chr8	10820196	Silent	rs368778352	P156P	0.89
COAD	chr8	10765454	Missense_Mutation	rs372632631	A312T	0.4
COAD	chr8	10765677	Silent	novel	E237E	0.37
COAD	chr8	10765623	Silent	rs780628077	A255A	0.17
COAD	chr8	10765837	Missense_Mutation	NA	K184T	0.34
COAD	chr8	10765438	Missense_Mutation	rs779941568	T317M	0.33
HNSC	chr8	10765540	Missense_Mutation	rs368843905	P283L	0.15
LUAD	chr8	10765555	Missense_Mutation	rs757948941	G278V	0.43
LUAD	chr8	10765830	Missense_Mutation	NA	M186I	0.68
LUAD	chr8	10765425	Missense_Mutation	novel	K321N	0.21
LUAD	chr8	10765834	Missense_Mutation	NA	R185L	0.04
LUAD	chr8	10765762	Missense_Mutation	novel	R209L	0.03
LUAD	chr8	10765787	Missense_Mutation	NA	D201N	0.24
LUAD	chr8	10765663	Missense_Mutation	novel	R242K	0.81
LUAD	chr8	10765472	Missense_Mutation	NA	V306L	0.47
OV	chr8	10765467	Missense_Mutation	novel	E307D	0.07
READ	chr8	10765454	Missense_Mutation	rs372632631	A312T	0.25
READ	chr8	10765875	Silent	rs374083715	T171T	0.16
SKCM	chr8	10765442	Missense_Mutation	novel	E316K	0.22
SKCM	chr8	10765801	Missense_Mutation	rs750637295	P196L	0.16
SKCM	chr8	10820197	Missense_Mutation	novel	P156L	0.29
STAD	chr8	10765517	Silent	NA	L291L	0.08
STAD	chr8	10765774	Missense_Mutation	rs374613074	T205M	0.06
STAD	chr8	10765773	Silent	rs774257473	T205T	0.15
STAD	chr8	10820196	Silent	rs368778352	P156P	0.19
UCEC	chr8	10820265	Missense_Mutation	novel	K133N	0.41
UCEC	chr8	10765809	Silent	novel	P193P	0.2
UCEC	chr8	10820229	Silent	NA	C145C	0.24
UCEC	chr8	10765426	Frame_Shift_Del	novel	*K321Rfs83**	0.25
UCEC	chr8	10765763	Missense_Mutation	rs756200490	R209C	0.35
UCEC	chr8	10765884	Silent	rs746882158	N168N	0.06
UCEC	chr8	10765764	Silent	novel	E208E	0.36
UCEC	chr8	10820237	Missense_Mutation	novel	L143F	0.33
UCEC	chr8	10765568	Missense_Mutation	novel	A274T	0.19
UCEC	chr8	10765626	Silent	rs530442735	S254S	0.29
UCEC	chr8	10765732	Missense_Mutation	rs760142409	A219V	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.5368	4.5185e-08
DLBC	DEL	0.2083	0.15679
PAAD	DEL	0.2283	0.050455
UCS	DEL	0.5357	0.0031922

Survival Analysis

Cancer	P-value	Q-value
MESO	0.00024	Kaplan-Meier Survival Analysis
SKCM	0.021	Kaplan-Meier Survival Analysis
LUSC	0.012	Kaplan-Meier Survival Analysis
COAD	0.02	Kaplan-Meier Survival Analysis
PCPG	0.021	Kaplan-Meier Survival Analysis
BLCA	0.028	Kaplan-Meier Survival Analysis
CESC	0.00011	Kaplan-Meier Survival Analysis
LAML	0.034	Kaplan-Meier Survival Analysis
LIHC	0.016	Kaplan-Meier Survival Analysis
LGG	0.0025	Kaplan-Meier Survival Analysis