EuRBPDB

Description

RBDs

Literatures

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000256453 (Gene tree)
Gene ID: 373863
Gene Symbol: DND1
Alias: MGC34750|RBMS4
Full Name: DND microRNA-mediated repression inhibitor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 2,793 bases
Position: chr5:140,670,794-140,673,586
Accession: 23799
RBP type: canonical RBP
Summary: This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000445366	DND1_DSRM	PF14709.7	6.3e-22	1	1
ENSP00000445366	RRM_1	PF00076.22	5.7e-15	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26740055	The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation.	Leuk Res	2016 Feb	Wampfler J	doi: 10.1016/j.leukres.2015.12.006
18155131	RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.	Cell	2007 Dec 28	Kedde M	-
28191469	RNA-Binding Protein Dnd1 Promotes Breast Cancer Apoptosis by Stabilizing the Bim mRNA in a miR-221 Binding Site.	Biomed Res Int	2017	Cheng F	doi: 10.1155/2017/9596152
19861488	Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3.	Reproduction	2010 Feb	Yamaji M	doi: 10.1530/REP-09-0373
18414021	Interplay between microRNAs and RNA-binding proteins determines developmental processes.	Cell Cycle	2008 Apr 1	Kedde M	-
22923694	Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.	Proc Natl Acad Sci U S A	2012 Oct 9	Nelson VR	doi: 10.1073/pnas.1207169109
18160032	A dead end for microRNAs.	Cell	2007 Dec 28	Ketting RF	-
22730312	Expression of RNA-binding proteins DND1 and FXR1 in the porcine ovary, and during oocyte maturation and early embryo development.	Mol Reprod Dev	2012 Aug	Yang CX	doi: 10.1002/mrd.22059
22614019	The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21 expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by RNA-binding protein DND1.	Oncogene	2013 Mar 21	Bhandari A	doi: 10.1038/onc.2012.168
21851623	Transcripts that associate with the RNA binding protein, DEAD-END (DND1), in embryonic stem (ES) cells.	BMC Mol Biol	2011 Aug 18	Zhu R	doi: 10.1186/1471-2199-12-37.
20816961	MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma.	FEBS Lett	2010 Sep 24	Liu X	doi: 10.1016/j.febslet.2010.08.040
23890083	APOBEC3 inhibits DEAD-END function to regulate microRNA activity.	BMC Mol Biol	2013 Jul 26	Ali S	doi: 10.1186/1471-2199-14-16.
23615278	Maternal Dead-End1 is required for vegetal cortical microtubule assembly during Xenopus axis specification.	Development	2013 Jun	Mei W	doi: 10.1242/dev.094748
28297718	DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.	Nature	2017 Mar 23	Yamaji M	doi: 10.1038/nature21690
26224005	Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites.	Biol Reprod	2015 Sep	Bustamante-Marin XM	doi: 10.1095/biolreprod.115.128850
28593479	RNA-binding protein Dnd1 inhibits epithelial-mesenchymal transition and cancer stem cell-related traits on hepatocellular carcinoma cells.	Biotechnol Lett	2017 Sep	Xu W	doi: 10.1007/s10529-017-2375-5
28870987	Maternal Dead-end 1 promotes translation of nanos1 by binding the eIF3 complex.	Development	2017 Oct 15	Aguero T	doi: 10.1242/dev.152611
29378702	Dnd1-mediated epigenetic control of teratoma formation in mouse.	Biol Open	2018 Jan 29	Gu W	doi: 10.1242/bio.032318.
31253634	The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.	Development	2019 Jul 25	Ruthig VA	doi: 10.1242/dev.175950.

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000542735	DND1-201	1605	-	ENSP00000445366	353 (aa)	-	Q8IYX4

Gene Model

Click here to download ENSG00000256453's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000256453	rs2530243	5	140672398	?	General cognitive ability	29844566	z-score decrease	4.736	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000256453's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000256453	DND1	59	42.584	ENSG00000151962	RBM46	85	55.752
ENSG00000256453	DND1	65	39.316	ENSG00000163694	RBM47	73	61.446
ENSG00000256453	DND1	58	42.512	ENSG00000148584	A1CF	93	43.548

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000256453	DND1	100	91.501	ENSAMEG00000010881	DND1	100	91.501	Ailuropoda_melanoleuca
ENSG00000256453	DND1	94	37.105	ENSACIG00000017877	dnd1	98	37.368	Amphilophus_citrinellus
ENSG00000256453	DND1	90	36.236	ENSAOCG00000009051	dnd1	97	36.723	Amphiprion_ocellaris
ENSG00000256453	DND1	90	36.338	ENSAPEG00000003554	dnd1	91	36.261	Amphiprion_percula
ENSG00000256453	DND1	89	35.734	ENSATEG00000015824	dnd1	93	35.734	Anabas_testudineus
ENSG00000256453	DND1	58	50.971	ENSATEG00000015421	dnd1	84	50.971	Anabas_testudineus
ENSG00000256453	DND1	57	60.697	ENSAPLG00000013518	DND1	98	60.697	Anas_platyrhynchos
ENSG00000256453	DND1	93	47.953	ENSACAG00000012925	DND1	93	47.953	Anolis_carolinensis
ENSG00000256453	DND1	100	90.935	ENSANAG00000034596	-	100	90.935	Aotus_nancymaae
ENSG00000256453	DND1	100	96.317	ENSANAG00000037212	-	100	96.317	Aotus_nancymaae
ENSG00000256453	DND1	61	47.442	ENSACLG00000006388	dnd1	99	37.598	Astatotilapia_calliptera
ENSG00000256453	DND1	61	49.074	ENSAMXG00000018752	dnd1	53	49.074	Astyanax_mexicanus
ENSG00000256453	DND1	100	89.577	ENSBTAG00000018845	DND1	100	89.577	Bos_taurus
ENSG00000256453	DND1	100	95.184	ENSCJAG00000016345	DND1	100	95.184	Callithrix_jacchus
ENSG00000256453	DND1	100	89.802	ENSCAFG00000005888	DND1	100	89.802	Canis_familiaris
ENSG00000256453	DND1	99	89.205	ENSCAFG00020001055	DND1	99	89.205	Canis_lupus_dingo
ENSG00000256453	DND1	100	89.577	ENSCHIG00000026376	DND1	100	89.577	Capra_hircus
ENSG00000256453	DND1	100	91.292	ENSTSYG00000026365	DND1	100	91.292	Carlito_syrichta
ENSG00000256453	DND1	100	89.518	ENSCPOG00000009192	DND1	100	89.518	Cavia_porcellus
ENSG00000256453	DND1	100	96.034	ENSCCAG00000020065	DND1	100	96.034	Cebus_capucinus
ENSG00000256453	DND1	100	98.300	ENSCATG00000025088	DND1	100	98.300	Cercocebus_atys
ENSG00000256453	DND1	100	90.652	ENSCLAG00000012746	DND1	100	90.652	Chinchilla_lanigera
ENSG00000256453	DND1	100	97.734	ENSCSAG00000012677	DND1	100	97.734	Chlorocebus_sabaeus
ENSG00000256453	DND1	93	56.548	ENSCPBG00000007689	DND1	95	56.548	Chrysemys_picta_bellii
ENSG00000256453	DND1	57	100.000	ENSCANG00000040596	DND1	100	100.000	Colobus_angolensis_palliatus
ENSG00000256453	DND1	100	86.686	ENSCGRG00001017900	Dnd1	100	86.686	Cricetulus_griseus_chok1gshd
ENSG00000256453	DND1	100	86.686	ENSCGRG00000011003	Dnd1	100	86.686	Cricetulus_griseus_crigri
ENSG00000256453	DND1	61	48.372	ENSCSEG00000001828	-	55	50.000	Cynoglossus_semilaevis
ENSG00000256453	DND1	89	37.429	ENSCVAG00000001991	-	96	37.429	Cyprinodon_variegatus
ENSG00000256453	DND1	100	90.652	ENSDNOG00000013017	DND1	100	90.652	Dasypus_novemcinctus
ENSG00000256453	DND1	100	87.535	ENSDORG00000014552	Dnd1	100	87.535	Dipodomys_ordii
ENSG00000256453	DND1	100	85.269	ENSETEG00000005397	DND1	100	85.269	Echinops_telfairi
ENSG00000256453	DND1	100	92.351	ENSEASG00005017533	DND1	100	92.351	Equus_asinus_asinus
ENSG00000256453	DND1	94	92.192	ENSECAG00000011014	DND1	100	92.192	Equus_caballus
ENSG00000256453	DND1	100	88.669	ENSEEUG00000004338	DND1	100	88.669	Erinaceus_europaeus
ENSG00000256453	DND1	90	38.827	ENSELUG00000002636	dnd1	96	39.106	Esox_lucius
ENSG00000256453	DND1	100	90.368	ENSFCAG00000042441	DND1	100	90.368	Felis_catus
ENSG00000256453	DND1	97	46.132	ENSFALG00000009513	DND1	99	45.556	Ficedula_albicollis
ENSG00000256453	DND1	94	81.481	ENSFDAG00000011596	DND1	100	81.481	Fukomys_damarensis
ENSG00000256453	DND1	63	43.750	ENSFHEG00000000128	-	81	47.594	Fundulus_heteroclitus
ENSG00000256453	DND1	57	51.485	ENSGMOG00000016112	-	62	51.485	Gadus_morhua
ENSG00000256453	DND1	93	55.120	ENSGALG00000051899	DND1	96	55.590	Gallus_gallus
ENSG00000256453	DND1	59	46.411	ENSGAFG00000019603	dnd1	98	35.616	Gambusia_affinis
ENSG00000256453	DND1	91	37.746	ENSGACG00000019630	dnd1	96	37.746	Gasterosteus_aculeatus
ENSG00000256453	DND1	93	56.548	ENSGAGG00000000023	DND1	95	56.548	Gopherus_agassizii
ENSG00000256453	DND1	100	99.717	ENSGGOG00000042535	-	100	99.717	Gorilla_gorilla
ENSG00000256453	DND1	98	99.422	ENSGGOG00000044128	-	98	99.422	Gorilla_gorilla
ENSG00000256453	DND1	100	85.994	ENSGGOG00000024497	-	100	86.402	Gorilla_gorilla
ENSG00000256453	DND1	61	47.907	ENSHBUG00000013920	dnd1	99	37.859	Haplochromis_burtoni
ENSG00000256453	DND1	100	89.518	ENSHGLG00000009358	DND1	100	89.518	Heterocephalus_glaber_female
ENSG00000256453	DND1	74	95.833	ENSHGLG00100002878	DND1	100	95.833	Heterocephalus_glaber_male
ENSG00000256453	DND1	58	47.805	ENSHCOG00000019493	dnd1	54	47.805	Hippocampus_comes
ENSG00000256453	DND1	90	35.676	ENSIPUG00000010743	dnd1	89	35.946	Ictalurus_punctatus
ENSG00000256453	DND1	100	90.368	ENSSTOG00000002000	DND1	100	90.368	Ictidomys_tridecemlineatus
ENSG00000256453	DND1	99	86.286	ENSJJAG00000023986	Dnd1	99	86.286	Jaculus_jaculus
ENSG00000256453	DND1	92	36.813	ENSKMAG00000001707	-	97	36.813	Kryptolebias_marmoratus
ENSG00000256453	DND1	94	36.154	ENSLBEG00000024151	dnd1	93	36.154	Labrus_bergylta
ENSG00000256453	DND1	94	47.093	ENSLACG00000005507	DND1	99	47.093	Latimeria_chalumnae
ENSG00000256453	DND1	57	46.040	ENSLOCG00000011212	dnd1	70	46.040	Lepisosteus_oculatus
ENSG00000256453	DND1	100	91.218	ENSLAFG00000008161	DND1	100	91.218	Loxodonta_africana
ENSG00000256453	DND1	100	98.300	ENSMFAG00000003284	DND1	100	98.300	Macaca_fascicularis
ENSG00000256453	DND1	100	98.300	ENSMMUG00000004480	DND1	100	98.300	Macaca_mulatta
ENSG00000256453	DND1	100	98.300	ENSMNEG00000038956	DND1	100	98.300	Macaca_nemestrina
ENSG00000256453	DND1	100	98.300	ENSMLEG00000044049	DND1	100	98.300	Mandrillus_leucophaeus
ENSG00000256453	DND1	96	35.751	ENSMAMG00000001857	dnd1	99	36.022	Mastacembelus_armatus
ENSG00000256453	DND1	95	37.598	ENSMZEG00005017442	dnd1	99	37.598	Maylandia_zebra
ENSG00000256453	DND1	99	53.693	ENSMGAG00000000896	DND1	99	53.693	Meleagris_gallopavo
ENSG00000256453	DND1	100	86.686	ENSMAUG00000019312	Dnd1	100	86.686	Mesocricetus_auratus
ENSG00000256453	DND1	100	92.351	ENSMICG00000029187	DND1	100	92.351	Microcebus_murinus
ENSG00000256453	DND1	100	86.969	ENSMOCG00000018076	Dnd1	100	86.969	Microtus_ochrogaster
ENSG00000256453	DND1	90	37.569	ENSMMOG00000017519	dnd1	95	37.569	Mola_mola
ENSG00000256453	DND1	87	37.429	ENSMALG00000000099	dnd1	98	36.364	Monopterus_albus
ENSG00000256453	DND1	100	86.686	MGP_CAROLIEiJ_G0022137	Dnd1	100	86.686	Mus_caroli
ENSG00000256453	DND1	100	86.402	ENSMUSG00000044595	Dnd1	100	86.402	Mus_musculus
ENSG00000256453	DND1	100	86.402	MGP_PahariEiJ_G0018871	Dnd1	100	86.402	Mus_pahari
ENSG00000256453	DND1	100	86.119	MGP_SPRETEiJ_G0023049	Dnd1	100	86.119	Mus_spretus
ENSG00000256453	DND1	100	89.548	ENSMLUG00000003195	DND1	100	89.548	Myotis_lucifugus
ENSG00000256453	DND1	75	83.333	ENSNGAG00000018511	Dnd1	100	83.333	Nannospalax_galili
ENSG00000256453	DND1	57	48.020	ENSNBRG00000007036	dnd1	93	36.800	Neolamprologus_brichardi
ENSG00000256453	DND1	100	99.433	ENSNLEG00000034318	DND1	100	99.433	Nomascus_leucogenys
ENSG00000256453	DND1	95	82.059	ENSMEUG00000016276	DND1	100	82.059	Notamacropus_eugenii
ENSG00000256453	DND1	100	88.669	ENSODEG00000003591	-	100	88.669	Octodon_degus
ENSG00000256453	DND1	100	86.402	ENSODEG00000009578	-	100	86.402	Octodon_degus
ENSG00000256453	DND1	57	48.515	ENSONIG00000011554	dnd1	75	45.000	Oreochromis_niloticus
ENSG00000256453	DND1	75	89.394	ENSOCUG00000004240	DND1	100	89.394	Oryctolagus_cuniculus
ENSG00000256453	DND1	92	37.297	ENSORLG00000025449	dnd1	97	37.297	Oryzias_latipes
ENSG00000256453	DND1	92	37.838	ENSORLG00020008313	dnd1	97	37.838	Oryzias_latipes_hni
ENSG00000256453	DND1	92	37.297	ENSORLG00015017254	dnd1	97	37.297	Oryzias_latipes_hsok
ENSG00000256453	DND1	92	37.705	ENSOMEG00000011374	dnd1	98	37.705	Oryzias_melastigma
ENSG00000256453	DND1	100	91.785	ENSOGAG00000033318	DND1	100	91.785	Otolemur_garnettii
ENSG00000256453	DND1	87	84.211	ENSOARG00000018418	DND1	100	84.211	Ovis_aries
ENSG00000256453	DND1	100	99.717	ENSPPAG00000031543	DND1	100	99.717	Pan_paniscus
ENSG00000256453	DND1	100	86.969	ENSPPRG00000016836	-	100	86.969	Panthera_pardus
ENSG00000256453	DND1	100	90.085	ENSPPRG00000009501	-	100	90.085	Panthera_pardus
ENSG00000256453	DND1	100	84.123	ENSPTRG00000048511	-	100	84.507	Pan_troglodytes
ENSG00000256453	DND1	100	84.078	ENSPTRG00000048632	-	100	84.463	Pan_troglodytes
ENSG00000256453	DND1	100	99.717	ENSPTRG00000017324	DND1	100	99.717	Pan_troglodytes
ENSG00000256453	DND1	100	84.358	ENSPTRG00000046773	-	100	84.746	Pan_troglodytes
ENSG00000256453	DND1	100	98.300	ENSPANG00000007892	DND1	100	98.300	Papio_anubis
ENSG00000256453	DND1	95	37.875	ENSPKIG00000020709	dnd1	97	38.418	Paramormyrops_kingsleyae
ENSG00000256453	DND1	60	48.357	ENSPMGG00000016223	dnd1	68	50.495	Periophthalmus_magnuspinnatus
ENSG00000256453	DND1	96	79.825	ENSPCIG00000017692	DND1	97	79.825	Phascolarctos_cinereus
ENSG00000256453	DND1	59	47.368	ENSPFOG00000005620	-	55	47.368	Poecilia_formosa
ENSG00000256453	DND1	59	47.368	ENSPLAG00000002152	-	50	47.761	Poecilia_latipinna
ENSG00000256453	DND1	100	99.150	ENSPPYG00000015863	DND1	100	99.150	Pongo_abelii
ENSG00000256453	DND1	98	82.029	ENSPCAG00000001453	DND1	100	82.029	Procavia_capensis
ENSG00000256453	DND1	100	92.918	ENSPCOG00000022204	DND1	100	92.918	Propithecus_coquereli
ENSG00000256453	DND1	100	86.969	ENSPVAG00000009710	DND1	100	86.969	Pteropus_vampyrus
ENSG00000256453	DND1	61	46.512	ENSPNYG00000018115	dnd1	99	37.076	Pundamilia_nyererei
ENSG00000256453	DND1	58	46.798	ENSPNAG00000013275	dnd1	52	46.798	Pygocentrus_nattereri
ENSG00000256453	DND1	100	86.402	ENSRNOG00000016894	Dnd1	100	86.402	Rattus_norvegicus
ENSG00000256453	DND1	100	98.017	ENSRBIG00000036511	DND1	100	98.017	Rhinopithecus_bieti
ENSG00000256453	DND1	100	98.017	ENSRROG00000039329	DND1	100	98.017	Rhinopithecus_roxellana
ENSG00000256453	DND1	100	95.467	ENSSBOG00000027247	DND1	100	95.467	Saimiri_boliviensis_boliviensis
ENSG00000256453	DND1	99	78.249	ENSSHAG00000016477	DND1	99	78.249	Sarcophilus_harrisii
ENSG00000256453	DND1	84	39.458	ENSSFOG00015011717	dnd1	84	39.458	Scleropages_formosus
ENSG00000256453	DND1	57	50.000	ENSSMAG00000003517	-	55	50.000	Scophthalmus_maximus
ENSG00000256453	DND1	94	35.401	ENSSMAG00000014775	dnd1	99	35.829	Scophthalmus_maximus
ENSG00000256453	DND1	81	47.442	ENSSDUG00000001174	dnd1	97	36.870	Seriola_dumerili
ENSG00000256453	DND1	78	49.505	ENSSLDG00000007909	dnd1	72	49.505	Seriola_lalandi_dorsalis
ENSG00000256453	DND1	76	82.463	ENSSARG00000007411	DND1	99	82.463	Sorex_araneus
ENSG00000256453	DND1	94	56.932	ENSSPUG00000000311	DND1	96	56.932	Sphenodon_punctatus
ENSG00000256453	DND1	80	32.941	ENSSPAG00000023520	dnd1	87	32.941	Stegastes_partitus
ENSG00000256453	DND1	100	91.785	ENSSSCG00000014374	DND1	100	91.785	Sus_scrofa
ENSG00000256453	DND1	90	34.294	ENSTRUG00000009108	-	96	34.294	Takifugu_rubripes
ENSG00000256453	DND1	91	36.765	ENSTNIG00000004367	-	96	36.765	Tetraodon_nigroviridis
ENSG00000256453	DND1	91	35.465	ENSTNIG00000000223	-	96	36.471	Tetraodon_nigroviridis
ENSG00000256453	DND1	99	90.057	ENSTBEG00000006754	DND1	99	90.057	Tupaia_belangeri
ENSG00000256453	DND1	61	92.202	ENSTTRG00000001755	-	100	92.202	Tursiops_truncatus
ENSG00000256453	DND1	86	88.235	ENSTTRG00000010411	-	100	88.235	Tursiops_truncatus
ENSG00000256453	DND1	99	90.000	ENSUAMG00000004664	DND1	99	90.000	Ursus_americanus
ENSG00000256453	DND1	98	89.595	ENSVVUG00000013559	DND1	98	89.595	Vulpes_vulpes
ENSG00000256453	DND1	94	50.149	ENSXETG00000016114	dnd1	89	50.149	Xenopus_tropicalis
ENSG00000256453	DND1	59	46.226	ENSXCOG00000000764	dnd1	55	46.226	Xiphophorus_couchianus
ENSG00000256453	DND1	57	47.264	ENSXMAG00000017784	dnd1	53	47.264	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	18155131.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	18155131.	IDA	Component
GO:0007275	multicellular organism development	-	IEA	Process
GO:0007281	germ cell development	-	IEA	Process
GO:0017091	AU-rich element binding	21873635.	IBA	Function
GO:0017091	AU-rich element binding	18155131.	IDA	Function
GO:0035198	miRNA binding	18155131.	IDA	Function
GO:0048255	mRNA stabilization	21873635.	IBA	Process
GO:0060965	negative regulation of gene silencing by miRNA	21873635.	IBA	Process
GO:0060965	negative regulation of gene silencing by miRNA	18155131.	IDA	Process