EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000256463 (Gene tree)
Gene ID: 27164
Gene Symbol: SALL3
Alias: ZNF796
Full Name: spalt like transcription factor 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 22,403 bases
Position: chr18:78,980,275-79,002,677
Accession: 10527
RBP type: canonical RBP
Summary: This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000441823	zf-C2H2	PF00096.26	2.2e-30	1	5
ENSP00000441823	zf-C2H2	PF00096.26	2.2e-30	2	5
ENSP00000441823	zf-C2H2	PF00096.26	2.2e-30	3	5
ENSP00000441823	zf-C2H2	PF00096.26	2.2e-30	4	5
ENSP00000441823	zf-C2H2	PF00096.26	2.2e-30	5	5
ENSP00000439975	zf-C2H2	PF00096.26	6.2e-27	1	5
ENSP00000439975	zf-C2H2	PF00096.26	6.2e-27	2	5
ENSP00000439975	zf-C2H2	PF00096.26	6.2e-27	3	5
ENSP00000439975	zf-C2H2	PF00096.26	6.2e-27	4	5
ENSP00000439975	zf-C2H2	PF00096.26	6.2e-27	5	5
ENSP00000481352	zf-C2H2	PF00096.26	4.2e-26	1	5
ENSP00000481352	zf-C2H2	PF00096.26	4.2e-26	2	5
ENSP00000481352	zf-C2H2	PF00096.26	4.2e-26	3	5
ENSP00000481352	zf-C2H2	PF00096.26	4.2e-26	4	5
ENSP00000481352	zf-C2H2	PF00096.26	4.2e-26	5	5
ENSP00000458360	zf-C2H2	PF00096.26	3.9e-25	1	5
ENSP00000458360	zf-C2H2	PF00096.26	3.9e-25	2	5
ENSP00000458360	zf-C2H2	PF00096.26	3.9e-25	3	5
ENSP00000458360	zf-C2H2	PF00096.26	3.9e-25	4	5
ENSP00000458360	zf-C2H2	PF00096.26	3.9e-25	5	5
ENSP00000461451	zf-C2H2	PF00096.26	3.2e-08	1	1
ENSP00000441823	zf-met	PF12874.7	1e-18	1	2
ENSP00000441823	zf-met	PF12874.7	1e-18	2	2
ENSP00000439975	zf-met	PF12874.7	2.9e-15	1	1
ENSP00000481352	zf-met	PF12874.7	3.8e-14	1	1
ENSP00000458360	zf-met	PF12874.7	3.1e-13	1	1
ENSP00000461451	zf-C2H2_jaz	PF12171.8	2.4e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000536229	SALL3-201	3997	-	ENSP00000439975	1095 (aa)	-	Q9BXA9
ENST00000573324	SALL3-204	838	-	ENSP00000461451	150 (aa)	-	I3L3L8
ENST00000537592	SALL3-202	6555	-	ENSP00000441823	1300 (aa)	-	Q9BXA9
ENST00000575389	SALL3-205	3996	-	ENSP00000458360	1228 (aa)	-	Q9BXA9
ENST00000572928	SALL3-203	150	-	-	- (aa)	-	-
ENST00000616649	SALL3-206	2958	-	ENSP00000481352	960 (aa)	-	A0A087WXW6

Gene Model

Click here to download ENSG00000256463's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000256463	Hemoglobin A, Glycosylated	4.3210000E-005	19875614
ENSG00000256463	Prostatic Neoplasms	2E-9	23535732

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000256463	rs2472640	18	78991058	T	Highest math class taken (MTAG)	30038396	[0.0075-0.0153] unit decrease	0.0114	EFO_0004875
ENSG00000256463	rs1787267	18	78982544	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000256463's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000256463	SALL3	100	63.462	ENSAPOG00000004264	sall3b	76	59.297	Acanthochromis_polyacanthus
ENSG00000256463	SALL3	97	69.307	ENSAPOG00000020922	sall3a	72	72.414	Acanthochromis_polyacanthus
ENSG00000256463	SALL3	99	85.088	ENSAMEG00000010206	SALL3	79	89.883	Ailuropoda_melanoleuca
ENSG00000256463	SALL3	98	69.325	ENSACIG00000014041	sall3a	99	78.824	Amphilophus_citrinellus
ENSG00000256463	SALL3	100	58.468	ENSACIG00000019407	sall3b	100	59.451	Amphilophus_citrinellus
ENSG00000256463	SALL3	97	69.959	ENSAOCG00000010863	sall3a	96	69.989	Amphiprion_ocellaris
ENSG00000256463	SALL3	99	63.462	ENSAOCG00000012779	sall3b	71	63.462	Amphiprion_ocellaris
ENSG00000256463	SALL3	100	68.364	ENSAPEG00000019278	sall3a	75	69.412	Amphiprion_percula
ENSG00000256463	SALL3	98	59.333	ENSAPEG00000018170	sall3b	100	63.462	Amphiprion_percula
ENSG00000256463	SALL3	98	64.463	ENSATEG00000004914	sall3b	75	59.820	Anabas_testudineus
ENSG00000256463	SALL3	99	76.587	ENSATEG00000024524	sall3a	98	76.923	Anabas_testudineus
ENSG00000256463	SALL3	98	87.823	ENSAPLG00000013214	SALL3	100	87.823	Anas_platyrhynchos
ENSG00000256463	SALL3	99	87.085	ENSACAG00000000478	SALL3	100	73.518	Anolis_carolinensis
ENSG00000256463	SALL3	100	95.402	ENSANAG00000032412	SALL3	100	89.954	Aotus_nancymaae
ENSG00000256463	SALL3	100	68.723	ENSACLG00000022451	sall3a	99	78.431	Astatotilapia_calliptera
ENSG00000256463	SALL3	99	63.462	ENSACLG00000001619	sall3b	75	59.015	Astatotilapia_calliptera
ENSG00000256463	SALL3	99	78.824	ENSAMXG00000011185	sall3a	96	78.824	Astyanax_mexicanus
ENSG00000256463	SALL3	100	55.647	ENSAMXG00000035442	sall3b	100	56.109	Astyanax_mexicanus
ENSG00000256463	SALL3	100	85.978	ENSBTAG00000050200	SALL3	100	85.978	Bos_taurus
ENSG00000256463	SALL3	100	95.402	ENSCJAG00000007332	SALL3	100	92.561	Callithrix_jacchus
ENSG00000256463	SALL3	99	83.974	ENSCAFG00000000013	SALL3	97	89.299	Canis_familiaris
ENSG00000256463	SALL3	99	89.474	ENSCAFG00020015092	SALL3	97	82.720	Canis_lupus_dingo
ENSG00000256463	SALL3	100	86.347	ENSCHIG00000000145	SALL3	100	86.347	Capra_hircus
ENSG00000256463	SALL3	99	84.564	ENSTSYG00000028846	SALL3	99	87.443	Carlito_syrichta
ENSG00000256463	SALL3	97	94.163	ENSCAPG00000006496	SALL3	93	90.775	Cavia_aperea
ENSG00000256463	SALL3	98	90.775	ENSCPOG00000008546	SALL3	99	90.775	Cavia_porcellus
ENSG00000256463	SALL3	100	94.761	ENSCCAG00000034863	SALL3	100	92.989	Cebus_capucinus
ENSG00000256463	SALL3	100	97.829	ENSCATG00000029727	SALL3	100	97.308	Cercocebus_atys
ENSG00000256463	SALL3	97	90.037	ENSCLAG00000007727	SALL3	99	90.037	Chinchilla_lanigera
ENSG00000256463	SALL3	100	97.923	ENSCSAG00000018244	SALL3	100	97.923	Chlorocebus_sabaeus
ENSG00000256463	SALL3	99	73.171	ENSCHOG00000013939	-	91	82.868	Choloepus_hoffmanni
ENSG00000256463	SALL3	100	86.716	ENSCPBG00000003657	SALL3	100	86.716	Chrysemys_picta_bellii
ENSG00000256463	SALL3	97	92.557	ENSCANG00000030302	SALL3	100	98.246	Colobus_angolensis_palliatus
ENSG00000256463	SALL3	100	93.385	ENSCGRG00001018203	Sall3	99	93.385	Cricetulus_griseus_chok1gshd
ENSG00000256463	SALL3	98	88.192	ENSCGRG00000017127	Sall3	100	88.192	Cricetulus_griseus_crigri
ENSG00000256463	SALL3	95	58.237	ENSCSEG00000009569	sall3b	97	63.462	Cynoglossus_semilaevis
ENSG00000256463	SALL3	100	67.351	ENSCSEG00000009058	sall3a	75	68.235	Cynoglossus_semilaevis
ENSG00000256463	SALL3	99	67.606	ENSCVAG00000009684	sall3a	96	68.840	Cyprinodon_variegatus
ENSG00000256463	SALL3	96	86.275	ENSCVAG00000017005	sall3b	75	86.275	Cyprinodon_variegatus
ENSG00000256463	SALL3	99	66.667	ENSDARG00000057586	sall3b	76	66.667	Danio_rerio
ENSG00000256463	SALL3	99	73.725	ENSDARG00000079613	sall3a	70	73.725	Danio_rerio
ENSG00000256463	SALL3	99	70.435	ENSDNOG00000025483	SALL3	98	82.456	Dasypus_novemcinctus
ENSG00000256463	SALL3	99	75.385	ENSDORG00000002702	Sall3	90	85.087	Dipodomys_ordii
ENSG00000256463	SALL3	99	83.478	ENSETEG00000001481	SALL3	99	88.372	Echinops_telfairi
ENSG00000256463	SALL3	65	65.306	ENSEBUG00000009706	sall3b	54	65.306	Eptatretus_burgeri
ENSG00000256463	SALL3	99	89.668	ENSEASG00005002071	SALL3	100	89.668	Equus_asinus_asinus
ENSG00000256463	SALL3	99	89.299	ENSECAG00000015414	SALL3	100	89.299	Equus_caballus
ENSG00000256463	SALL3	99	63.462	ENSELUG00000009541	sall3b	75	59.665	Esox_lucius
ENSG00000256463	SALL3	96	72.414	ENSELUG00000020351	sall3a	74	72.414	Esox_lucius
ENSG00000256463	SALL3	100	90.272	ENSFCAG00000028839	SALL3	99	90.272	Felis_catus
ENSG00000256463	SALL3	99	87.823	ENSFALG00000013343	SALL3	100	87.823	Ficedula_albicollis
ENSG00000256463	SALL3	99	90.037	ENSFDAG00000014697	SALL3	100	90.037	Fukomys_damarensis
ENSG00000256463	SALL3	96	70.237	ENSGMOG00000006649	sall3a	71	77.470	Gadus_morhua
ENSG00000256463	SALL3	99	87.823	ENSGALG00000041404	SALL3	100	87.823	Gallus_gallus
ENSG00000256463	SALL3	98	61.538	ENSGAFG00000014435	-	71	61.538	Gambusia_affinis
ENSG00000256463	SALL3	97	69.270	ENSGAFG00000001581	sall3a	98	76.078	Gambusia_affinis
ENSG00000256463	SALL3	97	77.647	ENSGACG00000005503	sall3a	70	77.647	Gasterosteus_aculeatus
ENSG00000256463	SALL3	99	60.156	ENSGACG00000002533	sall3b	77	57.255	Gasterosteus_aculeatus
ENSG00000256463	SALL3	100	85.666	ENSGAGG00000000925	SALL3	100	75.594	Gopherus_agassizii
ENSG00000256463	SALL3	100	100.000	ENSGGOG00000008127	SALL3	100	100.000	Gorilla_gorilla
ENSG00000256463	SALL3	100	57.794	ENSHBUG00000018127	sall3b	99	64.314	Haplochromis_burtoni
ENSG00000256463	SALL3	100	68.723	ENSHBUG00000004486	sall3a	74	75.510	Haplochromis_burtoni
ENSG00000256463	SALL3	99	90.775	ENSHGLG00000000824	SALL3	100	90.775	Heterocephalus_glaber_female
ENSG00000256463	SALL3	99	90.775	ENSHGLG00100008694	SALL3	100	90.775	Heterocephalus_glaber_male
ENSG00000256463	SALL3	87	63.462	ENSHCOG00000004745	sall3b	68	63.462	Hippocampus_comes
ENSG00000256463	SALL3	96	68.711	ENSHCOG00000010423	sall3a	99	71.930	Hippocampus_comes
ENSG00000256463	SALL3	92	63.462	ENSIPUG00000003006	sall3b	94	63.462	Ictalurus_punctatus
ENSG00000256463	SALL3	99	69.481	ENSIPUG00000003378	sall3	70	77.953	Ictalurus_punctatus
ENSG00000256463	SALL3	99	90.037	ENSSTOG00000004145	SALL3	100	90.037	Ictidomys_tridecemlineatus
ENSG00000256463	SALL3	100	89.668	ENSJJAG00000014351	Sall3	99	89.668	Jaculus_jaculus
ENSG00000256463	SALL3	100	68.472	ENSKMAG00000003846	sall3a	98	77.559	Kryptolebias_marmoratus
ENSG00000256463	SALL3	99	65.217	ENSKMAG00000012418	sall3b	72	63.462	Kryptolebias_marmoratus
ENSG00000256463	SALL3	100	57.889	ENSLBEG00000015706	sall3b	99	59.106	Labrus_bergylta
ENSG00000256463	SALL3	99	68.359	ENSLBEG00000005152	sall3a	70	77.255	Labrus_bergylta
ENSG00000256463	SALL3	100	78.676	ENSLOCG00000007831	sall3a	84	77.181	Lepisosteus_oculatus
ENSG00000256463	SALL3	100	86.347	ENSLAFG00000013521	SALL3	99	86.347	Loxodonta_africana
ENSG00000256463	SALL3	100	97.701	ENSMFAG00000031402	SALL3	99	98.123	Macaca_fascicularis
ENSG00000256463	SALL3	100	97.943	ENSMMUG00000000286	SALL3	85	97.943	Macaca_mulatta
ENSG00000256463	SALL3	97	98.333	ENSMNEG00000029916	SALL3	79	98.333	Macaca_nemestrina
ENSG00000256463	SALL3	95	97.887	ENSMLEG00000032518	-	100	99.000	Mandrillus_leucophaeus
ENSG00000256463	SALL3	99	60.131	ENSMAMG00000006101	sall3b	100	59.213	Mastacembelus_armatus
ENSG00000256463	SALL3	96	66.176	ENSMAMG00000001276	sall3a	78	74.510	Mastacembelus_armatus
ENSG00000256463	SALL3	100	68.723	ENSMZEG00005007586	sall3a	99	78.431	Maylandia_zebra
ENSG00000256463	SALL3	99	63.462	ENSMZEG00005026224	sall3b	75	59.127	Maylandia_zebra
ENSG00000256463	SALL3	99	88.192	ENSMGAG00000002297	SALL3	100	88.192	Meleagris_gallopavo
ENSG00000256463	SALL3	100	92.996	ENSMAUG00000011828	Sall3	99	92.996	Mesocricetus_auratus
ENSG00000256463	SALL3	100	92.607	ENSMICG00000017395	SALL3	100	88.761	Microcebus_murinus
ENSG00000256463	SALL3	100	89.668	ENSMOCG00000013205	Sall3	100	89.668	Microtus_ochrogaster
ENSG00000256463	SALL3	100	56.522	ENSMMOG00000014246	sall3b	99	63.462	Mola_mola
ENSG00000256463	SALL3	96	69.119	ENSMMOG00000003253	sall3a	97	78.400	Mola_mola
ENSG00000256463	SALL3	99	88.930	ENSMODG00000012231	SALL3	100	88.930	Monodelphis_domestica
ENSG00000256463	SALL3	96	77.647	ENSMALG00000003343	sall3a	71	77.647	Monopterus_albus
ENSG00000256463	SALL3	98	57.835	ENSMALG00000015200	sall3b	82	57.948	Monopterus_albus
ENSG00000256463	SALL3	100	90.775	MGP_CAROLIEiJ_G0022442	Sall3	100	90.775	Mus_caroli
ENSG00000256463	SALL3	100	90.775	ENSMUSG00000024565	Sall3	100	90.775	Mus_musculus
ENSG00000256463	SALL3	99	90.775	MGP_PahariEiJ_G0019170	Sall3	100	90.775	Mus_pahari
ENSG00000256463	SALL3	100	90.775	MGP_SPRETEiJ_G0023357	Sall3	100	90.775	Mus_spretus
ENSG00000256463	SALL3	99	82.051	ENSMPUG00000016646	SALL3	96	87.850	Mustela_putorius_furo
ENSG00000256463	SALL3	99	92.218	ENSMLUG00000010582	SALL3	100	88.561	Myotis_lucifugus
ENSG00000256463	SALL3	100	94.553	ENSNGAG00000023772	Sall3	99	94.553	Nannospalax_galili
ENSG00000256463	SALL3	96	68.811	ENSNBRG00000008974	sall3a	74	76.000	Neolamprologus_brichardi
ENSG00000256463	SALL3	100	57.704	ENSNBRG00000016034	sall3b	99	63.462	Neolamprologus_brichardi
ENSG00000256463	SALL3	100	97.943	ENSNLEG00000008217	SALL3	100	97.731	Nomascus_leucogenys
ENSG00000256463	SALL3	100	93.774	ENSODEG00000002692	SALL3	99	93.774	Octodon_degus
ENSG00000256463	SALL3	99	59.284	ENSONIG00000013791	sall3b	76	59.665	Oreochromis_niloticus
ENSG00000256463	SALL3	99	67.422	ENSONIG00000007305	sall3a	77	69.048	Oreochromis_niloticus
ENSG00000256463	SALL3	99	75.000	ENSOANG00000010135	-	100	84.615	Ornithorhynchus_anatinus
ENSG00000256463	SALL3	97	65.306	ENSOCUG00000004364	-	72	65.306	Oryctolagus_cuniculus
ENSG00000256463	SALL3	89	92.885	ENSOCUG00000029398	SALL3	100	92.885	Oryctolagus_cuniculus
ENSG00000256463	SALL3	99	68.797	ENSORLG00000020718	sall3a	75	68.730	Oryzias_latipes
ENSG00000256463	SALL3	99	65.217	ENSORLG00020015105	sall3b	56	63.462	Oryzias_latipes_hni
ENSG00000256463	SALL3	96	76.471	ENSORLG00020001794	sall3a	74	76.471	Oryzias_latipes_hni
ENSG00000256463	SALL3	96	76.471	ENSORLG00015018152	sall3a	99	76.800	Oryzias_latipes_hsok
ENSG00000256463	SALL3	99	65.217	ENSORLG00015005877	sall3b	89	63.462	Oryzias_latipes_hsok
ENSG00000256463	SALL3	99	70.588	ENSOMEG00000011390	sall3a	75	70.588	Oryzias_melastigma
ENSG00000256463	SALL3	99	93.860	ENSOGAG00000031681	SALL3	99	95.720	Otolemur_garnettii
ENSG00000256463	SALL3	97	79.310	ENSOARG00000004353	SALL3	93	80.639	Ovis_aries
ENSG00000256463	SALL3	97	96.892	ENSPPAG00000029586	-	100	98.742	Pan_paniscus
ENSG00000256463	SALL3	100	100.000	ENSPTRG00000010126	SALL3	100	100.000	Pan_troglodytes
ENSG00000256463	SALL3	100	97.626	ENSPANG00000006485	SALL3	100	97.285	Papio_anubis
ENSG00000256463	SALL3	96	73.585	ENSPKIG00000018271	SALL3	98	74.903	Paramormyrops_kingsleyae
ENSG00000256463	SALL3	97	79.021	ENSPKIG00000013427	sall3a	75	79.021	Paramormyrops_kingsleyae
ENSG00000256463	SALL3	98	87.823	ENSPSIG00000008556	SALL3	100	87.823	Pelodiscus_sinensis
ENSG00000256463	SALL3	99	68.496	ENSPMGG00000017042	sall3a	74	68.247	Periophthalmus_magnuspinnatus
ENSG00000256463	SALL3	89	59.259	ENSPMGG00000002913	sall3b	95	53.873	Periophthalmus_magnuspinnatus
ENSG00000256463	SALL3	100	93.774	ENSPEMG00000022799	Sall3	99	93.774	Peromyscus_maniculatus_bairdii
ENSG00000256463	SALL3	64	78.082	ENSPMAG00000004595	-	52	63.462	Petromyzon_marinus
ENSG00000256463	SALL3	99	88.561	ENSPCIG00000002472	SALL3	100	88.561	Phascolarctos_cinereus
ENSG00000256463	SALL3	100	68.108	ENSPFOG00000019127	sall3a	70	76.562	Poecilia_formosa
ENSG00000256463	SALL3	99	65.217	ENSPFOG00000013292	sall3b	75	63.462	Poecilia_formosa
ENSG00000256463	SALL3	98	76.562	ENSPLAG00000018123	sall3a	98	76.471	Poecilia_latipinna
ENSG00000256463	SALL3	99	65.217	ENSPLAG00000013919	sall3b	71	63.462	Poecilia_latipinna
ENSG00000256463	SALL3	99	65.217	ENSPMEG00000023703	sall3b	96	49.053	Poecilia_mexicana
ENSG00000256463	SALL3	88	73.451	ENSPMEG00000014946	sall3a	67	73.451	Poecilia_mexicana
ENSG00000256463	SALL3	94	59.259	ENSPREG00000015079	sall3b	77	49.332	Poecilia_reticulata
ENSG00000256463	SALL3	88	73.451	ENSPREG00000014420	sall3a	68	70.588	Poecilia_reticulata
ENSG00000256463	SALL3	100	97.443	ENSPPYG00000009253	SALL3	100	97.333	Pongo_abelii
ENSG00000256463	SALL3	100	86.716	ENSPCAG00000006522	SALL3	99	86.716	Procavia_capensis
ENSG00000256463	SALL3	100	92.996	ENSPCOG00000012553	SALL3	99	92.996	Propithecus_coquereli
ENSG00000256463	SALL3	99	85.965	ENSPVAG00000014645	SALL3	99	69.680	Pteropus_vampyrus
ENSG00000256463	SALL3	100	57.704	ENSPNYG00000005353	sall3b	99	58.974	Pundamilia_nyererei
ENSG00000256463	SALL3	96	68.811	ENSPNYG00000012783	sall3a	74	76.000	Pundamilia_nyererei
ENSG00000256463	SALL3	98	65.217	ENSPNAG00000017141	sall3b	76	62.791	Pygocentrus_nattereri
ENSG00000256463	SALL3	98	93.774	ENSRNOG00000026116	Sall3	97	93.774	Rattus_norvegicus
ENSG00000256463	SALL3	100	97.829	ENSRBIG00000036190	SALL3	80	97.829	Rhinopithecus_bieti
ENSG00000256463	SALL3	99	97.315	ENSRROG00000034130	SALL3	98	98.413	Rhinopithecus_roxellana
ENSG00000256463	SALL3	99	93.289	ENSSBOG00000023380	SALL3	100	93.957	Saimiri_boliviensis_boliviensis
ENSG00000256463	SALL3	99	88.561	ENSSHAG00000015872	SALL3	100	88.561	Sarcophilus_harrisii
ENSG00000256463	SALL3	97	69.360	ENSSFOG00015009159	SALL3	97	69.360	Scleropages_formosus
ENSG00000256463	SALL3	96	73.482	ENSSFOG00015012223	sall3a	100	75.290	Scleropages_formosus
ENSG00000256463	SALL3	98	64.822	ENSSMAG00000019762	sall3b	79	59.511	Scophthalmus_maximus
ENSG00000256463	SALL3	100	68.683	ENSSMAG00000007674	sall3a	72	78.431	Scophthalmus_maximus
ENSG00000256463	SALL3	100	70.621	ENSSDUG00000011099	sall3a	77	70.067	Seriola_dumerili
ENSG00000256463	SALL3	100	58.492	ENSSDUG00000010584	sall3b	99	63.462	Seriola_dumerili
ENSG00000256463	SALL3	99	63.529	ENSSLDG00000016800	sall3b	76	60.156	Seriola_lalandi_dorsalis
ENSG00000256463	SALL3	100	70.621	ENSSLDG00000012706	sall3a	77	70.067	Seriola_lalandi_dorsalis
ENSG00000256463	SALL3	98	61.333	ENSSPAG00000003172	sall3b	100	64.706	Stegastes_partitus
ENSG00000256463	SALL3	100	66.778	ENSSPAG00000013114	sall3a	98	77.647	Stegastes_partitus
ENSG00000256463	SALL3	100	84.444	ENSSSCG00000004858	SALL3	100	84.444	Sus_scrofa
ENSG00000256463	SALL3	97	80.752	ENSTGUG00000006541	SALL3	100	71.972	Taeniopygia_guttata
ENSG00000256463	SALL3	98	66.564	ENSTRUG00000017423	sall3a	100	67.920	Takifugu_rubripes
ENSG00000256463	SALL3	75	65.217	ENSTRUG00000003369	sall3b	67	67.391	Takifugu_rubripes
ENSG00000256463	SALL3	82	65.306	ENSTNIG00000001257	sall3a	71	66.250	Tetraodon_nigroviridis
ENSG00000256463	SALL3	83	83.067	ENSTBEG00000008964	SALL3	82	74.320	Tupaia_belangeri
ENSG00000256463	SALL3	99	81.967	ENSTTRG00000004958	SALL3	98	79.829	Tursiops_truncatus
ENSG00000256463	SALL3	100	91.829	ENSUAMG00000016908	SALL3	99	91.829	Ursus_americanus
ENSG00000256463	SALL3	94	82.711	ENSVVUG00000018838	SALL3	100	82.527	Vulpes_vulpes
ENSG00000256463	SALL3	100	83.764	ENSXETG00000000845	sall3	100	83.764	Xenopus_tropicalis
ENSG00000256463	SALL3	97	76.172	ENSXCOG00000016907	sall3a	69	76.172	Xiphophorus_couchianus
ENSG00000256463	SALL3	99	59.259	ENSXCOG00000018799	sall3b	89	61.538	Xiphophorus_couchianus
ENSG00000256463	SALL3	99	59.259	ENSXMAG00000000798	sall3b	99	50.450	Xiphophorus_maculatus
ENSG00000256463	SALL3	100	67.562	ENSXMAG00000023447	sall3a	70	75.781	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0021891	olfactory bulb interneuron development	-	IEA	Process
GO:0035136	forelimb morphogenesis	-	IEA	Process
GO:0035137	hindlimb morphogenesis	-	IEA	Process
GO:0045879	negative regulation of smoothened signaling pathway	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28616099	Epigenetic silencing of SALL3 is an independent predictor of poor survival in head and neck cancer.	Clin Epigenetics	2017 Jun 12	Misawa K	doi: 10.1186/s13148-017-0363-1
19139273	SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma.	Mol Cell Biol	2009 Apr	Shikauchi Y	doi: 10.1128/MCB.00840-08

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr18	78992223	Frame_Shift_Del	novel	*V79Cfs2**	0.59
BLCA	chr18	78995318	Silent	novel	T1109T	0.32
BLCA	chr18	78994415	Missense_Mutation	novel	D808E	0.19
BLCA	chr18	78994241	Silent	novel	N750N	0.51
BLCA	chr18	78993365	Silent	novel	S458S	0.33
BLCA	chr18	78993965	Silent	NA	T658T	0.54
BLCA	chr18	78993653	Silent	novel	Q554Q	0.18
BLCA	chr18	78994550	Silent	NA	V853V	0.48
BLCA	chr18	78992153	Missense_Mutation	novel	E54D	0.45
BLCA	chr18	78993467	Silent	NA	P492P	0.93
BLCA	chr18	78993543	Missense_Mutation	rs746622657	V518M	0.3
BLCA	chr18	78994241	Silent	novel	N750N	0.38
BLCA	chr18	78993098	Silent	rs773316503	S369S	0.26
BRCA	chr18	78993157	Missense_Mutation	novel	P389L	0.6
BRCA	chr18	78997973	3'UTR	novel		0.17
BRCA	chr18	78993358	Missense_Mutation	NA	R456H	0.58
BRCA	chr18	78994213	Missense_Mutation	NA	C741Y	0.57
BRCA	chr18	78994091	Silent	novel	T700T	0.14
CESC	chr18	78994981	Missense_Mutation	novel	R997H	0.11
CESC	chr18	78994968	Missense_Mutation	NA	E993Q	0.21
CESC	chr18	78998028	3'UTR	novel		0.12
CESC	chr18	78994104	Missense_Mutation	rs748726882	R705W	0.4
CESC	chr18	78992145	Missense_Mutation	novel	V52M	0.18
CESC	chr18	78993494	Missense_Mutation	novel	M501I	0.37
CESC	chr18	78994385	Silent	rs547166722	D798D	0.33
CESC	chr18	78994592	Silent	rs766510581	N867N	0.18
CESC	chr18	78992358	Missense_Mutation	novel	E123K	0.43	zf-C2H2
CESC	chr18	78994241	Silent	novel	N750N	0.3
COAD	chr18	78997169	Frame_Shift_Del	novel	*P1252Lfs52**	0.08
COAD	chr18	78996928	Missense_Mutation	rs533436270	A1170V	0.33
COAD	chr18	78994169	Silent	rs541206834	F726F	0.34
COAD	chr18	78997082	Silent	NA	N1221N	0.32
COAD	chr18	78993464	Silent	rs771619312	V491V	0.33
COAD	chr18	78993205	Nonsense_Mutation	NA	S405*	0.29
COAD	chr18	78994514	Silent	rs373611197	A841A	0.38
COAD	chr18	78993284	Silent	NA	S431S	0.5
COAD	chr18	78994394	Silent	rs747303117	D801D	0.3
COAD	chr18	78994251	Missense_Mutation	novel	L754M	0.06
COAD	chr18	78994664	Silent	NA	A891A	0.42
COAD	chr18	78995014	Missense_Mutation	rs760077198	A1008V	0.47
COAD	chr18	78994300	Missense_Mutation	NA	P770L	0.23
COAD	chr18	78993314	Silent	rs771343839	S441S	0.68
COAD	chr18	78994104	Missense_Mutation	rs748726882	R705W	0.3
COAD	chr18	78995160	Missense_Mutation	rs752173050	A1057T	0.27
COAD	chr18	78995312	Silent	novel	R1107R	0.16
COAD	chr18	78993324	Missense_Mutation	NA	E445K	0.19
COAD	chr18	78994865	Missense_Mutation	NA	E958D	0.09
COAD	chr18	78997345	3'UTR	novel		0.25
COAD	chr18	78995013	Missense_Mutation	novel	A1008T	0.52
COAD	chr18	78995050	Missense_Mutation	NA	L1020S	0.15
COAD	chr18	78994839	Missense_Mutation	NA	A950T	0.26
COAD	chr18	78994306	Missense_Mutation	rs772101192	P772L	0.27
COAD	chr18	78992099	Silent	rs766415840	D36D	0.75
COAD	chr18	78997116	Missense_Mutation	rs766672872	I1233V	0.12
COAD	chr18	78994430	Silent	novel	D813D	0.34
COAD	chr18	78993905	Silent	rs780801182	A638A	0.21
COAD	chr18	78994849	Missense_Mutation	rs755054197	R953H	0.75
COAD	chr18	78993206	Silent	novel	S405S	0.27
ESCA	chr18	78993906	Missense_Mutation	rs557725030	V639I	0.41
ESCA	chr18	78998151	3'UTR	novel		0.52
ESCA	chr18	78992159	Missense_Mutation	novel	C56W	0.34
ESCA	chr18	78993955	Missense_Mutation	rs765362184	S655L	0.55
ESCA	chr18	78993580	Missense_Mutation	novel	L530R	0.31
ESCA	chr18	78998136	3'UTR	novel		0.28
ESCA	chr18	78993309	Missense_Mutation	novel	R440C	0.48
GBM	chr18	78993975	Missense_Mutation	NA	S662A	0.73
GBM	chr18	78993290	Silent	novel	S433S	0.12
GBM	chr18	78995160	Missense_Mutation	rs752173050	A1057T	0.29
GBM	chr18	78992225	Silent	rs201950663	P78P	0.36
GBM	chr18	78997108	Missense_Mutation	novel	I1230S	0.16
GBM	chr18	78997007	Frame_Shift_Del	NA	*Q1197Rfs9**	0.24
GBM	chr18	78993193	Missense_Mutation	NA	P401L	0.43
HNSC	chr18	78994481	Silent	rs750721401	P830P	0.23
HNSC	chr18	78994386	Missense_Mutation	novel	D799N	0.25
HNSC	chr18	78993935	Silent	rs373055868	P648P	0.19
HNSC	chr18	78994998	Missense_Mutation	rs761366107	R1003W	0.29
HNSC	chr18	78992297	Silent	rs751683925	S102S	0.64
HNSC	chr18	78993296	Silent	novel	L435L	0.36
HNSC	chr18	78995393	Silent	rs780742305	T1134T	0.67
HNSC	chr18	78993377	Silent	novel	N462N	0.22
HNSC	chr18	78994699	Missense_Mutation	novel	Q903R	0.29
HNSC	chr18	78994297	Missense_Mutation	rs377294616	T769M	0.41
HNSC	chr18	78993497	Silent	rs774287520	S502S	0.31
HNSC	chr18	78994127	Silent	NA	C712C	0.36
HNSC	chr18	78997169	Frame_Shift_Del	novel	*P1252Lfs52**	0.12
HNSC	chr18	78997094	Missense_Mutation	novel	M1225I	0.17
HNSC	chr18	78996969	Missense_Mutation	novel	L1184V	0.33
HNSC	chr18	78993744	Nonsense_Mutation	novel	Q585*	0.14
HNSC	chr18	78994267	Missense_Mutation	NA	R759H	0.24
HNSC	chr18	78993093	Missense_Mutation	novel	A368T	0.08
HNSC	chr18	78994440	Missense_Mutation	rs565377995	D817N	0.48
KIRC	chr18	78993965	Silent	NA	T658T	0.26
KIRC	chr18	78992151	Missense_Mutation	NA	E54K	0.33
KIRP	chr18	78994972	Missense_Mutation	NA	I994T	0.42
KIRP	chr18	78993052	Missense_Mutation	rs761727616	A354V	0.22
LAML	chr18	78994198	Missense_Mutation	NA	R736L	0.5
LGG	chr18	78992248	Missense_Mutation	NA	A86V	0.38
LGG	chr18	78993213	Missense_Mutation	NA	E408Q	0.31
LGG	chr18	78994541	Silent	novel	I850I	0.45
LIHC	chr18	78997080	Missense_Mutation	novel	N1221Y	0.07
LIHC	chr18	78997118	Silent	novel	I1233I	0.33
LIHC	chr18	78994127	Silent	NA	C712C	0.42
LIHC	chr18	78993069	Missense_Mutation	novel	S360G	0.38
LIHC	chr18	78993827	Silent	novel	P612P	0.22
LIHC	chr18	78995362	Nonsense_Mutation	novel	S1124*	0.31
LIHC	chr18	78993074	Silent	rs377646222	P361P	0.26
LIHC	chr18	78994132	Missense_Mutation	NA	R714L	0.21
LUAD	chr18	78997442	3'UTR	novel		0.29
LUAD	chr18	78992652	Missense_Mutation	novel	Q221K	0.67
LUAD	chr18	78994097	Silent	novel	T702T	0.19
LUAD	chr18	78993279	Missense_Mutation	novel	G430C	0.08
LUAD	chr18	78997283	Silent	novel	T1288T	0.07
LUAD	chr18	78993582	Missense_Mutation	novel	P531S	0.29
LUAD	chr18	78993481	Missense_Mutation	NA	I497S	0.57
LUAD	chr18	78993878	Silent	novel	T629T	0.27
LUAD	chr18	78992256	Missense_Mutation	novel	P89S	0.5
LUAD	chr18	78994343	Silent	novel	A784A	0.42
LUAD	chr18	78994442	Missense_Mutation	novel	D817E	0.25
LUAD	chr18	78995282	Silent	novel	G1097G	0.56
LUAD	chr18	78994025	Silent	NA	P678P	0.37
LUAD	chr18	78994795	Missense_Mutation	NA	T935N	0.9
LUAD	chr18	78997344	3'UTR	novel		0.36
LUAD	chr18	78993743	Silent	NA	P584P	0.71
LUAD	chr18	78994904	Silent	novel	R971R	0.31
LUAD	chr18	78994668	Missense_Mutation	NA	S893C	0.19
LUAD	chr18	78995179	Missense_Mutation	NA	M1063T	0.3
LUAD	chr18	78994853	Silent	novel	A954A	0.35
LUAD	chr18	78993759	Missense_Mutation	novel	G590W	0.42
LUAD	chr18	78994811	Missense_Mutation	NA	S940R	0.33
LUAD	chr18	78993891	Missense_Mutation	novel	P634T	0.5
LUAD	chr18	78994985	Missense_Mutation	novel	S998R	0.38
LUAD	chr18	78994197	Missense_Mutation	novel	R736C	0.16
LUAD	chr18	78997063	Missense_Mutation	novel	Y1215C	0.07
LUAD	chr18	78993506	Silent	novel	P505P	0.33
LUAD	chr18	78994439	Silent	novel	T816T	0.63
LUAD	chr18	78993939	Frame_Shift_Del	NA	*L652Cfs2**	0.52
LUAD	chr18	78997009	Missense_Mutation	novel	Q1197L	0.12
LUAD	chr18	78996920	Missense_Mutation	novel	N1167K	0.28
LUAD	chr18	78993771	Missense_Mutation	NA	T594S	0.5
LUAD	chr18	78997010	Missense_Mutation	NA	Q1197H	0.19
LUAD	chr18	78994521	Nonsense_Mutation	NA	E844*	0.2
LUAD	chr18	78993602	Silent	novel	A537A	0.89
LUAD	chr18	78994643	Silent	rs187638087	G884G	0.45
LUAD	chr18	78994914	Missense_Mutation	NA	P975T	0.41
LUAD	chr18	78994453	Missense_Mutation	novel	P821R	0.24
LUAD	chr18	78994062	Missense_Mutation	novel	Q691K	0.21
LUAD	chr18	78993541	Missense_Mutation	novel	P517H	0.59
LUAD	chr18	78997146	Missense_Mutation	NA	V1243L	0.22
LUSC	chr18	78993968	Silent	NA	S659S	0.5
LUSC	chr18	78996945	Missense_Mutation	NA	L1176M	0.32
LUSC	chr18	78994334	Silent	novel	S781S	0.35
LUSC	chr18	78995137	Missense_Mutation	NA	T1049N	0.14
LUSC	chr18	78992151	Missense_Mutation	NA	E54K	0.26
LUSC	chr18	78992199	Nonsense_Mutation	rs371427282	Q70*	0.37
LUSC	chr18	78994096	Missense_Mutation	novel	T702M	0.12
LUSC	chr18	78994897	Missense_Mutation	NA	R969T	0.41
LUSC	chr18	78994925	Silent	novel	V978V	0.49
LUSC	chr18	78993157	Missense_Mutation	novel	P389L	0.47
LUSC	chr18	78994397	Silent	NA	E802E	0.2
LUSC	chr18	78992163	Missense_Mutation	novel	A58S	0.5
LUSC	chr18	78994395	Missense_Mutation	rs771174060	E802K	0.28
LUSC	chr18	78994397	Silent	NA	E802E	0.25
LUSC	chr18	78995125	Missense_Mutation	NA	P1045H	0.11
LUSC	chr18	78994204	Missense_Mutation	novel	Q738R	0.25
LUSC	chr18	78994665	Missense_Mutation	novel	G892S	0.06
LUSC	chr18	78993665	Silent	NA	P558P	0.6
LUSC	chr18	78992262	Missense_Mutation	novel	P91T	0.25
LUSC	chr18	78993205	Missense_Mutation	rs778812708	S405L	0.19
LUSC	chr18	78994281	Missense_Mutation	novel	G764R	0.45
LUSC	chr18	78993938	Frame_Shift_Del	novel	*F649Lfs5**	0.57
LUSC	chr18	78994623	Missense_Mutation	rs745575293	D878N	0.37
LUSC	chr18	78992207	Missense_Mutation	NA	S72R	0.28
LUSC	chr18	78993569	Silent	novel	V526V	0.28
LUSC	chr18	78992117	Missense_Mutation	novel	E42D	0.35
LUSC	chr18	78993467	Silent	NA	P492P	0.31
LUSC	chr18	78994271	Frame_Shift_Del	novel	*H761Afs30**	0.09
LUSC	chr18	78997273	Missense_Mutation	rs778334113	R1285H	0.1
LUSC	chr18	78993817	Missense_Mutation	NA	G609V	0.33
LUSC	chr18	78995246	Silent	novel	Q1085Q	0.47
LUSC	chr18	78997083	Missense_Mutation	novel	G1222R	0.26
LUSC	chr18	78992657	Silent	rs746486499	L222L	0.29
LUSC	chr18	78994513	Missense_Mutation	novel	A841D	0.61
LUSC	chr18	78993732	Missense_Mutation	novel	A581T	0.46
LUSC	chr18	78997333	3'UTR	novel		0.23
LUSC	chr18	78996976	Missense_Mutation	NA	G1186V	0.62
LUSC	chr18	78994570	Missense_Mutation	NA	T860S	0.34
LUSC	chr18	78993289	Missense_Mutation	NA	S433T	0.33
LUSC	chr18	78992671	Missense_Mutation	novel	R227H	0.6
LUSC	chr18	78993675	Missense_Mutation	NA	E562K	0.2
LUSC	chr18	78995006	Silent	NA	F1005F	0.19
LUSC	chr18	78996920	Silent	rs376239776	N1167N	0.37
LUSC	chr18	78993214	Missense_Mutation	NA	E408V	0.73
MESO	chr18	78993836	Silent	novel	A615A	0.54
OV	chr18	78993293	Silent	rs768341115	A434A	0.3
OV	chr18	78997273	Missense_Mutation	rs778334113	R1285H	0.2
OV	chr18	78997113	Missense_Mutation	rs760952537	V1232I	0.17
OV	chr18	78997179	Missense_Mutation	NA	G1254C	0.79
OV	chr18	78993216	Missense_Mutation	NA	P409T	0.44
PAAD	chr18	78997124	Silent	rs375447289	N1235N	0.21
PAAD	chr18	78993947	Silent	novel	L652L	0.09
PRAD	chr18	78994090	Missense_Mutation	NA	T700M	0.2
PRAD	chr18	78995234	Silent	NA	P1081P	0.25
PRAD	chr18	78994200	Missense_Mutation	rs147654064	V737M	0.55
PRAD	chr18	78996938	Silent	NA	G1173G	0.22
PRAD	chr18	78993607	Missense_Mutation	NA	G539A	0.31
PRAD	chr18	78993098	Silent	rs773316503	S369S	0.38
PRAD	chr18	78994985	Silent	novel	S998S	0.48
READ	chr18	78993938	Silent	rs766775310	F649F	0.38
READ	chr18	78994048	Missense_Mutation	NA	R686Q	0.26
READ	chr18	78993500	Frame_Shift_Ins	rs751298190	*E506Rfs90**	0.45
READ	chr18	78994090	Missense_Mutation	NA	T700M	0.73
READ	chr18	78994742	Silent	novel	S917S	0.56
READ	chr18	78997026	Missense_Mutation	rs761052930	R1203W	0.35
READ	chr18	78993313	Missense_Mutation	NA	S441L	0.63
SARC	chr18	78995241	Missense_Mutation	rs772346072	V1084I	0.89
SARC	chr18	78994525	Missense_Mutation	novel	N845S	0.23
SARC	chr18	78994954	Missense_Mutation	novel	C988Y	0.16
SARC	chr18	78997083	Missense_Mutation	rs745738298	G1222R	0.96
SARC	chr18	78997027	Missense_Mutation	rs766905615	R1203Q	0.14
SARC	chr18	78998016	3'UTR	novel		0.86
SARC	chr18	78993935	Silent	rs373055868	P648P	0.11
SARC	chr18	78998016	3'UTR	novel		0.53
SKCM	chr18	78994750	Missense_Mutation	rs781771204	P920L	0.59
SKCM	chr18	78997174	Missense_Mutation	rs180936492	P1252L	0.3
SKCM	chr18	78992273	Silent	NA	F94F	0.38
SKCM	chr18	78994898	Silent	rs761112279	R969R	0.48
SKCM	chr18	78993541	Missense_Mutation	NA	P517L	0.39
SKCM	chr18	78993933	Missense_Mutation	NA	P648S	0.87
SKCM	chr18	78997090	Missense_Mutation	NA	A1224V	0.56
SKCM	chr18	78992609	Silent	novel	L206L	0.28
SKCM	chr18	78993113	Silent	NA	P374P	0.42
SKCM	chr18	78994786	Missense_Mutation	rs753368702	P932L	0.5
SKCM	chr18	78993362	Silent	rs369963976	F457F	0.24
SKCM	chr18	78994968	Missense_Mutation	NA	E993K	0.28
SKCM	chr18	78994350	Missense_Mutation	rs2974290	D787N	0.39
SKCM	chr18	78992127	Missense_Mutation	NA	G46R	0.21
SKCM	chr18	78992615	Silent	NA	Q208Q	0.44
SKCM	chr18	78992241	Missense_Mutation	NA	E84K	0.46
SKCM	chr18	78994278	Missense_Mutation	NA	G763S	0.25
SKCM	chr18	78992151	Missense_Mutation	NA	E54K	0.21
SKCM	chr18	78993258	Missense_Mutation	NA	R423C	0.35
SKCM	chr18	78993646	Missense_Mutation	NA	S552F	0.16
SKCM	chr18	78995238	Missense_Mutation	NA	G1083S	0.46
SKCM	chr18	78996929	Silent	rs554029982	A1170A	0.32
SKCM	chr18	78997332	3'UTR	rs372682650		0.07
SKCM	chr18	78994300	Missense_Mutation	NA	P770L	0.19
SKCM	chr18	78995016	Missense_Mutation	NA	L1009F	0.13
SKCM	chr18	78993275	Silent	novel	V428V	0.1
SKCM	chr18	78995181	Missense_Mutation	novel	E1064K	0.6
SKCM	chr18	78993485	Silent	rs763495914	P498P	0.45
SKCM	chr18	78993069	Frame_Shift_Ins	novel	*S360Rfs236**	0.19
SKCM	chr18	78995193	Missense_Mutation	NA	H1068Y	0.69
SKCM	chr18	78993392	Silent	rs764219706	F467F	0.16
SKCM	chr18	78994504	Missense_Mutation	NA	S838F	0.2
SKCM	chr18	78992138	Silent	NA	E49E	0.38
SKCM	chr18	78994779	Missense_Mutation	NA	E930K	0.41
SKCM	chr18	78994504	Missense_Mutation	NA	S838F	0.39
SKCM	chr18	78993670	Missense_Mutation	NA	S560F	0.47
SKCM	chr18	78992328	Missense_Mutation	NA	E113K	0.83	zf-C2H2
SKCM	chr18	78992136	Missense_Mutation	NA	E49K	0.5
SKCM	chr18	78994462	Missense_Mutation	NA	S824F	0.23
SKCM	chr18	78997144	Missense_Mutation	novel	P1242L	0.26
SKCM	chr18	78997145	Silent	rs148335210	P1242P	0.26
SKCM	chr18	78994601	Silent	NA	G870G	0.15
SKCM	chr18	78993443	Silent	NA	V484V	0.34
SKCM	chr18	78994633	Missense_Mutation	rs772433157	S881L	0.41
SKCM	chr18	78997241	Silent	novel	L1274L	0.11
SKCM	chr18	78994495	Missense_Mutation	rs763342628	S835L	0.18
SKCM	chr18	78994470	Missense_Mutation	rs765703425	G827R	0.31
SKCM	chr18	78994779	Missense_Mutation	NA	E930K	0.41
SKCM	chr18	78992243	Silent	NA	E84E	0.32
SKCM	chr18	78995190	Missense_Mutation	NA	G1067S	0.4
SKCM	chr18	78994766	Silent	NA	P925P	0.75
SKCM	chr18	78994491	Missense_Mutation	rs760437377	P834S	0.42
SKCM	chr18	78994193	Silent	rs752301302	P734P	0.17
SKCM	chr18	78995144	Silent	novel	S1051S	0.24
SKCM	chr18	78994310	Silent	novel	E773E	0.23
SKCM	chr18	78993131	Silent	rs267605261	I380I	0.5
SKCM	chr18	78994898	Silent	rs761112279	R969R	0.78
SKCM	chr18	78992552	Silent	NA	A187A	0.4
SKCM	chr18	78994586	Silent	NA	V865V	0.46
SKCM	chr18	78994474	Missense_Mutation	novel	S828F	0.5
SKCM	chr18	78993506	Silent	rs755937032	P505P	0.28
SKCM	chr18	78992138	Silent	NA	E49E	0.25
SKCM	chr18	78994347	Missense_Mutation	NA	D786N	0.25
SKCM	chr18	78995226	Missense_Mutation	NA	P1079S	0.21
SKCM	chr18	78995153	Silent	rs746604663	S1054S	0.17
SKCM	chr18	78992141	Silent	novel	T50T	0.33
SKCM	chr18	78994623	Missense_Mutation	rs745575293	D878N	0.19
SKCM	chr18	78996910	Missense_Mutation	novel	M1164K	0.38
SKCM	chr18	78993956	Silent	rs369156685	S655S	0.11
SKCM	chr18	78995107	Missense_Mutation	rs763450217	P1039L	0.19
SKCM	chr18	78994683	Missense_Mutation	NA	E898K	0.43
SKCM	chr18	78993212	Silent	NA	F407F	0.38
SKCM	chr18	78994335	Missense_Mutation	NA	E782K	0.45
SKCM	chr18	78994350	Missense_Mutation	rs2974290	D787N	0.46
SKCM	chr18	78995055	Frame_Shift_Del	novel	*Q1022Sfs4**	0.58
SKCM	chr18	78994644	Missense_Mutation	rs776838246	D885N	0.45
SKCM	chr18	78993692	Silent	NA	S567S	0.29
SKCM	chr18	78992594	Silent	rs769324404	A201A	0.47
SKCM	chr18	78997125	Missense_Mutation	rs201141943	G1236S	0.79
SKCM	chr18	78993621	Missense_Mutation	NA	P544S	0.29
SKCM	chr18	78994643	Silent	rs187638087	G884G	0.25
SKCM	chr18	78993570	Missense_Mutation	NA	G527R	0.33
STAD	chr18	78997283	Silent	rs372422021	T1288T	0.36
STAD	chr18	78993964	Missense_Mutation	NA	T658M	0.43
STAD	chr18	78994750	Missense_Mutation	rs781771204	P920L	0.32
STAD	chr18	78994898	Missense_Mutation	NA	R969S	0.2
STAD	chr18	78995309	Silent	rs779333345	P1106P	0.27
STAD	chr18	78995442	Missense_Mutation	novel	T1151A	0.3
STAD	chr18	78992132	Silent	NA	G47G	0.18
STAD	chr18	78993543	Missense_Mutation	rs746622657	V518M	0.31
STAD	chr18	78995135	Silent	novel	S1048S	0.18
STAD	chr18	78997103	Silent	NA	N1228N	0.21
STAD	chr18	78994839	Missense_Mutation	NA	A950T	0.18
STAD	chr18	78996943	Missense_Mutation	novel	R1175H	0.27
STAD	chr18	78993340	Missense_Mutation	NA	C450Y	0.33
STAD	chr18	78994516	Missense_Mutation	NA	A842V	0.38
STAD	chr18	78993496	Missense_Mutation	NA	S502L	0.56
STAD	chr18	78994848	Missense_Mutation	rs75631933	R953C	0.54
STAD	chr18	78992225	Silent	rs201950663	P78P	0.59
STAD	chr18	78993496	Missense_Mutation	NA	S502L	0.27
STAD	chr18	78994360	Missense_Mutation	rs756965581	A790V	0.23
STAD	chr18	78994921	Frame_Shift_Ins	novel	*G980Vfs42**	0.15
STAD	chr18	78993717	Missense_Mutation	rs376550476	G576S	0.31
STAD	chr18	78995286	Missense_Mutation	NA	A1099S	0.31
STAD	chr18	78997400	3'UTR	novel		0.23
STAD	chr18	78995399	Silent	NA	T1136T	0.35
STAD	chr18	78992144	Silent	NA	S51S	0.29
STAD	chr18	78994622	Silent	rs367651872	N877N	0.49
STAD	chr18	78997282	Missense_Mutation	rs144491707	T1288M	0.4
STAD	chr18	78994796	Silent	rs567281901	T935T	0.33
STAD	chr18	78993954	Missense_Mutation	NA	S655P	0.33
STAD	chr18	78993092	Silent	rs370895727	S367S	0.46
STAD	chr18	78994571	Silent	rs774562749	T860T	0.29
STAD	chr18	78997125	Missense_Mutation	rs201141943	G1236S	0.12
STAD	chr18	78993554	Silent	rs749873911	T521T	0.27
STAD	chr18	78992182	Missense_Mutation	NA	A64E	0.52
STAD	chr18	78993965	Silent	NA	T658T	0.5
STAD	chr18	78994387	Missense_Mutation	NA	D799G	0.39
STAD	chr18	78997282	Missense_Mutation	rs144491707	T1288M	0.39
STAD	chr18	78993350	Silent	NA	C453C	0.17
STAD	chr18	78994298	Silent	rs778906774	T769T	0.25
STAD	chr18	78993440	Silent	NA	P483P	0.26
STAD	chr18	78993102	Missense_Mutation	rs765822599	V371I	0.25
STAD	chr18	78992229	Missense_Mutation	NA	L80M	0.19
STAD	chr18	78995232	Missense_Mutation	NA	P1081S	0.13
STAD	chr18	78993939	Frame_Shift_Del	NA	*L652Cfs2**	0.22
STAD	chr18	78993134	Silent	novel	A381A	0.46
STAD	chr18	78995287	Missense_Mutation	rs752632478	A1099V	0.5
STAD	chr18	78997273	Missense_Mutation	rs778334113	R1285H	0.2
STAD	chr18	78994298	Silent	NA	T769T	0.13
STAD	chr18	78994468	Missense_Mutation	rs772930651	A826V	0.22
THCA	chr18	78994115	Silent	NA	K708K	0.4
THYM	chr18	78995157	Missense_Mutation	rs139036373	A1056T	0.25
UCEC	chr18	78992126	Silent	rs376742118	S45S	0.18
UCEC	chr18	78997088	Silent	rs201370611	L1223L	0.21
UCEC	chr18	78997448	3'UTR	novel		0.54
UCEC	chr18	78994169	Silent	rs541206834	F726F	0.62
UCEC	chr18	78998040	3'UTR	novel		0.2
UCEC	chr18	78993955	Missense_Mutation	rs765362184	S655L	0.35
UCEC	chr18	78996969	Missense_Mutation	rs766342526	L1184F	0.4
UCEC	chr18	78997865	3'UTR	novel		0.43
UCEC	chr18	78997209	Missense_Mutation	rs146109999	R1264C	0.44
UCEC	chr18	78996894	Missense_Mutation	rs756279553	H1159Y	0.31
UCEC	chr18	78994115	Silent	NA	K708K	0.28
UCEC	chr18	78993258	Missense_Mutation	NA	R423C	0.49
UCEC	chr18	78997152	Missense_Mutation	novel	L1245I	0.41
UCEC	chr18	78997279	Missense_Mutation	novel	F1287S	0.35
UCEC	chr18	78997889	3'UTR	novel		0.93
UCEC	chr18	78998016	3'UTR	novel		0.61
UCEC	chr18	78997962	3'UTR	novel		0.05
UCEC	chr18	78993461	Silent	rs141579887	N490N	0.2
UCEC	chr18	78994243	Missense_Mutation	NA	A751D	0.22
UCEC	chr18	78992254	Missense_Mutation	NA	A88V	0.22
UCEC	chr18	78994402	Missense_Mutation	novel	S804Y	0.1
UCEC	chr18	78997268	Silent	novel	A1283A	0.27
UCEC	chr18	78992081	Silent	rs762052260	P30P	0.33
UCEC	chr18	78997038	Missense_Mutation	rs367585625	V1207I	0.12
UCEC	chr18	78994267	Missense_Mutation	NA	R759H	0.36
UCEC	chr18	78997282	Missense_Mutation	rs144491707	T1288M	0.86
UCEC	chr18	78995216	Silent	novel	G1075G	0.33
UCEC	chr18	78996960	Missense_Mutation	novel	P1181S	0.45
UCEC	chr18	78992086	Missense_Mutation	novel	E32G	0.5
UCEC	chr18	78998016	3'UTR	novel		0.62
UCEC	chr18	78993213	Missense_Mutation	NA	E408K	0.1
UCEC	chr18	78994347	Missense_Mutation	NA	D786N	0.38
UCEC	chr18	78993937	Missense_Mutation	novel	F649C	0.23
UCEC	chr18	78994849	Missense_Mutation	rs755054197	R953H	0.46
UCEC	chr18	78992180	Nonsense_Mutation	novel	W63*	0.21
UCEC	chr18	78993179	Silent	novel	H396H	0.32
UCEC	chr18	78997188	Missense_Mutation	novel	A1257T	0.29
UCEC	chr18	78994024	Missense_Mutation	rs555715986	P678L	0.46
UCEC	chr18	78994541	Silent	novel	I850I	0.33
UCEC	chr18	78993227	Silent	rs201160407	S412S	0.33
UCEC	chr18	78995040	Missense_Mutation	rs201364430	M1017V	0.48
UCEC	chr18	78998016	3'UTR	novel		0.85
UCEC	chr18	78995157	Missense_Mutation	rs139036373	A1056T	0.69
UCEC	chr18	78997284	Missense_Mutation	rs780459845	R1289W	0.27
UCEC	chr18	78993606	Missense_Mutation	rs760958244	G539S	0.27
UCEC	chr18	78993266	Silent	novel	C425C	0.41
UCEC	chr18	78994379	Silent	novel	Y796Y	0.32
UCEC	chr18	78998016	3'UTR	novel		0.67
UCEC	chr18	78994952	Silent	NA	A987A	0.14
UCEC	chr18	78997293	Missense_Mutation	rs556924052	E1292K	0.26
UCEC	chr18	78993217	Missense_Mutation	novel	P409L	0.19
UCEC	chr18	78993411	Missense_Mutation	novel	Y474H	0.4
UCEC	chr18	78994324	Missense_Mutation	rs776485395	A778V	0.34
UCEC	chr18	78997066	Missense_Mutation	NA	A1216V	0.26
UCEC	chr18	78994134	Missense_Mutation	novel	A715T	0.33
UCEC	chr18	78992171	Missense_Mutation	novel	F60L	0.23
UCEC	chr18	78994169	Silent	rs541206834	F726F	0.24
UCEC	chr18	78995006	Silent	NA	F1005F	0.21
UCEC	chr18	78998016	3'UTR	novel		0.71
UCEC	chr18	78995256	Missense_Mutation	rs200983101	G1089R	0.77
UCEC	chr18	78992162	Silent	NA	C57C	0.3
UCEC	chr18	78995174	Missense_Mutation	novel	I1061M	0.06
UCEC	chr18	78992234	Silent	rs762499418	I81I	0.45
UCEC	chr18	78993350	Silent	NA	C453C	0.38
UCEC	chr18	78998016	3'UTR	novel		0.72
UCEC	chr18	78998016	3'UTR	novel		0.52
UCEC	chr18	78992150	Silent	rs748334485	C53C	0.54
UCEC	chr18	78993180	Missense_Mutation	novel	R397C	0.45
UCEC	chr18	78994069	Missense_Mutation	rs767242808	A693V	0.57
UCEC	chr18	78994306	Missense_Mutation	rs772101192	P772L	0.14
UCEC	chr18	78995012	Silent	novel	C1007C	0.2
UCEC	chr18	78997209	Missense_Mutation	rs146109999	R1264C	0.58
UCEC	chr18	78994129	Missense_Mutation	novel	G713D	0.23
UCEC	chr18	78994927	Missense_Mutation	novel	C979F	0.15
UCEC	chr18	78997383	3'UTR	novel		0.38
UCEC	chr18	78997021	Missense_Mutation	NA	A1201E	0.39
UCEC	chr18	78993139	Missense_Mutation	NA	T383M	0.5
UCEC	chr18	78997088	Silent	rs201370611	L1223L	0.22
UCEC	chr18	78997975	3'UTR	novel		0.15
UCEC	chr18	78996931	Missense_Mutation	novel	R1171I	0.2
UCEC	chr18	78992121	Missense_Mutation	rs201059822	R44C	0.5
UCEC	chr18	78993566	Silent	rs767597542	S525S	0.34
UCEC	chr18	78994089	Missense_Mutation	novel	T700A	0.24
UCEC	chr18	78997889	3'UTR	novel		0.42
UCEC	chr18	78993939	Frame_Shift_Del	NA	*L652Cfs2**	0.38
UCEC	chr18	78992162	Silent	NA	C57C	0.4
UCEC	chr18	78995089	Missense_Mutation	novel	P1033H	0.08
UCEC	chr18	78997909	3'UTR	novel		0.41
UCEC	chr18	78997399	3'UTR	novel		0.25
UCEC	chr18	78993191	Silent	novel	K400K	0.39
UCEC	chr18	78994182	Missense_Mutation	novel	A731T	0.43
UCEC	chr18	78997216	Missense_Mutation	novel	G1266D	0.2
UCEC	chr18	78992242	Missense_Mutation	novel	E84G	0.41
UCEC	chr18	78993228	Missense_Mutation	novel	A413T	0.39
UCEC	chr18	78994108	Missense_Mutation	NA	P706L	0.15
UCS	chr18	78996943	Missense_Mutation	novel	R1175H	0.42
UCS	chr18	78992234	Missense_Mutation	novel	I81M	0.18
UCS	chr18	78994412	Silent	rs745703020	D807D	0.36
UCS	chr18	78994280	Silent	rs751203516	G763G	0.38
UVM	chr18	78994682	Silent	NA	S897S	0.62

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3775	2.627e-05
BRCA	DEL	0.2861	1.1472e-05
DLBC	AMP	0.3333	0.065049
ESCA	DEL	0.5163	1.0131e-05
HNSC	DEL	0.4943	7.936e-27
LGG	DEL	0.115	0.0021974
LIHC	DEL	0.2324	0.019373
LUAD	DEL	0.3857	7.7609e-08
LUSC	DEL	0.3892	1.9277e-09
OV	DEL	0.6321	2.5556e-31
PRAD	DEL	0.248	3.6438e-07
READ	DEL	0.8485	1.8694e-05
SARC	DEL	0.2802	0.019407
TGCT	DEL	0.7133	0.00010442
UCEC	DEL	0.1558	8.1745e-07
UCS	DEL	0.3393	0.12533

Survival Analysis

Cancer	P-value	Q-value
THYM	0.034	Kaplan-Meier Survival Analysis
KIRC	0.00028	Kaplan-Meier Survival Analysis
MESO	0.045	Kaplan-Meier Survival Analysis
HNSC	0.016	Kaplan-Meier Survival Analysis
BRCA	0.049	Kaplan-Meier Survival Analysis
LAML	0.029	Kaplan-Meier Survival Analysis
LGG	0.0018	Kaplan-Meier Survival Analysis
THCA	0.012	Kaplan-Meier Survival Analysis