EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000259494 (Gene tree)
Gene ID: 26589
Gene Symbol: MRPL46
Alias: LIECG2|P2ECSL|C15orf4
Full Name: mitochondrial ribosomal protein L46
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 7,944 bases
Position: chr15:88,459,476-88,467,419
Accession: 1192
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000312311	MRP-L46	PF11788.8	4.2e-17	1	1
ENSP00000477676	MRP-L46	PF11788.8	1.9e-16	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000558531	MRPL46-202	1002	-	ENSP00000477676	169 (aa)	-	A0A087WT90
ENST00000559538	MRPL46-204	727	-	ENSP00000477583	45 (aa)	-	A0A087WT51
ENST00000312475	MRPL46-201	1019	-	ENSP00000312311	279 (aa)	-	Q9H2W6
ENST00000560703	MRPL46-205	670	-	ENSP00000453881	86 (aa)	-	H0YN64
ENST00000558660	MRPL46-203	5561	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000259494's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000259494's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000259494	MRPL46	97	43.636	ENSAPOG00000018725	mrpl46	92	43.636	Acanthochromis_polyacanthus
ENSG00000259494	MRPL46	100	75.714	ENSAMEG00000005855	-	100	75.714	Ailuropoda_melanoleuca
ENSG00000259494	MRPL46	100	86.786	ENSAMEG00000012769	-	100	86.786	Ailuropoda_melanoleuca
ENSG00000259494	MRPL46	94	45.113	ENSACIG00000007620	mrpl46	90	45.113	Amphilophus_citrinellus
ENSG00000259494	MRPL46	97	44.364	ENSAOCG00000014108	mrpl46	92	44.364	Amphiprion_ocellaris
ENSG00000259494	MRPL46	97	44.000	ENSAPEG00000006612	mrpl46	92	44.000	Amphiprion_percula
ENSG00000259494	MRPL46	99	44.558	ENSATEG00000005654	mrpl46	99	44.558	Anabas_testudineus
ENSG00000259494	MRPL46	84	60.526	ENSAPLG00000013089	MRPL46	100	57.759	Anas_platyrhynchos
ENSG00000259494	MRPL46	100	91.039	ENSANAG00000023769	MRPL46	100	91.039	Aotus_nancymaae
ENSG00000259494	MRPL46	95	44.074	ENSACLG00000019884	mrpl46	89	44.444	Astatotilapia_calliptera
ENSG00000259494	MRPL46	99	46.181	ENSAMXG00000030876	mrpl46	86	46.181	Astyanax_mexicanus
ENSG00000259494	MRPL46	100	79.570	ENSBTAG00000019830	MRPL46	100	79.570	Bos_taurus
ENSG00000259494	MRPL46	73	32.243	WBGene00021935	mrpl-46	81	32.243	Caenorhabditis_elegans
ENSG00000259494	MRPL46	100	89.964	ENSCJAG00000044238	-	94	89.964	Callithrix_jacchus
ENSG00000259494	MRPL46	100	90.681	ENSCJAG00000013019	-	100	90.681	Callithrix_jacchus
ENSG00000259494	MRPL46	100	85.000	ENSCAFG00000011492	MRPL46	94	85.000	Canis_familiaris
ENSG00000259494	MRPL46	100	85.000	ENSCAFG00020018871	MRPL46	94	85.000	Canis_lupus_dingo
ENSG00000259494	MRPL46	100	80.287	ENSCHIG00000015964	MRPL46	100	80.287	Capra_hircus
ENSG00000259494	MRPL46	100	86.380	ENSTSYG00000011162	MRPL46	100	86.380	Carlito_syrichta
ENSG00000259494	MRPL46	100	83.214	ENSCPOG00000040189	MRPL46	100	83.214	Cavia_porcellus
ENSG00000259494	MRPL46	100	90.681	ENSCCAG00000026434	MRPL46	100	90.681	Cebus_capucinus
ENSG00000259494	MRPL46	100	95.349	ENSCATG00000041595	MRPL46	100	95.349	Cercocebus_atys
ENSG00000259494	MRPL46	99	81.004	ENSCLAG00000017048	MRPL46	98	81.004	Chinchilla_lanigera
ENSG00000259494	MRPL46	100	93.907	ENSCSAG00000017201	MRPL46	89	93.907	Chlorocebus_sabaeus
ENSG00000259494	MRPL46	87	74.359	ENSCPBG00000017913	MRPL46	95	61.151	Chrysemys_picta_bellii
ENSG00000259494	MRPL46	84	34.274	ENSCSAVG00000000559	-	82	34.274	Ciona_savignyi
ENSG00000259494	MRPL46	100	93.190	ENSCANG00000037267	MRPL46	100	93.190	Colobus_angolensis_palliatus
ENSG00000259494	MRPL46	100	75.357	ENSCGRG00001001727	Mrpl46	100	75.357	Cricetulus_griseus_chok1gshd
ENSG00000259494	MRPL46	99	73.477	ENSCGRG00000002612	Mrpl46	97	73.477	Cricetulus_griseus_crigri
ENSG00000259494	MRPL46	80	58.333	ENSCSEG00000010621	mrpl46	82	45.902	Cynoglossus_semilaevis
ENSG00000259494	MRPL46	78	54.286	ENSCVAG00000018564	mrpl46	88	48.804	Cyprinodon_variegatus
ENSG00000259494	MRPL46	82	62.162	ENSDARG00000016307	mrpl46	84	48.148	Danio_rerio
ENSG00000259494	MRPL46	100	79.928	ENSDNOG00000017151	MRPL46	100	79.928	Dasypus_novemcinctus
ENSG00000259494	MRPL46	90	37.945	FBgn0035272	mRpL46	97	37.945	Drosophila_melanogaster
ENSG00000259494	MRPL46	100	77.419	ENSETEG00000005085	MRPL46	100	77.419	Echinops_telfairi
ENSG00000259494	MRPL46	100	42.657	ENSEBUG00000008986	mrpl46	98	42.657	Eptatretus_burgeri
ENSG00000259494	MRPL46	100	85.000	ENSEASG00005015372	MRPL46	100	85.000	Equus_asinus_asinus
ENSG00000259494	MRPL46	100	85.714	ENSECAG00000007635	MRPL46	100	85.714	Equus_caballus
ENSG00000259494	MRPL46	99	76.449	ENSEEUG00000007892	MRPL46	100	76.449	Erinaceus_europaeus
ENSG00000259494	MRPL46	91	51.220	ENSELUG00000016469	mrpl46	93	45.683	Esox_lucius
ENSG00000259494	MRPL46	100	85.409	ENSFCAG00000014966	MRPL46	100	85.409	Felis_catus
ENSG00000259494	MRPL46	84	65.789	ENSFALG00000010432	MRPL46	96	55.598	Ficedula_albicollis
ENSG00000259494	MRPL46	100	79.359	ENSFDAG00000011643	MRPL46	87	79.359	Fukomys_damarensis
ENSG00000259494	MRPL46	100	42.712	ENSFHEG00000013987	mrpl46	100	42.712	Fundulus_heteroclitus
ENSG00000259494	MRPL46	88	41.434	ENSGMOG00000018618	mrpl46	95	41.833	Gadus_morhua
ENSG00000259494	MRPL46	93	55.725	ENSGALG00000006782	MRPL46	91	55.725	Gallus_gallus
ENSG00000259494	MRPL46	85	46.058	ENSGAFG00000001964	mrpl46	69	46.058	Gambusia_affinis
ENSG00000259494	MRPL46	99	45.552	ENSGACG00000014786	mrpl46	99	45.552	Gasterosteus_aculeatus
ENSG00000259494	MRPL46	99	61.429	ENSGAGG00000013560	MRPL46	99	61.429	Gopherus_agassizii
ENSG00000259494	MRPL46	100	97.674	ENSGGOG00000015148	MRPL46	100	97.674	Gorilla_gorilla
ENSG00000259494	MRPL46	95	44.444	ENSHBUG00000019818	mrpl46	90	44.815	Haplochromis_burtoni
ENSG00000259494	MRPL46	99	80.000	ENSHGLG00000007404	MRPL46	97	80.000	Heterocephalus_glaber_female
ENSG00000259494	MRPL46	99	80.000	ENSHGLG00100008704	MRPL46	97	80.000	Heterocephalus_glaber_male
ENSG00000259494	MRPL46	90	45.136	ENSHCOG00000001350	mrpl46	97	43.151	Hippocampus_comes
ENSG00000259494	MRPL46	82	56.757	ENSIPUG00000022487	mrpl46	85	48.361	Ictalurus_punctatus
ENSG00000259494	MRPL46	99	84.588	ENSSTOG00000011555	MRPL46	97	84.588	Ictidomys_tridecemlineatus
ENSG00000259494	MRPL46	99	82.500	ENSJJAG00000003742	-	97	82.500	Jaculus_jaculus
ENSG00000259494	MRPL46	100	44.966	ENSKMAG00000000840	mrpl46	100	44.966	Kryptolebias_marmoratus
ENSG00000259494	MRPL46	66	47.414	ENSLOCG00000014530	mrpl46	59	49.153	Lepisosteus_oculatus
ENSG00000259494	MRPL46	100	79.211	ENSLAFG00000011931	MRPL46	100	79.211	Loxodonta_africana
ENSG00000259494	MRPL46	100	94.624	ENSMFAG00000037394	MRPL46	100	94.624	Macaca_fascicularis
ENSG00000259494	MRPL46	100	94.265	ENSMMUG00000013658	MRPL46	100	94.265	Macaca_mulatta
ENSG00000259494	MRPL46	100	94.624	ENSMNEG00000041721	MRPL46	89	94.624	Macaca_nemestrina
ENSG00000259494	MRPL46	100	95.349	ENSMLEG00000043694	MRPL46	100	95.349	Mandrillus_leucophaeus
ENSG00000259494	MRPL46	85	47.737	ENSMAMG00000006593	mrpl46	83	47.737	Mastacembelus_armatus
ENSG00000259494	MRPL46	95	44.074	ENSMZEG00005005163	mrpl46	89	44.444	Maylandia_zebra
ENSG00000259494	MRPL46	90	57.708	ENSMGAG00000008771	MRPL46	98	57.708	Meleagris_gallopavo
ENSG00000259494	MRPL46	100	76.429	ENSMAUG00000009443	Mrpl46	100	76.429	Mesocricetus_auratus
ENSG00000259494	MRPL46	100	87.500	ENSMICG00000015826	MRPL46	100	87.500	Microcebus_murinus
ENSG00000259494	MRPL46	100	76.429	ENSMOCG00000012649	Mrpl46	100	76.429	Microtus_ochrogaster
ENSG00000259494	MRPL46	100	43.051	ENSMMOG00000015783	mrpl46	100	43.729	Mola_mola
ENSG00000259494	MRPL46	87	71.795	ENSMODG00000019591	MRPL46	91	65.428	Monodelphis_domestica
ENSG00000259494	MRPL46	100	42.088	ENSMALG00000012231	mrpl46	100	42.088	Monopterus_albus
ENSG00000259494	MRPL46	100	81.362	MGP_CAROLIEiJ_G0029869	Mrpl46	100	81.362	Mus_caroli
ENSG00000259494	MRPL46	99	80.935	ENSMUSG00000030612	Mrpl46	98	80.935	Mus_musculus
ENSG00000259494	MRPL46	99	80.797	MGP_PahariEiJ_G0013091	Mrpl46	99	80.797	Mus_pahari
ENSG00000259494	MRPL46	99	80.576	MGP_SPRETEiJ_G0030971	Mrpl46	98	80.576	Mus_spretus
ENSG00000259494	MRPL46	100	84.286	ENSMPUG00000015828	MRPL46	100	84.286	Mustela_putorius_furo
ENSG00000259494	MRPL46	100	82.143	ENSMLUG00000009624	MRPL46	100	82.143	Myotis_lucifugus
ENSG00000259494	MRPL46	100	82.206	ENSNGAG00000015215	Mrpl46	100	82.206	Nannospalax_galili
ENSG00000259494	MRPL46	95	44.444	ENSNBRG00000006597	mrpl46	90	44.815	Neolamprologus_brichardi
ENSG00000259494	MRPL46	100	97.674	ENSNLEG00000011430	MRPL46	100	97.674	Nomascus_leucogenys
ENSG00000259494	MRPL46	100	70.775	ENSOPRG00000008241	MRPL46	100	71.127	Ochotona_princeps
ENSG00000259494	MRPL46	99	80.287	ENSODEG00000015622	MRPL46	98	80.287	Octodon_degus
ENSG00000259494	MRPL46	95	44.444	ENSONIG00000003015	mrpl46	89	44.815	Oreochromis_niloticus
ENSG00000259494	MRPL46	100	78.853	ENSOCUG00000001362	MRPL46	100	78.853	Oryctolagus_cuniculus
ENSG00000259494	MRPL46	99	44.178	ENSORLG00000014585	mrpl46	99	44.178	Oryzias_latipes
ENSG00000259494	MRPL46	99	44.521	ENSORLG00020001089	mrpl46	99	44.521	Oryzias_latipes_hni
ENSG00000259494	MRPL46	99	44.863	ENSORLG00015017107	mrpl46	99	44.863	Oryzias_latipes_hsok
ENSG00000259494	MRPL46	92	46.743	ENSOMEG00000017928	mrpl46	87	47.126	Oryzias_melastigma
ENSG00000259494	MRPL46	99	87.319	ENSOGAG00000004736	MRPL46	97	87.319	Otolemur_garnettii
ENSG00000259494	MRPL46	99	76.619	ENSOARG00000010876	MRPL46	100	76.619	Ovis_aries
ENSG00000259494	MRPL46	100	100.000	ENSPPAG00000040630	MRPL46	100	100.000	Pan_paniscus
ENSG00000259494	MRPL46	100	85.053	ENSPPRG00000002180	MRPL46	100	85.053	Panthera_pardus
ENSG00000259494	MRPL46	100	77.224	ENSPTIG00000020791	MRPL46	100	77.224	Panthera_tigris_altaica
ENSG00000259494	MRPL46	100	100.000	ENSPTRG00000007419	MRPL46	100	100.000	Pan_troglodytes
ENSG00000259494	MRPL46	100	93.548	ENSPANG00000000922	MRPL46	100	93.548	Papio_anubis
ENSG00000259494	MRPL46	82	62.162	ENSPKIG00000014232	mrpl46	95	46.667	Paramormyrops_kingsleyae
ENSG00000259494	MRPL46	95	46.324	ENSPMGG00000023145	mrpl46	90	46.691	Periophthalmus_magnuspinnatus
ENSG00000259494	MRPL46	99	78.136	ENSPEMG00000018885	Mrpl46	99	78.136	Peromyscus_maniculatus_bairdii
ENSG00000259494	MRPL46	91	46.415	ENSPMAG00000008138	mrpl46	90	47.727	Petromyzon_marinus
ENSG00000259494	MRPL46	99	66.783	ENSPCIG00000006388	MRPL46	92	68.683	Phascolarctos_cinereus
ENSG00000259494	MRPL46	100	41.414	ENSPFOG00000017386	mrpl46	100	41.414	Poecilia_formosa
ENSG00000259494	MRPL46	100	41.077	ENSPLAG00000001299	mrpl46	100	41.077	Poecilia_latipinna
ENSG00000259494	MRPL46	100	41.414	ENSPMEG00000012447	mrpl46	100	41.414	Poecilia_mexicana
ENSG00000259494	MRPL46	100	41.751	ENSPREG00000005001	mrpl46	100	41.751	Poecilia_reticulata
ENSG00000259494	MRPL46	100	97.133	ENSPPYG00000006750	MRPL46	100	97.133	Pongo_abelii
ENSG00000259494	MRPL46	100	78.136	ENSPCAG00000003010	MRPL46	100	78.136	Procavia_capensis
ENSG00000259494	MRPL46	100	90.357	ENSPCOG00000014191	MRPL46	100	90.357	Propithecus_coquereli
ENSG00000259494	MRPL46	87	74.359	ENSPVAG00000001593	MRPL46	100	87.745	Pteropus_vampyrus
ENSG00000259494	MRPL46	95	43.704	ENSPNYG00000008444	mrpl46	90	44.074	Pundamilia_nyererei
ENSG00000259494	MRPL46	87	51.210	ENSPNAG00000013468	mrpl46	84	51.210	Pygocentrus_nattereri
ENSG00000259494	MRPL46	100	81.004	ENSRNOG00000018547	Mrpl46	100	81.004	Rattus_norvegicus
ENSG00000259494	MRPL46	100	93.548	ENSRBIG00000041366	MRPL46	100	93.548	Rhinopithecus_bieti
ENSG00000259494	MRPL46	100	93.190	ENSRROG00000025867	MRPL46	89	93.190	Rhinopithecus_roxellana
ENSG00000259494	MRPL46	100	80.287	ENSSBOG00000034438	-	100	80.287	Saimiri_boliviensis_boliviensis
ENSG00000259494	MRPL46	100	89.964	ENSSBOG00000032094	-	94	89.964	Saimiri_boliviensis_boliviensis
ENSG00000259494	MRPL46	87	69.231	ENSSHAG00000018436	MRPL46	100	71.770	Sarcophilus_harrisii
ENSG00000259494	MRPL46	92	48.846	ENSSFOG00015018980	mrpl46	97	50.000	Scleropages_formosus
ENSG00000259494	MRPL46	100	44.056	ENSSMAG00000010974	mrpl46	95	44.406	Scophthalmus_maximus
ENSG00000259494	MRPL46	85	46.721	ENSSDUG00000008387	mrpl46	90	45.018	Seriola_dumerili
ENSG00000259494	MRPL46	95	45.387	ENSSLDG00000015671	mrpl46	90	45.387	Seriola_lalandi_dorsalis
ENSG00000259494	MRPL46	82	72.973	ENSSPUG00000012000	-	76	55.392	Sphenodon_punctatus
ENSG00000259494	MRPL46	99	44.521	ENSSPAG00000017096	mrpl46	99	44.521	Stegastes_partitus
ENSG00000259494	MRPL46	100	85.305	ENSSSCG00000005105	MRPL46	100	85.305	Sus_scrofa
ENSG00000259494	MRPL46	84	65.789	ENSTGUG00000015561	-	98	57.806	Taeniopygia_guttata
ENSG00000259494	MRPL46	84	65.789	ENSTGUG00000008361	-	98	58.403	Taeniopygia_guttata
ENSG00000259494	MRPL46	99	43.537	ENSTRUG00000023585	mrpl46	98	43.537	Takifugu_rubripes
ENSG00000259494	MRPL46	76	64.706	ENSTNIG00000011910	mrpl46	97	44.649	Tetraodon_nigroviridis
ENSG00000259494	MRPL46	91	83.071	ENSTBEG00000009495	MRPL46	100	83.071	Tupaia_belangeri
ENSG00000259494	MRPL46	100	85.714	ENSTTRG00000008690	MRPL46	100	85.714	Tursiops_truncatus
ENSG00000259494	MRPL46	100	86.429	ENSUAMG00000019058	MRPL46	100	86.429	Ursus_americanus
ENSG00000259494	MRPL46	100	87.500	ENSUMAG00000006255	MRPL46	100	87.500	Ursus_maritimus
ENSG00000259494	MRPL46	83	83.621	ENSVPAG00000004712	MRPL46	100	83.621	Vicugna_pacos
ENSG00000259494	MRPL46	100	84.286	ENSVVUG00000012054	MRPL46	100	84.286	Vulpes_vulpes
ENSG00000259494	MRPL46	100	55.872	ENSXETG00000007594	mrpl46	100	55.872	Xenopus_tropicalis
ENSG00000259494	MRPL46	94	42.545	ENSXCOG00000018106	mrpl46	93	42.545	Xiphophorus_couchianus
ENSG00000259494	MRPL46	100	41.946	ENSXMAG00000018093	mrpl46	100	41.946	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003674	molecular_function	-	ND	Function
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0008150	biological_process	-	ND	Process
GO:0016787	hydrolase activity	-	IEA	Function
GO:0030054	cell junction	-	IDA	Component
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process