EuRBPDB

Description

RBDs

RBPome

Literatures

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000259956 (Gene tree)
Gene ID: 29890
Gene Symbol: RBM15B
Alias: HUMAGCGB|OTT3
Full Name: RNA binding motif protein 15B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 6,641 bases
Position: chr3:51,391,268-51,397,908
Accession: 24303
RBP type: canonical RBP
Summary: Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000454545	RRM_1	PF00076.22	2.7e-29	1	2
ENSP00000454545	RRM_1	PF00076.22	2.7e-29	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27602518	m(6)A RNA methylation promotes XIST-mediated transcriptional repression.	Nature	2016 Sep 15	Patil DP	doi: 10.1038/nature19342
19586903	The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.	J Biol Chem	2009 Sep 18	Uranishi H	doi: 10.1074/jbc.M109.040113
21044963	The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2α complex on splicing.	J Biol Chem	2011 Jan 7	Loyer P	doi: 10.1074/jbc.M110.192518

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000563281	RBM15B-201	6641	-	ENSP00000454545	890 (aa)	-	Q8NDT2

Gene Model

Click here to download ENSG00000259956's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000259956's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000259956	RBM15B	84	47.713	ENSG00000162775	RBM15	64	50.828

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000259956	RBM15B	89	89.354	ENSAMEG00000009353	RBM15B	99	89.354	Ailuropoda_melanoleuca
ENSG00000259956	RBM15B	87	52.743	ENSAPEG00000023123	rbm15b	88	52.813	Amphiprion_percula
ENSG00000259956	RBM15B	85	51.875	ENSATEG00000008514	rbm15b	87	52.442	Anabas_testudineus
ENSG00000259956	RBM15B	85	76.258	ENSACAG00000007689	RBM15B	91	75.355	Anolis_carolinensis
ENSG00000259956	RBM15B	100	94.855	ENSANAG00000026817	RBM15B	100	100.000	Aotus_nancymaae
ENSG00000259956	RBM15B	87	52.625	ENSACLG00000013346	rbm15b	88	52.792	Astatotilapia_calliptera
ENSG00000259956	RBM15B	63	53.659	ENSAMXG00000025805	rbm15b	90	55.268	Astyanax_mexicanus
ENSG00000259956	RBM15B	100	96.425	ENSBTAG00000006500	RBM15B	100	96.425	Bos_taurus
ENSG00000259956	RBM15B	100	96.333	ENSCAFG00000010266	RBM15B	100	96.333	Canis_familiaris
ENSG00000259956	RBM15B	100	94.308	ENSCHIG00000016926	-	100	93.834	Capra_hircus
ENSG00000259956	RBM15B	100	94.065	ENSCPOG00000031950	RBM15B	100	93.841	Cavia_porcellus
ENSG00000259956	RBM15B	100	98.989	ENSCSAG00000018788	RBM15B	100	98.989	Chlorocebus_sabaeus
ENSG00000259956	RBM15B	67	95.492	ENSCHOG00000009175	RBM15B	99	95.477	Choloepus_hoffmanni
ENSG00000259956	RBM15B	100	93.169	ENSCGRG00001015903	Rbm15b	100	92.945	Cricetulus_griseus_chok1gshd
ENSG00000259956	RBM15B	86	50.446	ENSCSEG00000014504	rbm15b	86	51.160	Cynoglossus_semilaevis
ENSG00000259956	RBM15B	86	52.025	ENSCVAG00000018913	rbm15b	88	52.625	Cyprinodon_variegatus
ENSG00000259956	RBM15B	89	58.272	ENSDARG00000078966	rbm15b	98	61.985	Danio_rerio
ENSG00000259956	RBM15B	67	92.797	ENSDNOG00000036695	RBM15B	96	92.797	Dasypus_novemcinctus
ENSG00000259956	RBM15B	53	91.121	ENSETEG00000008333	RBM15B	53	91.121	Echinops_telfairi
ENSG00000259956	RBM15B	100	93.430	ENSEASG00005012861	RBM15B	100	93.207	Equus_asinus_asinus
ENSG00000259956	RBM15B	100	93.973	ENSECAG00000011809	RBM15B	100	93.973	Equus_caballus
ENSG00000259956	RBM15B	85	57.342	ENSELUG00000000768	rbm15b	87	55.542	Esox_lucius
ENSG00000259956	RBM15B	77	80.932	ENSFALG00000014346	RBM15B	100	80.349	Ficedula_albicollis
ENSG00000259956	RBM15B	92	74.590	ENSGALG00000050969	RBM15B	81	79.739	Gallus_gallus
ENSG00000259956	RBM15B	87	52.949	ENSGAFG00000018303	rbm15b	88	52.455	Gambusia_affinis
ENSG00000259956	RBM15B	95	98.814	ENSGGOG00000001037	RBM15B	98	98.814	Gorilla_gorilla
ENSG00000259956	RBM15B	87	53.066	ENSHBUG00000009487	rbm15b	88	53.121	Haplochromis_burtoni
ENSG00000259956	RBM15B	100	94.619	ENSHGLG00000020882	-	100	94.843	Heterocephalus_glaber_female
ENSG00000259956	RBM15B	86	49.288	ENSHCOG00000014262	rbm15b	90	50.389	Hippocampus_comes
ENSG00000259956	RBM15B	83	59.249	ENSIPUG00000008345	rbm15b	86	58.344	Ictalurus_punctatus
ENSG00000259956	RBM15B	87	97.169	ENSSTOG00000008657	RBM15B	100	97.169	Ictidomys_tridecemlineatus
ENSG00000259956	RBM15B	88	91.614	ENSJJAG00000024067	Rbm15b	94	93.659	Jaculus_jaculus
ENSG00000259956	RBM15B	100	62.651	ENSLACG00000016607	RBM15B	87	68.099	Latimeria_chalumnae
ENSG00000259956	RBM15B	100	60.265	ENSLOCG00000013409	rbm15b	88	65.245	Lepisosteus_oculatus
ENSG00000259956	RBM15B	63	96.277	ENSLAFG00000012673	RBM15B	100	96.277	Loxodonta_africana
ENSG00000259956	RBM15B	100	98.989	ENSMFAG00000029773	RBM15B	100	98.989	Macaca_fascicularis
ENSG00000259956	RBM15B	85	52.497	ENSMAMG00000010212	rbm15b	88	52.412	Mastacembelus_armatus
ENSG00000259956	RBM15B	63	84.452	ENSMGAG00000002238	RBM15B	100	84.452	Meleagris_gallopavo
ENSG00000259956	RBM15B	100	93.274	ENSMOCG00000001646	Rbm15b	100	92.489	Microtus_ochrogaster
ENSG00000259956	RBM15B	63	86.903	ENSMODG00000011903	RBM15B	100	86.903	Monodelphis_domestica
ENSG00000259956	RBM15B	84	53.017	ENSMALG00000020264	rbm15b	95	52.465	Monopterus_albus
ENSG00000259956	RBM15B	100	93.042	MGP_CAROLIEiJ_G0032637	Rbm15b	100	92.368	Mus_caroli
ENSG00000259956	RBM15B	100	93.378	ENSMUSG00000074102	Rbm15b	100	92.705	Mus_musculus
ENSG00000259956	RBM15B	100	94.388	MGP_PahariEiJ_G0015504	Rbm15b	100	93.939	Mus_pahari
ENSG00000259956	RBM15B	100	93.378	MGP_SPRETEiJ_G0033782	Rbm15b	100	92.705	Mus_spretus
ENSG00000259956	RBM15B	72	96.552	ENSMPUG00000019339	RBM15B	100	96.552	Mustela_putorius_furo
ENSG00000259956	RBM15B	100	89.810	ENSNGAG00000022552	Rbm15b	86	94.882	Nannospalax_galili
ENSG00000259956	RBM15B	84	97.855	ENSNLEG00000018541	RBM15B	93	97.858	Nomascus_leucogenys
ENSG00000259956	RBM15B	64	86.515	ENSMEUG00000006207	RBM15B	100	86.515	Notamacropus_eugenii
ENSG00000259956	RBM15B	100	94.501	ENSODEG00000020563	-	100	95.174	Octodon_degus
ENSG00000259956	RBM15B	63	53.041	ENSONIG00000021253	rbm15b	99	55.184	Oreochromis_niloticus
ENSG00000259956	RBM15B	56	64.870	ENSOANG00000001071	-	100	67.665	Ornithorhynchus_anatinus
ENSG00000259956	RBM15B	63	93.262	ENSOCUG00000010322	RBM15B	100	93.262	Oryctolagus_cuniculus
ENSG00000259956	RBM15B	86	52.949	ENSORLG00000025754	rbm15b	88	52.308	Oryzias_latipes
ENSG00000259956	RBM15B	86	53.392	ENSORLG00020022257	rbm15b	88	52.941	Oryzias_latipes_hni
ENSG00000259956	RBM15B	63	97.691	ENSOGAG00000001996	RBM15B	100	97.691	Otolemur_garnettii
ENSG00000259956	RBM15B	67	95.960	ENSOARG00000007757	RBM15B	96	95.973	Ovis_aries
ENSG00000259956	RBM15B	67	63.894	ENSPKIG00000010201	rbm15b	100	64.784	Paramormyrops_kingsleyae
ENSG00000259956	RBM15B	63	83.894	ENSPSIG00000000576	RBM15B	100	83.894	Pelodiscus_sinensis
ENSG00000259956	RBM15B	87	52.519	ENSPFOG00000014574	rbm15b	88	52.369	Poecilia_formosa
ENSG00000259956	RBM15B	72	96.667	ENSPVAG00000003221	RBM15B	73	96.667	Pteropus_vampyrus
ENSG00000259956	RBM15B	87	52.934	ENSPNYG00000019263	rbm15b	88	53.113	Pundamilia_nyererei
ENSG00000259956	RBM15B	100	93.154	ENSRNOG00000014161	Rbm15b	100	92.480	Rattus_norvegicus
ENSG00000259956	RBM15B	89	98.992	ENSRROG00000017232	RBM15B	89	98.992	Rhinopithecus_roxellana
ENSG00000259956	RBM15B	63	86.396	ENSSHAG00000010976	RBM15B	100	86.396	Sarcophilus_harrisii
ENSG00000259956	RBM15B	100	96.644	ENSSSCG00000011420	RBM15B	100	96.644	Sus_scrofa
ENSG00000259956	RBM15B	63	84.629	ENSTGUG00000004850	RBM15B	100	84.629	Taeniopygia_guttata
ENSG00000259956	RBM15B	100	86.607	ENSTBEG00000008724	RBM15B	100	86.719	Tupaia_belangeri
ENSG00000259956	RBM15B	100	92.049	ENSTTRG00000001431	RBM15B	100	92.049	Tursiops_truncatus
ENSG00000259956	RBM15B	87	52.185	ENSXMAG00000012197	rbm15b	88	52.455	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	16129689.	IDA	Process
GO:0001510	RNA methylation	27602518.	IDA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	27602518.	IDA	Function
GO:0003723	RNA binding	16129689.	NAS	Function
GO:0005515	protein binding	16129689.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005635	nuclear envelope	19586903.	IDA	Component
GO:0005654	nucleoplasm	16129689.	IDA	Component
GO:0005730	nucleolus	16129689.	IDA	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0006406	mRNA export from nucleus	-	ISS	Process
GO:0006913	nucleocytoplasmic transport	16129689.	IDA	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0009048	dosage compensation by inactivation of X chromosome	27602518.	IDA	Process
GO:0016032	viral process	-	IEA	Process
GO:0016607	nuclear speck	19586903.	IDA	Component
GO:0036396	RNA N6-methyladenosine methyltransferase complex	27602518.	IDA	Component
GO:0045892	negative regulation of transcription, DNA-templated	16129689.	IDA	Process