EuRBPDB

Description

RBPome

Literatures

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000263001 (Gene tree)
Gene ID: 2969
Gene Symbol: GTF2I
Alias: TFII-I|BAP-135|SPIN|BTKAP1|DIWS|IB291|WBSCR6
Full Name: general transcription factor IIi
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 103,028 bases
Position: chr7:74,657,665-74,760,692
Accession: 4659
RBP type: non-canonical RBP
Summary: This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18536009	Solution structure of the yeast URN1 splicing factor FF domain: comparative analysis of charge distributions in FF domain structures-FFs and SURPs, two domains with a similar fold.	Proteins	2008 Dec	Bonet R	doi: 10.1002/prot.22127.
25646466	Genome-wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I.	Proc Natl Acad Sci U S A	2015 Feb 17	Pena-Hernandez R	doi: 10.1073/pnas.1416674112
23547113	A stimulation-dependent alternate core promoter links lymphotoxin α expression with TGF-β1 and fibroblast growth factor-7 signaling in primary human T cells.	J Immunol	2013 May 1	Yokley BH	doi: 10.4049/jimmunol.1201068

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000613513	GTF2I-213	538	-	-	- (aa)	-	-
ENST00000438130	GTF2I-202	836	-	-	- (aa)	-	-
ENST00000476035	GTF2I-207	653	-	-	- (aa)	-	-
ENST00000615596	GTF2I-216	717	-	-	- (aa)	-	-
ENST00000462915	GTF2I-204	347	-	-	- (aa)	-	-
ENST00000464471	GTF2I-205	555	-	-	- (aa)	-	-
ENST00000482232	GTF2I-208	860	-	-	- (aa)	-	-
ENST00000490431	GTF2I-210	252	-	-	- (aa)	-	-
ENST00000614986	GTF2I-215	4415	-	ENSP00000484526	978 (aa)	-	P78347
ENST00000621040	GTF2I-219	3437	-	-	- (aa)	-	-
ENST00000484840	GTF2I-209	574	-	-	- (aa)	-	-
ENST00000432143	GTF2I-201	572	-	ENSP00000405022	106 (aa)	-	C9J6M0
ENST00000620631	GTF2I-217	868	-	-	- (aa)	-	-
ENST00000621734	GTF2I-221	4412	-	ENSP00000482476	977 (aa)	-	P78347
ENST00000491325	GTF2I-211	539	-	-	- (aa)	-	-
ENST00000573035	GTF2I-212	4548	-	ENSP00000460070	998 (aa)	-	P78347
ENST00000614048	GTF2I-214	2844	-	-	- (aa)	-	-
ENST00000620879	GTF2I-218	4352	-	ENSP00000477837	957 (aa)	-	P78347
ENST00000473333	GTF2I-206	567	-	-	- (aa)	-	-
ENST00000621640	GTF2I-220	674	-	-	- (aa)	-	-
ENST00000443166	GTF2I-203	979	-	ENSP00000404240	274 (aa)	-	P78347

Gene Model

Click here to download ENSG00000263001's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03022	Basal transcription factors	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000263001	Sjogren's Syndrome	1E-53	24097066
ENSG00000263001	Menarche	5E-12	25231870
ENSG00000263001	Sjogren's Syndrome	1E-15	27503288

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000263001	rs6964833	7	74687575	T	Menarche (age at onset)	25231870	[0.028-0.052] unit increase	0.04	EFO_0004703
ENSG00000263001	rs117026326	7	74711703	T	Sjögren's syndrome	24097066	[1.99-2.42]	2.2	EFO_0000699
ENSG00000263001	rs35005436	7	74720592	C	Atrial fibrillation	30061737	[1.04-1.08]	1.06	EFO_0000275
ENSG00000263001	rs2718277	7	74719610	T	Educational attainment (MTAG)	30038396	[0.011-0.02] unit increase	0.0154	EFO_0004784
ENSG00000263001	rs2465936	7	74697950	G	Highest math class taken	30038396	[0.014-0.029] unit increase	0.0219	EFO_0004875
ENSG00000263001	rs2718277	7	74719610	T	Highest math class taken (MTAG)	30038396	[0.015-0.026] unit increase	0.0205	EFO_0004875
ENSG00000263001	rs74910854	7	74696373	G	Atrial fibrillation	29892015	[1.07-1.13]	1.1	EFO_0000275
ENSG00000263001	rs377080180	7	74706675	?	Heel bone mineral density	30048462	[0.017-0.033] unit increase	0.0250922	EFO_0009270
ENSG00000263001	rs2718277	7	74719610	T	Educational attainment (years of education)	30038396	[0.0091-0.0193] unit increase	0.0142	EFO_0004784
ENSG00000263001	rs74910854	7	74696373	A	Heel bone mineral density	30598549	[0.017-0.031] unit increase	0.0236685	EFO_0009270
ENSG00000263001	rs35005436	7	74720592	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000263001	rs2527366	7	74684615	?	Body mass index	30595370			EFO_0004340
ENSG00000263001	rs13238568	7	74662156	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000263001	rs7794284	7	74683722	?	Cardiovascular disease	30595370			EFO_0000319
ENSG00000263001	rs34324971	7	74693042	A	Diastolic blood pressure	30224653	[0.081-0.159] mmHg increase	0.1199	EFO_0006336
ENSG00000263001	rs74910854	7	74696373	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000263001	rs74910854	7	74696373	G	Breast cancer	29059683	[0.034-0.087] unit increase	0.0607	EFO_0000305
ENSG00000263001	rs36044436	7	74675495	?	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy)	30940143			EFO_0004325\|EFO_0000341
ENSG00000263001	rs7795281	7	74708523	A	C-reactive protein levels	30388399	[0.018-0.038] unit increase	0.028	EFO_0004458

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000263001's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000263001	GTF2I	100	97.344	ENSMUSG00000060261	Gtf2i	100	98.113	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	-	IEA	Function
GO:0003700	DNA-binding transcription factor activity	-	IEA	Function
GO:0005515	protein binding	9012831.19214191.21407215.	IPI	Function
GO:0005634	nucleus	19242469.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006355	regulation of transcription, DNA-templated	-	IEA	Process
GO:0006366	transcription by RNA polymerase II	9334314.	TAS	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	9334314.	TAS	Process
GO:0007165	signal transduction	9012831.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016525	negative regulation of angiogenesis	19242469.	IDA	Process
GO:0051481	negative regulation of cytosolic calcium ion concentration	-	IEA	Process