EuRBPDB

Description

Ensembl ID: ENSG00000263465 (Gene tree)
Gene ID: 10929
Gene Symbol: SRSF8
Alias: SRP46|SFRS2B
Full Name: serine and arginine rich splicing factor 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 4,351 bases
Position: chr11:95,066,877-95,071,227
Accession: 16988
RBP type: canonical RBP
Summary: This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000480140	RRM_1	PF00076.22	2e-18	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000638426	SRSF8-202	560	-	ENSP00000491254	5 (aa)	-	UPI00097BA5A7
ENST00000587424	SRSF8-201	4028	XM_017017142	ENSP00000480140	282 (aa)	XP_016872631	Q9BRL6

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000263465	SRSF8	52	58.108	ENSG00000161547	SRSF2	82	78.302

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000263465	SRSF8	100	86.525	ENSANAG00000031642	SRSF8	64	88.043	Aotus_nancymaae
ENSG00000263465	SRSF8	69	94.330	ENSCATG00000018279	SRSF8	64	95.652	Cercocebus_atys
ENSG00000263465	SRSF8	52	64.865	ENSDARG00000057484	srsf2a	90	77.358	Danio_rerio
ENSG00000263465	SRSF8	100	98.227	ENSGGOG00000022679	SRSF8	100	98.227	Gorilla_gorilla
ENSG00000263465	SRSF8	69	94.845	ENSMFAG00000028658	SRSF8	64	96.196	Macaca_fascicularis
ENSG00000263465	SRSF8	52	58.108	ENSMMUG00000022413	SRSF2	51	78.302	Macaca_mulatta
ENSG00000263465	SRSF8	69	94.845	ENSMMUG00000007639	SRSF8	64	96.196	Macaca_mulatta
ENSG00000263465	SRSF8	66	96.216	ENSMNEG00000027570	SRSF8	63	96.196	Macaca_nemestrina
ENSG00000263465	SRSF8	100	99.645	ENSPTRG00000046909	SRSF8	100	99.645	Pan_troglodytes
ENSG00000263465	SRSF8	69	94.845	ENSPANG00000032291	SRSF8	64	96.196	Papio_anubis
ENSG00000263465	SRSF8	71	96.500	ENSRROG00000026503	SRSF8	64	97.283	Rhinopithecus_roxellana

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005515	protein binding	23602568.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0016607	nuclear speck	21873635.	IBA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0045292	mRNA cis splicing, via spliceosome	21873635.	IBA	Process