EuRBPDB

Description

RBDs

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000264522 (Gene tree)
Gene ID: 56957
Gene Symbol: OTUD7B
Alias: CEZANNE|ZA20D1
Full Name: OTU deubiquitinase 7B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 72,961 bases
Position: chr1:149,937,812-150,010,772
Accession: 16683
RBP type: canonical RBP
Summary: OTUD7B (OTU Deubiquitinase 7B) is a Protein Coding gene. Among its related pathways are TNF signaling (REACTOME) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity and obsolete ubiquitin thiolesterase activity. An important paralog of this gene is OTUD7A.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000408231	TAP_C	PF03943.13	0.00045	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000417191	OTUD7B-201	1425	-	ENSP00000408231	427 (aa)	-	Q5SZ59
ENST00000581312	OTUD7B-202	8872	XM_011509782	ENSP00000462729	843 (aa)	XP_011508084	Q6GQQ9
ENST00000619871	OTUD7B-203	3818	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000264522's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000264522	Schizophrenia	4E-10	26198764
ENSG00000264522	Neoplasms	5E-6	25963547
ENSG00000264522	Obesity	5E-6	25963547
ENSG00000264522	Alanine Transaminase	4E-6	23251661
ENSG00000264522	Aspartate Aminotransferases	4E-6	23251661
ENSG00000264522	Paliperidone Palmitate	8E-6	27846195
ENSG00000264522	Schizophrenia	8E-6	27846195
ENSG00000264522	Body Height	4E-19	25282103
ENSG00000264522	Schizophrenia	4E-10	25056061

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000264522	rs1061955	1	149942458	A	Obesity-related traits	23251661	[NR] unit increase	0.03	EFO_0004736\|EFO_0004735
ENSG00000264522	rs12048493	1	149955122	C	Breast cancer	25751625	[1.05-1.10]	1.07	EFO_0000305
ENSG00000264522	rs3767627	1	149966973	T	Height	25282103	[0.028-0.044] unit increase	0.036	EFO_0004339
ENSG00000264522	rs12048493	1	149955122	?	Heel bone mineral density	30048462	[0.013-0.022] unit decrease	0.0176397	EFO_0009270
ENSG00000264522	rs115390301	1	149981477	?	Eczema	30595370			HP_0000964
ENSG00000264522	rs72692823	1	149938875	?	Lung function (FEV1/FVC)	30595370			EFO_0004713
ENSG00000264522	rs12048493	1	149955122	C	Breast cancer	29059683	[1.02-1.06] (Oncoarray)	1.04	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000264522's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21097510.	IDA	Process
GO:0002250	adaptive immune response	-	IEA	Process
GO:0002385	mucosal immune response	-	ISS	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	21873635.	IBA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	23827681.	IDA	Function
GO:0005515	protein binding	11463333.18029035.21097510.25814554.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11463333.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	11463333.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0008234	cysteine-type peptidase activity	-	ISS	Function
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0032717	negative regulation of interleukin-8 production	21097510.	IDA	Process
GO:0035871	protein K11-linked deubiquitination	21873635.	IBA	Process
GO:0035871	protein K11-linked deubiquitination	20622874.23827681.	IDA	Process
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	-	ISS	Function
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	21873635.	IBA	Process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	11463333.	IDA	Process
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	21873635.	IBA	Function
GO:0070536	protein K63-linked deubiquitination	21873635.	IBA	Process
GO:0070536	protein K63-linked deubiquitination	20622874.	IDA	Process
GO:0071108	protein K48-linked deubiquitination	21873635.	IBA	Process
GO:0071108	protein K48-linked deubiquitination	21097510.	IDA	Process
GO:0071108	protein K48-linked deubiquitination	-	ISS	Process
GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:1900181	negative regulation of protein localization to nucleus	21097510.	IDA	Process
GO:1990380	Lys48-specific deubiquitinase activity	21097510.	IDA	Function
GO:1990380	Lys48-specific deubiquitinase activity	-	TAS	Function