EuRBPDB

Description

RBDs

RBPome

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000266472 (Gene tree)
Gene ID: 54460
Gene Symbol: MRPS21
Alias: N
Full Name: mitochondrial ribosomal protein S21
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 15,260 bases
Position: chr1:150,293,720-150,308,979
Accession: 14046
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000461930	Ribosomal_S21	PF01165.20	1.9e-17	1	1
ENSP00000480129	Ribosomal_S21	PF01165.20	1.9e-17	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000581066	MRPS21-201	1462	-	ENSP00000461930	87 (aa)	-	P82921
ENST00000614145	MRPS21-202	1226	-	ENSP00000480129	87 (aa)	-	P82921

Gene Model

Click here to download ENSG00000266472's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000266472	Dermatitis, Atopic	5E-9	26482879
ENSG00000266472	Substance-Related Disorders	5E-6	23942779
ENSG00000266472	Dermatitis, Atopic	1E-7	26482879

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000266472	rs12403795	1	150305958	A	Illicit drug use	23942779	[NR] unit decrease	12.28	EFO_0005431

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000266472's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000266472	MRPS21	100	93.103	ENSAMEG00000001703	MRPS21	100	93.103	Ailuropoda_melanoleuca
ENSG00000266472	MRPS21	100	75.862	ENSACAG00000003279	MRPS21	100	75.862	Anolis_carolinensis
ENSG00000266472	MRPS21	100	93.103	ENSANAG00000026132	-	100	93.103	Aotus_nancymaae
ENSG00000266472	MRPS21	99	84.884	ENSANAG00000026598	-	100	84.884	Aotus_nancymaae
ENSG00000266472	MRPS21	100	95.402	ENSBTAG00000024378	MRPS21	100	95.402	Bos_taurus
ENSG00000266472	MRPS21	100	79.310	ENSCJAG00000042724	-	100	79.310	Callithrix_jacchus
ENSG00000266472	MRPS21	100	96.552	ENSCJAG00000041203	MRPS21	100	96.552	Callithrix_jacchus
ENSG00000266472	MRPS21	100	93.103	ENSCAFG00000011810	MRPS21	100	93.103	Canis_familiaris
ENSG00000266472	MRPS21	100	93.103	ENSCAFG00020019663	MRPS21	100	93.103	Canis_lupus_dingo
ENSG00000266472	MRPS21	100	95.402	ENSCHIG00000021516	MRPS21	100	95.402	Capra_hircus
ENSG00000266472	MRPS21	100	95.402	ENSTSYG00000019342	MRPS21	100	95.402	Carlito_syrichta
ENSG00000266472	MRPS21	100	91.954	ENSCPOG00000020443	MRPS21	100	91.954	Cavia_porcellus
ENSG00000266472	MRPS21	100	72.414	ENSCATG00000033653	-	100	72.414	Cercocebus_atys
ENSG00000266472	MRPS21	93	69.136	ENSCATG00000012398	-	99	69.136	Cercocebus_atys
ENSG00000266472	MRPS21	100	90.805	ENSCLAG00000013383	MRPS21	100	90.805	Chinchilla_lanigera
ENSG00000266472	MRPS21	100	96.552	ENSCSAG00000018085	-	100	96.552	Chlorocebus_sabaeus
ENSG00000266472	MRPS21	100	80.460	ENSCHOG00000009012	-	100	80.460	Choloepus_hoffmanni
ENSG00000266472	MRPS21	70	78.689	ENSCHOG00000000023	-	98	78.689	Choloepus_hoffmanni
ENSG00000266472	MRPS21	100	81.609	ENSCPBG00000008212	MRPS21	100	81.609	Chrysemys_picta_bellii
ENSG00000266472	MRPS21	100	71.264	ENSCANG00000001620	-	100	71.264	Colobus_angolensis_palliatus
ENSG00000266472	MRPS21	100	73.563	ENSCANG00000039137	-	100	73.563	Colobus_angolensis_palliatus
ENSG00000266472	MRPS21	67	94.828	ENSCANG00000035554	-	100	94.828	Colobus_angolensis_palliatus
ENSG00000266472	MRPS21	95	91.566	ENSCANG00000030545	-	95	91.358	Colobus_angolensis_palliatus
ENSG00000266472	MRPS21	99	80.233	ENSCGRG00001003574	-	99	80.233	Cricetulus_griseus_chok1gshd
ENSG00000266472	MRPS21	100	86.207	ENSCGRG00001015258	-	100	86.207	Cricetulus_griseus_chok1gshd
ENSG00000266472	MRPS21	99	70.213	ENSCGRG00001007646	-	99	70.213	Cricetulus_griseus_chok1gshd
ENSG00000266472	MRPS21	100	86.207	ENSCGRG00000007102	-	100	86.207	Cricetulus_griseus_crigri
ENSG00000266472	MRPS21	99	72.222	ENSCGRG00000011200	-	99	72.222	Cricetulus_griseus_crigri
ENSG00000266472	MRPS21	99	77.907	ENSCGRG00000019214	-	99	77.907	Cricetulus_griseus_crigri
ENSG00000266472	MRPS21	100	93.103	ENSDNOG00000025657	MRPS21	100	93.103	Dasypus_novemcinctus
ENSG00000266472	MRPS21	100	94.253	ENSDORG00000030111	Mrps21	100	94.253	Dipodomys_ordii
ENSG00000266472	MRPS21	100	95.402	ENSEASG00005001557	MRPS21	100	95.402	Equus_asinus_asinus
ENSG00000266472	MRPS21	100	95.402	ENSECAG00000009845	MRPS21	100	95.402	Equus_caballus
ENSG00000266472	MRPS21	99	75.581	ENSFCAG00000041074	-	63	75.581	Felis_catus
ENSG00000266472	MRPS21	67	94.828	ENSFCAG00000027385	-	66	94.828	Felis_catus
ENSG00000266472	MRPS21	100	95.402	ENSFCAG00000034082	-	100	95.402	Felis_catus
ENSG00000266472	MRPS21	56	77.551	ENSFCAG00000036915	-	54	77.551	Felis_catus
ENSG00000266472	MRPS21	100	94.253	ENSFDAG00000013088	MRPS21	100	94.253	Fukomys_damarensis
ENSG00000266472	MRPS21	100	80.460	ENSGAGG00000013763	MRPS21	100	80.460	Gopherus_agassizii
ENSG00000266472	MRPS21	100	98.851	ENSGGOG00000027532	-	100	98.851	Gorilla_gorilla
ENSG00000266472	MRPS21	100	78.161	ENSGGOG00000003672	-	100	78.161	Gorilla_gorilla
ENSG00000266472	MRPS21	100	94.253	ENSHGLG00000016350	MRPS21	100	94.253	Heterocephalus_glaber_female
ENSG00000266472	MRPS21	100	94.253	ENSHGLG00100010283	MRPS21	100	94.253	Heterocephalus_glaber_male
ENSG00000266472	MRPS21	100	83.908	ENSSTOG00000026764	-	100	83.908	Ictidomys_tridecemlineatus
ENSG00000266472	MRPS21	100	91.954	ENSSTOG00000019516	-	100	91.954	Ictidomys_tridecemlineatus
ENSG00000266472	MRPS21	99	89.535	ENSJJAG00000012932	-	100	89.535	Jaculus_jaculus
ENSG00000266472	MRPS21	100	78.161	ENSLACG00000011137	MRPS21	100	78.161	Latimeria_chalumnae
ENSG00000266472	MRPS21	100	89.655	ENSLAFG00000030348	MRPS21	100	89.655	Loxodonta_africana
ENSG00000266472	MRPS21	100	94.253	ENSMFAG00000042375	-	100	94.253	Macaca_fascicularis
ENSG00000266472	MRPS21	100	72.414	ENSMFAG00000044027	-	100	72.414	Macaca_fascicularis
ENSG00000266472	MRPS21	100	66.667	ENSMMUG00000021391	-	100	66.667	Macaca_mulatta
ENSG00000266472	MRPS21	100	91.954	ENSMMUG00000030177	-	100	91.954	Macaca_mulatta
ENSG00000266472	MRPS21	100	71.264	ENSMMUG00000038856	-	100	71.264	Macaca_mulatta
ENSG00000266472	MRPS21	100	72.414	ENSMNEG00000045518	-	100	72.414	Macaca_nemestrina
ENSG00000266472	MRPS21	100	94.253	ENSMNEG00000011218	-	100	94.253	Macaca_nemestrina
ENSG00000266472	MRPS21	100	94.253	ENSMNEG00000031239	-	100	94.253	Macaca_nemestrina
ENSG00000266472	MRPS21	100	72.414	ENSMLEG00000002979	-	100	72.414	Mandrillus_leucophaeus
ENSG00000266472	MRPS21	100	70.115	ENSMLEG00000032496	-	100	70.115	Mandrillus_leucophaeus
ENSG00000266472	MRPS21	100	89.655	ENSMAUG00000014535	-	100	89.655	Mesocricetus_auratus
ENSG00000266472	MRPS21	99	75.581	ENSMAUG00000008870	-	100	75.581	Mesocricetus_auratus
ENSG00000266472	MRPS21	83	90.278	ENSMICG00000035458	-	90	90.278	Microcebus_murinus
ENSG00000266472	MRPS21	100	93.103	ENSMICG00000046505	-	100	93.103	Microcebus_murinus
ENSG00000266472	MRPS21	100	93.103	ENSMICG00000044161	-	100	93.103	Microcebus_murinus
ENSG00000266472	MRPS21	100	93.103	ENSMICG00000042557	-	100	93.103	Microcebus_murinus
ENSG00000266472	MRPS21	100	87.356	ENSMOCG00000002252	-	100	87.356	Microtus_ochrogaster
ENSG00000266472	MRPS21	91	83.544	ENSMOCG00000019005	-	84	83.544	Microtus_ochrogaster
ENSG00000266472	MRPS21	100	83.908	ENSMOCG00000001677	-	100	83.908	Microtus_ochrogaster
ENSG00000266472	MRPS21	100	87.356	ENSMOCG00000004675	-	100	87.356	Microtus_ochrogaster
ENSG00000266472	MRPS21	100	91.954	ENSMODG00000018783	MRPS21	100	91.954	Monodelphis_domestica
ENSG00000266472	MRPS21	100	90.805	MGP_CAROLIEiJ_G0025355	Mrps21	100	90.805	Mus_caroli
ENSG00000266472	MRPS21	100	89.655	ENSMUSG00000054312	Mrps21	100	89.655	Mus_musculus
ENSG00000266472	MRPS21	100	90.805	MGP_PahariEiJ_G0026799	Mrps21	100	90.805	Mus_pahari
ENSG00000266472	MRPS21	100	89.655	MGP_SPRETEiJ_G0026299	Mrps21	100	89.655	Mus_spretus
ENSG00000266472	MRPS21	100	93.103	ENSMPUG00000005221	MRPS21	100	93.103	Mustela_putorius_furo
ENSG00000266472	MRPS21	100	93.103	ENSMLUG00000025875	MRPS21	100	93.103	Myotis_lucifugus
ENSG00000266472	MRPS21	100	90.805	ENSNGAG00000001847	Mrps21	100	90.805	Nannospalax_galili
ENSG00000266472	MRPS21	100	97.701	ENSNLEG00000031023	MRPS21	100	97.701	Nomascus_leucogenys
ENSG00000266472	MRPS21	100	73.864	ENSNLEG00000035995	-	98	73.864	Nomascus_leucogenys
ENSG00000266472	MRPS21	85	74.324	ENSNLEG00000031560	-	100	74.324	Nomascus_leucogenys
ENSG00000266472	MRPS21	100	90.805	ENSMEUG00000006844	MRPS21	100	90.805	Notamacropus_eugenii
ENSG00000266472	MRPS21	100	90.805	ENSODEG00000019301	-	100	90.805	Octodon_degus
ENSG00000266472	MRPS21	79	84.058	ENSODEG00000002986	-	99	84.058	Octodon_degus
ENSG00000266472	MRPS21	100	90.805	ENSODEG00000018956	-	100	90.805	Octodon_degus
ENSG00000266472	MRPS21	100	90.805	ENSODEG00000018960	-	100	90.805	Octodon_degus
ENSG00000266472	MRPS21	100	93.103	ENSODEG00000019335	-	100	93.103	Octodon_degus
ENSG00000266472	MRPS21	100	93.103	ENSODEG00000011678	-	100	93.103	Octodon_degus
ENSG00000266472	MRPS21	100	93.103	ENSOCUG00000027120	-	100	93.103	Oryctolagus_cuniculus
ENSG00000266472	MRPS21	91	86.076	ENSOCUG00000001395	-	100	86.076	Oryctolagus_cuniculus
ENSG00000266472	MRPS21	100	88.506	ENSOCUG00000002069	-	100	88.506	Oryctolagus_cuniculus
ENSG00000266472	MRPS21	100	95.402	ENSOARG00000020796	MRPS21	100	95.402	Ovis_aries
ENSG00000266472	MRPS21	100	75.862	ENSPPAG00000012534	-	100	75.862	Pan_paniscus
ENSG00000266472	MRPS21	100	98.851	ENSPPAG00000041557	-	100	98.851	Pan_paniscus
ENSG00000266472	MRPS21	100	93.103	ENSPPRG00000016782	-	100	93.103	Panthera_pardus
ENSG00000266472	MRPS21	100	95.402	ENSPPRG00000000903	-	100	95.402	Panthera_pardus
ENSG00000266472	MRPS21	100	93.103	ENSPPRG00000019973	-	100	93.103	Panthera_pardus
ENSG00000266472	MRPS21	57	78.000	ENSPPRG00000012913	-	70	78.000	Panthera_pardus
ENSG00000266472	MRPS21	99	77.907	ENSPPRG00000021564	-	74	77.907	Panthera_pardus
ENSG00000266472	MRPS21	100	95.402	ENSPTIG00000003850	-	100	95.402	Panthera_tigris_altaica
ENSG00000266472	MRPS21	100	90.805	ENSPTIG00000002970	-	100	90.805	Panthera_tigris_altaica
ENSG00000266472	MRPS21	87	85.526	ENSPTRG00000050946	-	100	85.526	Pan_troglodytes
ENSG00000266472	MRPS21	100	75.862	ENSPTRG00000048290	-	100	75.862	Pan_troglodytes
ENSG00000266472	MRPS21	100	98.851	ENSPTRG00000034372	MRPS21	100	98.851	Pan_troglodytes
ENSG00000266472	MRPS21	100	96.552	ENSPANG00000003349	-	100	96.552	Papio_anubis
ENSG00000266472	MRPS21	100	71.264	ENSPANG00000030104	-	100	71.264	Papio_anubis
ENSG00000266472	MRPS21	100	79.310	ENSPSIG00000014569	MRPS21	100	79.310	Pelodiscus_sinensis
ENSG00000266472	MRPS21	100	90.805	ENSPEMG00000013980	-	100	90.805	Peromyscus_maniculatus_bairdii
ENSG00000266472	MRPS21	100	68.966	ENSPEMG00000021950	-	100	68.966	Peromyscus_maniculatus_bairdii
ENSG00000266472	MRPS21	100	87.356	ENSPCIG00000007733	-	100	87.356	Phascolarctos_cinereus
ENSG00000266472	MRPS21	100	89.655	ENSPCIG00000008793	-	100	89.655	Phascolarctos_cinereus
ENSG00000266472	MRPS21	100	94.253	ENSPCOG00000023504	-	100	94.253	Propithecus_coquereli
ENSG00000266472	MRPS21	100	85.057	ENSPCOG00000007203	-	100	85.057	Propithecus_coquereli
ENSG00000266472	MRPS21	100	93.103	ENSPVAG00000024222	MRPS21	100	93.103	Pteropus_vampyrus
ENSG00000266472	MRPS21	100	88.636	ENSRNOG00000049921	Mrps21l	100	88.636	Rattus_norvegicus
ENSG00000266472	MRPS21	100	90.805	ENSRNOG00000024845	Mrps21	100	90.805	Rattus_norvegicus
ENSG00000266472	MRPS21	100	88.636	ENSRNOG00000048409	AABR07032582.1	100	88.636	Rattus_norvegicus
ENSG00000266472	MRPS21	100	73.563	ENSRBIG00000006532	-	100	73.563	Rhinopithecus_bieti
ENSG00000266472	MRPS21	100	75.862	ENSRBIG00000028389	-	100	75.862	Rhinopithecus_bieti
ENSG00000266472	MRPS21	100	71.264	ENSRROG00000031728	-	100	71.264	Rhinopithecus_roxellana
ENSG00000266472	MRPS21	100	74.713	ENSRROG00000031792	-	100	74.713	Rhinopithecus_roxellana
ENSG00000266472	MRPS21	100	96.552	ENSRROG00000035197	-	100	96.552	Rhinopithecus_roxellana
ENSG00000266472	MRPS21	100	94.253	ENSSBOG00000000667	MRPS21	100	94.253	Saimiri_boliviensis_boliviensis
ENSG00000266472	MRPS21	100	79.310	ENSSPUG00000000814	MRPS21	100	79.310	Sphenodon_punctatus
ENSG00000266472	MRPS21	100	78.161	ENSSSCG00000039302	-	100	78.161	Sus_scrofa
ENSG00000266472	MRPS21	100	94.253	ENSSSCG00000040782	-	100	94.253	Sus_scrofa
ENSG00000266472	MRPS21	100	88.506	ENSSSCG00000002409	-	100	88.506	Sus_scrofa
ENSG00000266472	MRPS21	100	95.402	ENSTTRG00000021389	MRPS21	100	95.402	Tursiops_truncatus
ENSG00000266472	MRPS21	100	94.253	ENSUAMG00000009340	MRPS21	100	94.253	Ursus_americanus
ENSG00000266472	MRPS21	100	95.402	ENSUMAG00000003735	MRPS21	100	95.402	Ursus_maritimus
ENSG00000266472	MRPS21	100	95.402	ENSVPAG00000015525	MRPS21	100	95.402	Vicugna_pacos
ENSG00000266472	MRPS21	100	86.207	ENSVVUG00000023300	-	100	86.207	Vulpes_vulpes
ENSG00000266472	MRPS21	100	93.103	ENSVVUG00000007865	-	100	93.103	Vulpes_vulpes
ENSG00000266472	MRPS21	100	70.115	ENSXETG00000028038	mrps21	100	70.115	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003735	structural constituent of ribosome	11402041.	ISS	Function
GO:0003735	structural constituent of ribosome	11279123.	NAS	Function
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005763	mitochondrial small ribosomal subunit	11279123.	IDA	Component
GO:0006412	translation	11279123.	NAS	Process
GO:0032543	mitochondrial translation	11402041.	ISS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process