EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000268940 (Gene tree)
Gene ID: 541466
Gene Symbol: CT45A1
Alias: CT45-1|CT45.1
Full Name: cancer/testis antigen family 45 member A1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 15,142 bases
Position: chrX:135,708,398-135,723,539
Accession: 33267
RBP type: canonical RBP
Summary: CT45A1 (Cancer/Testis Antigen Family 45 Member A1) is a Protein Coding gene. An important paralog of this gene is CT45A3.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000470185	INT_SG_DDX_CT_C	PF15300.6	1.1e-24	1	1
ENSP00000472303	INT_SG_DDX_CT_C	PF15300.6	1.1e-24	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000594117	CT45A1-201	1087	XM_011531352	ENSP00000470185	189 (aa)	XP_011529654	Q5HYN5
ENST00000594565	CT45A1-202	1007	XM_005278141	ENSP00000472303	189 (aa)	XP_005278198	Q5HYN5

Gene Model

Click here to download ENSG00000268940's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000268940's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000268940	CT45A1	69	36.765	ENSAMEG00000005934	-	80	36.765	Ailuropoda_melanoleuca
ENSG00000268940	CT45A1	98	68.817	ENSANAG00000006559	-	98	68.817	Aotus_nancymaae
ENSG00000268940	CT45A1	99	66.489	ENSCJAG00000004135	-	99	66.489	Callithrix_jacchus
ENSG00000268940	CT45A1	92	30.857	ENSCAFG00000014436	-	90	30.857	Canis_familiaris
ENSG00000268940	CT45A1	87	39.535	ENSCAFG00020000069	-	61	39.535	Canis_lupus_dingo
ENSG00000268940	CT45A1	85	43.529	ENSCAFG00020024726	-	76	43.529	Canis_lupus_dingo
ENSG00000268940	CT45A1	100	50.259	ENSTSYG00000003411	-	99	50.259	Carlito_syrichta
ENSG00000268940	CT45A1	100	79.365	ENSCATG00000026275	-	89	79.365	Cercocebus_atys
ENSG00000268940	CT45A1	100	78.836	ENSCSAG00000007640	-	93	78.836	Chlorocebus_sabaeus
ENSG00000268940	CT45A1	100	66.138	ENSCSAG00000015072	-	100	66.138	Chlorocebus_sabaeus
ENSG00000268940	CT45A1	100	77.249	ENSCANG00000040837	-	99	77.249	Colobus_angolensis_palliatus
ENSG00000268940	CT45A1	68	34.559	ENSCGRG00001016867	Gm648	60	34.559	Cricetulus_griseus_chok1gshd
ENSG00000268940	CT45A1	68	34.559	ENSCGRG00000002325	Gm648	58	34.559	Cricetulus_griseus_crigri
ENSG00000268940	CT45A1	100	79.365	ENSMFAG00000035558	-	93	79.365	Macaca_fascicularis
ENSG00000268940	CT45A1	96	77.348	ENSMFAG00000036609	-	100	77.348	Macaca_fascicularis
ENSG00000268940	CT45A1	100	78.836	ENSMMUG00000021984	-	91	78.836	Macaca_mulatta
ENSG00000268940	CT45A1	100	52.910	ENSMMUG00000042170	-	100	52.910	Macaca_mulatta
ENSG00000268940	CT45A1	100	79.894	ENSMNEG00000028699	-	93	79.894	Macaca_nemestrina
ENSG00000268940	CT45A1	96	77.348	ENSMNEG00000040510	-	100	77.348	Macaca_nemestrina
ENSG00000268940	CT45A1	100	79.365	ENSMLEG00000000289	-	93	79.365	Mandrillus_leucophaeus
ENSG00000268940	CT45A1	69	74.615	ENSMLEG00000042160	-	68	74.615	Mandrillus_leucophaeus
ENSG00000268940	CT45A1	99	32.271	MGP_CAROLIEiJ_G0033085	Ints6l	77	49.153	Mus_caroli
ENSG00000268940	CT45A1	71	34.965	MGP_CAROLIEiJ_G0033087	Gm648	64	36.111	Mus_caroli
ENSG00000268940	CT45A1	99	32.271	ENSMUSG00000035967	Ints6l	76	50.847	Mus_musculus
ENSG00000268940	CT45A1	71	34.028	ENSMUSG00000064016	Gm648	64	34.028	Mus_musculus
ENSG00000268940	CT45A1	99	32.271	MGP_PahariEiJ_G0031627	Ints6l	77	50.847	Mus_pahari
ENSG00000268940	CT45A1	71	36.111	MGP_SPRETEiJ_G0034242	Gm648	64	36.111	Mus_spretus
ENSG00000268940	CT45A1	99	34.400	MGP_SPRETEiJ_G0034240	Ints6l	77	50.847	Mus_spretus
ENSG00000268940	CT45A1	100	86.772	ENSNLEG00000002303	-	100	86.772	Nomascus_leucogenys
ENSG00000268940	CT45A1	100	43.005	ENSOCUG00000027335	-	93	43.005	Oryctolagus_cuniculus
ENSG00000268940	CT45A1	99	37.566	ENSOARG00000011598	-	91	37.566	Ovis_aries
ENSG00000268940	CT45A1	100	70.899	ENSPTRG00000028196	-	100	70.899	Pan_troglodytes
ENSG00000268940	CT45A1	100	94.709	ENSPTRG00000047355	-	100	94.709	Pan_troglodytes
ENSG00000268940	CT45A1	100	94.709	ENSPTRG00000047577	CT45A10	100	94.709	Pan_troglodytes
ENSG00000268940	CT45A1	100	79.365	ENSPANG00000014397	-	89	79.365	Papio_anubis
ENSG00000268940	CT45A1	100	78.307	ENSPANG00000023647	-	99	78.307	Papio_anubis
ENSG00000268940	CT45A1	100	74.737	ENSPPYG00000020754	-	99	74.737	Pongo_abelii
ENSG00000268940	CT45A1	100	90.476	ENSPPYG00000020755	-	100	90.476	Pongo_abelii
ENSG00000268940	CT45A1	90	87.719	ENSPPYG00000020753	-	99	87.719	Pongo_abelii
ENSG00000268940	CT45A1	69	43.846	ENSPVAG00000002652	-	96	43.846	Pteropus_vampyrus
ENSG00000268940	CT45A1	99	79.787	ENSRBIG00000006469	-	99	79.787	Rhinopithecus_bieti
ENSG00000268940	CT45A1	100	78.307	ENSRROG00000017978	-	93	78.307	Rhinopithecus_roxellana
ENSG00000268940	CT45A1	99	67.553	ENSSBOG00000024560	-	99	67.553	Saimiri_boliviensis_boliviensis
ENSG00000268940	CT45A1	96	38.021	ENSUAMG00000005870	-	99	38.021	Ursus_americanus
ENSG00000268940	CT45A1	99	37.563	ENSUAMG00000003018	-	93	37.563	Ursus_americanus
ENSG00000268940	CT45A1	89	36.872	ENSUAMG00000021456	-	83	36.872	Ursus_americanus
ENSG00000268940	CT45A1	51	46.392	ENSVPAG00000011549	-	60	44.538	Vicugna_pacos
ENSG00000268940	CT45A1	99	32.105	ENSVVUG00000010778	-	91	32.105	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0032039	integrator complex	21873635.	IBA	Component
GO:0034472	snRNA 3'-end processing	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19296537	Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancer.	Int J Cancer	2009 Jun 15	Chen YT	doi: 10.1002/ijc.24296.
26098711	DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45 (CT45) genes is associated with disease progression and reduced survival in epithelial ovarian cancer.	Epigenetics	2015	Zhang W	doi: 10.1080/15592294.2015.1062206.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chrX	135722987	Missense_Mutation	novel	R175Q	0.38	INT_SG_DDX_CT_C
BLCA	chrX	135723120	3'UTR	novel		0.22
BLCA	chrX	135719048	Silent	novel	L36L	0.07
BRCA	chrX	135719103	Missense_Mutation	novel	A55T	0.12
BRCA	chrX	135723218	3'UTR	novel		0.2
CESC	chrX	135722989	Missense_Mutation	novel	D176Y	0.13	INT_SG_DDX_CT_C
CESC	chrX	135723169	3'UTR	novel		0.26
CESC	chrX	135723128	3'UTR	novel		0.12
ESCA	chrX	135719018	Silent	novel	S26S	0.26
ESCA	chrX	135718938	5'UTR	novel		0.1
HNSC	chrX	135723166	3'UTR	novel		0.38
HNSC	chrX	135718977	Missense_Mutation	novel	E13K	0.1
LUAD	chrX	135719061	Nonsense_Mutation	novel	G41*	0.11
LUAD	chrX	135723064	3'UTR	novel		0.16
LUAD	chrX	135723122	3'UTR	novel		0.16
LUAD	chrX	135723161	3'UTR	novel		0.19
LUAD	chrX	135719090	Silent	novel	S50S	0.11
LUAD	chrX	135719091	Missense_Mutation	novel	A51T	0.11
LUAD	chrX	135718948	Missense_Mutation	novel	D3V	0.09
LUAD	chrX	135719085	Missense_Mutation	novel	G49C	0.11
LUSC	chrX	135719051	Frame_Shift_Ins	novel	*R38Qfs37**	0.3
LUSC	chrX	135723164	3'UTR	novel		0.2
LUSC	chrX	135719026	Missense_Mutation	novel	K29I	0.13
OV	chrX	135719090	Silent	novel	S50S	0.03
OV	chrX	135723081	3'UTR	novel		0.06
OV	chrX	135723097	3'UTR	novel		0.14
PRAD	chrX	135719105	Frame_Shift_Del	novel	*K56Efs18**	0.09
READ	chrX	135719065	Missense_Mutation	novel	A42E	0.17
SKCM	chrX	135718996	Missense_Mutation	novel	P19L	0.14
SKCM	chrX	135719092	Missense_Mutation	novel	A51V	0.09
SKCM	chrX	135719017	Missense_Mutation	novel	S26L	0.19
SKCM	chrX	135719035	Missense_Mutation	novel	R32K	0.15
SKCM	chrX	135719017	Missense_Mutation	novel	S26L	0.19
SKCM	chrX	135723128	3'UTR	novel		0.15
SKCM	chrX	135719054	Silent	novel	R38R	0.16
SKCM	chrX	135719040	Missense_Mutation	novel	A34T	0.19
SKCM	chrX	135723052	3'UTR	novel		0.1
SKCM	chrX	135719022	Nonsense_Mutation	novel	Q28*	0.14
SKCM	chrX	135719001	Missense_Mutation	novel	E21K	0.08
STAD	chrX	135723153	3'UTR	novel		0.11
UCEC	chrX	135723009	Missense_Mutation	novel	K182N	0.06	INT_SG_DDX_CT_C
UCEC	chrX	135719064	Missense_Mutation	novel	A42S	0.09
UCEC	chrX	135719009	Silent	novel	D23D	0.13
UCEC	chrX	135723012	Silent	novel	K183K	0.05
UCEC	chrX	135719009	Silent	novel	D23D	0.05
UCEC	chrX	135723007	Missense_Mutation	novel	K182E	0.07	INT_SG_DDX_CT_C
UCEC	chrX	135723108	3'UTR	novel		0.09
UCEC	chrX	135718951	Missense_Mutation	novel	K4T	0.08
UCEC	chrX	135722982	Missense_Mutation	novel	M173I	0.06	INT_SG_DDX_CT_C
UCEC	chrX	135718951	Missense_Mutation	novel	K4T	0.13
UCEC	chrX	135723103	3'UTR	novel		0.1
UCEC	chrX	135719064	Missense_Mutation	novel	A42T	0.09
UCEC	chrX	135723199	3'UTR	novel		0.24
UCEC	chrX	135723012	Missense_Mutation	novel	K183N	0.08	INT_SG_DDX_CT_C
UCEC	chrX	135723007	Missense_Mutation	novel	K182E	0.05	INT_SG_DDX_CT_C
UCEC	chrX	135723217	3'UTR	novel		0.15
UCEC	chrX	135723146	3'UTR	novel		0.22
UCEC	chrX	135723012	Silent	novel	K183K	0.07
UCEC	chrX	135719087	Silent	novel	G49G	0.12

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.0833	0.24013
KIRC	AMP	0.0303	0.12739
READ	AMP	0.1394	0.14805
TGCT	DEL	0.0667	0.08422
THCA	DEL	0	0.21991
UCS	DEL	0.3036	0.063955

Survival Analysis

Cancer	P-value	Q-value
UCS	0.03	Kaplan-Meier Survival Analysis
LGG	0.0057	Kaplan-Meier Survival Analysis
OV	0.00095	Kaplan-Meier Survival Analysis