EuRBPDB

Description

RBDs

RBPome

Literatures

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000272886 (Gene tree)
Gene ID: 55802
Gene Symbol: DCP1A
Alias: HSA275986|SMIF|SMAD4IP1
Full Name: decapping mRNA 1A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 64,205 bases
Position: chr3:53,283,423-53,347,627
Accession: 18714
RBP type: canonical RBP
Summary: Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000476046	DCP1	PF06058.13	1.1e-40	1	1
ENSP00000476386	DCP1	PF06058.13	1.2e-40	1	1
ENSP00000479387	DCP1	PF06058.13	2.4e-37	1	1
ENSP00000477594	DCP1	PF06058.13	3.3e-29	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26134871	Mobilization of Dormant Cnot7 mRNA Promotes Deadenylation of Maternal Transcripts During Mouse Oocyte Maturation.	Biol Reprod	2015 Aug	Ma J	doi: 10.1095/biolreprod.115.130344

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000558034	DCP1A-202	592	-	-	- (aa)	-	-
ENST00000559748	DCP1A-203	581	-	ENSP00000479387	191 (aa)	-	A0A087WVE6
ENST00000294241	DCP1A-201	1853	-	ENSP00000476046	544 (aa)	-	Q9NPI6
ENST00000560624	DCP1A-205	849	-	ENSP00000477594	260 (aa)	-	A0A087WT55
ENST00000560076	DCP1A-204	625	-	ENSP00000480912	102 (aa)	-	A0A087WXD0
ENST00000610213	DCP1A-206	5994	-	ENSP00000476386	582 (aa)	-	Q9NPI6

Gene Model

Click here to download ENSG00000272886's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000272886	Blood Pressure	2.45352744820537E-6	17903302
ENSG00000272886	Blood Pressure	2.14647790761686E-6	17903302
ENSG00000272886	Echocardiography	8.92867062780578E-5	17903301
ENSG00000272886	Angiography	6.7545714925115E-6	17903301
ENSG00000272886	Heart Rate	7E-6	23583979
ENSG00000272886	Subcutaneous Fat, Abdominal	6E-7	26480920
ENSG00000272886	Electrocardiography	4E-7	25055868
ENSG00000272886	Schizophrenia	5E-7	26198764
ENSG00000272886	Heart Rate	4E-9	27798624
ENSG00000272886	Premature Birth	5E-6	25599974
ENSG00000272886	Live Birth	5E-6	25599974

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000272886	rs2029213	3	53344218	C	Heart rate	23583979			EFO_0004326
ENSG00000272886	rs189767158	3	53291219	?	Erosive tooth wear (severe vs non-severe)	29898447	[2.29-10.42]	4.9	EFO_0009331

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000272886's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000272886	DCP1A	98	67.000	ENSG00000151065	DCP1B	82	67.347

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000272886	DCP1A	96	72.449	ENSAPOG00000000313	-	81	72.449	Acanthochromis_polyacanthus
ENSG00000272886	DCP1A	100	98.446	ENSAMEG00000007875	DCP1A	100	90.893	Ailuropoda_melanoleuca
ENSG00000272886	DCP1A	99	62.376	ENSACIG00000001522	-	82	62.376	Amphilophus_citrinellus
ENSG00000272886	DCP1A	94	72.917	ENSAOCG00000021194	dcp1a	67	56.388	Amphiprion_ocellaris
ENSG00000272886	DCP1A	95	72.165	ENSAPEG00000012770	dcp1a	72	58.537	Amphiprion_percula
ENSG00000272886	DCP1A	95	78.788	ENSAPLG00000014921	DCP1A	99	57.479	Anas_platyrhynchos
ENSG00000272886	DCP1A	98	92.000	ENSACAG00000011028	DCP1A	100	53.020	Anolis_carolinensis
ENSG00000272886	DCP1A	99	99.010	ENSANAG00000025834	DCP1A	100	96.507	Aotus_nancymaae
ENSG00000272886	DCP1A	92	73.404	ENSACLG00000020963	dcp1a	67	54.348	Astatotilapia_calliptera
ENSG00000272886	DCP1A	99	71.287	ENSAMXG00000014974	dcp1a	100	39.564	Astyanax_mexicanus
ENSG00000272886	DCP1A	99	99.010	ENSBTAG00000010863	DCP1A	100	89.175	Bos_taurus
ENSG00000272886	DCP1A	99	99.010	ENSCJAG00000007337	DCP1A	100	95.588	Callithrix_jacchus
ENSG00000272886	DCP1A	100	98.446	ENSCAFG00000008637	DCP1A	100	90.378	Canis_familiaris
ENSG00000272886	DCP1A	100	98.446	ENSCAFG00020004562	DCP1A	98	90.550	Canis_lupus_dingo
ENSG00000272886	DCP1A	99	99.010	ENSCHIG00000023880	DCP1A	98	89.175	Capra_hircus
ENSG00000272886	DCP1A	99	99.010	ENSTSYG00000000596	DCP1A	100	93.814	Carlito_syrichta
ENSG00000272886	DCP1A	99	99.010	ENSCPOG00000000073	DCP1A	97	89.519	Cavia_porcellus
ENSG00000272886	DCP1A	99	99.010	ENSCCAG00000035664	DCP1A	100	96.140	Cebus_capucinus
ENSG00000272886	DCP1A	99	100.000	ENSCATG00000044027	DCP1A	100	98.625	Cercocebus_atys
ENSG00000272886	DCP1A	99	99.010	ENSCLAG00000006913	DCP1A	97	89.863	Chinchilla_lanigera
ENSG00000272886	DCP1A	99	100.000	ENSCSAG00000013034	DCP1A	100	98.110	Chlorocebus_sabaeus
ENSG00000272886	DCP1A	92	80.819	ENSCHOG00000006436	DCP1A	100	80.819	Choloepus_hoffmanni
ENSG00000272886	DCP1A	99	91.089	ENSCPBG00000022400	DCP1A	99	60.135	Chrysemys_picta_bellii
ENSG00000272886	DCP1A	99	100.000	ENSCANG00000001755	DCP1A	100	97.610	Colobus_angolensis_palliatus
ENSG00000272886	DCP1A	99	99.010	ENSCGRG00001023753	Dcp1a	97	90.223	Cricetulus_griseus_chok1gshd
ENSG00000272886	DCP1A	99	99.010	ENSCGRG00000005738	Dcp1a	97	90.223	Cricetulus_griseus_crigri
ENSG00000272886	DCP1A	100	69.608	ENSCSEG00000000411	-	83	62.393	Cynoglossus_semilaevis
ENSG00000272886	DCP1A	98	71.000	ENSCVAG00000001779	dcp1a	76	51.953	Cyprinodon_variegatus
ENSG00000272886	DCP1A	98	75.000	ENSDARG00000100136	dcp1a	73	57.658	Danio_rerio
ENSG00000272886	DCP1A	100	98.446	ENSDNOG00000036524	DCP1A	97	77.320	Dasypus_novemcinctus
ENSG00000272886	DCP1A	100	95.855	ENSDORG00000001396	Dcp1a	97	89.691	Dipodomys_ordii
ENSG00000272886	DCP1A	99	98.020	ENSETEG00000001601	DCP1A	69	84.790	Echinops_telfairi
ENSG00000272886	DCP1A	99	99.010	ENSEASG00005014966	DCP1A	100	90.206	Equus_asinus_asinus
ENSG00000272886	DCP1A	99	99.010	ENSECAG00000024754	DCP1A	100	90.378	Equus_caballus
ENSG00000272886	DCP1A	100	88.601	ENSEEUG00000009966	DCP1A	100	81.004	Erinaceus_europaeus
ENSG00000272886	DCP1A	98	73.000	ENSELUG00000013077	dcp1a	99	41.426	Esox_lucius
ENSG00000272886	DCP1A	100	98.446	ENSFCAG00000003903	DCP1A	100	90.893	Felis_catus
ENSG00000272886	DCP1A	87	55.299	ENSFALG00000008704	DCP1A	100	55.299	Ficedula_albicollis
ENSG00000272886	DCP1A	98	99.000	ENSFDAG00000005588	DCP1A	97	89.863	Fukomys_damarensis
ENSG00000272886	DCP1A	98	72.000	ENSFHEG00000022838	dcp1a	100	37.605	Fundulus_heteroclitus
ENSG00000272886	DCP1A	94	72.917	ENSGMOG00000014258	dcp1a	59	61.702	Gadus_morhua
ENSG00000272886	DCP1A	99	92.079	ENSGALG00000041547	DCP1A	100	58.923	Gallus_gallus
ENSG00000272886	DCP1A	98	71.000	ENSGAFG00000019076	dcp1a	51	52.918	Gambusia_affinis
ENSG00000272886	DCP1A	92	73.404	ENSGACG00000005995	dcp1a	54	56.250	Gasterosteus_aculeatus
ENSG00000272886	DCP1A	99	92.079	ENSGAGG00000010217	DCP1A	99	59.328	Gopherus_agassizii
ENSG00000272886	DCP1A	99	100.000	ENSGGOG00000012817	DCP1A	100	98.969	Gorilla_gorilla
ENSG00000272886	DCP1A	92	73.404	ENSHBUG00000007164	dcp1a	80	54.348	Haplochromis_burtoni
ENSG00000272886	DCP1A	99	99.010	ENSHGLG00000004679	DCP1A	97	88.660	Heterocephalus_glaber_female
ENSG00000272886	DCP1A	99	99.010	ENSHGLG00100017160	DCP1A	97	88.660	Heterocephalus_glaber_male
ENSG00000272886	DCP1A	93	73.684	ENSHCOG00000002646	-	85	73.684	Hippocampus_comes
ENSG00000272886	DCP1A	99	74.257	ENSIPUG00000024374	dcp1a	80	58.904	Ictalurus_punctatus
ENSG00000272886	DCP1A	99	99.010	ENSSTOG00000004632	DCP1A	100	91.753	Ictidomys_tridecemlineatus
ENSG00000272886	DCP1A	100	98.039	ENSJJAG00000015125	-	88	98.039	Jaculus_jaculus
ENSG00000272886	DCP1A	93	72.632	ENSKMAG00000011720	dcp1a	99	45.426	Kryptolebias_marmoratus
ENSG00000272886	DCP1A	100	72.549	ENSLBEG00000007888	-	95	72.549	Labrus_bergylta
ENSG00000272886	DCP1A	99	81.188	ENSLACG00000013895	DCP1A	99	50.169	Latimeria_chalumnae
ENSG00000272886	DCP1A	98	80.000	ENSLOCG00000014108	dcp1a	100	47.508	Lepisosteus_oculatus
ENSG00000272886	DCP1A	99	99.010	ENSLAFG00000005837	DCP1A	98	89.573	Loxodonta_africana
ENSG00000272886	DCP1A	99	100.000	ENSMFAG00000040374	DCP1A	100	97.978	Macaca_fascicularis
ENSG00000272886	DCP1A	99	100.000	ENSMMUG00000011208	DCP1A	100	97.978	Macaca_mulatta
ENSG00000272886	DCP1A	99	100.000	ENSMNEG00000015025	DCP1A	100	97.610	Macaca_nemestrina
ENSG00000272886	DCP1A	99	100.000	ENSMLEG00000042471	DCP1A	100	98.346	Mandrillus_leucophaeus
ENSG00000272886	DCP1A	94	72.917	ENSMAMG00000016948	dcp1a	84	65.766	Mastacembelus_armatus
ENSG00000272886	DCP1A	98	71.000	ENSMZEG00005020706	dcp1a	69	54.348	Maylandia_zebra
ENSG00000272886	DCP1A	72	82.609	ENSMGAG00000005731	DCP1A	100	56.466	Meleagris_gallopavo
ENSG00000272886	DCP1A	100	99.020	ENSMAUG00000004516	-	64	99.020	Mesocricetus_auratus
ENSG00000272886	DCP1A	100	98.446	ENSMICG00000010929	DCP1A	100	92.955	Microcebus_murinus
ENSG00000272886	DCP1A	100	99.020	ENSMOCG00000021702	-	99	99.020	Microtus_ochrogaster
ENSG00000272886	DCP1A	100	59.804	ENSMMOG00000021667	-	99	59.804	Mola_mola
ENSG00000272886	DCP1A	99	91.089	ENSMODG00000012554	DCP1A	100	55.426	Monodelphis_domestica
ENSG00000272886	DCP1A	99	98.020	MGP_CAROLIEiJ_G0019050	Dcp1a	97	89.022	Mus_caroli
ENSG00000272886	DCP1A	99	98.020	ENSMUSG00000021962	Dcp1a	98	97.110	Mus_musculus
ENSG00000272886	DCP1A	99	98.020	MGP_PahariEiJ_G0030067	Dcp1a	97	88.679	Mus_pahari
ENSG00000272886	DCP1A	99	98.020	MGP_SPRETEiJ_G0019935	Dcp1a	97	89.194	Mus_spretus
ENSG00000272886	DCP1A	99	99.010	ENSMPUG00000016817	DCP1A	97	91.237	Mustela_putorius_furo
ENSG00000272886	DCP1A	99	99.010	ENSMLUG00000000956	DCP1A	97	84.708	Myotis_lucifugus
ENSG00000272886	DCP1A	100	99.020	ENSNGAG00000019963	-	97	93.578	Nannospalax_galili
ENSG00000272886	DCP1A	98	67.000	ENSNBRG00000001616	-	65	65.686	Neolamprologus_brichardi
ENSG00000272886	DCP1A	100	99.081	ENSNLEG00000007219	DCP1A	100	99.081	Nomascus_leucogenys
ENSG00000272886	DCP1A	99	78.218	ENSMEUG00000000054	-	99	49.317	Notamacropus_eugenii
ENSG00000272886	DCP1A	90	87.189	ENSOPRG00000009919	DCP1A	100	87.189	Ochotona_princeps
ENSG00000272886	DCP1A	100	99.020	ENSODEG00000008427	-	82	99.020	Octodon_degus
ENSG00000272886	DCP1A	92	74.468	ENSONIG00000001897	dcp1a	83	50.973	Oreochromis_niloticus
ENSG00000272886	DCP1A	91	55.914	ENSOANG00000030354	-	75	55.294	Ornithorhynchus_anatinus
ENSG00000272886	DCP1A	99	99.010	ENSOCUG00000011971	DCP1A	97	89.519	Oryctolagus_cuniculus
ENSG00000272886	DCP1A	98	72.000	ENSORLG00000003413	dcp1a	71	56.034	Oryzias_latipes
ENSG00000272886	DCP1A	98	72.000	ENSORLG00020017737	dcp1a	71	56.034	Oryzias_latipes_hni
ENSG00000272886	DCP1A	98	72.000	ENSORLG00015009618	dcp1a	71	55.603	Oryzias_latipes_hsok
ENSG00000272886	DCP1A	99	70.297	ENSOMEG00000006207	dcp1a	71	56.944	Oryzias_melastigma
ENSG00000272886	DCP1A	99	99.010	ENSOGAG00000016915	DCP1A	100	92.955	Otolemur_garnettii
ENSG00000272886	DCP1A	99	99.010	ENSOARG00000016637	DCP1A	97	88.547	Ovis_aries
ENSG00000272886	DCP1A	100	99.656	ENSPPAG00000043127	DCP1A	100	99.656	Pan_paniscus
ENSG00000272886	DCP1A	100	98.446	ENSPPRG00000005751	DCP1A	100	91.065	Panthera_pardus
ENSG00000272886	DCP1A	100	98.446	ENSPTIG00000012296	DCP1A	100	91.065	Panthera_tigris_altaica
ENSG00000272886	DCP1A	100	99.656	ENSPTRG00000046314	DCP1A	100	99.656	Pan_troglodytes
ENSG00000272886	DCP1A	99	100.000	ENSPANG00000011562	DCP1A	100	98.162	Papio_anubis
ENSG00000272886	DCP1A	99	78.218	ENSPKIG00000024486	dcp1a	82	63.182	Paramormyrops_kingsleyae
ENSG00000272886	DCP1A	100	89.216	ENSPSIG00000003282	DCP1A	99	59.459	Pelodiscus_sinensis
ENSG00000272886	DCP1A	100	71.569	ENSPMGG00000001138	-	71	71.569	Periophthalmus_magnuspinnatus
ENSG00000272886	DCP1A	99	92.079	ENSPCIG00000002143	DCP1A	100	58.603	Phascolarctos_cinereus
ENSG00000272886	DCP1A	98	71.000	ENSPFOG00000024583	dcp1a	51	52.529	Poecilia_formosa
ENSG00000272886	DCP1A	98	71.000	ENSPLAG00000009422	dcp1a	88	37.607	Poecilia_latipinna
ENSG00000272886	DCP1A	98	71.000	ENSPMEG00000006366	dcp1a	51	52.529	Poecilia_mexicana
ENSG00000272886	DCP1A	98	70.000	ENSPREG00000000750	dcp1a	51	51.807	Poecilia_reticulata
ENSG00000272886	DCP1A	100	99.141	ENSPPYG00000013788	DCP1A	100	99.141	Pongo_abelii
ENSG00000272886	DCP1A	99	98.020	ENSPCAG00000016213	-	54	97.596	Procavia_capensis
ENSG00000272886	DCP1A	99	99.010	ENSPCOG00000028534	DCP1A	100	93.299	Propithecus_coquereli
ENSG00000272886	DCP1A	99	99.010	ENSPVAG00000016284	DCP1A	100	90.378	Pteropus_vampyrus
ENSG00000272886	DCP1A	87	73.034	ENSPNYG00000009483	-	66	73.034	Pundamilia_nyererei
ENSG00000272886	DCP1A	99	73.267	ENSPNAG00000001685	dcp1a	77	54.430	Pygocentrus_nattereri
ENSG00000272886	DCP1A	99	98.020	ENSRNOG00000016015	Dcp1a	97	87.479	Rattus_norvegicus
ENSG00000272886	DCP1A	99	100.000	ENSRBIG00000032220	DCP1A	100	98.162	Rhinopithecus_bieti
ENSG00000272886	DCP1A	99	100.000	ENSRROG00000043106	DCP1A	100	98.162	Rhinopithecus_roxellana
ENSG00000272886	DCP1A	100	85.223	ENSSBOG00000018181	DCP1A	100	85.223	Saimiri_boliviensis_boliviensis
ENSG00000272886	DCP1A	88	76.190	ENSSHAG00000017202	DCP1A	94	57.011	Sarcophilus_harrisii
ENSG00000272886	DCP1A	99	81.188	ENSSFOG00015019471	dcp1a	98	42.450	Scleropages_formosus
ENSG00000272886	DCP1A	92	73.404	ENSSMAG00000014519	dcp1a	70	53.200	Scophthalmus_maximus
ENSG00000272886	DCP1A	92	73.404	ENSSDUG00000015866	dcp1a	99	37.158	Seriola_dumerili
ENSG00000272886	DCP1A	92	73.404	ENSSLDG00000023089	dcp1a	99	36.364	Seriola_lalandi_dorsalis
ENSG00000272886	DCP1A	100	91.192	ENSSARG00000000970	DCP1A	99	83.765	Sorex_araneus
ENSG00000272886	DCP1A	100	93.137	ENSSPUG00000001785	-	96	93.137	Sphenodon_punctatus
ENSG00000272886	DCP1A	93	74.737	ENSSPAG00000006215	dcp1a	94	50.357	Stegastes_partitus
ENSG00000272886	DCP1A	99	99.010	ENSSSCG00000022616	DCP1A	100	90.378	Sus_scrofa
ENSG00000272886	DCP1A	84	69.683	ENSTGUG00000006820	DCP1A	100	57.952	Taeniopygia_guttata
ENSG00000272886	DCP1A	93	72.632	ENSTRUG00000003429	dcp1a	99	38.462	Takifugu_rubripes
ENSG00000272886	DCP1A	99	68.317	ENSTNIG00000001969	dcp1a	58	49.057	Tetraodon_nigroviridis
ENSG00000272886	DCP1A	88	95.175	ENSTBEG00000012697	DCP1A	100	83.302	Tupaia_belangeri
ENSG00000272886	DCP1A	100	98.446	ENSUAMG00000007386	DCP1A	99	91.237	Ursus_americanus
ENSG00000272886	DCP1A	100	98.446	ENSUMAG00000020222	DCP1A	97	91.237	Ursus_maritimus
ENSG00000272886	DCP1A	88	100.000	ENSVPAG00000002194	DCP1A	88	100.000	Vicugna_pacos
ENSG00000272886	DCP1A	100	98.446	ENSVVUG00000023423	DCP1A	100	90.378	Vulpes_vulpes
ENSG00000272886	DCP1A	55	91.071	ENSXETG00000015662	dcp1a	100	44.322	Xenopus_tropicalis
ENSG00000272886	DCP1A	94	71.875	ENSXCOG00000003158	-	82	71.875	Xiphophorus_couchianus
ENSG00000272886	DCP1A	98	71.000	ENSXMAG00000028395	dcp1a	99	37.966	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	Process
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	21873635.	IBA	Process
GO:0000932	P-body	21873635.	IBA	Component
GO:0000932	P-body	-	ISS	Component
GO:0005515	protein binding	12417715.15231747.15231748.15687258.16364915.19150429.19966221.20584987.21876179.23085078.24862572.25036637.25416956.25609649.26133670.26496610.27107012.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	24965446.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0008047	enzyme activator activity	-	IEA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016787	hydrolase activity	-	IEA	Function
GO:0019894	kinesin binding	-	IEA	Function
GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA	21873635.	IBA	Process
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	Component
GO:0042802	identical protein binding	16364915.19966221.	IPI	Function
GO:0043085	positive regulation of catalytic activity	-	IEA	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	Process
GO:1903608	protein localization to cytoplasmic stress granule	24965446.	IMP	Process