EuRBPDB

Description

RBDs

RBPome

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000273559 (Gene tree)
Gene ID: 54883
Gene Symbol: CWC25
Alias: FLJ20291|CCDC49
Full Name: CWC25 spliceosome associated protein homolog
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 25,048 bases
Position: chr17:38,800,434-38,825,481
Accession: 25989
RBP type: canonical RBP
Summary: This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000478070	CWC25	PF12542.8	2.1e-19	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000614790	CWC25-202	3234	-	ENSP00000478070	425 (aa)	-	Q9NXE8
ENST00000619818	CWC25-206	1127	-	-	- (aa)	-	-
ENST00000611845	CWC25-201	581	-	-	- (aa)	-	-
ENST00000619299	CWC25-204	1894	-	ENSP00000482247	68 (aa)	-	A0A087WY60
ENST00000622665	CWC25-207	976	-	ENSP00000481539	68 (aa)	-	A0A087WY60
ENST00000618122	CWC25-203	1160	-	ENSP00000478244	3 (aa)	-	UPI0002840F2D
ENST00000619462	CWC25-205	650	-	ENSP00000479527	59 (aa)	-	A0A087WVL7

Gene Model

Click here to download ENSG00000273559's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000273559	Platelet Function Tests	1.3789300E-005	-
ENSG00000273559	Platelet Function Tests	1.0508500E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000273559	rs7219007	17	38811968	C	Intraocular pressure	29617998	[0.051-0.106] unit increase	0.0785	EFO_0004695
ENSG00000273559	rs113435706	17	38812457	A	Cognitive empathy	28584286	[0.13-0.35] unit increase	0.2403	EFO_0009183

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000273559's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000273559	CWC25	94	100.000	ENSAMEG00000004292	CWC25	100	90.588	Ailuropoda_melanoleuca
ENSG00000273559	CWC25	94	82.812	ENSAPEG00000013237	cwc25	100	51.142	Amphiprion_percula
ENSG00000273559	CWC25	85	93.103	ENSAPLG00000003710	CWC25	99	66.432	Anas_platyrhynchos
ENSG00000273559	CWC25	94	98.438	ENSACAG00000013140	CWC25	100	68.384	Anolis_carolinensis
ENSG00000273559	CWC25	94	100.000	ENSANAG00000033550	CWC25	90	96.774	Aotus_nancymaae
ENSG00000273559	CWC25	94	79.688	ENSACLG00000009352	cwc25	100	51.591	Astatotilapia_calliptera
ENSG00000273559	CWC25	94	100.000	ENSBTAG00000030591	CWC25	100	93.412	Bos_taurus
ENSG00000273559	CWC25	100	96.000	ENSCJAG00000008289	CWC25	100	96.000	Callithrix_jacchus
ENSG00000273559	CWC25	94	100.000	ENSCAFG00000016561	CWC25	100	90.118	Canis_familiaris
ENSG00000273559	CWC25	94	100.000	ENSCAFG00020023017	CWC25	100	89.882	Canis_lupus_dingo
ENSG00000273559	CWC25	94	100.000	ENSCHIG00000015063	CWC25	100	92.706	Capra_hircus
ENSG00000273559	CWC25	94	100.000	ENSTSYG00000011332	CWC25	100	82.864	Carlito_syrichta
ENSG00000273559	CWC25	93	95.312	ENSCAPG00000014542	CWC25	99	78.220	Cavia_aperea
ENSG00000273559	CWC25	94	100.000	ENSCPOG00000015127	CWC25	100	75.644	Cavia_porcellus
ENSG00000273559	CWC25	100	95.765	ENSCCAG00000028719	CWC25	100	95.765	Cebus_capucinus
ENSG00000273559	CWC25	94	100.000	ENSCATG00000040771	CWC25	100	93.176	Cercocebus_atys
ENSG00000273559	CWC25	94	100.000	ENSCLAG00000017102	CWC25	87	99.301	Chinchilla_lanigera
ENSG00000273559	CWC25	100	97.647	ENSCSAG00000002654	CWC25	100	97.647	Chlorocebus_sabaeus
ENSG00000273559	CWC25	85	100.000	ENSCPBG00000027490	CWC25	88	72.381	Chrysemys_picta_bellii
ENSG00000273559	CWC25	94	100.000	ENSCANG00000037099	CWC25	100	92.706	Colobus_angolensis_palliatus
ENSG00000273559	CWC25	94	100.000	ENSCGRG00001020785	Cwc25	100	92.000	Cricetulus_griseus_chok1gshd
ENSG00000273559	CWC25	94	100.000	ENSCGRG00000005085	Cwc25	100	92.000	Cricetulus_griseus_crigri
ENSG00000273559	CWC25	94	100.000	ENSDNOG00000042410	CWC25	100	92.488	Dasypus_novemcinctus
ENSG00000273559	CWC25	94	100.000	ENSDORG00000003061	Cwc25	100	93.412	Dipodomys_ordii
ENSG00000273559	CWC25	65	59.091	FBgn0031452	Cwc25	54	42.553	Drosophila_melanogaster
ENSG00000273559	CWC25	94	76.562	ENSEBUG00000002947	cwc25	82	62.676	Eptatretus_burgeri
ENSG00000273559	CWC25	100	94.824	ENSEASG00005001871	CWC25	100	94.824	Equus_asinus_asinus
ENSG00000273559	CWC25	100	95.059	ENSECAG00000019122	CWC25	100	95.059	Equus_caballus
ENSG00000273559	CWC25	76	78.019	ENSEEUG00000000018	CWC25	100	78.019	Erinaceus_europaeus
ENSG00000273559	CWC25	94	100.000	ENSFCAG00000028119	CWC25	100	92.235	Felis_catus
ENSG00000273559	CWC25	85	91.379	ENSFALG00000013293	CWC25	99	60.000	Ficedula_albicollis
ENSG00000273559	CWC25	94	98.438	ENSFDAG00000007745	CWC25	100	75.059	Fukomys_damarensis
ENSG00000273559	CWC25	94	75.000	ENSGMOG00000013001	cwc25	67	71.687	Gadus_morhua
ENSG00000273559	CWC25	94	92.188	ENSGALG00000001624	CWC25	100	72.897	Gallus_gallus
ENSG00000273559	CWC25	94	100.000	ENSGAGG00000022972	CWC25	100	73.005	Gopherus_agassizii
ENSG00000273559	CWC25	100	99.529	ENSGGOG00000007083	CWC25	100	99.529	Gorilla_gorilla
ENSG00000273559	CWC25	94	79.688	ENSHBUG00000001392	cwc25	100	51.708	Haplochromis_burtoni
ENSG00000273559	CWC25	94	100.000	ENSHGLG00000014785	CWC25	100	80.328	Heterocephalus_glaber_female
ENSG00000273559	CWC25	94	100.000	ENSHGLG00100017354	CWC25	100	76.279	Heterocephalus_glaber_male
ENSG00000273559	CWC25	94	100.000	ENSSTOG00000014268	CWC25	100	92.000	Ictidomys_tridecemlineatus
ENSG00000273559	CWC25	94	81.250	ENSKMAG00000015418	cwc25	99	50.450	Kryptolebias_marmoratus
ENSG00000273559	CWC25	94	87.500	ENSLOCG00000013707	cwc25	100	54.587	Lepisosteus_oculatus
ENSG00000273559	CWC25	94	100.000	ENSLAFG00000002238	CWC25	100	91.822	Loxodonta_africana
ENSG00000273559	CWC25	85	98.338	ENSMFAG00000002357	CWC25	100	98.338	Macaca_fascicularis
ENSG00000273559	CWC25	85	98.338	ENSMMUG00000002944	CWC25	90	98.338	Macaca_mulatta
ENSG00000273559	CWC25	100	98.588	ENSMNEG00000033729	CWC25	100	98.588	Macaca_nemestrina
ENSG00000273559	CWC25	94	100.000	ENSMLEG00000033355	CWC25	99	98.191	Mandrillus_leucophaeus
ENSG00000273559	CWC25	94	79.688	ENSMZEG00005012421	cwc25	100	51.591	Maylandia_zebra
ENSG00000273559	CWC25	93	92.063	ENSMGAG00000005158	CWC25	99	71.795	Meleagris_gallopavo
ENSG00000273559	CWC25	100	96.706	ENSMICG00000003004	CWC25	100	96.706	Microcebus_murinus
ENSG00000273559	CWC25	94	100.000	ENSMOCG00000000224	Cwc25	100	91.294	Microtus_ochrogaster
ENSG00000273559	CWC25	94	100.000	ENSMODG00000012627	CWC25	100	79.294	Monodelphis_domestica
ENSG00000273559	CWC25	94	100.000	MGP_CAROLIEiJ_G0017064	Cwc25	100	85.647	Mus_caroli
ENSG00000273559	CWC25	94	100.000	ENSMUSG00000018541	Cwc25	100	88.235	Mus_musculus
ENSG00000273559	CWC25	94	100.000	MGP_PahariEiJ_G0018193	Cwc25	100	84.742	Mus_pahari
ENSG00000273559	CWC25	94	100.000	MGP_SPRETEiJ_G0017910	Cwc25	100	88.471	Mus_spretus
ENSG00000273559	CWC25	94	100.000	ENSMPUG00000015077	CWC25	100	90.118	Mustela_putorius_furo
ENSG00000273559	CWC25	94	100.000	ENSMLUG00000029248	-	98	99.401	Myotis_lucifugus
ENSG00000273559	CWC25	100	94.353	ENSMLUG00000029653	CWC25	100	94.353	Myotis_lucifugus
ENSG00000273559	CWC25	94	100.000	ENSNGAG00000007394	Cwc25	100	88.263	Nannospalax_galili
ENSG00000273559	CWC25	100	99.294	ENSNLEG00000000617	CWC25	100	99.294	Nomascus_leucogenys
ENSG00000273559	CWC25	85	98.276	ENSMEUG00000004156	CWC25	100	83.055	Notamacropus_eugenii
ENSG00000273559	CWC25	85	74.515	ENSOPRG00000001941	CWC25	100	74.515	Ochotona_princeps
ENSG00000273559	CWC25	94	98.438	ENSODEG00000017487	CWC25	100	79.577	Octodon_degus
ENSG00000273559	CWC25	94	100.000	ENSOANG00000001231	-	100	68.462	Ornithorhynchus_anatinus
ENSG00000273559	CWC25	94	100.000	ENSOCUG00000013906	CWC25	100	92.235	Oryctolagus_cuniculus
ENSG00000273559	CWC25	94	79.688	ENSORLG00020012087	cwc25	61	60.000	Oryzias_latipes_hni
ENSG00000273559	CWC25	94	100.000	ENSOGAG00000008785	CWC25	100	82.710	Otolemur_garnettii
ENSG00000273559	CWC25	94	100.000	ENSOARG00000009937	CWC25	100	92.471	Ovis_aries
ENSG00000273559	CWC25	100	100.000	ENSPPAG00000023487	CWC25	100	100.000	Pan_paniscus
ENSG00000273559	CWC25	94	100.000	ENSPPRG00000005029	CWC25	100	92.471	Panthera_pardus
ENSG00000273559	CWC25	94	100.000	ENSPTIG00000020264	CWC25	100	92.471	Panthera_tigris_altaica
ENSG00000273559	CWC25	100	99.765	ENSPTRG00000009077	CWC25	100	99.765	Pan_troglodytes
ENSG00000273559	CWC25	100	97.882	ENSPANG00000022017	CWC25	100	97.882	Papio_anubis
ENSG00000273559	CWC25	88	69.067	ENSPSIG00000011817	CWC25	99	67.380	Pelodiscus_sinensis
ENSG00000273559	CWC25	94	100.000	ENSPEMG00000000026	Cwc25	100	89.412	Peromyscus_maniculatus_bairdii
ENSG00000273559	CWC25	94	98.438	ENSPCIG00000002943	CWC25	100	82.353	Phascolarctos_cinereus
ENSG00000273559	CWC25	100	98.824	ENSPPYG00000008503	CWC25	100	98.824	Pongo_abelii
ENSG00000273559	CWC25	85	100.000	ENSPCAG00000000433	CWC25	100	84.031	Procavia_capensis
ENSG00000273559	CWC25	100	96.000	ENSPCOG00000023678	CWC25	100	96.000	Propithecus_coquereli
ENSG00000273559	CWC25	99	94.749	ENSPVAG00000002273	CWC25	100	94.749	Pteropus_vampyrus
ENSG00000273559	CWC25	94	100.000	ENSRNOG00000004091	Cwc25	100	87.765	Rattus_norvegicus
ENSG00000273559	CWC25	100	97.647	ENSRBIG00000033457	CWC25	100	97.647	Rhinopithecus_bieti
ENSG00000273559	CWC25	100	98.118	ENSRROG00000039968	CWC25	100	98.118	Rhinopithecus_roxellana
ENSG00000273559	CWC25	78	43.396	YNL245C	-	54	32.323	Saccharomyces_cerevisiae
ENSG00000273559	CWC25	94	100.000	ENSSHAG00000017267	CWC25	100	83.294	Sarcophilus_harrisii
ENSG00000273559	CWC25	85	80.055	ENSSARG00000006871	CWC25	100	83.657	Sorex_araneus
ENSG00000273559	CWC25	94	100.000	ENSSPUG00000018024	CWC25	100	73.256	Sphenodon_punctatus
ENSG00000273559	CWC25	94	100.000	ENSSSCG00000021478	CWC25	100	92.706	Sus_scrofa
ENSG00000273559	CWC25	85	91.379	ENSTGUG00000003011	CWC25	100	63.594	Taeniopygia_guttata
ENSG00000273559	CWC25	94	78.125	ENSTRUG00000004650	cwc25	62	61.441	Takifugu_rubripes
ENSG00000273559	CWC25	94	81.250	ENSTNIG00000014143	cwc25	100	49.206	Tetraodon_nigroviridis
ENSG00000273559	CWC25	85	100.000	ENSTBEG00000013187	CWC25	100	79.236	Tupaia_belangeri
ENSG00000273559	CWC25	99	93.556	ENSTTRG00000006662	CWC25	100	93.556	Tursiops_truncatus
ENSG00000273559	CWC25	94	100.000	ENSUAMG00000005592	CWC25	100	90.824	Ursus_americanus
ENSG00000273559	CWC25	94	100.000	ENSUMAG00000017097	CWC25	100	90.588	Ursus_maritimus
ENSG00000273559	CWC25	85	100.000	ENSVPAG00000005680	CWC25	100	83.771	Vicugna_pacos
ENSG00000273559	CWC25	94	100.000	ENSVVUG00000002182	CWC25	100	90.353	Vulpes_vulpes
ENSG00000273559	CWC25	85	96.552	ENSXETG00000023722	cwc25	100	59.574	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0005654	nucleoplasm	-	TAS	Component
GO:0016607	nuclear speck	-	IDA	Component