EuRBPDB

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  • Basic Information
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  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000273899 (Gene tree)
Gene ID
79159
Gene Symbol
NOL12
Alias
MGC3731|Nop25|RRP17
Full Name
nucleolar protein 12
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
11,806 bases
Position
chr22:37,681,673-37,693,478
Accession
28585
RBP type
canonical RBP
Summary
(Nucleolar Protein 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include rRNA binding. An important paralog of this gene is ENSG00000100101.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000352021Nop25PF09805.92.8e-1511
ENSP00000482349Nop25PF09805.92.8e-1511
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
16515785Mapping a nucleolar targeting sequence of an RNA binding nucleolar protein, Nop25.Exp Cell Res2006 Jun 10Fujiwara T-
29069457Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.Nucleic Acids Res2017 Dec 1Scott DDdoi: 10.1093/nar/gkx963.
16430885Molecular cloning and characterization of Nop25, a novel nucleolar RNA binding protein, highly conserved in vertebrate species.Exp Cell Res2006 Apr 15Suzuki S-
17524363Nucleolar protein Nop25 is involved in nucleolar architecture.Biochem Biophys Res Commun2007 Jul 13Suzuki S-
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000468597NOL12-203632--- (aa)--
ENST00000611699NOL12-207903-ENSP00000482349213 (aa)-Q9UGY1
ENST00000484650NOL12-205813--- (aa)--
ENST00000359114NOL12-2012854-ENSP00000352021213 (aa)-Q9UGY1
ENST00000493862NOL12-2061011--- (aa)--
ENST00000438329NOL12-202945-ENSP00000403059213 (aa)-Q9UGY1
ENST00000474032NOL12-204523--- (aa)--
Gene Model
Click here to download ENSG00000273899's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000273899's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000273899NOL129249.528ENSAPOG00000006332nol128949.048Acanthochromis_polyacanthus
ENSG00000273899NOL129892.344ENSAMEG00000010139-10092.344Ailuropoda_melanoleuca
ENSG00000273899NOL129249.528ENSACIG00000000239nol129048.815Amphilophus_citrinellus
ENSG00000273899NOL129249.524ENSAOCG00000004207nol128948.571Amphiprion_ocellaris
ENSG00000273899NOL129249.048ENSAPEG00000013488nol128948.095Amphiprion_percula
ENSG00000273899NOL129250.239ENSATEG00000009548nol128949.282Anabas_testudineus
ENSG00000273899NOL1210063.889ENSACAG00000015549-10063.889Anolis_carolinensis
ENSG00000273899NOL1210096.262ENSANAG00000025653-10096.262Aotus_nancymaae
ENSG00000273899NOL129250.000ENSACLG00000016476nol129049.048Astatotilapia_calliptera
ENSG00000273899NOL127361.538ENSAMXG00000041317nol128955.502Astyanax_mexicanus
ENSG00000273899NOL1210089.720ENSBTAG00000051118NOL1210089.720Bos_taurus
ENSG00000273899NOL1210093.897ENSCJAG00000012487-10093.897Callithrix_jacchus
ENSG00000273899NOL1210086.854ENSCJAG00000005559-9686.854Callithrix_jacchus
ENSG00000273899NOL1210092.523ENSCAFG00000028770-10092.523Canis_familiaris
ENSG00000273899NOL1210092.523ENSCAFG00020003735-10092.523Canis_lupus_dingo
ENSG00000273899NOL1210090.187ENSCHIG00000021736-10090.187Capra_hircus
ENSG00000273899NOL1210075.234ENSTSYG00000036100-10075.234Carlito_syrichta
ENSG00000273899NOL1210090.654ENSTSYG00000008865-10090.654Carlito_syrichta
ENSG00000273899NOL1210075.234ENSTSYG00000027029-10075.234Carlito_syrichta
ENSG00000273899NOL1210089.252ENSCPOG00000037340-10089.252Cavia_porcellus
ENSG00000273899NOL1210096.244ENSCCAG00000033458-10096.244Cebus_capucinus
ENSG00000273899NOL1210091.549ENSCCAG00000034277-10091.549Cebus_capucinus
ENSG00000273899NOL1210094.836ENSCATG00000038470-10094.836Cercocebus_atys
ENSG00000273899NOL1210087.850ENSCLAG00000016784-10087.850Chinchilla_lanigera
ENSG00000273899NOL1210094.366ENSCSAG00000007256-10094.366Chlorocebus_sabaeus
ENSG00000273899NOL129766.190ENSCPBG00000023060-9766.190Chrysemys_picta_bellii
ENSG00000273899NOL1210095.305ENSCANG00000027973-10095.305Colobus_angolensis_palliatus
ENSG00000273899NOL1210090.233ENSCGRG00001016078Nol1210090.233Cricetulus_griseus_chok1gshd
ENSG00000273899NOL1210090.233ENSCGRG00000007664Nol1210090.233Cricetulus_griseus_crigri
ENSG00000273899NOL127650.307ENSCSEG00000007082nol126947.239Cynoglossus_semilaevis
ENSG00000273899NOL129150.242ENSCVAG00000004424nol128850.725Cyprinodon_variegatus
ENSG00000273899NOL127260.784ENSDARG00000038027nol128850.962Danio_rerio
ENSG00000273899NOL1210071.889ENSDNOG00000007681-9569.469Dasypus_novemcinctus
ENSG00000273899NOL129875.598ENSETEG00000008089-9875.598Echinops_telfairi
ENSG00000273899NOL127938.857ENSEBUG00000008264nol127438.286Eptatretus_burgeri
ENSG00000273899NOL1210092.558ENSEASG00005018821-10092.558Equus_asinus_asinus
ENSG00000273899NOL1210091.628ENSECAG00000032748NOL1210091.628Equus_caballus
ENSG00000273899NOL1210088.318ENSEEUG00000002597-10088.318Erinaceus_europaeus
ENSG00000273899NOL129449.550ENSELUG00000008885nol128950.000Esox_lucius
ENSG00000273899NOL129391.457ENSFCAG00000038953-10091.589Felis_catus
ENSG00000273899NOL129263.725ENSFALG00000012807-8663.725Ficedula_albicollis
ENSG00000273899NOL1210085.514ENSFDAG00000000919-10087.850Fukomys_damarensis
ENSG00000273899NOL129250.476ENSFHEG00000005900nol129049.524Fundulus_heteroclitus
ENSG00000273899NOL129249.519ENSGMOG00000006313nol128946.635Gadus_morhua
ENSG00000273899NOL129164.286ENSGALG00000012410-9764.623Gallus_gallus
ENSG00000273899NOL129148.780ENSGAFG00000017520nol128849.268Gambusia_affinis
ENSG00000273899NOL129248.558ENSGACG00000007246nol128947.596Gasterosteus_aculeatus
ENSG00000273899NOL129765.238ENSGAGG00000017727-9766.190Gopherus_agassizii
ENSG00000273899NOL1210098.592ENSGGOG00000040937-10098.592Gorilla_gorilla
ENSG00000273899NOL129250.233ENSHBUG00000021873nol129049.048Haplochromis_burtoni
ENSG00000273899NOL1210086.449ENSHGLG00000015482-10086.449Heterocephalus_glaber_female
ENSG00000273899NOL1210086.449ENSHGLG00100003937-10086.449Heterocephalus_glaber_male
ENSG00000273899NOL129648.869ENSHCOG00000005941nol128848.571Hippocampus_comes
ENSG00000273899NOL129255.072ENSIPUG00000000672nol128856.039Ictalurus_punctatus
ENSG00000273899NOL1210091.163ENSSTOG00000028960-10091.163Ictidomys_tridecemlineatus
ENSG00000273899NOL129253.140ENSKMAG00000014033nol129052.174Kryptolebias_marmoratus
ENSG00000273899NOL129854.460ENSLACG00000005267-9753.881Latimeria_chalumnae
ENSG00000273899NOL1210090.187ENSLAFG00000010072-10090.187Loxodonta_africana
ENSG00000273899NOL1210096.244ENSMFAG00000006832-10096.244Macaca_fascicularis
ENSG00000273899NOL1210095.775ENSMMUG00000047489NOL1210095.775Macaca_mulatta
ENSG00000273899NOL1210096.244ENSMNEG00000016463-10096.244Macaca_nemestrina
ENSG00000273899NOL129349.289ENSMAMG00000008197nol129051.174Mastacembelus_armatus
ENSG00000273899NOL129250.000ENSMZEG00005005326nol129049.048Maylandia_zebra
ENSG00000273899NOL128466.298ENSMGAG00000012548-9765.728Meleagris_gallopavo
ENSG00000273899NOL1210090.233ENSMAUG00000020440Nol1210090.233Mesocricetus_auratus
ENSG00000273899NOL1210090.187ENSMICG00000033461-10090.187Microcebus_murinus
ENSG00000273899NOL1210089.252ENSMOCG00000021388Nol1210089.252Microtus_ochrogaster
ENSG00000273899NOL129150.971ENSMMOG00000005012nol128748.780Mola_mola
ENSG00000273899NOL129662.911ENSMODG00000000273-9662.911Monodelphis_domestica
ENSG00000273899NOL129950.450ENSMALG00000001721nol129449.550Monopterus_albus
ENSG00000273899NOL1210087.097MGP_CAROLIEiJ_G0019998Nol1210089.401Mus_caroli
ENSG00000273899NOL1210087.097ENSMUSG00000033099Nol1210089.401Mus_musculus
ENSG00000273899NOL1210089.815MGP_PahariEiJ_G0020000Nol1210089.815Mus_pahari
ENSG00000273899NOL1210089.352MGP_SPRETEiJ_G0020896Nol1210089.352Mus_spretus
ENSG00000273899NOL1210089.720ENSMPUG00000012830-10089.720Mustela_putorius_furo
ENSG00000273899NOL1210092.523ENSMLUG00000014280-10092.523Myotis_lucifugus
ENSG00000273899NOL129249.767ENSNBRG00000002104nol129049.048Neolamprologus_brichardi
ENSG00000273899NOL1210076.995ENSNLEG00000014859-10076.995Nomascus_leucogenys
ENSG00000273899NOL128768.947ENSMEUG00000000228-9968.947Notamacropus_eugenii
ENSG00000273899NOL127585.535ENSOPRG00000013360-10085.535Ochotona_princeps
ENSG00000273899NOL128985.789ENSODEG00000000101-9985.789Octodon_degus
ENSG00000273899NOL129250.935ENSONIG00000008373nol129050.239Oreochromis_niloticus
ENSG00000273899NOL128774.074ENSOANG00000005801-10074.074Ornithorhynchus_anatinus
ENSG00000273899NOL1210088.263ENSOCUG00000017013-10088.263Oryctolagus_cuniculus
ENSG00000273899NOL129248.558ENSORLG00000014684nol128948.558Oryzias_latipes
ENSG00000273899NOL129248.558ENSORLG00020006235nol128949.038Oryzias_latipes_hni
ENSG00000273899NOL129247.847ENSORLG00015018366nol128950.000Oryzias_latipes_hsok
ENSG00000273899NOL129447.907ENSOMEG00000006905nol129047.907Oryzias_melastigma
ENSG00000273899NOL1210089.862ENSOGAG00000008255-10090.323Otolemur_garnettii
ENSG00000273899NOL1210089.720ENSOARG00000013969-10089.720Ovis_aries
ENSG00000273899NOL1210099.061ENSPPAG00000032357-10099.061Pan_paniscus
ENSG00000273899NOL1210092.056ENSPPRG00000024913-10092.056Panthera_pardus
ENSG00000273899NOL1210092.991ENSPTIG00000012596-10092.991Panthera_tigris_altaica
ENSG00000273899NOL1210098.592ENSPTRG00000014345NOL1210098.592Pan_troglodytes
ENSG00000273899NOL1210094.836ENSPANG00000033918-10094.836Papio_anubis
ENSG00000273899NOL129252.857ENSPKIG00000007375nol129752.252Paramormyrops_kingsleyae
ENSG00000273899NOL128870.681ENSPSIG00000012103-9766.981Pelodiscus_sinensis
ENSG00000273899NOL126757.241ENSPMGG00000009583nol128354.211Periophthalmus_magnuspinnatus
ENSG00000273899NOL1210086.175ENSPEMG00000010657Nol1210088.940Peromyscus_maniculatus_bairdii
ENSG00000273899NOL129150.000ENSPFOG00000022176nol128850.000Poecilia_formosa
ENSG00000273899NOL129251.429ENSPLAG00000023807nol128950.000Poecilia_latipinna
ENSG00000273899NOL129149.289ENSPMEG00000018335nol128849.761Poecilia_mexicana
ENSG00000273899NOL1210089.252ENSPCAG00000000561-10089.252Procavia_capensis
ENSG00000273899NOL1210092.056ENSPCOG00000014514-10092.056Propithecus_coquereli
ENSG00000273899NOL1210091.121ENSPVAG00000010097-10091.121Pteropus_vampyrus
ENSG00000273899NOL129250.233ENSPNYG00000020267nol129049.048Pundamilia_nyererei
ENSG00000273899NOL126461.314ENSPNAG00000023112nol128753.883Pygocentrus_nattereri
ENSG00000273899NOL1210088.426ENSRNOG00000010209Nol1210088.426Rattus_norvegicus
ENSG00000273899NOL1210096.244ENSRBIG00000042117-10096.244Rhinopithecus_bieti
ENSG00000273899NOL1210095.775ENSRROG00000037912-10095.775Rhinopithecus_roxellana
ENSG00000273899NOL1210093.897ENSSBOG00000036236-10093.897Saimiri_boliviensis_boliviensis
ENSG00000273899NOL129451.852ENSSFOG00015012468nol1210050.655Scleropages_formosus
ENSG00000273899NOL129143.541ENSSMAG00000004745nol128844.976Scophthalmus_maximus
ENSG00000273899NOL129247.867ENSSDUG00000016769nol128947.867Seriola_dumerili
ENSG00000273899NOL129248.571ENSSLDG00000024826nol128947.619Seriola_lalandi_dorsalis
ENSG00000273899NOL129968.095ENSSPUG00000011564-9968.095Sphenodon_punctatus
ENSG00000273899NOL129448.624ENSSPAG00000007292nol129148.837Stegastes_partitus
ENSG00000273899NOL1210092.523ENSSSCG00000021663-10092.523Sus_scrofa
ENSG00000273899NOL129766.351ENSTGUG00000010526NOL129567.453Taeniopygia_guttata
ENSG00000273899NOL128249.432ENSTRUG00000019689nol129148.341Takifugu_rubripes
ENSG00000273899NOL129750.000ENSTNIG00000010836nol128950.000Tetraodon_nigroviridis
ENSG00000273899NOL1210080.841ENSTBEG00000009745-10080.841Tupaia_belangeri
ENSG00000273899NOL129683.010ENSTTRG00000004799-10083.010Tursiops_truncatus
ENSG00000273899NOL1210092.991ENSUAMG00000020483-10092.991Ursus_americanus
ENSG00000273899NOL1210092.523ENSUMAG00000015210-10092.523Ursus_maritimus
ENSG00000273899NOL1210092.056ENSVVUG00000023997-10092.056Vulpes_vulpes
ENSG00000273899NOL129750.711ENSXETG00000015984nol129750.711Xenopus_tropicalis
ENSG00000273899NOL129150.242ENSXCOG00000015936nol128749.515Xiphophorus_couchianus
ENSG00000273899NOL129150.242ENSXMAG00000006120nol128749.515Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003697single-stranded DNA binding21873635.IBAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding21873635.IBAFunction
GO:0005515protein binding21044950.25416956.IPIFunction
GO:0005730nucleolus21873635.IBAComponent
GO:0006364rRNA processing21873635.IBAProcess
GO:0007000nucleolus organization21873635.IBAProcess
GO:0008284positive regulation of cell proliferation21873635.IBAProcess
GO:0019843rRNA binding21873635.IBAFunction
GO:0030307positive regulation of cell growth21873635.IBAProcess
GO:0043066negative regulation of apoptotic process21873635.IBAProcess

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2237688974SilentnovelL121L0.09
BLCAchr2237691179Missense_MutationNAS162C0.32
BLCAchr2237688990Missense_Mutationrs756287059E127K0.28
BRCAchr2237687911Missense_MutationNAE29K0.57Nop25
BRCAchr2237686440Silentrs757228384P16P0.29
BRCAchr2237690762Silentrs138812020P149P0.06
BRCAchr2237691239Missense_Mutationrs141736495R182Q0.46
BRCAchr2237686456Missense_MutationNAF22V0.11Nop25
BRCAchr2237690712Missense_MutationnovelR133W0.33
BRCAchr2237687943Silentrs767529367V39V0.14
CESCchr2237691182Missense_MutationNAS163F0.19
CHOLchr2237688856Missense_MutationnovelA82E0.3Nop25
COADchr2237691238Nonsense_MutationnovelR182*0.07
COADchr2237688946Missense_MutationnovelD112V0.35
COADchr2237691241Missense_Mutationrs775776838R183W0.33
COADchr2237691212Missense_Mutationrs377073310R173H0.28
COADchr2237691280Missense_MutationnovelT196A0.23
ESCAchr2237687944Nonsense_MutationnovelE40*0.44Nop25
HNSCchr2237688946Missense_MutationnovelD112G0.23
KIRCchr2237688982Missense_MutationNAT124S0.35
KIRPchr2237691319Silentrs760440711R209R0.45
LGGchr2237691295Missense_Mutationrs757854451R201C0.34
LIHCchr2237687910Splice_RegionnovelR28R0.07
LIHCchr2237686394Translation_Start_SitenovelM1?0.42
LUADchr22376913863'UTRnovel0.57
LUADchr2237690795Splice_SitenovelX160_splice0.33
LUADchr2237688906Missense_MutationNAD99N0.07
LUSCchr2237688975Missense_Mutationrs752018030G122W0.43
LUSCchr2237690703Missense_MutationnovelA130S0.2
PAADchr2237690897Intronnovel0.22
PRADchr2237688890Silentrs753142556T93T0.43
SARCchr2237688909Missense_Mutationrs746027481H100Y0.34
SKCMchr2237690696Splice_SiteNAX128_splice0.1
SKCMchr22376913823'UTRnovel0.19
SKCMchr2237690697Missense_MutationNAG128R0.3
SKCMchr22376913393'UTRrs3677553190.26
SKCMchr2237690694Splice_Regionnovel0.29
STADchr2237688927Missense_MutationnovelT106A0.26
UCECchr22376913913'UTRnovel0.44
UCECchr22376934513'UTRnovel0.29
UCECchr2237686413Missense_MutationNAK7N0.32
UCECchr2237691242Missense_Mutationrs371438425R183Q0.41
UCECchr2237690728Missense_MutationNAA138V0.28
UCECchr2237691265Missense_Mutationrs767390432P191S0.44
UCECchr22376913473'UTRnovel0.35
UCECchr2237687948Missense_Mutationrs573370291R41Q0.69Nop25
UCECchr2237691199Missense_MutationnovelH169N0.64
UCECchr2237691212Missense_Mutationrs377073310R173H0.41
UCECchr2237688890Silentrs753142556T93T0.16
UCSchr22376913963'UTRnovel0.64

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
PCPGDEL0.3210.044123
THCADEL0.15630.046486
THYMDEL0.07320.063154

Survival Analysis
CancerP-value Q-value
ACC0.0092

Kaplan-Meier Survival Analysis

UCS0.013

Kaplan-Meier Survival Analysis

LUSC0.00033

Kaplan-Meier Survival Analysis

ESCA0.021

Kaplan-Meier Survival Analysis

PAAD0.0034

Kaplan-Meier Survival Analysis

PCPG0.017

Kaplan-Meier Survival Analysis

BLCA0.00065

Kaplan-Meier Survival Analysis

CESC0.00028

Kaplan-Meier Survival Analysis

READ0.006

Kaplan-Meier Survival Analysis

LIHC0.0028

Kaplan-Meier Survival Analysis

CHOL0.03

Kaplan-Meier Survival Analysis

OV0.046

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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