EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000276966 (Gene tree)
Gene ID: 8367
Gene Symbol: HIST1H4E
Alias: H4/j|H4FJ
Full Name: histone cluster 1 H4 family member e
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 1,487 bases
Position: chr6:26,204,552-26,206,038
Accession: 4790
RBP type: non-canonical RBP
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000615164	HIST1H4E-201	1487	-	ENSP00000484789	103 (aa)	-	P62805

Gene Model

Click here to download ENSG00000276966's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05034	Alcoholism	KEGG
hsa05203	Viral carcinogenesis	KEGG
hsa05322	Systemic lupus erythematosus	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000276966	Gout	2E-8	27899376
ENSG00000276966	Gout	9E-7	27899376

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000276966	rs806795	6	26205065	G	Mosquito bite size	28199695	[0.014-0.035] unit decrease	0.024494	EFO_0008378

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000276966's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000276966	HIST1H4E	100	99.029	WBGene00001941	his-67	100	99.029	Caenorhabditis_elegans
ENSG00000276966	HIST1H4E	100	100.000	ENSG00000276180	HIST1H4I	100	100.000	Homo_sapiens
ENSG00000276966	HIST1H4E	100	100.000	ENSG00000278705	HIST1H4B	100	100.000	Homo_sapiens
ENSG00000276966	HIST1H4E	100	100.000	ENSG00000275126	HIST1H4L	100	100.000	Homo_sapiens
ENSG00000276966	HIST1H4E	100	100.000	ENSG00000197061	HIST1H4C	100	100.000	Homo_sapiens
ENSG00000276966	HIST1H4E	100	100.000	ENSG00000197837	HIST4H4	100	100.000	Homo_sapiens
ENSG00000276966	HIST1H4E	100	100.000	ENSG00000274618	HIST1H4F	100	100.000	Homo_sapiens
ENSG00000276966	HIST1H4E	100	100.000	ENSG00000270882	HIST2H4A	100	100.000	Homo_sapiens
ENSG00000276966	HIST1H4E	100	100.000	ENSG00000270276	HIST2H4B	100	100.000	Homo_sapiens
ENSG00000276966	HIST1H4E	100	92.233	YBR009C		100	92.233	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000183	chromatin silencing at rDNA	-	TAS	Process
GO:0000228	nuclear chromosome	14718166.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000786	nucleosome	21636898.24699735.25615412.	IDA	Component
GO:0000786	nucleosome	3035717.	TAS	Component
GO:0000788	nuclear nucleosome	20498094.	IDA	Component
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003677	DNA binding	3035717.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	9540062.10220385.14585971.15161933.15933069.16415788.16917504.17540172.18404153.18408754.18474616.18571423.19410544.19494831.19498464.19710015.19862764.20000738.20224553.20498094.20618440.20709061.20739937.20951943.21085121.21478274.21596426.21743476.21888893.21983900.22343720.22368283.22373579.22615379.23071334.23075851.23142979.23377543.23760478.23831576.24183680.24360279.24361270.24525235.24596249.24726341.25281266.25416956.25556234.25579814.25619998.25651062.25910212.26167883.26496610.26912361.30021884.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	14585971.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	Process
GO:0006334	nucleosome assembly	21873635.	IBA	Process
GO:0006334	nucleosome assembly	20498094.21636898.24699735.25615412.	IDA	Process
GO:0006335	DNA replication-dependent nucleosome assembly	14718166.	IDA	Process
GO:0006336	DNA replication-independent nucleosome assembly	14718166.	IDA	Process
GO:0006352	DNA-templated transcription, initiation	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016233	telomere capping	-	TAS	Process
GO:0019904	protein domain specific binding	22368283.	IPI	Function
GO:0032200	telomere organization	17675446.	TAS	Process
GO:0032991	protein-containing complex	14718166.	IDA	Component
GO:0034080	CENP-A containing nucleosome assembly	-	TAS	Process
GO:0044267	cellular protein metabolic process	-	TAS	Process
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0045653	negative regulation of megakaryocyte differentiation	18474616.	IDA	Process
GO:0045814	negative regulation of gene expression, epigenetic	-	TAS	Process
GO:0046982	protein heterodimerization activity	-	IEA	Function
GO:0051290	protein heterotetramerization	20498094.	IDA	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0070062	extracellular exosome	19199708.20458337.23533145.	HDA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	26204649	Missense_Mutation	rs201304438	S2F	0.4
BLCA	chr6	26204717	Missense_Mutation	NA	D25H	0.26
BLCA	chr6	26204729	In_Frame_Del	novel	G29_P33del	0.04
BLCA	chr6	26204982	3'Flank	novel		0.1
BLCA	chr6	26204801	Missense_Mutation	novel	E53K	0.11
BLCA	chr6	26204672	Missense_Mutation	rs749157094	G10R	0.36
BLCA	chr6	26204750	Missense_Mutation	novel	R36W	0.51
BRCA	chr6	26204723	Missense_Mutation	novel	I27F	0.05
BRCA	chr6	26204865	Missense_Mutation	novel	T74M	0.04
BRCA	chr6	26204972	3'Flank	novel		0.37
BRCA	chr6	26204677	Silent	rs778674883	L11L	0.16
BRCA	chr6	26204842	Silent	NA	V66V	0.21
BRCA	chr6	26204984	3'Flank	rs759801933		0.08
BRCA	chr6	26204794	Silent	rs145281411	L50L	0.15
CESC	chr6	26204842	Silent	rs145407769	V66V	0.31
CESC	chr6	26204698	Frame_Shift_Del	novel	*H19Cfs31**	0.14
CESC	chr6	26204797	Missense_Mutation	novel	I51M	0.31
CESC	chr6	26204936	Missense_Mutation	NA	L98V	0.8
CESC	chr6	26204834	Missense_Mutation	NA	E64K	0.2
CESC	chr6	26204922	Missense_Mutation	NA	R93T	0.42
COAD	chr6	26204869	Silent	NA	E75E	0.09
COAD	chr6	26204792	Missense_Mutation	NA	L50F	0.17
COAD	chr6	26204920	Missense_Mutation	rs754130463	K92N	0.22
COAD	chr6	26204645	Translation_Start_Site	rs184503150	M1?	0.38
ESCA	chr6	26204842	Silent	NA	V66V	0.24
ESCA	chr6	26205010	3'Flank	novel		0.17
ESCA	chr6	26204922	Missense_Mutation	NA	R93T	0.22
ESCA	chr6	26204763	Missense_Mutation	novel	R40P	0.32
HNSC	chr6	26204810	Missense_Mutation	rs572454026	R56C	0.47
HNSC	chr6	26204917	Silent	rs143252055	L91L	0.24
HNSC	chr6	26204797	Silent	novel	I51I	0.35
HNSC	chr6	26204842	Silent	NA	V66V	0.5
HNSC	chr6	26204829	Missense_Mutation	NA	F62C	0.13
HNSC	chr6	26204928	Missense_Mutation	novel	G95E	0.22
HNSC	chr6	26204922	Missense_Mutation	NA	R93T	0.12
HNSC	chr6	26204657	Missense_Mutation	novel	G5S	0.3
HNSC	chr6	26204825	Missense_Mutation	novel	V61L	0.09
KIRC	chr6	26204841	Missense_Mutation	NA	V66A	0.43
KIRP	chr6	26204704	Silent	novel	R20R	0.47
LIHC	chr6	26204671	Missense_Mutation	NA	K9N	0.22
LUAD	chr6	26204702	Missense_Mutation	NA	R20S	0.2
LUAD	chr6	26204657	Missense_Mutation	NA	G5C	0.32
LUAD	chr6	26204696	Missense_Mutation	novel	R18G	0.23
LUAD	chr6	26204972	3'Flank	novel		0.22
LUAD	chr6	26204947	Missense_Mutation	novel	F101L	0.45
LUSC	chr6	26205001	3'Flank	rs756514353		0.39
LUSC	chr6	26204717	Missense_Mutation	NA	D25H	0.23
LUSC	chr6	26204873	Missense_Mutation	novel	A77S	0.17
LUSC	chr6	26204772	Missense_Mutation	novel	G43A	0.09
LUSC	chr6	26204667	Frame_Shift_Ins	novel	*L11Tfs3**	0.95
LUSC	chr6	26205010	3'Flank	novel		0.31
LUSC	chr6	26205001	3'Flank	novel		0.24
LUSC	chr6	26204795	Missense_Mutation	rs756223901	I51V	0.12
LUSC	chr6	26205010	3'Flank	novel		0.57
LUSC	chr6	26204922	Missense_Mutation	NA	R93T	0.47
LUSC	chr6	26204857	Silent	rs779424083	V71V	0.14
LUSC	chr6	26204857	Silent	rs779424083	V71V	0.13
OV	chr6	26204920	Missense_Mutation	rs754130463	K92N	0.13
OV	chr6	26204880	Missense_Mutation	rs745509791	R79H	0.11
PAAD	chr6	26204719	Frame_Shift_Ins	novel	*N26Kfs44**	0.06
PRAD	chr6	26204936	Missense_Mutation	novel	L98F	0.31
SKCM	chr6	26204928	Missense_Mutation	novel	G95E	0.16
SKCM	chr6	26204754	Missense_Mutation	rs753083420	R37H	0.29
STAD	chr6	26204757	Missense_Mutation	NA	L38H	0.38
STAD	chr6	26204901	Missense_Mutation	NA	D86G	0.21
STAD	chr6	26205018	3'Flank	novel		0.54
STAD	chr6	26204961	3'Flank	novel		0.37
UCEC	chr6	26204785	Missense_Mutation	novel	I47M	0.09
UCEC	chr6	26204701	Frame_Shift_Del	NA	*R20Efs36**	0.37
UCEC	chr6	26204725	Frame_Shift_Del	novel	*G29Afs37**	0.21
UCEC	chr6	26204885	Missense_Mutation	novel	T81A	0.14
UCEC	chr6	26204734	Missense_Mutation	novel	I30M	0.15
UCEC	chr6	26204749	Silent	rs571073582	I35I	0.55
UCEC	chr6	26204859	Missense_Mutation	novel	T72I	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PAAD	DEL	0.2609	0.00045039

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00018	Kaplan-Meier Survival Analysis
STAD	0.035	Kaplan-Meier Survival Analysis
SARC	0.0061	Kaplan-Meier Survival Analysis
MESO	0.022	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
KIRP	0.0033	Kaplan-Meier Survival Analysis
COAD	0.021	Kaplan-Meier Survival Analysis
PAAD	0.0053	Kaplan-Meier Survival Analysis
BLCA	0.022	Kaplan-Meier Survival Analysis
CESC	0.029	Kaplan-Meier Survival Analysis
LIHC	0.0073	Kaplan-Meier Survival Analysis
DLBC	0.023	Kaplan-Meier Survival Analysis
LGG	0.045	Kaplan-Meier Survival Analysis
UVM	0.037	Kaplan-Meier Survival Analysis
OV	0.038	Kaplan-Meier Survival Analysis