EuRBPDB

Description

RBDs

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000277149 (Gene tree)
Gene ID: 441250
Gene Symbol: TYW1B
Alias: RSAFD2|MGC87315|NCRNA00069|LINC00069
Full Name: tRNA-yW synthesizing protein 1 homolog B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 269,491 bases
Position: chr7:72,558,744-72,828,234
Accession: 33908
RBP type: canonical RBP
Summary: Wybutosine is a hypermodified guanosine found in phenylalanine tRNA. Wybutosine functions to stabilize codon-anticodon interactions during ribosome decoding and therefore supports the maintenance of the reading frame. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. The human genome contains two closely related genes that putatively function in wybutosine synthesis. The open reading frame of this locus is disrupted in some individuals. Thus, this locus appears to be an evolving pseudogene, but may still be functional in some members of the population. [provided by RefSeq, Apr 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000480534	Wyosine_form	PF08608.12	2.1e-23	1	1
ENSP00000482502	Wyosine_form	PF08608.12	3.1e-23	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000620995	TYW1B-203	3113	XM_011516230	ENSP00000482502	668 (aa)	XP_011514532	Q6NUM6
ENST00000612372	TYW1B-202	1543	-	ENSP00000480534	471 (aa)	-	A0A087WWV6
ENST00000610600	TYW1B-201	1086	XM_011516232	ENSP00000484480	325 (aa)	XP_011514534	A0A087X1V1

Gene Model

Click here to download ENSG00000277149's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000277149	Parkinson Disease	1.156E-5	17052657
ENSG00000277149	Parkinson Disease	2.844627E-7	17052657
ENSG00000277149	Stroke	1.72E-7	17434096
ENSG00000277149	Stroke	9.6304450E-005	-
ENSG00000277149	Triglycerides	3E-6	24097068
ENSG00000277149	Education	4E-8	27225129
ENSG00000277149	Triglycerides	1E-9	20686565

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000277149	rs11976020	7	72782785	A	Educational attainment (years of education)	27225129	NR unit decrease	0.014528254	EFO_0004784
ENSG00000277149	rs13238203	7	72664689	T	Triglycerides	24097068	[NR] mg/dL decrease	0.059	EFO_0004530
ENSG00000277149	rs56004000	7	72774864	T	Educational attainment (MTAG)	30038396	[0.0064-0.0126] unit decrease	0.0095	EFO_0004784
ENSG00000277149	rs139453187	7	72690844	T	Highest math class taken	30038396	[0.017-0.034] unit increase	0.0258	EFO_0004875
ENSG00000277149	rs139453187	7	72690844	T	Self-reported math ability (MTAG)	30038396	[0.013-0.026] unit increase	0.0195	EFO_0004875
ENSG00000277149	rs139453187	7	72690844	T	Highest math class taken (MTAG)	30038396	[0.016-0.028] unit increase	0.0218	EFO_0004875
ENSG00000277149	rs13238203	7	72664689	T	Triglycerides	20686565	[5.28-10.54] mg/dL decrease	7.91	EFO_0004530
ENSG00000277149	rs13238203	7	72664689	C	Triglycerides	29507422	unit increase	0.108	EFO_0004530
ENSG00000277149	rs13238203	7	72664689	C	Triglycerides	29507422	unit increase	0.107	EFO_0004530
ENSG00000277149	rs34881399	7	72769162	T	Triglycerides	29507422	unit increase	0.112	EFO_0004530
ENSG00000277149	rs34881399	7	72769162	T	Triglycerides	29507422	unit increase	0.111	EFO_0004530

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000277149's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000277149	TYW1B	99	58.197	ENSAPOG00000014391	tyw1	100	59.389	Acanthochromis_polyacanthus
ENSG00000277149	TYW1B	93	64.660	ENSACIG00000007325	tyw1	89	64.177	Amphilophus_citrinellus
ENSG00000277149	TYW1B	99	58.333	ENSAOCG00000016792	tyw1	97	59.153	Amphiprion_ocellaris
ENSG00000277149	TYW1B	99	58.333	ENSAPEG00000015939	tyw1	95	63.622	Amphiprion_percula
ENSG00000277149	TYW1B	88	58.410	ENSATEG00000006856	tyw1	90	58.193	Anabas_testudineus
ENSG00000277149	TYW1B	97	87.692	ENSANAG00000037051	-	97	87.692	Aotus_nancymaae
ENSG00000277149	TYW1B	93	65.123	ENSACLG00000018688	tyw1	86	64.264	Astatotilapia_calliptera
ENSG00000277149	TYW1B	98	64.053	ENSAMXG00000004157	tyw1	97	64.933	Astyanax_mexicanus
ENSG00000277149	TYW1B	100	75.683	ENSBTAG00000008446	TYW1	100	75.683	Bos_taurus
ENSG00000277149	TYW1B	100	82.104	ENSCJAG00000004295	-	100	82.104	Callithrix_jacchus
ENSG00000277149	TYW1B	100	73.134	ENSCAFG00000010867	-	100	73.677	Canis_familiaris
ENSG00000277149	TYW1B	100	79.822	ENSCAFG00020005367	-	100	79.822	Canis_lupus_dingo
ENSG00000277149	TYW1B	100	76.366	ENSCHIG00000019510	-	100	76.366	Capra_hircus
ENSG00000277149	TYW1B	92	87.187	ENSTSYG00000008236	-	100	86.723	Carlito_syrichta
ENSG00000277149	TYW1B	93	79.483	ENSCAPG00000013569	-	100	78.617	Cavia_aperea
ENSG00000277149	TYW1B	96	76.590	ENSCPOG00000011182	-	100	71.216	Cavia_porcellus
ENSG00000277149	TYW1B	99	86.809	ENSCCAG00000026643	-	100	86.809	Cebus_capucinus
ENSG00000277149	TYW1B	100	93.572	ENSCATG00000043677	-	100	93.572	Cercocebus_atys
ENSG00000277149	TYW1B	100	71.506	ENSCLAG00000006321	-	100	71.506	Chinchilla_lanigera
ENSG00000277149	TYW1B	100	79.335	ENSCSAG00000018274	-	100	79.335	Chlorocebus_sabaeus
ENSG00000277149	TYW1B	76	93.103	ENSCHOG00000003801	-	75	91.453	Choloepus_hoffmanni
ENSG00000277149	TYW1B	96	70.960	ENSCPBG00000014896	-	97	65.541	Chrysemys_picta_bellii
ENSG00000277149	TYW1B	69	63.492	ENSCING00000004125	-	97	53.130	Ciona_intestinalis
ENSG00000277149	TYW1B	90	51.320	ENSCSAVG00000005712	-	100	51.471	Ciona_savignyi
ENSG00000277149	TYW1B	99	94.043	ENSCANG00000033209	-	99	94.043	Colobus_angolensis_palliatus
ENSG00000277149	TYW1B	85	74.737	ENSCGRG00001003679	Tyw1	80	79.021	Cricetulus_griseus_chok1gshd
ENSG00000277149	TYW1B	93	65.265	ENSCSEG00000005810	tyw1	84	64.174	Cynoglossus_semilaevis
ENSG00000277149	TYW1B	83	63.212	ENSCVAG00000001054	tyw1	81	63.212	Cyprinodon_variegatus
ENSG00000277149	TYW1B	98	61.528	ENSDARG00000062987	tyw1	95	61.528	Danio_rerio
ENSG00000277149	TYW1B	100	76.913	ENSDNOG00000024165	-	100	75.956	Dasypus_novemcinctus
ENSG00000277149	TYW1B	100	75.599	ENSDORG00000014772	Tyw1	99	75.599	Dipodomys_ordii
ENSG00000277149	TYW1B	57	52.768	ENSETEG00000009904	-	61	52.920	Echinops_telfairi
ENSG00000277149	TYW1B	65	71.296	ENSEBUG00000004494	tyw1	90	71.296	Eptatretus_burgeri
ENSG00000277149	TYW1B	100	77.732	ENSEASG00005008818	-	100	77.732	Equus_asinus_asinus
ENSG00000277149	TYW1B	100	75.385	ENSECAG00000023164	-	100	74.965	Equus_caballus
ENSG00000277149	TYW1B	53	90.769	ENSEEUG00000005950	-	51	90.769	Erinaceus_europaeus
ENSG00000277149	TYW1B	99	61.493	ENSELUG00000008449	tyw1	82	78.488	Esox_lucius
ENSG00000277149	TYW1B	100	81.886	ENSFCAG00000014262	-	99	80.386	Felis_catus
ENSG00000277149	TYW1B	95	64.268	ENSFALG00000013810	-	99	59.290	Ficedula_albicollis
ENSG00000277149	TYW1B	99	73.051	ENSFDAG00000013270	-	99	73.051	Fukomys_damarensis
ENSG00000277149	TYW1B	88	62.701	ENSFHEG00000020824	tyw1	81	62.359	Fundulus_heteroclitus
ENSG00000277149	TYW1B	100	61.321	ENSGALG00000001110	-	99	62.838	Gallus_gallus
ENSG00000277149	TYW1B	98	58.357	ENSGACG00000012692	tyw1	98	58.182	Gasterosteus_aculeatus
ENSG00000277149	TYW1B	96	71.212	ENSGAGG00000022393	-	100	65.135	Gopherus_agassizii
ENSG00000277149	TYW1B	100	90.400	ENSGGOG00000001473	TYW1	100	91.092	Gorilla_gorilla
ENSG00000277149	TYW1B	93	65.177	ENSHBUG00000002640	tyw1	99	52.712	Haplochromis_burtoni
ENSG00000277149	TYW1B	93	73.791	ENSHGLG00000012093	-	100	73.479	Heterocephalus_glaber_female
ENSG00000277149	TYW1B	100	73.634	ENSHGLG00100011743	TYW1	100	73.634	Heterocephalus_glaber_male
ENSG00000277149	TYW1B	98	55.745	ENSHCOG00000019949	tyw1	56	69.666	Hippocampus_comes
ENSG00000277149	TYW1B	98	59.861	ENSIPUG00000016330	tyw1	95	60.000	Ictalurus_punctatus
ENSG00000277149	TYW1B	100	72.268	ENSSTOG00000004067	-	92	71.175	Ictidomys_tridecemlineatus
ENSG00000277149	TYW1B	100	79.940	ENSJJAG00000022959	Tyw1	100	79.940	Jaculus_jaculus
ENSG00000277149	TYW1B	98	58.310	ENSKMAG00000018599	tyw1	96	58.864	Kryptolebias_marmoratus
ENSG00000277149	TYW1B	98	56.946	ENSLACG00000018917	tyw1	96	58.654	Latimeria_chalumnae
ENSG00000277149	TYW1B	99	61.528	ENSLOCG00000004035	tyw1	96	61.528	Lepisosteus_oculatus
ENSG00000277149	TYW1B	99	93.830	ENSMFAG00000035457	-	99	93.830	Macaca_fascicularis
ENSG00000277149	TYW1B	100	93.413	ENSMMUG00000030374	-	100	93.413	Macaca_mulatta
ENSG00000277149	TYW1B	99	94.255	ENSMNEG00000041992	-	99	94.255	Macaca_nemestrina
ENSG00000277149	TYW1B	100	85.246	ENSMLEG00000039741	-	100	87.662	Mandrillus_leucophaeus
ENSG00000277149	TYW1B	98	60.232	ENSMAMG00000016089	tyw1	97	60.232	Mastacembelus_armatus
ENSG00000277149	TYW1B	93	64.915	ENSMZEG00005024386	tyw1	94	64.165	Maylandia_zebra
ENSG00000277149	TYW1B	100	61.134	ENSMGAG00000002176	-	100	62.213	Meleagris_gallopavo
ENSG00000277149	TYW1B	99	77.795	ENSMAUG00000002959	Tyw1	100	75.559	Mesocricetus_auratus
ENSG00000277149	TYW1B	100	86.677	ENSMICG00000014374	-	100	86.677	Microcebus_murinus
ENSG00000277149	TYW1B	100	71.646	ENSMOCG00000017720	Tyw1	100	71.646	Microtus_ochrogaster
ENSG00000277149	TYW1B	98	58.140	ENSMMOG00000005064	tyw1	97	58.009	Mola_mola
ENSG00000277149	TYW1B	100	63.904	ENSMODG00000025697	-	100	65.094	Monodelphis_domestica
ENSG00000277149	TYW1B	98	59.780	ENSMALG00000010238	tyw1	96	59.366	Monopterus_albus
ENSG00000277149	TYW1B	99	71.012	MGP_CAROLIEiJ_G0027801	Tyw1	99	71.012	Mus_caroli
ENSG00000277149	TYW1B	99	71.567	ENSMUSG00000056310	Tyw1	99	71.567	Mus_musculus
ENSG00000277149	TYW1B	99	69.209	MGP_PahariEiJ_G0024383	Tyw1	99	69.071	Mus_pahari
ENSG00000277149	TYW1B	99	71.290	MGP_SPRETEiJ_G0028799	Tyw1	99	71.290	Mus_spretus
ENSG00000277149	TYW1B	93	75.857	ENSMPUG00000016191	-	92	73.988	Mustela_putorius_furo
ENSG00000277149	TYW1B	100	74.627	ENSMLUG00000013582	-	100	74.627	Myotis_lucifugus
ENSG00000277149	TYW1B	99	70.827	ENSNGAG00000002742	Tyw1	99	69.285	Nannospalax_galili
ENSG00000277149	TYW1B	93	63.313	ENSNBRG00000016996	tyw1	92	62.946	Neolamprologus_brichardi
ENSG00000277149	TYW1B	100	93.284	ENSNLEG00000013210	-	100	96.104	Nomascus_leucogenys
ENSG00000277149	TYW1B	86	69.444	ENSOPRG00000008734	-	85	62.326	Ochotona_princeps
ENSG00000277149	TYW1B	99	77.545	ENSODEG00000014729	-	99	77.545	Octodon_degus
ENSG00000277149	TYW1B	93	65.581	ENSONIG00000005872	tyw1	86	64.869	Oreochromis_niloticus
ENSG00000277149	TYW1B	57	78.229	ENSOANG00000008147	-	84	78.229	Ornithorhynchus_anatinus
ENSG00000277149	TYW1B	100	75.000	ENSOCUG00000003173	-	100	75.000	Oryctolagus_cuniculus
ENSG00000277149	TYW1B	98	58.964	ENSORLG00000001393	tyw1	98	56.806	Oryzias_latipes
ENSG00000277149	TYW1B	98	59.104	ENSORLG00020019361	tyw1	98	57.222	Oryzias_latipes_hni
ENSG00000277149	TYW1B	98	58.939	ENSORLG00015008095	tyw1	98	55.650	Oryzias_latipes_hsok
ENSG00000277149	TYW1B	93	83.022	ENSOGAG00000016555	-	87	83.022	Otolemur_garnettii
ENSG00000277149	TYW1B	100	75.712	ENSOARG00000010673	-	100	75.712	Ovis_aries
ENSG00000277149	TYW1B	100	81.764	ENSPPRG00000004945	-	100	81.764	Panthera_pardus
ENSG00000277149	TYW1B	100	81.737	ENSPTIG00000019545	-	100	80.238	Panthera_tigris_altaica
ENSG00000277149	TYW1B	100	91.330	ENSPTRG00000023076	TYW1B	98	91.330	Pan_troglodytes
ENSG00000277149	TYW1B	100	93.124	ENSPANG00000019053	-	99	94.043	Papio_anubis
ENSG00000277149	TYW1B	99	58.219	ENSPKIG00000006545	tyw1	97	59.041	Paramormyrops_kingsleyae
ENSG00000277149	TYW1B	93	62.250	ENSPMGG00000004240	tyw1	92	61.905	Periophthalmus_magnuspinnatus
ENSG00000277149	TYW1B	99	71.330	ENSPEMG00000008274	Tyw1	99	71.330	Peromyscus_maniculatus_bairdii
ENSG00000277149	TYW1B	93	65.948	ENSPFOG00000015855	tyw1	88	64.815	Poecilia_formosa
ENSG00000277149	TYW1B	93	64.969	ENSPLAG00000000838	tyw1	92	61.431	Poecilia_latipinna
ENSG00000277149	TYW1B	93	64.969	ENSPMEG00000019437	tyw1	100	58.406	Poecilia_mexicana
ENSG00000277149	TYW1B	99	57.063	ENSPREG00000018773	tyw1	99	57.542	Poecilia_reticulata
ENSG00000277149	TYW1B	100	86.339	ENSPPYG00000017514	TYW1	100	86.339	Pongo_abelii
ENSG00000277149	TYW1B	88	84.444	ENSPCOG00000015294	-	100	68.311	Propithecus_coquereli
ENSG00000277149	TYW1B	93	65.123	ENSPNYG00000022381	tyw1	86	64.264	Pundamilia_nyererei
ENSG00000277149	TYW1B	98	60.665	ENSPNAG00000009001	tyw1	98	60.665	Pygocentrus_nattereri
ENSG00000277149	TYW1B	100	72.490	ENSRNOG00000024352	Tyw1	100	72.490	Rattus_norvegicus
ENSG00000277149	TYW1B	100	84.836	ENSRBIG00000039619	-	100	84.836	Rhinopithecus_bieti
ENSG00000277149	TYW1B	99	93.830	ENSRROG00000039780	-	99	93.830	Rhinopithecus_roxellana
ENSG00000277149	TYW1B	99	87.234	ENSSBOG00000025873	-	100	87.234	Saimiri_boliviensis_boliviensis
ENSG00000277149	TYW1B	100	64.674	ENSSHAG00000010346	-	100	64.016	Sarcophilus_harrisii
ENSG00000277149	TYW1B	99	60.523	ENSSFOG00015001054	tyw1	94	64.557	Scleropages_formosus
ENSG00000277149	TYW1B	98	58.897	ENSSMAG00000020514	tyw1	96	57.300	Scophthalmus_maximus
ENSG00000277149	TYW1B	93	65.385	ENSSDUG00000001552	tyw1	91	64.615	Seriola_dumerili
ENSG00000277149	TYW1B	98	59.780	ENSSLDG00000003554	tyw1	96	59.366	Seriola_lalandi_dorsalis
ENSG00000277149	TYW1B	55	78.125	ENSSARG00000013126	-	70	78.125	Sorex_araneus
ENSG00000277149	TYW1B	100	62.999	ENSSPUG00000002715	-	100	62.842	Sphenodon_punctatus
ENSG00000277149	TYW1B	100	74.863	ENSSSCG00000007733	-	100	74.863	Sus_scrofa
ENSG00000277149	TYW1B	93	69.312	ENSTGUG00000003428	-	100	57.522	Taeniopygia_guttata
ENSG00000277149	TYW1B	98	57.997	ENSTRUG00000016107	tyw1	93	57.441	Takifugu_rubripes
ENSG00000277149	TYW1B	93	64.264	ENSTNIG00000018999	tyw1	98	63.497	Tetraodon_nigroviridis
ENSG00000277149	TYW1B	100	74.084	ENSUMAG00000015343	-	100	73.134	Ursus_maritimus
ENSG00000277149	TYW1B	100	71.642	ENSVVUG00000016457	-	100	72.727	Vulpes_vulpes
ENSG00000277149	TYW1B	91	69.519	ENSXETG00000010094	tyw1	99	61.872	Xenopus_tropicalis
ENSG00000277149	TYW1B	93	63.190	ENSXMAG00000013125	tyw1	95	61.586	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0008033	tRNA processing	-	IEA	Process
GO:0010181	FMN binding	-	IEA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0051539	4 iron, 4 sulfur cluster binding	-	IEA	Function
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0102521	tRNA-4-demethylwyosine synthase activity	-	IEA	Function