EuRBPDB

Description

RBDs

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000284770 (Gene tree)
Gene ID: 6905
Gene Symbol: TBCE
Alias: KCS1|pac2|KCS|HRD
Full Name: tubulin folding cofactor E
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 85,084 bases
Position: chr1:235,367,360-235,452,443
Accession: 11582
RBP type: canonical RBP
Summary: Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000439170	Ribosomal_S21e	PF01249.18	2.4e-10	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000646463	TBCE-260	2028	-	ENSP00000494541	127 (aa)	-	A0A2R8Y5H6
ENST00000644265	TBCE-245	649	-	ENSP00000496033	116 (aa)	-	A0A2R8Y7H8
ENST00000647407	TBCE-273	512	-	ENSP00000495319	134 (aa)	-	A0A2R8Y6L2
ENST00000406207	TBCE-221	2071	-	ENSP00000384571	527 (aa)	-	Q15813
ENST00000644037	TBCE-242	2473	-	ENSP00000496408	127 (aa)	-	A0A2R8Y5H6
ENST00000366601	TBCE-220	1683	-	ENSP00000355560	464 (aa)	-	A0A2U3TZJ6
ENST00000646104	TBCE-256	2426	-	ENSP00000495475	46 (aa)	-	A0A2R8YH53
ENST00000647332	TBCE-271	761	-	ENSP00000495024	46 (aa)	-	A0A2R8YH53
ENST00000461651	TBCE-222	567	-	-	- (aa)	-	-
ENST00000643142	TBCE-235	1779	-	ENSP00000494755	139 (aa)	-	A0A2R8Y787
ENST00000646384	TBCE-259	1897	-	-	- (aa)	-	-
ENST00000645582	TBCE-252	1869	-	ENSP00000494980	46 (aa)	-	A0A2R8YH53
ENST00000644910	TBCE-249	2353	-	ENSP00000495738	23 (aa)	-	A0A2R8Y720
ENST00000644625	TBCE-247	2001	-	-	- (aa)	-	-
ENST00000642372	TBCE-228	621	-	ENSP00000495295	159 (aa)	-	A0A2R8Y6G3
ENST00000647338	TBCE-272	518	-	-	- (aa)	-	-
ENST00000643125	TBCE-234	1667	-	ENSP00000494102	252 (aa)	-	A0A2R8Y4V6
ENST00000646848	TBCE-266	1642	-	ENSP00000495831	235 (aa)	-	A0A2R8YER9
ENST00000642463	TBCE-229	2126	-	ENSP00000495007	127 (aa)	-	A0A2R8Y5H6
ENST00000646929	TBCE-267	562	-	ENSP00000493539	39 (aa)	-	A0A2R8Y3S1
ENST00000647233	TBCE-269	2754	-	-	- (aa)	-	-
ENST00000643994	TBCE-241	2036	-	ENSP00000496322	46 (aa)	-	A0A2R8YH53
ENST00000644838	TBCE-248	2181	-	ENSP00000495910	311 (aa)	-	A0A2R8Y809
ENST00000643993	TBCE-240	1914	-	-	- (aa)	-	-
ENST00000646821	TBCE-264	1897	-	ENSP00000495257	248 (aa)	-	A0A2R8YFM3
ENST00000645899	TBCE-254	1788	-	ENSP00000496773	520 (aa)	-	A0A2R8YHI9
ENST00000643487	TBCE-237	2458	-	-	- (aa)	-	-
ENST00000643615	TBCE-239	1833	-	ENSP00000496103	46 (aa)	-	A0A2R8YH53
ENST00000645372	TBCE-250	442	-	ENSP00000496612	110 (aa)	-	A0A2R8Y897
ENST00000465463	TBCE-223	1724	-	-	- (aa)	-	-
ENST00000645662	TBCE-253	907	-	ENSP00000495964	46 (aa)	-	A0A2R8YH53
ENST00000644126	TBCE-243	3469	-	-	- (aa)	-	-
ENST00000644578	TBCE-246	1778	-	ENSP00000495953	487 (aa)	-	A0A2R8Y7E7
ENST00000644217	TBCE-244	1772	-	ENSP00000494646	549 (aa)	-	A0A2R8Y5Q8
ENST00000646661	TBCE-263	458	-	-	- (aa)	-	-
ENST00000642981	TBCE-233	323	-	-	- (aa)	-	-
ENST00000647151	TBCE-268	509	-	ENSP00000495125	40 (aa)	-	A0A2R8YFG9
ENST00000645964	TBCE-255	2131	-	ENSP00000494208	160 (aa)	-	A0A2R8Y4P2
ENST00000482230	TBCE-225	398	-	-	- (aa)	-	-
ENST00000647418	TBCE-274	1801	-	ENSP00000493552	46 (aa)	-	A0A2R8YH53
ENST00000543662	TBCE-226	1980	-	ENSP00000439170	578 (aa)	-	Q15813
ENST00000472011	TBCE-224	2478	-	-	- (aa)	-	-
ENST00000646495	TBCE-261	494	-	-	- (aa)	-	-
ENST00000647322	TBCE-270	1331	-	ENSP00000493737	175 (aa)	-	A0A2R8Y4E7
ENST00000647489	TBCE-275	537	-	ENSP00000494232	46 (aa)	-	A0A2R8YH53
ENST00000642610	TBCE-230	5441	-	ENSP00000494796	527 (aa)	-	Q15813
ENST00000646536	TBCE-262	2102	-	ENSP00000494801	311 (aa)	-	A0A2R8Y809
ENST00000642764	TBCE-231	2577	-	-	- (aa)	-	-
ENST00000643524	TBCE-238	1598	-	ENSP00000494026	46 (aa)	-	A0A2R8YH53
ENST00000646286	TBCE-258	1897	-	ENSP00000494291	47 (aa)	-	A0A2R8Y597
ENST00000642339	TBCE-227	1659	-	ENSP00000495425	46 (aa)	-	A0A2R8YH53
ENST00000646842	TBCE-265	776	-	-	- (aa)	-	-
ENST00000646186	TBCE-257	1908	-	ENSP00000493806	127 (aa)	-	A0A2R8Y5H6
ENST00000643238	TBCE-236	1216	-	ENSP00000495916	217 (aa)	-	A0A2R8Y784
ENST00000645551	TBCE-251	1894	-	ENSP00000495928	139 (aa)	-	A0A2R8Y787
ENST00000642926	TBCE-232	1857	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000284770's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000284770	Obesity	3E-7	19557161

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000284770's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000284770	TBCE	97	94.118	ENSCJAG00000018023	-	100	90.328	Callithrix_jacchus
ENSG00000284770	TBCE	97	100.000	ENSGGOG00000013627	-	100	94.118	Gorilla_gorilla
ENSG00000284770	TBCE	97	97.059	ENSMFAG00000003983	-	100	93.080	Macaca_fascicularis
ENSG00000284770	TBCE	97	97.059	ENSMMUG00000008426	TBCE	100	86.577	Macaca_mulatta
ENSG00000284770	TBCE	97	95.935	ENSMLEG00000030382	-	100	92.734	Mandrillus_leucophaeus
ENSG00000284770	TBCE	100	96.194	ENSNLEG00000002823	-	100	96.194	Nomascus_leucogenys
ENSG00000284770	TBCE	100	100.000	ENSPPAG00000028683	-	100	99.308	Pan_paniscus
ENSG00000284770	TBCE	97	97.059	ENSPTRG00000002131	TBCE	100	93.276	Pan_troglodytes
ENSG00000284770	TBCE	97	97.059	ENSPANG00000021031	-	100	92.561	Papio_anubis
ENSG00000284770	TBCE	97	95.122	ENSRBIG00000033206	-	100	91.869	Rhinopithecus_bieti
ENSG00000284770	TBCE	97	95.122	ENSRROG00000010869	-	100	92.042	Rhinopithecus_roxellana

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000226	microtubule cytoskeleton organization	27666369.	IMP	Process
GO:0005515	protein binding	27666374.	IPI	Function
GO:0005737	cytoplasm	-	IEA	Component
GO:0005874	microtubule	8706133.	TAS	Component
GO:0006457	protein folding	8706133.	TAS	Process
GO:0007023	post-chaperonin tubulin folding pathway	11847227.	IDA	Process
GO:0007052	mitotic spindle organization	27666369.	IMP	Process
GO:0051087	chaperone binding	8706133.	TAS	Function