EuRBPDB

Description

RBDs

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Description

Ensembl ID: ENSGAGG00000013550 (Gene tree)
Gene ID: -
Gene Symbol: ARL4C
Alias: ARL7|LAK
Full Name: ADP ribosylation factor like GTPase 4C
Gene Type: protein_coding
Species: Gopherus_agassizii
Status: putative
Strand: Minus strand
Length: 579 bases
Position: chrPPEB01009956.1:519-1097
Accession: 698
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSGAGP00000018310	MMR_HSR1	PF01926.23	3.2e-07	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSGAGT00000020866	ARL4C-201	579	-	ENSGAGP00000018310	192 (aa)	-	-

Gene Model

Click here to download ENSGAGG00000013550's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSGAGG00000013550's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSGAGG00000013550	ARL4C	97	42.784	ENSGAGG00000019477	ARL11	97	42.784
ENSGAGG00000013550	ARL4C	89	41.040	ENSGAGG00000014554	-	75	41.040
ENSGAGG00000013550	ARL4C	91	45.810	ENSGAGG00000004417	-	96	45.810
ENSGAGG00000013550	ARL4C	100	66.332	ENSGAGG00000019544	ARL4A	99	66.332
ENSGAGG00000013550	ARL4C	100	56.784	ENSGAGG00000024318	ARL4D	99	56.784
ENSGAGG00000013550	ARL4C	78	36.000	ENSGAGG00000013245	ARL10	81	35.948
ENSGAGG00000013550	ARL4C	85	39.634	ENSGAGG00000013388	ARL5A	57	39.634
ENSGAGG00000013550	ARL4C	87	41.279	ENSGAGG00000011435	ARL5B	65	41.279
ENSGAGG00000013550	ARL4C	93	46.927	ENSGAGG00000000231	ARF5	96	46.927
ENSGAGG00000013550	ARL4C	88	39.080	ENSGAGG00000024365	ARL3	98	39.080
ENSGAGG00000013550	ARL4C	69	34.091	ENSGAGG00000013705	SAR1A	64	34.091
ENSGAGG00000013550	ARL4C	64	32.031	ENSGAGG00000018569	RAB22A	62	32.031
ENSGAGG00000013550	ARL4C	61	31.933	ENSGAGG00000023956	RAB1B	58	31.933
ENSGAGG00000013550	ARL4C	91	46.927	ENSGAGG00000001786	ARF1	96	46.927
ENSGAGG00000013550	ARL4C	61	31.933	ENSGAGG00000006802	RAB1A	57	31.933
ENSGAGG00000013550	ARL4C	86	33.523	ENSGAGG00000019506	ARFRP1	85	33.523
ENSGAGG00000013550	ARL4C	67	30.147	ENSGAGG00000004988	RAB14	60	30.147
ENSGAGG00000013550	ARL4C	69	33.333	ENSGAGG00000022935	SAR1B	64	33.333
ENSGAGG00000013550	ARL4C	100	43.005	ENSGAGG00000014586	ARL14	94	43.005
ENSGAGG00000013550	ARL4C	72	30.128	ENSGAGG00000022367	-	57	30.128
ENSGAGG00000013550	ARL4C	95	44.505	ENSGAGG00000010263	ARF4	98	44.505
ENSGAGG00000013550	ARL4C	88	34.302	ENSGAGG00000010966	ARL6	89	33.721
ENSGAGG00000013550	ARL4C	96	45.405	ENSGAGG00000017012	-	93	46.286

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSGAGG00000013550	ARL4C	100	96.875	ENSG00000188042	ARL4C	100	96.875	Homo_sapiens
ENSGAGG00000013550	ARL4C	100	93.750	ENSAPOG00000023273	arl4cb	100	93.750	Acanthochromis_polyacanthus
ENSGAGG00000013550	ARL4C	100	96.875	ENSAMEG00000016052	ARL4C	80	96.875	Ailuropoda_melanoleuca
ENSGAGG00000013550	ARL4C	100	94.271	ENSACIG00000000312	arl4cb	100	94.271	Amphilophus_citrinellus
ENSGAGG00000013550	ARL4C	91	84.091	ENSACIG00000024420	-	96	84.043	Amphilophus_citrinellus
ENSGAGG00000013550	ARL4C	100	93.750	ENSAPEG00000019862	arl4cb	100	93.750	Amphiprion_percula
ENSGAGG00000013550	ARL4C	100	83.938	ENSATEG00000013007	-	99	83.938	Anabas_testudineus
ENSGAGG00000013550	ARL4C	100	94.792	ENSATEG00000019469	arl4cb	100	94.792	Anabas_testudineus
ENSGAGG00000013550	ARL4C	100	95.312	ENSAPLG00000015708	ARL4C	100	95.312	Anas_platyrhynchos
ENSGAGG00000013550	ARL4C	100	96.354	ENSACAG00000010087	ARL4C	100	96.354	Anolis_carolinensis
ENSGAGG00000013550	ARL4C	100	96.875	ENSANAG00000038361	ARL4C	96	96.875	Aotus_nancymaae
ENSGAGG00000013550	ARL4C	100	93.750	ENSACLG00000014218	arl4cb	100	93.750	Astatotilapia_calliptera
ENSGAGG00000013550	ARL4C	94	83.978	ENSACLG00000014159	-	99	83.938	Astatotilapia_calliptera
ENSGAGG00000013550	ARL4C	100	92.708	ENSAMXG00000024926	arl4cb	100	92.708	Astyanax_mexicanus
ENSGAGG00000013550	ARL4C	99	70.000	ENSAMXG00000024897	-	98	70.000	Astyanax_mexicanus
ENSGAGG00000013550	ARL4C	100	96.875	ENSCJAG00000042179	ARL4C	96	96.875	Callithrix_jacchus
ENSGAGG00000013550	ARL4C	93	96.648	ENSCAFG00000012001	ARL4C	99	96.648	Canis_familiaris
ENSGAGG00000013550	ARL4C	100	96.875	ENSCAFG00020024408	ARL4C	100	96.875	Canis_lupus_dingo
ENSGAGG00000013550	ARL4C	100	96.875	ENSCHIG00000008457	ARL4C	100	96.875	Capra_hircus
ENSGAGG00000013550	ARL4C	100	96.875	ENSTSYG00000033922	ARL4C	96	96.875	Carlito_syrichta
ENSGAGG00000013550	ARL4C	100	96.875	ENSCCAG00000024558	ARL4C	96	96.875	Cebus_capucinus
ENSGAGG00000013550	ARL4C	100	96.875	ENSCATG00000041801	ARL4C	95	96.875	Cercocebus_atys
ENSGAGG00000013550	ARL4C	100	96.875	ENSCLAG00000010525	ARL4C	99	96.875	Chinchilla_lanigera
ENSGAGG00000013550	ARL4C	100	96.875	ENSCSAG00000018795	ARL4C	100	96.875	Chlorocebus_sabaeus
ENSGAGG00000013550	ARL4C	100	99.479	ENSCPBG00000024707	ARL4C	100	99.479	Chrysemys_picta_bellii
ENSGAGG00000013550	ARL4C	100	96.875	ENSCANG00000035065	ARL4C	95	96.875	Colobus_angolensis_palliatus
ENSGAGG00000013550	ARL4C	100	96.875	ENSCGRG00001010866	Arl4c	100	96.875	Cricetulus_griseus_chok1gshd
ENSGAGG00000013550	ARL4C	100	96.875	ENSCGRG00000018449	Arl4c	100	96.875	Cricetulus_griseus_crigri
ENSGAGG00000013550	ARL4C	97	82.888	ENSCSEG00000005387	-	98	82.888	Cynoglossus_semilaevis
ENSGAGG00000013550	ARL4C	100	91.667	ENSCSEG00000000838	arl4cb	89	91.667	Cynoglossus_semilaevis
ENSGAGG00000013550	ARL4C	99	94.241	ENSCVAG00000020902	arl4cb	99	94.241	Cyprinodon_variegatus
ENSGAGG00000013550	ARL4C	100	81.865	ENSCVAG00000023139	-	99	81.865	Cyprinodon_variegatus
ENSGAGG00000013550	ARL4C	100	93.229	ENSDARG00000057606	arl4ca	100	93.229	Danio_rerio
ENSGAGG00000013550	ARL4C	100	92.708	ENSDARG00000032708	arl4cb	100	92.708	Danio_rerio
ENSGAGG00000013550	ARL4C	100	96.875	ENSDNOG00000045362	ARL4C	100	96.875	Dasypus_novemcinctus
ENSGAGG00000013550	ARL4C	100	96.875	ENSDORG00000028955	Arl4c	100	96.875	Dipodomys_ordii
ENSGAGG00000013550	ARL4C	79	65.132	ENSEBUG00000004741	arl4cb	74	65.132	Eptatretus_burgeri
ENSGAGG00000013550	ARL4C	100	96.875	ENSEASG00005019989	ARL4C	100	96.875	Equus_asinus_asinus
ENSGAGG00000013550	ARL4C	99	96.316	ENSEEUG00000012728	ARL4C	100	96.316	Erinaceus_europaeus
ENSGAGG00000013550	ARL4C	96	95.109	ENSELUG00000015699	arl4ca	97	95.109	Esox_lucius
ENSGAGG00000013550	ARL4C	100	93.750	ENSELUG00000004400	arl4cb	100	93.750	Esox_lucius
ENSGAGG00000013550	ARL4C	100	96.875	ENSFCAG00000033226	ARL4C	95	96.875	Felis_catus
ENSGAGG00000013550	ARL4C	100	97.396	ENSFALG00000015098	ARL4C	100	97.396	Ficedula_albicollis
ENSGAGG00000013550	ARL4C	100	96.875	ENSFDAG00000000777	ARL4C	100	96.875	Fukomys_damarensis
ENSGAGG00000013550	ARL4C	100	80.311	ENSFHEG00000013017	-	99	80.311	Fundulus_heteroclitus
ENSGAGG00000013550	ARL4C	100	94.271	ENSFHEG00000009894	arl4cb	97	94.271	Fundulus_heteroclitus
ENSGAGG00000013550	ARL4C	100	94.792	ENSGMOG00000020467	arl4cb	100	94.792	Gadus_morhua
ENSGAGG00000013550	ARL4C	91	97.143	ENSGALG00000052743	ARL4C	100	97.143	Gallus_gallus
ENSGAGG00000013550	ARL4C	100	95.312	ENSGAFG00000020556	arl4cb	99	95.312	Gambusia_affinis
ENSGAGG00000013550	ARL4C	100	94.271	ENSGACG00000008143	arl4cb	100	94.271	Gasterosteus_aculeatus
ENSGAGG00000013550	ARL4C	100	96.875	ENSGGOG00000023462	ARL4C	96	96.875	Gorilla_gorilla
ENSGAGG00000013550	ARL4C	100	93.750	ENSHBUG00000002490	arl4cb	100	93.750	Haplochromis_burtoni
ENSGAGG00000013550	ARL4C	94	83.978	ENSHBUG00000009561	-	99	83.938	Haplochromis_burtoni
ENSGAGG00000013550	ARL4C	100	96.875	ENSHGLG00000020294	ARL4C	100	96.875	Heterocephalus_glaber_female
ENSGAGG00000013550	ARL4C	97	81.915	ENSHCOG00000008233	arl4cb	94	81.915	Hippocampus_comes
ENSGAGG00000013550	ARL4C	100	78.646	ENSIPUG00000006298	-	100	78.646	Ictalurus_punctatus
ENSGAGG00000013550	ARL4C	100	92.708	ENSIPUG00000002122	arl4cb	100	92.708	Ictalurus_punctatus
ENSGAGG00000013550	ARL4C	100	96.875	ENSSTOG00000023217	ARL4C	100	96.875	Ictidomys_tridecemlineatus
ENSGAGG00000013550	ARL4C	100	96.354	ENSJJAG00000010006	Arl4c	100	96.354	Jaculus_jaculus
ENSGAGG00000013550	ARL4C	100	94.792	ENSKMAG00000011334	arl4cb	100	94.792	Kryptolebias_marmoratus
ENSGAGG00000013550	ARL4C	100	95.312	ENSLBEG00000012677	arl4cb	100	95.312	Labrus_bergylta
ENSGAGG00000013550	ARL4C	100	83.420	ENSLBEG00000010335	-	99	83.420	Labrus_bergylta
ENSGAGG00000013550	ARL4C	100	93.229	ENSLACG00000015350	ARL4C	96	93.229	Latimeria_chalumnae
ENSGAGG00000013550	ARL4C	100	93.750	ENSLOCG00000017842	arl4cb	98	93.750	Lepisosteus_oculatus
ENSGAGG00000013550	ARL4C	100	96.875	ENSLAFG00000028097	ARL4C	100	96.875	Loxodonta_africana
ENSGAGG00000013550	ARL4C	100	96.875	ENSMFAG00000045232	ARL4C	95	96.875	Macaca_fascicularis
ENSGAGG00000013550	ARL4C	100	96.875	ENSMMUG00000011516	ARL4C	100	96.875	Macaca_mulatta
ENSGAGG00000013550	ARL4C	100	96.875	ENSMNEG00000031224	ARL4C	95	96.875	Macaca_nemestrina
ENSGAGG00000013550	ARL4C	100	96.875	ENSMLEG00000027620	ARL4C	95	96.875	Mandrillus_leucophaeus
ENSGAGG00000013550	ARL4C	100	94.271	ENSMAMG00000013367	arl4cb	100	94.271	Mastacembelus_armatus
ENSGAGG00000013550	ARL4C	100	84.456	ENSMAMG00000022482	-	97	84.456	Mastacembelus_armatus
ENSGAGG00000013550	ARL4C	100	93.750	ENSMZEG00005020500	arl4cb	100	93.750	Maylandia_zebra
ENSGAGG00000013550	ARL4C	90	97.093	ENSMGAG00000016127	ARL4C	99	97.093	Meleagris_gallopavo
ENSGAGG00000013550	ARL4C	100	96.875	ENSMICG00000017503	ARL4C	94	96.875	Microcebus_murinus
ENSGAGG00000013550	ARL4C	100	96.875	ENSMOCG00000006232	Arl4c	100	96.875	Microtus_ochrogaster
ENSGAGG00000013550	ARL4C	100	96.875	ENSMODG00000023112	ARL4C	100	96.875	Monodelphis_domestica
ENSGAGG00000013550	ARL4C	100	92.708	ENSMALG00000011378	arl4cb	100	92.708	Monopterus_albus
ENSGAGG00000013550	ARL4C	100	84.974	ENSMALG00000006786	-	97	84.974	Monopterus_albus
ENSGAGG00000013550	ARL4C	100	96.875	MGP_CAROLIEiJ_G0014402	Arl4c	100	96.875	Mus_caroli
ENSGAGG00000013550	ARL4C	100	96.875	ENSMUSG00000049866	Arl4c	100	96.875	Mus_musculus
ENSGAGG00000013550	ARL4C	100	96.875	MGP_PahariEiJ_G0027638	Arl4c	100	96.875	Mus_pahari
ENSGAGG00000013550	ARL4C	100	96.875	MGP_SPRETEiJ_G0015206	Arl4c	100	96.875	Mus_spretus
ENSGAGG00000013550	ARL4C	100	96.875	ENSMPUG00000019267	ARL4C	100	96.875	Mustela_putorius_furo
ENSGAGG00000013550	ARL4C	100	96.875	ENSNGAG00000012405	Arl4c	100	96.875	Nannospalax_galili
ENSGAGG00000013550	ARL4C	97	94.652	ENSNBRG00000020745	arl4cb	94	94.652	Neolamprologus_brichardi
ENSGAGG00000013550	ARL4C	92	84.270	ENSNBRG00000015182	-	96	84.211	Neolamprologus_brichardi
ENSGAGG00000013550	ARL4C	100	96.354	ENSMEUG00000006551	ARL4C	96	96.354	Notamacropus_eugenii
ENSGAGG00000013550	ARL4C	100	96.875	ENSODEG00000019668	ARL4C	100	96.875	Octodon_degus
ENSGAGG00000013550	ARL4C	94	83.978	ENSONIG00000021039	arl4ca	98	83.938	Oreochromis_niloticus
ENSGAGG00000013550	ARL4C	99	96.316	ENSOANG00000011765	ARL4C	99	96.316	Ornithorhynchus_anatinus
ENSGAGG00000013550	ARL4C	100	96.875	ENSOCUG00000005758	ARL4C	100	96.875	Oryctolagus_cuniculus
ENSGAGG00000013550	ARL4C	100	94.792	ENSORLG00000013843	arl4cb	100	94.792	Oryzias_latipes
ENSGAGG00000013550	ARL4C	88	67.059	ENSORLG00000026726	-	95	65.556	Oryzias_latipes
ENSGAGG00000013550	ARL4C	100	94.792	ENSORLG00020007137	arl4cb	100	94.792	Oryzias_latipes_hni
ENSGAGG00000013550	ARL4C	88	67.647	ENSORLG00020011692	-	95	66.111	Oryzias_latipes_hni
ENSGAGG00000013550	ARL4C	100	94.792	ENSORLG00015009897	arl4cb	100	94.792	Oryzias_latipes_hsok
ENSGAGG00000013550	ARL4C	90	67.630	ENSORLG00015014008	-	97	65.574	Oryzias_latipes_hsok
ENSGAGG00000013550	ARL4C	100	94.792	ENSOMEG00000007253	arl4cb	100	94.792	Oryzias_melastigma
ENSGAGG00000013550	ARL4C	100	96.875	ENSOGAG00000034868	ARL4C	100	96.875	Otolemur_garnettii
ENSGAGG00000013550	ARL4C	100	93.229	ENSOARG00000025194	ARL4C	100	93.229	Ovis_aries
ENSGAGG00000013550	ARL4C	100	96.875	ENSPPAG00000002191	ARL4C	100	96.875	Pan_paniscus
ENSGAGG00000013550	ARL4C	100	96.875	ENSPPRG00000016572	ARL4C	100	96.875	Panthera_pardus
ENSGAGG00000013550	ARL4C	100	96.875	ENSPTIG00000011404	ARL4C	95	96.875	Panthera_tigris_altaica
ENSGAGG00000013550	ARL4C	100	96.875	ENSPTRG00000013065	ARL4C	96	96.875	Pan_troglodytes
ENSGAGG00000013550	ARL4C	100	96.875	ENSPANG00000006874	ARL4C	96	96.875	Papio_anubis
ENSGAGG00000013550	ARL4C	100	92.188	ENSPKIG00000020450	arl4cb	100	92.188	Paramormyrops_kingsleyae
ENSGAGG00000013550	ARL4C	100	93.750	ENSPKIG00000008422	ARL4C	100	93.750	Paramormyrops_kingsleyae
ENSGAGG00000013550	ARL4C	95	78.689	ENSPMGG00000014369	-	93	78.689	Periophthalmus_magnuspinnatus
ENSGAGG00000013550	ARL4C	100	96.875	ENSPEMG00000006610	Arl4c	100	96.875	Peromyscus_maniculatus_bairdii
ENSGAGG00000013550	ARL4C	100	96.354	ENSPCIG00000003836	ARL4C	100	96.354	Phascolarctos_cinereus
ENSGAGG00000013550	ARL4C	94	95.556	ENSPFOG00000020283	arl4cb	99	94.792	Poecilia_formosa
ENSGAGG00000013550	ARL4C	94	95.556	ENSPLAG00000007735	arl4cb	99	94.792	Poecilia_latipinna
ENSGAGG00000013550	ARL4C	91	96.571	ENSPMEG00000007028	arl4cb	94	95.722	Poecilia_mexicana
ENSGAGG00000013550	ARL4C	100	80.829	ENSPREG00000021699	-	100	80.829	Poecilia_reticulata
ENSGAGG00000013550	ARL4C	100	95.833	ENSPREG00000015645	arl4cb	99	95.833	Poecilia_reticulata
ENSGAGG00000013550	ARL4C	100	96.875	ENSPPYG00000013299	ARL4C	96	96.875	Pongo_abelii
ENSGAGG00000013550	ARL4C	100	96.875	ENSPCOG00000028187	ARL4C	94	96.875	Propithecus_coquereli
ENSGAGG00000013550	ARL4C	100	93.750	ENSPNYG00000012693	arl4cb	100	93.750	Pundamilia_nyererei
ENSGAGG00000013550	ARL4C	94	82.162	ENSPNYG00000021646	-	99	82.234	Pundamilia_nyererei
ENSGAGG00000013550	ARL4C	100	69.271	ENSPNAG00000022337	-	100	69.271	Pygocentrus_nattereri
ENSGAGG00000013550	ARL4C	100	92.188	ENSPNAG00000028458	arl4cb	100	92.188	Pygocentrus_nattereri
ENSGAGG00000013550	ARL4C	100	96.875	ENSRBIG00000032960	-	95	96.875	Rhinopithecus_bieti
ENSGAGG00000013550	ARL4C	100	96.875	ENSRROG00000029871	ARL4C	95	96.875	Rhinopithecus_roxellana
ENSGAGG00000013550	ARL4C	100	96.875	ENSSBOG00000033162	ARL4C	96	96.875	Saimiri_boliviensis_boliviensis
ENSGAGG00000013550	ARL4C	97	95.187	ENSSFOG00015018615	ARL4C	95	95.187	Scleropages_formosus
ENSGAGG00000013550	ARL4C	98	95.238	ENSSFOG00015007064	arl4cb	95	95.238	Scleropages_formosus
ENSGAGG00000013550	ARL4C	100	83.938	ENSSMAG00000013072	-	99	83.938	Scophthalmus_maximus
ENSGAGG00000013550	ARL4C	100	91.667	ENSSMAG00000016399	arl4cb	100	91.667	Scophthalmus_maximus
ENSGAGG00000013550	ARL4C	100	94.271	ENSSDUG00000012868	arl4cb	100	94.271	Seriola_dumerili
ENSGAGG00000013550	ARL4C	100	94.271	ENSSLDG00000017889	arl4cb	100	94.271	Seriola_lalandi_dorsalis
ENSGAGG00000013550	ARL4C	100	84.456	ENSSLDG00000012103	-	97	84.456	Seriola_lalandi_dorsalis
ENSGAGG00000013550	ARL4C	97	84.574	ENSSPAG00000022062	-	94	84.574	Stegastes_partitus
ENSGAGG00000013550	ARL4C	97	95.699	ENSSPAG00000010587	arl4cb	94	95.722	Stegastes_partitus
ENSGAGG00000013550	ARL4C	100	96.875	ENSSSCG00000034293	ARL4C	100	96.875	Sus_scrofa
ENSGAGG00000013550	ARL4C	100	97.396	ENSTGUG00000003095	ARL4C	100	97.396	Taeniopygia_guttata
ENSGAGG00000013550	ARL4C	100	93.229	ENSTRUG00000003085	arl4cb	100	93.229	Takifugu_rubripes
ENSGAGG00000013550	ARL4C	94	82.320	ENSTRUG00000003183	-	99	82.383	Takifugu_rubripes
ENSGAGG00000013550	ARL4C	94	77.901	ENSTNIG00000003426	-	96	78.238	Tetraodon_nigroviridis
ENSGAGG00000013550	ARL4C	100	96.875	ENSUAMG00000007888	ARL4C	100	96.875	Ursus_americanus
ENSGAGG00000013550	ARL4C	96	84.783	ENSUMAG00000013306	ARL4C	87	84.783	Ursus_maritimus
ENSGAGG00000013550	ARL4C	100	96.875	ENSVVUG00000025311	ARL4C	100	96.875	Vulpes_vulpes
ENSGAGG00000013550	ARL4C	100	92.188	ENSXETG00000010915	arl4c	99	92.188	Xenopus_tropicalis
ENSGAGG00000013550	ARL4C	100	94.792	ENSXCOG00000016119	arl4cb	96	94.792	Xiphophorus_couchianus
ENSGAGG00000013550	ARL4C	96	83.243	ENSXCOG00000003923	-	91	83.243	Xiphophorus_couchianus
ENSGAGG00000013550	ARL4C	95	82.514	ENSXMAG00000000086	-	93	82.514	Xiphophorus_maculatus
ENSGAGG00000013550	ARL4C	98	95.238	ENSXMAG00000020364	arl4cb	96	95.238	Xiphophorus_maculatus