EuRBPDB

Description

RBDs

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Description

Ensembl ID: ENSMMOG00000008348 (Gene tree)
Gene ID: -
Gene Symbol: msi2a
Alias: cb746|fi47b09|msi2|wu:fb02d08|wu:fi32d12|wu:fi47b09
Full Name: musashi RNA-binding protein 2a
Gene Type: protein_coding
Species: Mola_mola
Status: putative
Strand: Plus strand
Length: 236163 bases
Position: chrKV751332.1:2393458-2629620
Accession: ZDB-GENE-030826-25
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSMMOP00000011296	RRM_1	PF00076.22	6e-33	1	2
ENSMMOP00000011296	RRM_1	PF00076.22	6e-33	2	2
ENSMMOP00000011293	RRM_1	PF00076.22	7.1e-33	1	2
ENSMMOP00000011293	RRM_1	PF00076.22	7.1e-33	2	2
ENSMMOP00000011231	RRM_1	PF00076.22	5.5e-29	1	2
ENSMMOP00000011231	RRM_1	PF00076.22	5.5e-29	2	2
ENSMMOP00000011252	RRM_1	PF00076.22	8.6e-23	1	2
ENSMMOP00000011252	RRM_1	PF00076.22	8.6e-23	2	2
ENSMMOP00000011305	RRM_1	PF00076.22	7.9e-05	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSMMOT00000011488	-	1053	-	ENSMMOP00000011293	350 (aa)	-	-
ENSMMOT00000011491	-	975	-	ENSMMOP00000011296	324 (aa)	-	-
ENSMMOT00000011427	-	1080	-	ENSMMOP00000011231	359 (aa)	-	-
ENSMMOT00000011448	-	462	-	ENSMMOP00000011252	153 (aa)	-	-
ENSMMOT00000011501	-	693	-	ENSMMOP00000011305	230 (aa)	-	-

Gene Model

Click here to download ENSMMOG00000008348's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSMMOG00000008348's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSMMOG00000008348	msi2a	78	49.167	ENSMMOG00000008627	hnrnpd	52	48.810
ENSMMOG00000008348	msi2a	83	38.760	ENSMMOG00000008251	hnrnpa1a	80	38.798
ENSMMOG00000008348	msi2a	92	41.270	ENSMMOG00000004165	HNRNPAB	80	41.270
ENSMMOG00000008348	msi2a	86	39.583	ENSMMOG00000000540	HNRNPA3	64	40.698
ENSMMOG00000008348	msi2a	83	80.315	ENSMMOG00000010492	MSI1	92	77.828
ENSMMOG00000008348	msi2a	80	36.047	ENSMMOG00000012104	-	52	36.047
ENSMMOG00000008348	msi2a	90	75.182	ENSMMOG00000012265	-	94	68.621
ENSMMOG00000008348	msi2a	78	42.857	ENSMMOG00000001750	rbm24b	66	42.857
ENSMMOG00000008348	msi2a	83	37.705	ENSMMOG00000004242	-	98	34.211
ENSMMOG00000008348	msi2a	83	37.209	ENSMMOG00000004241	-	95	39.344
ENSMMOG00000008348	msi2a	89	41.912	ENSMMOG00000016852	-	67	46.196
ENSMMOG00000008348	msi2a	58	46.512	ENSMMOG00000008822	-	81	49.020

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSMMOG00000008348	msi2a	91	84.858	ENSG00000153944	MSI2	99	88.889	Homo_sapiens
ENSMMOG00000008348	msi2a	90	100.000	ENSAPOG00000001658	msi2a	96	93.827	Acanthochromis_polyacanthus
ENSMMOG00000008348	msi2a	91	82.675	ENSAMEG00000002697	MSI2	96	81.515	Ailuropoda_melanoleuca
ENSMMOG00000008348	msi2a	90	100.000	ENSACIG00000009475	msi2a	72	98.113	Amphilophus_citrinellus
ENSMMOG00000008348	msi2a	95	86.395	ENSAOCG00000014822	msi2a	81	87.500	Amphiprion_ocellaris
ENSMMOG00000008348	msi2a	90	100.000	ENSAPEG00000007706	msi2a	96	87.500	Amphiprion_percula
ENSMMOG00000008348	msi2a	91	84.028	ENSATEG00000003301	-	95	83.712	Anabas_testudineus
ENSMMOG00000008348	msi2a	90	100.000	ENSATEG00000010498	msi2a	96	93.827	Anabas_testudineus
ENSMMOG00000008348	msi2a	85	94.022	ENSACAG00000005452	MSI2	63	89.950	Anolis_carolinensis
ENSMMOG00000008348	msi2a	91	84.858	ENSANAG00000037827	MSI2	99	88.492	Aotus_nancymaae
ENSMMOG00000008348	msi2a	90	100.000	ENSACLG00000007752	msi2a	96	93.416	Astatotilapia_calliptera
ENSMMOG00000008348	msi2a	90	95.620	ENSAMXG00000010474	msi2b	92	92.661	Astyanax_mexicanus
ENSMMOG00000008348	msi2a	89	91.139	ENSAMXG00000032796	msi2a	94	83.871	Astyanax_mexicanus
ENSMMOG00000008348	msi2a	97	84.345	ENSBTAG00000004406	MSI2	96	83.923	Bos_taurus
ENSMMOG00000008348	msi2a	76	71.552	WBGene00003423	msi-1	67	71.552	Caenorhabditis_elegans
ENSMMOG00000008348	msi2a	91	84.858	ENSCJAG00000013998	MSI2	99	88.492	Callithrix_jacchus
ENSMMOG00000008348	msi2a	91	82.372	ENSCAFG00020025620	MSI2	71	91.628	Canis_lupus_dingo
ENSMMOG00000008348	msi2a	91	85.174	ENSCHIG00000016580	MSI2	90	85.034	Capra_hircus
ENSMMOG00000008348	msi2a	91	79.795	ENSCPOG00000034042	MSI2	95	79.182	Cavia_porcellus
ENSMMOG00000008348	msi2a	91	84.858	ENSCCAG00000033927	MSI2	99	88.492	Cebus_capucinus
ENSMMOG00000008348	msi2a	91	84.858	ENSCATG00000040879	MSI2	99	88.492	Cercocebus_atys
ENSMMOG00000008348	msi2a	90	84.211	ENSCLAG00000014325	MSI2	90	81.459	Chinchilla_lanigera
ENSMMOG00000008348	msi2a	91	84.858	ENSCSAG00000005633	MSI2	90	84.694	Chlorocebus_sabaeus
ENSMMOG00000008348	msi2a	90	64.516	ENSCHOG00000008660	MSI2	83	82.000	Choloepus_hoffmanni
ENSMMOG00000008348	msi2a	85	94.505	ENSCPBG00000009942	MSI2	85	91.534	Chrysemys_picta_bellii
ENSMMOG00000008348	msi2a	76	83.333	ENSCING00000018579	-	90	51.707	Ciona_intestinalis
ENSMMOG00000008348	msi2a	83	63.235	ENSCSAVG00000010397	-	94	53.642	Ciona_savignyi
ENSMMOG00000008348	msi2a	90	83.942	ENSCANG00000036414	MSI2	99	88.492	Colobus_angolensis_palliatus
ENSMMOG00000008348	msi2a	91	84.591	ENSCGRG00001013330	Msi2	90	84.407	Cricetulus_griseus_chok1gshd
ENSMMOG00000008348	msi2a	92	82.090	ENSCGRG00000003141	Msi2	96	80.952	Cricetulus_griseus_crigri
ENSMMOG00000008348	msi2a	89	67.157	ENSCSEG00000013557	msi2a	77	76.667	Cynoglossus_semilaevis
ENSMMOG00000008348	msi2a	91	75.325	ENSCSEG00000003266	-	96	67.416	Cynoglossus_semilaevis
ENSMMOG00000008348	msi2a	90	86.029	ENSCSEG00000013549	msi2a	100	69.399	Cynoglossus_semilaevis
ENSMMOG00000008348	msi2a	90	100.000	ENSCVAG00000017075	msi2a	96	90.741	Cyprinodon_variegatus
ENSMMOG00000008348	msi2a	89	88.608	ENSDARG00000033901	msi2a	96	76.203	Danio_rerio
ENSMMOG00000008348	msi2a	84	96.380	ENSDARG00000032614	msi2b	100	97.030	Danio_rerio
ENSMMOG00000008348	msi2a	91	84.564	ENSDNOG00000014501	MSI2	95	84.364	Dasypus_novemcinctus
ENSMMOG00000008348	msi2a	87	69.118	ENSDORG00000005394	Msi2	82	68.780	Dipodomys_ordii
ENSMMOG00000008348	msi2a	83	88.182	ENSDORG00000028440	-	100	94.690	Dipodomys_ordii
ENSMMOG00000008348	msi2a	76	83.333	FBgn0260943	Rbp6	92	63.576	Drosophila_melanogaster
ENSMMOG00000008348	msi2a	75	96.667	ENSETEG00000012450	-	64	72.368	Echinops_telfairi
ENSMMOG00000008348	msi2a	86	74.809	ENSEBUG00000006732	msi2a	83	65.772	Eptatretus_burgeri
ENSMMOG00000008348	msi2a	97	86.207	ENSEASG00005002965	MSI2	96	77.901	Equus_asinus_asinus
ENSMMOG00000008348	msi2a	92	82.530	ENSECAG00000011435	MSI2	90	81.459	Equus_caballus
ENSMMOG00000008348	msi2a	83	79.275	ENSEEUG00000007810	MSI2	100	69.675	Erinaceus_europaeus
ENSMMOG00000008348	msi2a	90	97.080	ENSELUG00000011747	msi2a	96	81.977	Esox_lucius
ENSMMOG00000008348	msi2a	90	95.652	ENSELUG00000001361	msi2b	96	80.580	Esox_lucius
ENSMMOG00000008348	msi2a	91	84.858	ENSFCAG00000041686	MSI2	99	88.492	Felis_catus
ENSMMOG00000008348	msi2a	90	75.342	ENSFCAG00000033787	-	80	75.342	Felis_catus
ENSMMOG00000008348	msi2a	91	82.622	ENSFDAG00000016118	MSI2	96	81.459	Fukomys_damarensis
ENSMMOG00000008348	msi2a	90	100.000	ENSFHEG00000000084	msi2a	96	90.066	Fundulus_heteroclitus
ENSMMOG00000008348	msi2a	86	82.692	ENSGMOG00000007596	-	100	82.692	Gadus_morhua
ENSMMOG00000008348	msi2a	91	82.317	ENSGALG00000005567	MSI2	90	81.155	Gallus_gallus
ENSMMOG00000008348	msi2a	95	95.205	ENSGAFG00000006974	msi2a	90	90.066	Gambusia_affinis
ENSMMOG00000008348	msi2a	85	95.050	ENSGAGG00000016542	MSI2	96	81.333	Gopherus_agassizii
ENSMMOG00000008348	msi2a	90	83.942	ENSGGOG00000013182	MSI2	99	88.889	Gorilla_gorilla
ENSMMOG00000008348	msi2a	90	100.000	ENSHBUG00000020800	msi2a	96	93.416	Haplochromis_burtoni
ENSMMOG00000008348	msi2a	96	68.802	ENSHGLG00000012444	MSI2	96	66.389	Heterocephalus_glaber_female
ENSMMOG00000008348	msi2a	83	88.288	ENSHGLG00100004028	-	87	94.737	Heterocephalus_glaber_male
ENSMMOG00000008348	msi2a	82	71.795	ENSHGLG00100003744	MSI2	94	74.408	Heterocephalus_glaber_male
ENSMMOG00000008348	msi2a	83	86.124	ENSHCOG00000017241	-	80	77.455	Hippocampus_comes
ENSMMOG00000008348	msi2a	85	98.643	ENSHCOG00000000266	msi2a	96	86.464	Hippocampus_comes
ENSMMOG00000008348	msi2a	90	93.431	ENSIPUG00000021097	msi2a	95	88.889	Ictalurus_punctatus
ENSMMOG00000008348	msi2a	85	95.928	ENSIPUG00000003732	msi2b	86	85.811	Ictalurus_punctatus
ENSMMOG00000008348	msi2a	91	79.795	ENSSTOG00000007884	MSI2	95	79.182	Ictidomys_tridecemlineatus
ENSMMOG00000008348	msi2a	83	88.182	ENSJJAG00000009467	-	100	94.690	Jaculus_jaculus
ENSMMOG00000008348	msi2a	82	74.468	ENSJJAG00000006292	-	93	74.731	Jaculus_jaculus
ENSMMOG00000008348	msi2a	90	99.270	ENSKMAG00000009494	msi2a	90	91.156	Kryptolebias_marmoratus
ENSMMOG00000008348	msi2a	83	86.275	ENSLBEG00000026223	-	96	64.634	Labrus_bergylta
ENSMMOG00000008348	msi2a	93	99.160	ENSLBEG00000007061	msi2a	96	85.507	Labrus_bergylta
ENSMMOG00000008348	msi2a	76	92.754	ENSLACG00000016798	MSI2	100	90.099	Latimeria_chalumnae
ENSMMOG00000008348	msi2a	84	96.380	ENSLOCG00000004675	msi2b	96	79.088	Lepisosteus_oculatus
ENSMMOG00000008348	msi2a	90	83.942	ENSMFAG00000003775	MSI2	99	88.492	Macaca_fascicularis
ENSMMOG00000008348	msi2a	90	83.942	ENSMMUG00000002069	MSI2	99	88.492	Macaca_mulatta
ENSMMOG00000008348	msi2a	91	84.858	ENSMNEG00000045275	MSI2	99	88.492	Macaca_nemestrina
ENSMMOG00000008348	msi2a	90	83.942	ENSMLEG00000033888	MSI2	99	88.492	Mandrillus_leucophaeus
ENSMMOG00000008348	msi2a	90	100.000	ENSMAMG00000010503	msi2a	96	93.827	Mastacembelus_armatus
ENSMMOG00000008348	msi2a	90	93.431	ENSMAMG00000002488	-	99	84.106	Mastacembelus_armatus
ENSMMOG00000008348	msi2a	90	100.000	ENSMZEG00005007676	msi2a	96	90.741	Maylandia_zebra
ENSMMOG00000008348	msi2a	90	83.553	ENSMAUG00000003862	Msi2	90	81.212	Mesocricetus_auratus
ENSMMOG00000008348	msi2a	94	83.030	ENSMICG00000013598	-	99	88.492	Microcebus_murinus
ENSMMOG00000008348	msi2a	90	75.000	ENSMICG00000032913	-	94	65.569	Microcebus_murinus
ENSMMOG00000008348	msi2a	91	82.622	ENSMOCG00000005820	Msi2	90	81.459	Microtus_ochrogaster
ENSMMOG00000008348	msi2a	82	71.795	ENSMODG00000014790	MSI2	94	74.408	Monodelphis_domestica
ENSMMOG00000008348	msi2a	90	100.000	ENSMALG00000000071	msi2a	96	93.827	Monopterus_albus
ENSMMOG00000008348	msi2a	91	84.858	MGP_CAROLIEiJ_G0016948	Msi2	100	94.690	Mus_caroli
ENSMMOG00000008348	msi2a	91	84.858	ENSMUSG00000069769	Msi2	100	94.690	Mus_musculus
ENSMMOG00000008348	msi2a	91	84.858	MGP_PahariEiJ_G0018079	Msi2	100	94.690	Mus_pahari
ENSMMOG00000008348	msi2a	91	84.858	MGP_SPRETEiJ_G0017795	Msi2	100	94.690	Mus_spretus
ENSMMOG00000008348	msi2a	95	84.516	ENSMPUG00000015377	MSI2	96	84.244	Mustela_putorius_furo
ENSMMOG00000008348	msi2a	95	83.871	ENSMLUG00000007865	MSI2	96	83.601	Myotis_lucifugus
ENSMMOG00000008348	msi2a	91	82.622	ENSNGAG00000017807	Msi2	90	81.459	Nannospalax_galili
ENSMMOG00000008348	msi2a	90	100.000	ENSNBRG00000014596	msi2a	92	90.132	Neolamprologus_brichardi
ENSMMOG00000008348	msi2a	91	82.428	ENSNLEG00000008059	MSI2	99	89.545	Nomascus_leucogenys
ENSMMOG00000008348	msi2a	75	98.387	ENSOPRG00000000872	-	64	83.553	Ochotona_princeps
ENSMMOG00000008348	msi2a	90	84.211	ENSODEG00000011974	MSI2	90	81.459	Octodon_degus
ENSMMOG00000008348	msi2a	100	83.626	ENSONIG00000001972	msi2a	95	83.626	Oreochromis_niloticus
ENSMMOG00000008348	msi2a	88	91.845	ENSOANG00000005667	MSI2	76	88.506	Ornithorhynchus_anatinus
ENSMMOG00000008348	msi2a	95	84.516	ENSOCUG00000010440	MSI2	96	84.244	Oryctolagus_cuniculus
ENSMMOG00000008348	msi2a	90	94.161	ENSORLG00000009671	msi2a	97	93.827	Oryzias_latipes
ENSMMOG00000008348	msi2a	90	99.160	ENSORLG00020021556	msi2a	96	93.827	Oryzias_latipes_hni
ENSMMOG00000008348	msi2a	90	94.161	ENSORLG00015004592	msi2a	97	93.827	Oryzias_latipes_hsok
ENSMMOG00000008348	msi2a	84	99.095	ENSOMEG00000000146	msi2a	96	93.827	Oryzias_melastigma
ENSMMOG00000008348	msi2a	91	81.447	ENSOGAG00000005621	MSI2	96	81.017	Otolemur_garnettii
ENSMMOG00000008348	msi2a	90	83.942	ENSPPAG00000037697	MSI2	99	88.889	Pan_paniscus
ENSMMOG00000008348	msi2a	91	84.858	ENSPPRG00000001848	MSI2	99	88.492	Panthera_pardus
ENSMMOG00000008348	msi2a	85	69.784	ENSPTIG00000021873	-	95	71.429	Panthera_tigris_altaica
ENSMMOG00000008348	msi2a	91	82.428	ENSPTIG00000021678	MSI2	87	89.545	Panthera_tigris_altaica
ENSMMOG00000008348	msi2a	90	83.942	ENSPTRG00000009437	MSI2	99	88.889	Pan_troglodytes
ENSMMOG00000008348	msi2a	91	84.858	ENSPANG00000022319	MSI2	99	88.492	Papio_anubis
ENSMMOG00000008348	msi2a	90	92.701	ENSPKIG00000007038	-	92	86.831	Paramormyrops_kingsleyae
ENSMMOG00000008348	msi2a	77	79.121	ENSPKIG00000017107	-	81	79.121	Paramormyrops_kingsleyae
ENSMMOG00000008348	msi2a	85	94.570	ENSPSIG00000008618	MSI2	75	88.845	Pelodiscus_sinensis
ENSMMOG00000008348	msi2a	90	100.000	ENSPMGG00000005888	msi2a	96	84.928	Periophthalmus_magnuspinnatus
ENSMMOG00000008348	msi2a	83	88.182	ENSPEMG00000021793	-	100	94.690	Peromyscus_maniculatus_bairdii
ENSMMOG00000008348	msi2a	97	80.663	ENSPCIG00000006063	MSI2	90	81.763	Phascolarctos_cinereus
ENSMMOG00000008348	msi2a	86	84.762	ENSPFOG00000019337	MSI2	92	84.762	Poecilia_formosa
ENSMMOG00000008348	msi2a	90	88.971	ENSPLAG00000000436	msi2a	72	88.971	Poecilia_latipinna
ENSMMOG00000008348	msi2a	79	100.000	ENSPMEG00000013247	msi2a	75	100.000	Poecilia_mexicana
ENSMMOG00000008348	msi2a	90	100.000	ENSPREG00000000881	msi2a	93	88.435	Poecilia_reticulata
ENSMMOG00000008348	msi2a	76	98.387	ENSPPYG00000008244	-	94	79.111	Pongo_abelii
ENSMMOG00000008348	msi2a	83	60.204	ENSPCAG00000010552	MSI2	95	55.020	Procavia_capensis
ENSMMOG00000008348	msi2a	90	83.824	ENSPCOG00000019195	-	100	92.517	Propithecus_coquereli
ENSMMOG00000008348	msi2a	76	95.690	ENSPVAG00000017053	MSI2	95	77.500	Pteropus_vampyrus
ENSMMOG00000008348	msi2a	90	100.000	ENSPNYG00000018393	msi2a	96	93.416	Pundamilia_nyererei
ENSMMOG00000008348	msi2a	90	95.620	ENSPNAG00000000844	msi2b	90	85.614	Pygocentrus_nattereri
ENSMMOG00000008348	msi2a	90	94.891	ENSPNAG00000014957	msi2a	94	83.548	Pygocentrus_nattereri
ENSMMOG00000008348	msi2a	91	84.028	ENSRNOG00000025338	Msi2	95	83.774	Rattus_norvegicus
ENSMMOG00000008348	msi2a	50	88.158	ENSRBIG00000032064	-	84	88.158	Rhinopithecus_bieti
ENSMMOG00000008348	msi2a	90	82.500	ENSRROG00000034421	-	100	92.366	Rhinopithecus_roxellana
ENSMMOG00000008348	msi2a	90	83.942	ENSSBOG00000026425	MSI2	99	88.492	Saimiri_boliviensis_boliviensis
ENSMMOG00000008348	msi2a	91	82.875	ENSSHAG00000008672	MSI2	96	81.707	Sarcophilus_harrisii
ENSMMOG00000008348	msi2a	94	88.341	ENSSFOG00015021687	-	93	88.341	Scleropages_formosus
ENSMMOG00000008348	msi2a	90	75.497	ENSSFOG00015012168	msi2b	60	83.471	Scleropages_formosus
ENSMMOG00000008348	msi2a	90	100.000	ENSSMAG00000018484	msi2a	96	93.827	Scophthalmus_maximus
ENSMMOG00000008348	msi2a	90	100.000	ENSSDUG00000014507	msi2a	96	93.827	Seriola_dumerili
ENSMMOG00000008348	msi2a	93	83.226	ENSSDUG00000021968	-	99	84.106	Seriola_dumerili
ENSMMOG00000008348	msi2a	90	100.000	ENSSLDG00000017172	msi2a	97	93.827	Seriola_lalandi_dorsalis
ENSMMOG00000008348	msi2a	50	78.409	ENSSLDG00000021332	-	68	78.409	Seriola_lalandi_dorsalis
ENSMMOG00000008348	msi2a	90	85.621	ENSSPUG00000000913	-	91	85.621	Sphenodon_punctatus
ENSMMOG00000008348	msi2a	84	99.095	ENSSPAG00000017793	msi2a	96	89.695	Stegastes_partitus
ENSMMOG00000008348	msi2a	95	82.319	ENSSSCG00000038505	MSI2	95	87.243	Sus_scrofa
ENSMMOG00000008348	msi2a	82	71.795	ENSTGUG00000008452	MSI2	94	74.408	Taeniopygia_guttata
ENSMMOG00000008348	msi2a	85	98.190	ENSTRUG00000021248	msi2a	97	80.549	Takifugu_rubripes
ENSMMOG00000008348	msi2a	78	70.992	ENSTBEG00000001241	MSI2	73	73.950	Tupaia_belangeri
ENSMMOG00000008348	msi2a	76	98.387	ENSTTRG00000002189	MSI2	85	94.737	Tursiops_truncatus
ENSMMOG00000008348	msi2a	95	85.065	ENSUAMG00000000700	MSI2	99	88.492	Ursus_americanus
ENSMMOG00000008348	msi2a	90	84.411	ENSUMAG00000000505	MSI2	95	93.782	Ursus_maritimus
ENSMMOG00000008348	msi2a	75	95.652	ENSVPAG00000006837	-	62	81.768	Vicugna_pacos
ENSMMOG00000008348	msi2a	95	86.207	ENSVVUG00000011783	MSI2	97	83.566	Vulpes_vulpes
ENSMMOG00000008348	msi2a	90	100.000	ENSXCOG00000006113	msi2a	96	84.146	Xiphophorus_couchianus
ENSMMOG00000008348	msi2a	90	100.000	ENSXMAG00000000608	msi2a	96	92.593	Xiphophorus_maculatus