EuRBPDB

Pathway ID	Pathway Name	Source
mdo01522	Endocrine resistance	KEGG
mdo01524	Platinum drug resistance	KEGG
mdo04068	FoxO signaling pathway	KEGG
mdo04110	Cell cycle	KEGG
mdo04115	p53 signaling pathway	KEGG
mdo04120	Ubiquitin mediated proteolysis	KEGG
mdo04144	Endocytosis	KEGG
mdo04151	PI3K-Akt signaling pathway	KEGG
mdo04218	Cellular senescence	KEGG
mdo04625	C-type lectin receptor signaling pathway	KEGG
mdo04919	Thyroid hormone signaling pathway	KEGG
mdo05163	Human cytomegalovirus infection	KEGG
mdo05165	Human papillomavirus infection	KEGG
mdo05169	Epstein-Barr virus infection	KEGG
mdo05200	Pathways in cancer	KEGG
mdo05202	Transcriptional misregulation in cancer	KEGG
mdo05203	Viral carcinogenesis	KEGG
mdo05205	Proteoglycans in cancer	KEGG
mdo05206	MicroRNAs in cancer	KEGG
mdo05214	Glioma	KEGG
mdo05215	Prostate cancer	KEGG
mdo05218	Melanoma	KEGG
mdo05219	Bladder cancer	KEGG
mdo05220	Chronic myeloid leukemia	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSMODG00000007219's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSMODG00000007219	-	94	34.783	ENSMODG00000001605	MDM4	92	33.617

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSMODG00000007219	-	94	34.979	ENSG00000198625	MDM4	92	34.672	Homo_sapiens
ENSMODG00000007219	-	99	76.016	ENSG00000135679	MDM2	99	84.211	Homo_sapiens
ENSMODG00000007219	-	99	75.665	ENSAMEG00000008526	MDM2	99	75.665	Ailuropoda_melanoleuca
ENSMODG00000007219	-	95	34.870	ENSAMEG00000001126	MDM4	96	34.870	Ailuropoda_melanoleuca
ENSMODG00000007219	-	99	69.530	ENSAPLG00000011164	MDM2	99	69.530	Anas_platyrhynchos
ENSMODG00000007219	-	94	60.730	ENSACAG00000004204	MDM2	85	62.017	Anolis_carolinensis
ENSMODG00000007219	-	96	33.194	ENSACAG00000007350	-	96	33.134	Anolis_carolinensis
ENSMODG00000007219	-	85	75.916	ENSANAG00000027171	-	99	80.769	Aotus_nancymaae
ENSMODG00000007219	-	94	34.898	ENSANAG00000036891	MDM4	92	34.382	Aotus_nancymaae
ENSMODG00000007219	-	56	31.071	ENSANAG00000025757	-	68	31.071	Aotus_nancymaae
ENSMODG00000007219	-	95	34.483	ENSBTAG00000006255	MDM4	96	34.483	Bos_taurus
ENSMODG00000007219	-	99	75.051	ENSBTAG00000010422	MDM2	99	75.051	Bos_taurus
ENSMODG00000007219	-	99	75.000	ENSCJAG00000007464	-	86	75.000	Callithrix_jacchus
ENSMODG00000007219	-	94	35.185	ENSCJAG00000016986	MDM4	92	34.672	Callithrix_jacchus
ENSMODG00000007219	-	54	47.761	ENSCJAG00000040017	-	99	47.761	Callithrix_jacchus
ENSMODG00000007219	-	99	74.187	ENSCJAG00000042596	-	98	74.187	Callithrix_jacchus
ENSMODG00000007219	-	95	35.234	ENSCAFG00000009669	MDM4	96	35.234	Canis_familiaris
ENSMODG00000007219	-	97	73.895	ENSCAFG00000000418	MDM2	94	73.895	Canis_familiaris
ENSMODG00000007219	-	57	34.228	ENSCAFG00020005984	MDM4	83	34.228	Canis_lupus_dingo
ENSMODG00000007219	-	99	74.642	ENSCAFG00020017002	MDM2	99	74.642	Canis_lupus_dingo
ENSMODG00000007219	-	99	34.517	ENSCHIG00000010343	-	96	34.809	Capra_hircus
ENSMODG00000007219	-	99	75.051	ENSCHIG00000019939	-	99	75.051	Capra_hircus
ENSMODG00000007219	-	92	62.832	ENSTSYG00000031248	-	96	62.832	Carlito_syrichta
ENSMODG00000007219	-	94	35.041	ENSTSYG00000010731	MDM4	92	34.656	Carlito_syrichta
ENSMODG00000007219	-	94	33.333	ENSCAPG00000011380	MDM4	93	33.263	Cavia_aperea
ENSMODG00000007219	-	97	33.267	ENSCPOG00000008227	MDM4	99	33.855	Cavia_porcellus
ENSMODG00000007219	-	99	72.967	ENSCPOG00000004323	MDM2	99	72.967	Cavia_porcellus
ENSMODG00000007219	-	99	75.506	ENSCCAG00000006745	-	99	79.630	Cebus_capucinus
ENSMODG00000007219	-	94	34.369	ENSCCAG00000031000	MDM4	92	33.830	Cebus_capucinus
ENSMODG00000007219	-	99	75.610	ENSCATG00000045264	-	99	79.630	Cercocebus_atys
ENSMODG00000007219	-	94	34.845	ENSCATG00000027086	MDM4	92	34.534	Cercocebus_atys
ENSMODG00000007219	-	94	34.269	ENSCLAG00000011995	MDM4	92	33.539	Chinchilla_lanigera
ENSMODG00000007219	-	99	72.561	ENSCLAG00000009877	MDM2	98	72.561	Chinchilla_lanigera
ENSMODG00000007219	-	94	34.433	ENSCSAG00000014561	MDM4	92	34.110	Chlorocebus_sabaeus
ENSMODG00000007219	-	99	75.407	ENSCSAG00000004244	MDM2	99	75.407	Chlorocebus_sabaeus
ENSMODG00000007219	-	54	34.767	ENSCHOG00000008147	-	67	34.767	Choloepus_hoffmanni
ENSMODG00000007219	-	99	71.487	ENSCPBG00000013316	MDM2	99	72.358	Chrysemys_picta_bellii
ENSMODG00000007219	-	57	32.872	ENSCANG00000032288	MDM4	83	32.872	Colobus_angolensis_palliatus
ENSMODG00000007219	-	99	75.203	ENSCANG00000034475	MDM2	99	77.778	Colobus_angolensis_palliatus
ENSMODG00000007219	-	99	69.262	ENSCGRG00001022261	Mdm2	99	69.262	Cricetulus_griseus_chok1gshd
ENSMODG00000007219	-	98	34.682	ENSCGRG00001004339	Mdm4	92	34.016	Cricetulus_griseus_chok1gshd
ENSMODG00000007219	-	98	34.682	ENSCGRG00000008463	Mdm4	92	34.016	Cricetulus_griseus_crigri
ENSMODG00000007219	-	99	69.262	ENSCGRG00000017891	Mdm2	99	69.262	Cricetulus_griseus_crigri
ENSMODG00000007219	-	94	36.270	ENSDNOG00000000842	MDM4	92	35.579	Dasypus_novemcinctus
ENSMODG00000007219	-	99	74.390	ENSDNOG00000046929	-	96	74.390	Dasypus_novemcinctus
ENSMODG00000007219	-	99	60.649	ENSDORG00000007222	Mdm2	99	76.923	Dipodomys_ordii
ENSMODG00000007219	-	97	33.723	ENSDORG00000006873	Mdm4	93	32.848	Dipodomys_ordii
ENSMODG00000007219	-	99	34.185	ENSETEG00000011245	MDM4	98	33.592	Echinops_telfairi
ENSMODG00000007219	-	100	60.887	ENSETEG00000011183	MDM2	100	60.887	Echinops_telfairi
ENSMODG00000007219	-	95	35.246	ENSEASG00005011431	MDM4	92	34.468	Equus_asinus_asinus
ENSMODG00000007219	-	99	68.507	ENSEASG00005008055	-	99	68.507	Equus_asinus_asinus
ENSMODG00000007219	-	95	35.246	ENSECAG00000004843	MDM4	95	33.406	Equus_caballus
ENSMODG00000007219	-	99	68.024	ENSECAG00000013604	MDM2	99	68.024	Equus_caballus
ENSMODG00000007219	-	99	67.689	ENSEEUG00000013849	MDM2	99	67.689	Erinaceus_europaeus
ENSMODG00000007219	-	68	48.182	ENSEEUG00000013912	MDM4	66	48.182	Erinaceus_europaeus
ENSMODG00000007219	-	94	32.465	ENSELUG00000011889	mdm4	92	32.252	Esox_lucius
ENSMODG00000007219	-	99	75.610	ENSFCAG00000024456	MDM2	99	84.615	Felis_catus
ENSMODG00000007219	-	96	35.163	ENSFCAG00000014851	MDM4	96	35.163	Felis_catus
ENSMODG00000007219	-	99	72.358	ENSFDAG00000007913	-	97	72.358	Fukomys_damarensis
ENSMODG00000007219	-	94	34.161	ENSFDAG00000021356	MDM4	92	33.194	Fukomys_damarensis
ENSMODG00000007219	-	94	30.723	ENSGMOG00000016389	mdm4	93	31.303	Gadus_morhua
ENSMODG00000007219	-	99	69.592	ENSGALG00000009942	MDM2	99	69.592	Gallus_gallus
ENSMODG00000007219	-	86	70.519	ENSGAGG00000017565	-	80	71.294	Gopherus_agassizii
ENSMODG00000007219	-	94	34.979	ENSGGOG00000012957	MDM4	92	34.672	Gorilla_gorilla
ENSMODG00000007219	-	99	75.813	ENSGGOG00000012907	MDM2	99	79.630	Gorilla_gorilla
ENSMODG00000007219	-	95	32.465	ENSHGLG00000007642	MDM4	92	32.432	Heterocephalus_glaber_female
ENSMODG00000007219	-	99	68.357	ENSHGLG00000016066	-	99	68.357	Heterocephalus_glaber_female
ENSMODG00000007219	-	99	72.672	ENSHGLG00000000856	-	99	72.672	Heterocephalus_glaber_female
ENSMODG00000007219	-	99	70.325	ENSHGLG00000020526	-	97	70.325	Heterocephalus_glaber_female
ENSMODG00000007219	-	84	71.566	ENSHGLG00100000441	-	100	70.698	Heterocephalus_glaber_male
ENSMODG00000007219	-	95	32.465	ENSHGLG00100006704	-	92	32.432	Heterocephalus_glaber_male
ENSMODG00000007219	-	94	32.365	ENSHCOG00000008924	mdm4	92	31.915	Hippocampus_comes
ENSMODG00000007219	-	99	32.485	ENSIPUG00000024447	mdm4	92	32.495	Ictalurus_punctatus
ENSMODG00000007219	-	99	74.390	ENSSTOG00000014702	-	99	74.390	Ictidomys_tridecemlineatus
ENSMODG00000007219	-	94	33.603	ENSSTOG00000004184	MDM4	92	32.848	Ictidomys_tridecemlineatus
ENSMODG00000007219	-	96	34.280	ENSJJAG00000017144	Mdm4	92	33.750	Jaculus_jaculus
ENSMODG00000007219	-	99	60.408	ENSLACG00000010207	MDM2	99	61.837	Latimeria_chalumnae
ENSMODG00000007219	-	100	74.141	ENSLAFG00000005885	MDM2	100	74.141	Loxodonta_africana
ENSMODG00000007219	-	96	33.200	ENSLAFG00000002169	MDM4	92	32.708	Loxodonta_africana
ENSMODG00000007219	-	99	31.225	ENSMFAG00000033606	MDM4	95	33.477	Macaca_fascicularis
ENSMODG00000007219	-	99	75.610	ENSMFAG00000042359	MDM2	99	79.630	Macaca_fascicularis
ENSMODG00000007219	-	99	75.610	ENSMMUG00000014193	MDM2	99	80.769	Macaca_mulatta
ENSMODG00000007219	-	93	32.640	ENSMMUG00000011236	MDM4	95	33.477	Macaca_mulatta
ENSMODG00000007219	-	99	75.610	ENSMNEG00000041135	MDM2	99	79.630	Macaca_nemestrina
ENSMODG00000007219	-	93	32.675	ENSMNEG00000026547	MDM4	99	34.194	Macaca_nemestrina
ENSMODG00000007219	-	94	34.845	ENSMLEG00000032041	MDM4	92	34.534	Mandrillus_leucophaeus
ENSMODG00000007219	-	99	75.610	ENSMLEG00000042099	MDM2	99	79.630	Mandrillus_leucophaeus
ENSMODG00000007219	-	92	69.058	ENSMGAG00000010513	MDM2	97	68.904	Meleagris_gallopavo
ENSMODG00000007219	-	99	67.689	ENSMICG00000029037	-	99	75.000	Microcebus_murinus
ENSMODG00000007219	-	99	58.656	ENSMICG00000046928	-	98	58.656	Microcebus_murinus
ENSMODG00000007219	-	94	35.041	ENSMICG00000017021	MDM4	92	34.737	Microcebus_murinus
ENSMODG00000007219	-	96	34.783	ENSMOCG00000002099	Mdm4	96	34.783	Microtus_ochrogaster
ENSMODG00000007219	-	99	70.061	ENSMOCG00000008043	Mdm2	99	70.061	Microtus_ochrogaster
ENSMODG00000007219	-	94	32.335	ENSMALG00000020663	mdm4	92	32.150	Monopterus_albus
ENSMODG00000007219	-	99	64.414	MGP_CAROLIEiJ_G0015836	Mdm2	99	64.811	Mus_caroli
ENSMODG00000007219	-	98	33.852	MGP_CAROLIEiJ_G0014593	Mdm4	96	34.132	Mus_caroli
ENSMODG00000007219	-	98	33.721	ENSMUSG00000054387	Mdm4	96	33.996	Mus_musculus
ENSMODG00000007219	-	99	65.462	ENSMUSG00000020184	Mdm2	99	65.462	Mus_musculus
ENSMODG00000007219	-	99	66.071	MGP_PahariEiJ_G0031251	Mdm2	99	66.270	Mus_pahari
ENSMODG00000007219	-	98	33.855	MGP_PahariEiJ_G0027829	Mdm4	96	34.137	Mus_pahari
ENSMODG00000007219	-	98	33.658	MGP_SPRETEiJ_G0015400	Mdm4	96	33.932	Mus_spretus
ENSMODG00000007219	-	99	65.323	MGP_SPRETEiJ_G0016659	Mdm2	99	66.129	Mus_spretus
ENSMODG00000007219	-	99	75.460	ENSMPUG00000017505	MDM2	99	75.460	Mustela_putorius_furo
ENSMODG00000007219	-	95	33.806	ENSMPUG00000011721	MDM4	96	33.740	Mustela_putorius_furo
ENSMODG00000007219	-	99	73.684	ENSMLUG00000009997	MDM2	99	74.089	Myotis_lucifugus
ENSMODG00000007219	-	98	32.540	ENSMLUG00000007129	MDM4	92	31.635	Myotis_lucifugus
ENSMODG00000007219	-	99	71.111	ENSNGAG00000012154	Mdm2	99	71.111	Nannospalax_galili
ENSMODG00000007219	-	96	34.538	ENSNGAG00000012344	Mdm4	96	34.350	Nannospalax_galili
ENSMODG00000007219	-	94	34.979	ENSNLEG00000014271	MDM4	92	34.672	Nomascus_leucogenys
ENSMODG00000007219	-	99	75.813	ENSNLEG00000003757	MDM2	99	79.630	Nomascus_leucogenys
ENSMODG00000007219	-	77	56.098	ENSMEUG00000012624	-	74	56.098	Notamacropus_eugenii
ENSMODG00000007219	-	99	66.667	ENSOPRG00000009677	MDM2	99	68.089	Ochotona_princeps
ENSMODG00000007219	-	94	34.221	ENSOPRG00000013878	MDM4	97	33.895	Ochotona_princeps
ENSMODG00000007219	-	99	60.451	ENSODEG00000006648	-	99	60.451	Octodon_degus
ENSMODG00000007219	-	99	56.301	ENSODEG00000000416	-	96	67.633	Octodon_degus
ENSMODG00000007219	-	94	35.062	ENSODEG00000013499	MDM4	92	33.820	Octodon_degus
ENSMODG00000007219	-	99	69.512	ENSODEG00000004028	-	99	69.512	Octodon_degus
ENSMODG00000007219	-	90	75.964	ENSOANG00000005942	MDM2	99	75.964	Ornithorhynchus_anatinus
ENSMODG00000007219	-	94	33.936	ENSOANG00000013464	MDM4	97	33.196	Ornithorhynchus_anatinus
ENSMODG00000007219	-	98	69.772	ENSOCUG00000011354	-	98	69.772	Oryctolagus_cuniculus
ENSMODG00000007219	-	99	74.089	ENSOCUG00000010899	-	64	74.089	Oryctolagus_cuniculus
ENSMODG00000007219	-	94	35.124	ENSOCUG00000000005	MDM4	92	34.395	Oryctolagus_cuniculus
ENSMODG00000007219	-	99	67.807	ENSOGAG00000034779	MDM2	99	67.807	Otolemur_garnettii
ENSMODG00000007219	-	98	33.789	ENSOGAG00000011679	MDM4	98	33.789	Otolemur_garnettii
ENSMODG00000007219	-	99	69.184	ENSOGAG00000011845	-	99	69.184	Otolemur_garnettii
ENSMODG00000007219	-	99	74.545	ENSOARG00000000570	-	99	74.545	Ovis_aries
ENSMODG00000007219	-	99	74.645	ENSOARG00000013821	-	99	74.645	Ovis_aries
ENSMODG00000007219	-	97	34.185	ENSOARG00000002783	-	99	34.247	Ovis_aries
ENSMODG00000007219	-	99	76.016	ENSPPAG00000032775	MDM2	99	79.630	Pan_paniscus
ENSMODG00000007219	-	94	35.185	ENSPPAG00000030518	MDM4	92	34.249	Pan_paniscus
ENSMODG00000007219	-	96	35.163	ENSPPRG00000025076	MDM4	96	35.163	Panthera_pardus
ENSMODG00000007219	-	99	75.610	ENSPPRG00000000082	MDM2	99	84.615	Panthera_pardus
ENSMODG00000007219	-	99	75.610	ENSPTIG00000016929	MDM2	99	84.615	Panthera_tigris_altaica
ENSMODG00000007219	-	96	34.949	ENSPTIG00000011372	MDM4	96	35.000	Panthera_tigris_altaica
ENSMODG00000007219	-	94	35.185	ENSPTRG00000001889	MDM4	92	34.884	Pan_troglodytes
ENSMODG00000007219	-	99	76.016	ENSPTRG00000005203	MDM2	99	79.630	Pan_troglodytes
ENSMODG00000007219	-	94	34.845	ENSPANG00000008555	MDM4	92	34.534	Papio_anubis
ENSMODG00000007219	-	99	75.610	ENSPANG00000005563	MDM2	99	79.630	Papio_anubis
ENSMODG00000007219	-	92	68.860	ENSPSIG00000016379	-	99	69.683	Pelodiscus_sinensis
ENSMODG00000007219	-	94	35.464	ENSPEMG00000018483	Mdm4	92	34.746	Peromyscus_maniculatus_bairdii
ENSMODG00000007219	-	94	34.845	ENSPCIG00000017446	MDM4	95	32.613	Phascolarctos_cinereus
ENSMODG00000007219	-	100	92.990	ENSPCIG00000005357	-	100	94.170	Phascolarctos_cinereus
ENSMODG00000007219	-	94	34.979	ENSPPYG00000000315	MDM4	92	34.672	Pongo_abelii
ENSMODG00000007219	-	99	75.610	ENSPPYG00000004754	MDM2	99	75.610	Pongo_abelii
ENSMODG00000007219	-	100	73.038	ENSPCAG00000008949	MDM2	99	73.038	Procavia_capensis
ENSMODG00000007219	-	96	31.992	ENSPCAG00000007019	MDM4	92	31.884	Procavia_capensis
ENSMODG00000007219	-	89	73.923	ENSPCOG00000018521	-	99	75.510	Propithecus_coquereli
ENSMODG00000007219	-	96	34.827	ENSPCOG00000024397	MDM4	92	34.183	Propithecus_coquereli
ENSMODG00000007219	-	73	61.728	ENSPVAG00000005663	MDM4	92	31.458	Pteropus_vampyrus
ENSMODG00000007219	-	99	70.505	ENSPVAG00000006202	MDM2	99	70.505	Pteropus_vampyrus
ENSMODG00000007219	-	94	34.369	ENSRNOG00000009696	Mdm4	92	33.617	Rattus_norvegicus
ENSMODG00000007219	-	99	67.073	ENSRNOG00000006304	Mdm2	99	67.073	Rattus_norvegicus
ENSMODG00000007219	-	99	75.610	ENSRBIG00000028561	MDM2	99	79.630	Rhinopithecus_bieti
ENSMODG00000007219	-	94	34.845	ENSRBIG00000038824	MDM4	92	34.534	Rhinopithecus_bieti
ENSMODG00000007219	-	99	75.610	ENSRROG00000045589	-	98	83.000	Rhinopithecus_roxellana
ENSMODG00000007219	-	94	34.845	ENSRROG00000027771	MDM4	92	34.534	Rhinopithecus_roxellana
ENSMODG00000007219	-	93	32.505	ENSSBOG00000020446	-	93	32.636	Saimiri_boliviensis_boliviensis
ENSMODG00000007219	-	99	75.813	ENSSBOG00000014544	-	99	80.769	Saimiri_boliviensis_boliviensis
ENSMODG00000007219	-	94	34.774	ENSSBOG00000036183	-	92	34.249	Saimiri_boliviensis_boliviensis
ENSMODG00000007219	-	94	35.246	ENSSHAG00000007767	MDM4	92	34.958	Sarcophilus_harrisii
ENSMODG00000007219	-	100	91.411	ENSSHAG00000010284	-	99	91.411	Sarcophilus_harrisii
ENSMODG00000007219	-	84	79.562	ENSSHAG00000000124	-	100	79.562	Sarcophilus_harrisii
ENSMODG00000007219	-	99	32.184	ENSSFOG00015001112	mdm4	99	34.118	Scleropages_formosus
ENSMODG00000007219	-	95	32.924	ENSSARG00000004179	MDM4	95	32.924	Sorex_araneus
ENSMODG00000007219	-	99	70.909	ENSSARG00000005801	MDM2	100	70.909	Sorex_araneus
ENSMODG00000007219	-	99	70.385	ENSSPUG00000000964	MDM2	99	70.385	Sphenodon_punctatus
ENSMODG00000007219	-	99	75.556	ENSSSCG00000000488	MDM2	99	75.556	Sus_scrofa
ENSMODG00000007219	-	95	34.731	ENSSSCG00000015284	MDM4	95	34.731	Sus_scrofa
ENSMODG00000007219	-	57	34.266	ENSTGUG00000017483	MDM4	87	34.266	Taeniopygia_guttata
ENSMODG00000007219	-	92	69.778	ENSTGUG00000006836	MDM2	97	69.623	Taeniopygia_guttata
ENSMODG00000007219	-	75	63.760	ENSTBEG00000013758	MDM2	73	65.940	Tupaia_belangeri
ENSMODG00000007219	-	95	34.086	ENSTTRG00000012174	MDM4	96	34.086	Tursiops_truncatus
ENSMODG00000007219	-	92	65.188	ENSTTRG00000015715	MDM2	91	65.188	Tursiops_truncatus
ENSMODG00000007219	-	95	34.827	ENSUAMG00000007328	MDM4	96	34.827	Ursus_americanus
ENSMODG00000007219	-	92	83.019	ENSUAMG00000018322	-	99	82.692	Ursus_americanus
ENSMODG00000007219	-	95	33.803	ENSUMAG00000003452	MDM4	95	34.016	Ursus_maritimus
ENSMODG00000007219	-	99	76.074	ENSUMAG00000020757	MDM2	99	76.074	Ursus_maritimus
ENSMODG00000007219	-	99	70.732	ENSVPAG00000007456	MDM2	99	70.732	Vicugna_pacos
ENSMODG00000007219	-	94	34.091	ENSVPAG00000012034	MDM4	96	33.121	Vicugna_pacos
ENSMODG00000007219	-	95	35.366	ENSVVUG00000014855	MDM4	96	35.366	Vulpes_vulpes
ENSMODG00000007219	-	99	58.350	ENSXETG00000001434	mdm2	99	58.248	Xenopus_tropicalis