EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSMUSG00000004040 (Gene tree)
Gene ID: 20848
Gene Symbol: Stat3
Alias: 1110034C02Rik|Aprf
Full Name: signal transducer and activator of transcription 3
Gene Type: protein_coding
Species: Mus_musculus
Status: putative
Strand: Minus strand
Length: 54443
Position: chr11: 100885098-100939540
Accession: 103038
RBP type: non-canonical RBP
Summary: -

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
27452465	The Cardiomyocyte RNA Binding Proteome: Links to Intermediary Metabolism and Heart Disease	IC & HL_1	2016 Jul 21	Liao Y	DOI: 10.1016/j.celrep.2016.06.084

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSMUST00000137367	-	646	-	-	- (aa)	-	-
ENSMUST00000092671	-	2927	-	ENSMUSP00000090342	769 (aa)	-	P42227
ENSMUST00000146971	-	1995	-	-	- (aa)	-	-
ENSMUST00000138438	-	2506	-	ENSMUSP00000121677	744 (aa)	-	B7ZC18
ENSMUST00000152601	-	826	-	-	- (aa)	-	-
ENSMUST00000154170	-	672	-	-	- (aa)	-	-
ENSMUST00000151544	-	408	-	-	- (aa)	-	-
ENSMUST00000155972	-	396	-	-	- (aa)	-	-
ENSMUST00000156645	-	651	-	-	- (aa)	-	-
ENSMUST00000137093	-	1079	-	-	- (aa)	-	-
ENSMUST00000103114	-	6042	XM_011248846	ENSMUSP00000099403	722 (aa)	XP_011247148	P42227
ENSMUST00000152623	-	609	-	-	- (aa)	-	-
ENSMUST00000127638	-	4516	-	ENSMUSP00000120152	770 (aa)	-	P42227
ENSMUST00000130686	-	349	-	-	- (aa)	-	-

Gene Model

Click here to download ENSMUSG00000004040's gene model file

Pathways

Pathway ID	Pathway Name	Source
mmu01521	EGFR tyrosine kinase inhibitor resistance	KEGG
mmu04062	Chemokine signaling pathway	KEGG
mmu04066	HIF-1 signaling pathway	KEGG
mmu04068	FoxO signaling pathway	KEGG
mmu04217	Necroptosis	KEGG
mmu04550	Signaling pathways regulating pluripotency of stem cells	KEGG
mmu04630	JAK-STAT signaling pathway	KEGG
mmu04659	Th17 cell differentiation	KEGG
mmu04917	Prolactin signaling pathway	KEGG
mmu04920	Adipocytokine signaling pathway	KEGG
mmu04931	Insulin resistance	KEGG
mmu04933	AGE-RAGE signaling pathway in diabetic complications	KEGG
mmu05145	Toxoplasmosis	KEGG
mmu05160	Hepatitis C	KEGG
mmu05161	Hepatitis B	KEGG
mmu05162	Measles	KEGG
mmu05163	Human cytomegalovirus infection	KEGG
mmu05167	Kaposi sarcoma-associated herpesvirus infection	KEGG
mmu05169	Epstein-Barr virus infection	KEGG
mmu05200	Pathways in cancer	KEGG
mmu05203	Viral carcinogenesis	KEGG
mmu05205	Proteoglycans in cancer	KEGG
mmu05206	MicroRNAs in cancer	KEGG
mmu05212	Pancreatic cancer	KEGG
mmu05221	Acute myeloid leukemia	KEGG
mmu05223	Non-small cell lung cancer	KEGG
mmu05321	Inflammatory bowel disease (IBD)	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSMUSG00000004040's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSMUSG00000004040	Stat3	100	100.000	ENSG00000168610	STAT3	100	100.000	Homo_sapiens
ENSMUSG00000004040	Stat3	99	53.556	ENSG00000115415	STAT1	100	62.319	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000790	nuclear chromatin	-	ISO	Component
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISO	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	15096606.26026268.	IDA	Function
GO:0001103	RNA polymerase II repressing transcription factor binding	-	ISO	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	-	ISO	Function
GO:0001659	temperature homeostasis	15070774.	IMP	Process
GO:0001754	eye photoreceptor cell differentiation	15207851.	IMP	Process
GO:0003677	DNA binding	11579100.12746441.15096606.15659653.	IDA	Function
GO:0003677	DNA binding	-	ISO	Function
GO:0003700	DNA-binding transcription factor activity	28065600.	IMP	Function
GO:0003700	DNA-binding transcription factor activity	-	ISO	Function
GO:0004879	nuclear receptor activity	-	ISO	Function
GO:0005515	protein binding	8662591.10954736.10982829.11254359.12426389.12738762.15096606.15102471.15156153.15659653.16219639.16801560.18200042.18234692.20133729.20530874.20876300.21184768.21812053.23416296.23948297.23972987.24129709.24396070.26026268.27724964.	IPI	Function
GO:0005634	nucleus	12634107.12826573.15096606.15156153.15659653.16801560.19796622.21234744.22891351.24211183.	IDA	Component
GO:0005634	nucleus	-	ISO	Component
GO:0005654	nucleoplasm	-	ISO	Component
GO:0005667	transcription factor complex	-	ISO	Component
GO:0005737	cytoplasm	12634107.12746441.15096606.15156153.15749075.19796622.21234744.	IDA	Component
GO:0005737	cytoplasm	-	ISO	Component
GO:0005739	mitochondrion	-	ISO	Component
GO:0005743	mitochondrial inner membrane	-	ISO	Component
GO:0005829	cytosol	-	ISO	Component
GO:0005886	plasma membrane	12826573.	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	-	ISO	Process
GO:0006355	regulation of transcription, DNA-templated	15664994.	NAS	Process
GO:0006366	transcription by RNA polymerase II	11579100.	IDA	Process
GO:0006606	protein import into nucleus	-	ISO	Process
GO:0006953	acute-phase response	-	IEA	Process
GO:0006954	inflammatory response	28065600.	IMP	Process
GO:0007165	signal transduction	-	IEA	Process
GO:0007259	JAK-STAT cascade	15664994.	TAS	Process
GO:0008134	transcription factor binding	-	ISO	Function
GO:0008283	cell proliferation	15659653.	IDA	Process
GO:0008284	positive regulation of cell proliferation	-	ISO	Process
GO:0008285	negative regulation of cell proliferation	22891351.	IGI	Process
GO:0010507	negative regulation of autophagy	-	ISO	Process
GO:0010628	positive regulation of gene expression	24255059.	IGI	Process
GO:0010628	positive regulation of gene expression	-	ISO	Process
GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	-	ISO	Process
GO:0014069	postsynaptic density	-	ISO	Component
GO:0016310	phosphorylation	23401489.	IDA	Process
GO:0019221	cytokine-mediated signaling pathway	15664994.	NAS	Process
GO:0019827	stem cell population maintenance	20720539.	IMP	Process
GO:0019901	protein kinase binding	15004007.	IPI	Function
GO:0019903	protein phosphatase binding	-	ISO	Function
GO:0019953	sexual reproduction	15070774.	IMP	Process
GO:0030335	positive regulation of cell migration	-	ISO	Process
GO:0030522	intracellular receptor signaling pathway	-	ISO	Process
GO:0031490	chromatin DNA binding	-	ISO	Function
GO:0031730	CCR5 chemokine receptor binding	-	ISO	Function
GO:0032355	response to estradiol	-	ISO	Process
GO:0032870	cellular response to hormone stimulus	-	ISO	Process
GO:0033210	leptin-mediated signaling pathway	16825198.	IDA	Process
GO:0033210	leptin-mediated signaling pathway	12594516.	IMP	Process
GO:0033210	leptin-mediated signaling pathway	-	ISO	Process
GO:0034097	response to cytokine	-	ISO	Process
GO:0035259	glucocorticoid receptor binding	-	ISO	Function
GO:0035278	miRNA mediated inhibition of translation	-	ISO	Process
GO:0040014	regulation of multicellular organism growth	15070774.	IMP	Process
GO:0042593	glucose homeostasis	12594516.15070774.	IMP	Process
GO:0042755	eating behavior	15070774.	IMP	Process
GO:0042789	mRNA transcription by RNA polymerase II	26026268.	IDA	Process
GO:0042802	identical protein binding	17463090.23434585.	IPI	Function
GO:0042802	identical protein binding	-	ISO	Function
GO:0042803	protein homodimerization activity	28065600.	IDA	Function
GO:0043066	negative regulation of apoptotic process	-	ISO	Process
GO:0043565	sequence-specific DNA binding	16801560.	IDA	Function
GO:0043565	sequence-specific DNA binding	-	ISO	Function
GO:0044212	transcription regulatory region DNA binding	-	ISO	Function
GO:0044320	cellular response to leptin stimulus	-	ISO	Process
GO:0044321	response to leptin	16825198.	IDA	Process
GO:0044321	response to leptin	12594516.	IMP	Process
GO:0044321	response to leptin	-	ISO	Process
GO:0045410	positive regulation of interleukin-6 biosynthetic process	-	ISO	Process
GO:0045648	positive regulation of erythrocyte differentiation	-	ISO	Process
GO:0045747	positive regulation of Notch signaling pathway	15156153.	IMP	Process
GO:0045766	positive regulation of angiogenesis	26505789.	IDA	Process
GO:0045820	negative regulation of glycolytic process	22891351.	IMP	Process
GO:0045893	positive regulation of transcription, DNA-templated	11579100.23401489.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	28065600.	IMP	Process
GO:0045893	positive regulation of transcription, DNA-templated	-	ISO	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	15096606.15659653.19666510.24843164.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	16801560.20530874.	IGI	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISO	Process
GO:0046902	regulation of mitochondrial membrane permeability	-	ISO	Process
GO:0046983	protein dimerization activity	11579100.	IPI	Function
GO:0048708	astrocyte differentiation	15156153.	IMP	Process
GO:0050804	modulation of chemical synaptic transmission	-	ISO	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	ISO	Process
GO:0051726	regulation of cell cycle	16825198.	IDA	Process
GO:0051726	regulation of cell cycle	-	ISO	Process
GO:0060019	radial glial cell differentiation	15156153.	IMP	Process
GO:0060259	regulation of feeding behavior	12594516.	IMP	Process
GO:0060396	growth hormone receptor signaling pathway	-	ISO	Process
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	8923468.	IDA	Process
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	-	ISO	Process
GO:0060548	negative regulation of cell death	-	ISO	Process
GO:0070102	interleukin-6-mediated signaling pathway	-	ISO	Process
GO:0071345	cellular response to cytokine stimulus	19414010.	ISO	Process
GO:0071407	cellular response to organic cyclic compound	19414010.	ISO	Process
GO:0072540	T-helper 17 cell lineage commitment	28065600.	IMP	Process
GO:0090575	RNA polymerase II transcription factor complex	-	ISO	Component
GO:0097009	energy homeostasis	12594516.	IMP	Process
GO:0098685	Schaffer collateral - CA1 synapse	-	ISO	Component
GO:0098978	glutamatergic synapse	-	ISO	Component
GO:0099527	postsynapse to nucleus signaling pathway	-	ISO	Process
GO:1901215	negative regulation of neuron death	-	ISO	Process
GO:1902728	positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	-	ISO	Process
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	20546595.	IMP	Process
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	-	ISO	Process
GO:1904685	positive regulation of metalloendopeptidase activity	-	ISO	Process
GO:1905564	positive regulation of vascular endothelial cell proliferation	26505789.	IDA	Process
GO:2000637	positive regulation of gene silencing by miRNA	-	ISO	Process
GO:2000737	negative regulation of stem cell differentiation	25335925.	IMP	Process
GO:2001171	positive regulation of ATP biosynthetic process	-	ISO	Process
GO:2001223	negative regulation of neuron migration	23321696.	IGI	Process