EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSMUSG00000020715 (Gene tree)
Gene ID: 78943
Gene Symbol: Ern1
Alias: 9030414B18Rik|Ire1a|Ire1alpha|Ire1p
Full Name: endoplasmic reticulum (ER) to nucleus signalling 1
Gene Type: protein_coding
Species: Mus_musculus
Status: putative
Strand: Minus strand
Length: 93203 bases
Position: chr11:106394650-106487852
Accession: 1930134
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSMUSP00000001059	Ribonuc_2-5A	PF06479.12	1.8e-40	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSMUST00000131895	-	3354	-	-	- (aa)	-	-
ENSMUST00000106799	-	660	-	ENSMUSP00000102411	66 (aa)	-	B1ATQ7
ENSMUST00000106800	-	654	-	ENSMUSP00000102412	118 (aa)	-	B1ARJ5
ENSMUST00000001059	-	6946	-	ENSMUSP00000001059	977 (aa)	-	Q9EQY0
ENSMUST00000106801	-	1957	-	ENSMUSP00000102413	408 (aa)	-	Q9EQY0

Gene Model

Click here to download ENSMUSG00000020715's gene model file

Pathways

Pathway ID	Pathway Name	Source
mmu04140	Autophagy - animal	KEGG
mmu04141	Protein processing in endoplasmic reticulum	KEGG
mmu04210	Apoptosis	KEGG
mmu04932	Non-alcoholic fatty liver disease (NAFLD)	KEGG
mmu05010	Alzheimer disease	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSMUSG00000020715's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSMUSG00000020715	Ern1	98	47.260	ENSMUSG00000030866	Ern2	95	47.290

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSMUSG00000020715	Ern1	97	93.333	ENSG00000178607	ERN1	98	93.215	Homo_sapiens
ENSMUSG00000020715	Ern1	96	93.100	ENSAMEG00000002855	ERN1	97	93.100	Ailuropoda_melanoleuca
ENSMUSG00000020715	Ern1	96	82.128	ENSAPLG00000007775	ERN1	98	82.128	Anas_platyrhynchos
ENSMUSG00000020715	Ern1	98	78.438	ENSACAG00000016707	ERN1	96	78.579	Anolis_carolinensis
ENSMUSG00000020715	Ern1	98	93.179	ENSANAG00000019640	ERN1	98	92.992	Aotus_nancymaae
ENSMUSG00000020715	Ern1	98	93.028	ENSBTAG00000016799	ERN1	98	93.096	Bos_taurus
ENSMUSG00000020715	Ern1	98	93.704	ENSCJAG00000019415	ERN1	99	93.515	Callithrix_jacchus
ENSMUSG00000020715	Ern1	98	93.305	ENSCAFG00000011784	ERN1	99	93.305	Canis_familiaris
ENSMUSG00000020715	Ern1	98	93.305	ENSCAFG00020026580	ERN1	97	93.305	Canis_lupus_dingo
ENSMUSG00000020715	Ern1	98	92.887	ENSCHIG00000025852	ERN1	100	92.887	Capra_hircus
ENSMUSG00000020715	Ern1	98	86.311	ENSTSYG00000029092	ERN1	99	86.311	Carlito_syrichta
ENSMUSG00000020715	Ern1	99	87.876	ENSCAPG00000011651	ERN1	98	89.017	Cavia_aperea
ENSMUSG00000020715	Ern1	97	93.987	ENSCPOG00000000570	ERN1	98	93.828	Cavia_porcellus
ENSMUSG00000020715	Ern1	94	91.385	ENSCCAG00000034845	ERN1	100	92.725	Cebus_capucinus
ENSMUSG00000020715	Ern1	96	93.008	ENSCATG00000040819	ERN1	98	92.589	Cercocebus_atys
ENSMUSG00000020715	Ern1	87	95.486	ENSCLAG00000006912	ERN1	99	95.486	Chinchilla_lanigera
ENSMUSG00000020715	Ern1	97	92.722	ENSCSAG00000003990	ERN1	98	92.685	Chlorocebus_sabaeus
ENSMUSG00000020715	Ern1	97	79.684	ENSCPBG00000009183	ERN1	96	79.368	Chrysemys_picta_bellii
ENSMUSG00000020715	Ern1	69	59.753	ENSCSAVG00000010472	-	74	59.753	Ciona_savignyi
ENSMUSG00000020715	Ern1	97	92.737	ENSCANG00000032329	ERN1	98	92.596	Colobus_angolensis_palliatus
ENSMUSG00000020715	Ern1	100	96.520	ENSCGRG00001003211	Ern1	100	96.520	Cricetulus_griseus_chok1gshd
ENSMUSG00000020715	Ern1	98	96.552	ENSCGRG00000010036	Ern1	98	96.552	Cricetulus_griseus_crigri
ENSMUSG00000020715	Ern1	97	90.651	ENSDNOG00000009467	ERN1	98	91.109	Dasypus_novemcinctus
ENSMUSG00000020715	Ern1	97	84.517	ENSETEG00000004162	ERN1	94	84.122	Echinops_telfairi
ENSMUSG00000020715	Ern1	52	67.213	ENSEBUG00000003040	ERN1	70	67.213	Eptatretus_burgeri
ENSMUSG00000020715	Ern1	97	92.903	ENSEASG00005014413	ERN1	99	92.678	Equus_asinus_asinus
ENSMUSG00000020715	Ern1	97	94.093	ENSECAG00000011262	ERN1	98	93.933	Equus_caballus
ENSMUSG00000020715	Ern1	86	90.141	ENSEEUG00000006091	ERN1	82	90.812	Erinaceus_europaeus
ENSMUSG00000020715	Ern1	98	93.515	ENSFCAG00000003507	ERN1	98	93.515	Felis_catus
ENSMUSG00000020715	Ern1	97	81.587	ENSFALG00000002305	ERN1	97	81.501	Ficedula_albicollis
ENSMUSG00000020715	Ern1	97	93.849	ENSFDAG00000013825	ERN1	99	93.619	Fukomys_damarensis
ENSMUSG00000020715	Ern1	99	80.869	ENSGALG00000003476	ERN1	97	81.693	Gallus_gallus
ENSMUSG00000020715	Ern1	82	78.012	ENSGAGG00000006329	-	99	77.640	Gopherus_agassizii
ENSMUSG00000020715	Ern1	97	93.439	ENSGGOG00000006532	ERN1	99	93.111	Gorilla_gorilla
ENSMUSG00000020715	Ern1	98	93.965	ENSHGLG00000010207	ERN1	98	94.038	Heterocephalus_glaber_female
ENSMUSG00000020715	Ern1	98	93.828	ENSHGLG00100019030	ERN1	99	93.828	Heterocephalus_glaber_male
ENSMUSG00000020715	Ern1	98	94.069	ENSSTOG00000009067	ERN1	98	94.351	Ictidomys_tridecemlineatus
ENSMUSG00000020715	Ern1	98	73.563	ENSLACG00000016078	ERN1	99	74.059	Latimeria_chalumnae
ENSMUSG00000020715	Ern1	97	75.551	ENSLOCG00000013703	ERN1	97	75.605	Lepisosteus_oculatus
ENSMUSG00000020715	Ern1	96	93.312	ENSLAFG00000008504	ERN1	100	92.880	Loxodonta_africana
ENSMUSG00000020715	Ern1	97	92.624	ENSMFAG00000040147	ERN1	99	92.589	Macaca_fascicularis
ENSMUSG00000020715	Ern1	97	92.624	ENSMMUG00000015185	ERN1	98	92.589	Macaca_mulatta
ENSMUSG00000020715	Ern1	97	92.624	ENSMNEG00000044337	ERN1	100	91.977	Macaca_nemestrina
ENSMUSG00000020715	Ern1	96	93.114	ENSMLEG00000033739	ERN1	99	92.693	Mandrillus_leucophaeus
ENSMUSG00000020715	Ern1	99	80.849	ENSMGAG00000007831	ERN1	97	81.818	Meleagris_gallopavo
ENSMUSG00000020715	Ern1	97	93.671	ENSMICG00000010050	ERN1	98	93.403	Microcebus_murinus
ENSMUSG00000020715	Ern1	100	95.394	ENSMOCG00000003999	Ern1	100	95.394	Microtus_ochrogaster
ENSMUSG00000020715	Ern1	97	79.813	ENSMODG00000009349	ERN1	97	79.854	Monodelphis_domestica
ENSMUSG00000020715	Ern1	100	98.567	MGP_CAROLIEiJ_G0017324	Ern1	100	98.567	Mus_caroli
ENSMUSG00000020715	Ern1	100	98.362	MGP_PahariEiJ_G0018454	Ern1	100	98.362	Mus_pahari
ENSMUSG00000020715	Ern1	100	99.591	MGP_SPRETEiJ_G0018168	Ern1	100	99.591	Mus_spretus
ENSMUSG00000020715	Ern1	98	93.305	ENSMPUG00000014770	ERN1	98	93.375	Mustela_putorius_furo
ENSMUSG00000020715	Ern1	99	92.021	ENSMLUG00000016729	ERN1	98	92.842	Myotis_lucifugus
ENSMUSG00000020715	Ern1	98	96.146	ENSNGAG00000019135	Ern1	98	96.234	Nannospalax_galili
ENSMUSG00000020715	Ern1	97	93.757	ENSNLEG00000015074	ERN1	99	93.424	Nomascus_leucogenys
ENSMUSG00000020715	Ern1	89	86.207	ENSMEUG00000008103	ERN1	89	86.207	Notamacropus_eugenii
ENSMUSG00000020715	Ern1	98	91.042	ENSOPRG00000008129	ERN1	99	91.213	Ochotona_princeps
ENSMUSG00000020715	Ern1	98	91.390	ENSODEG00000007755	ERN1	98	92.461	Octodon_degus
ENSMUSG00000020715	Ern1	92	86.429	ENSOANG00000008033	ERN1	99	86.429	Ornithorhynchus_anatinus
ENSMUSG00000020715	Ern1	99	92.523	ENSOCUG00000012090	ERN1	100	92.426	Oryctolagus_cuniculus
ENSMUSG00000020715	Ern1	91	93.386	ENSOGAG00000003863	ERN1	99	93.237	Otolemur_garnettii
ENSMUSG00000020715	Ern1	98	92.155	ENSOARG00000014398	ERN1	98	92.155	Ovis_aries
ENSMUSG00000020715	Ern1	97	93.333	ENSPPAG00000031054	ERN1	99	93.006	Pan_paniscus
ENSMUSG00000020715	Ern1	98	93.410	ENSPPRG00000009424	ERN1	98	93.410	Panthera_pardus
ENSMUSG00000020715	Ern1	98	93.515	ENSPTIG00000000179	ERN1	98	93.515	Panthera_tigris_altaica
ENSMUSG00000020715	Ern1	97	93.439	ENSPTRG00000009535	ERN1	99	93.111	Pan_troglodytes
ENSMUSG00000020715	Ern1	96	93.114	ENSPANG00000020738	ERN1	99	92.693	Papio_anubis
ENSMUSG00000020715	Ern1	98	77.720	ENSPSIG00000017320	ERN1	99	77.720	Pelodiscus_sinensis
ENSMUSG00000020715	Ern1	100	96.827	ENSPEMG00000002339	Ern1	100	96.827	Peromyscus_maniculatus_bairdii
ENSMUSG00000020715	Ern1	97	85.115	ENSPCIG00000005771	ERN1	97	85.115	Phascolarctos_cinereus
ENSMUSG00000020715	Ern1	98	91.536	ENSPPYG00000008539	ERN1	100	92.899	Pongo_abelii
ENSMUSG00000020715	Ern1	84	80.665	ENSPCAG00000016275	ERN1	100	72.817	Procavia_capensis
ENSMUSG00000020715	Ern1	92	93.909	ENSPCOG00000023564	ERN1	98	93.661	Propithecus_coquereli
ENSMUSG00000020715	Ern1	97	90.275	ENSPVAG00000000484	ERN1	98	90.167	Pteropus_vampyrus
ENSMUSG00000020715	Ern1	100	97.441	ENSRNOG00000012864	Ern1	100	97.441	Rattus_norvegicus
ENSMUSG00000020715	Ern1	98	92.380	ENSRBIG00000033096	ERN1	98	92.484	Rhinopithecus_bieti
ENSMUSG00000020715	Ern1	98	92.484	ENSRROG00000017577	ERN1	100	91.977	Rhinopithecus_roxellana
ENSMUSG00000020715	Ern1	98	91.183	ENSSBOG00000035494	ERN1	100	93.473	Saimiri_boliviensis_boliviensis
ENSMUSG00000020715	Ern1	94	84.004	ENSSHAG00000014118	ERN1	99	84.004	Sarcophilus_harrisii
ENSMUSG00000020715	Ern1	97	73.502	ENSSFOG00015005661	ern1	96	72.766	Scleropages_formosus
ENSMUSG00000020715	Ern1	97	78.233	ENSSPUG00000004797	ERN1	97	79.065	Sphenodon_punctatus
ENSMUSG00000020715	Ern1	97	92.365	ENSSSCG00000017279	ERN1	98	92.050	Sus_scrofa
ENSMUSG00000020715	Ern1	97	81.760	ENSTGUG00000004752	-	99	81.760	Taeniopygia_guttata
ENSMUSG00000020715	Ern1	97	87.712	ENSTTRG00000007006	ERN1	99	87.461	Tursiops_truncatus
ENSMUSG00000020715	Ern1	97	91.109	ENSUAMG00000007437	ERN1	97	92.097	Ursus_americanus
ENSMUSG00000020715	Ern1	98	91.201	ENSUMAG00000017551	ERN1	97	92.308	Ursus_maritimus
ENSMUSG00000020715	Ern1	97	93.955	ENSVVUG00000006214	ERN1	96	93.410	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000166	nucleotide binding	-	IEA	Function
GO:0000287	magnesium ion binding	-	ISO	Function
GO:0001935	endothelial cell proliferation	-	ISO	Process
GO:0003824	catalytic activity	-	IEA	Function
GO:0004519	endonuclease activity	11850408.	IDA	Function
GO:0004521	endoribonuclease activity	21873635.	IBA	Function
GO:0004521	endoribonuclease activity	15601821.25164867.	IDA	Function
GO:0004521	endoribonuclease activity	-	ISO	Function
GO:0004540	ribonuclease activity	-	IEA	Function
GO:0004672	protein kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	25164867.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	-	ISO	Function
GO:0005161	platelet-derived growth factor receptor binding	-	ISO	Function
GO:0005515	protein binding	16680093.18281285.19135427.19328063.23942232.	IPI	Function
GO:0005524	ATP binding	-	ISO	Function
GO:0005637	nuclear inner membrane	11850408.	IDA	Component
GO:0005737	cytoplasm	-	ISO	Component
GO:0005739	mitochondrion	23028046.	IDA	Component
GO:0005783	endoplasmic reticulum	-	ISO	Component
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	9755171.	IDA	Component
GO:0006379	mRNA cleavage	25164867.	IDA	Process
GO:0006397	mRNA processing	-	IEA	Process
GO:0006468	protein phosphorylation	-	ISO	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0006986	response to unfolded protein	-	IEA	Process
GO:0007050	cell cycle arrest	11146108.	IDA	Process
GO:0007257	activation of JUN kinase activity	10650002.	IMP	Process
GO:0007257	activation of JUN kinase activity	-	ISO	Process
GO:0008152	metabolic process	-	IEA	Process
GO:0016020	membrane	-	IEA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0016301	kinase activity	-	IEA	Function
GO:0016310	phosphorylation	-	IEA	Process
GO:0016740	transferase activity	-	IEA	Function
GO:0016787	hydrolase activity	-	IEA	Function
GO:0019899	enzyme binding	-	ISO	Function
GO:0030176	integral component of endoplasmic reticulum membrane	-	ISO	Component
GO:0030544	Hsp70 protein binding	-	ISO	Function
GO:0030968	endoplasmic reticulum unfolded protein response	21873635.	IBA	Process
GO:0030968	endoplasmic reticulum unfolded protein response	10882126.11430819.15601821.	IDA	Process
GO:0033120	positive regulation of RNA splicing	25164867.	IDA	Process
GO:0033120	positive regulation of RNA splicing	-	ISO	Process
GO:0034620	cellular response to unfolded protein	-	ISO	Process
GO:0034976	response to endoplasmic reticulum stress	-	ISO	Process
GO:0035924	cellular response to vascular endothelial growth factor stimulus	-	ISO	Process
GO:0036289	peptidyl-serine autophosphorylation	-	ISO	Process
GO:0036498	IRE1-mediated unfolded protein response	21873635.	IBA	Process
GO:0036498	IRE1-mediated unfolded protein response	25164867.	IDA	Process
GO:0036498	IRE1-mediated unfolded protein response	-	ISO	Process
GO:0042802	identical protein binding	-	ISO	Function
GO:0042803	protein homodimerization activity	25164867.	IDA	Function
GO:0042803	protein homodimerization activity	-	ISO	Function
GO:0043531	ADP binding	-	ISO	Function
GO:0046777	protein autophosphorylation	11430819.25164867.	IDA	Process
GO:0046777	protein autophosphorylation	-	ISO	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:0051879	Hsp90 protein binding	-	ISO	Function
GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	-	ISO	Process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	21873635.	IBA	Process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	11146108.	IDA	Process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	19328063.	IMP	Process
GO:0071333	cellular response to glucose stimulus	-	ISO	Process
GO:0098787	mRNA cleavage involved in mRNA processing	-	ISO	Process
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	-	ISO	Process
GO:1901142	insulin metabolic process	-	ISO	Process
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	-	ISO	Process
GO:1990579	peptidyl-serine trans-autophosphorylation	-	ISO	Process
GO:1990597	AIP1-IRE1 complex	18281285.	IPI	Component
GO:1990604	IRE1-TRAF2-ASK1 complex	21873635.	IBA	Component
GO:1990604	IRE1-TRAF2-ASK1 complex	-	ISO	Component
GO:1990630	IRE1-RACK1-PP2A complex	-	ISO	Component