EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSMUSG00000020914 (Gene tree)
Gene ID: 21973
Gene Symbol: Top2a
Alias: DNA Topoisomerase II alpha|Top-2
Full Name: topoisomerase (DNA) II alpha
Gene Type: protein_coding
Species: Mus_musculus
Status: putative
Strand: Minus strand
Length: 31247
Position: chr11: 98992943-99024189
Accession: 98790
RBP type: non-canonical RBP
Summary: -

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
27768875	High Resolution Mapping of RNA Binding Regions in the Nuclear Proteome of Embryonic Stem Cells	nIC & mESC	2016.09	He C	DOI: 10.1016/j.molcel.2016.09.034

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSMUST00000139730	-	2849	-	-	- (aa)	-	-
ENSMUST00000129777	-	632	-	-	- (aa)	-	-
ENSMUST00000144318	-	970	-	-	- (aa)	-	-
ENSMUST00000068031	-	5221	XM_006533153	ENSMUSP00000068896	1528 (aa)	XP_006533216	Q01320
ENSMUST00000151997	-	599	-	-	- (aa)	-	-
ENSMUST00000154332	-	803	-	-	- (aa)	-	-
ENSMUST00000139460	-	796	-	-	- (aa)	-	-

Gene Model

Click here to download ENSMUSG00000020914's gene model file

Pathways

Pathway ID	Pathway Name	Source
mmu01524	Platinum drug resistance	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSMUSG00000020914's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSMUSG00000020914	Top2a	99	89.426	ENSG00000131747	TOP2A	100	95.238	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000166	nucleotide binding	-	IEA	Function
GO:0000228	nuclear chromosome	-	ISO	Component
GO:0000287	magnesium ion binding	-	ISO	Function
GO:0000712	resolution of meiotic recombination intermediates	21873635.	IBA	Process
GO:0000793	condensed chromosome	11835579.	IDA	Component
GO:0000793	condensed chromosome	21795393.	IMP	Component
GO:0000819	sister chromatid segregation	21873635.	IBA	Process
GO:0002244	hematopoietic progenitor cell differentiation	24029230.	IMP	Process
GO:0003677	DNA binding	-	ISO	Function
GO:0003682	chromatin binding	-	ISO	Function
GO:0003916	DNA topoisomerase activity	-	ISO	Function
GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	1331984.7842491.9094096.	IDA	Function
GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	1331984.7937150.	IGI	Function
GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	-	ISO	Function
GO:0005080	protein kinase C binding	-	ISO	Function
GO:0005515	protein binding	23698369.	IPI	Function
GO:0005524	ATP binding	-	ISO	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9094096.9224616.25961503.	IDA	Component
GO:0005634	nucleus	-	ISO	Component
GO:0005654	nucleoplasm	-	ISO	Component
GO:0005730	nucleolus	11835579.	IDA	Component
GO:0005730	nucleolus	-	ISO	Component
GO:0005814	centriole	-	ISO	Component
GO:0006259	DNA metabolic process	-	IEA	Process
GO:0006265	DNA topological change	1331984.9224616.	IDA	Process
GO:0006265	DNA topological change	-	ISO	Process
GO:0006266	DNA ligation	-	ISO	Process
GO:0006974	cellular response to DNA damage stimulus	-	ISO	Process
GO:0007059	chromosome segregation	7842491.	IDA	Process
GO:0007059	chromosome segregation	11835580.	IMP	Process
GO:0007059	chromosome segregation	-	ISO	Process
GO:0007143	female meiotic nuclear division	25961503.	IMP	Process
GO:0008022	protein C-terminus binding	-	ISO	Function
GO:0008094	DNA-dependent ATPase activity	-	ISO	Function
GO:0008144	drug binding	-	ISO	Function
GO:0008301	DNA binding, bending	-	ISO	Function
GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)	-	ISO	Component
GO:0016853	isomerase activity	-	IEA	Function
GO:0019035	viral integration complex	-	ISO	Component
GO:0019899	enzyme binding	-	ISO	Function
GO:0030261	chromosome condensation	11835580.	IMP	Process
GO:0030263	apoptotic chromosome condensation	21873635.	IBA	Process
GO:0030263	apoptotic chromosome condensation	-	ISO	Process
GO:0032991	protein-containing complex	-	ISO	Component
GO:0040016	embryonic cleavage	11835580.	IMP	Process
GO:0042752	regulation of circadian rhythm	24321095.	IMP	Process
GO:0042803	protein homodimerization activity	-	ISO	Function
GO:0042826	histone deacetylase binding	-	ISO	Function
GO:0043065	positive regulation of apoptotic process	-	ISO	Process
GO:0043130	ubiquitin binding	-	ISO	Function
GO:0043565	sequence-specific DNA binding	-	ISO	Function
GO:0044774	mitotic DNA integrity checkpoint	21873635.	IBA	Process
GO:0045870	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	-	ISO	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	1683482.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0046982	protein heterodimerization activity	-	ISO	Function
GO:0048511	rhythmic process	-	IEA	Process
GO:0051309	female meiosis chromosome separation	25961503.	TAS	Process
GO:1905463	negative regulation of DNA duplex unwinding	-	ISO	Process
GO:1990904	ribonucleoprotein complex	-	ISO	Component