EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSMUSG00000021109 (Gene tree)
Gene ID: 15251
Gene Symbol: Hif1a
Alias: HIF-1alpha|HIF1alpha|MOP1|bHLHe78
Full Name: hypoxia inducible factor 1%2C alpha subunit
Gene Type: protein_coding
Species: Mus_musculus
Status: putative
Strand: Plus strand
Length: 46156
Position: chr12: 73901375-73947530
Accession: 106918
RBP type: non-canonical RBP
Summary: -

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
27768875	High Resolution Mapping of RNA Binding Regions in the Nuclear Proteome of Embryonic Stem Cells	nIC & mESC	2016.09	He C	DOI: 10.1016/j.molcel.2016.09.034

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSMUST00000110464	-	1759	-	ENSMUSP00000106091	258 (aa)	-	A0A0R4J1F0
ENSMUST00000149740	-	693	-	-	- (aa)	-	-
ENSMUST00000021530	-	4724	XM_006515478	ENSMUSP00000021530	836 (aa)	XP_006515541	Q61221
ENSMUST00000110461	-	4385	-	ENSMUSP00000106088	810 (aa)	-	A0A0R4J1E9
ENSMUST00000157041	-	484	-	-	- (aa)	-	-

Gene Model

Click here to download ENSMUSG00000021109's gene model file

Pathways

Pathway ID	Pathway Name	Source
mmu04066	HIF-1 signaling pathway	KEGG
mmu04137	Mitophagy - animal	KEGG
mmu04140	Autophagy - animal	KEGG
mmu04659	Th17 cell differentiation	KEGG
mmu04919	Thyroid hormone signaling pathway	KEGG
mmu05167	Kaposi sarcoma-associated herpesvirus infection	KEGG
mmu05200	Pathways in cancer	KEGG
mmu05205	Proteoglycans in cancer	KEGG
mmu05211	Renal cell carcinoma	KEGG
mmu05230	Central carbon metabolism in cancer	KEGG
mmu05231	Choline metabolism in cancer	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSMUSG00000021109's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISO	Process
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	21873635.	IBA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	24030251.	IDA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISO	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISO	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	21856340.	IDA	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	-	ISO	Function
GO:0001525	angiogenesis	14659802.15073147.	IMP	Process
GO:0001568	blood vessel development	9436976.	IMP	Process
GO:0001666	response to hypoxia	8702901.11801735.	IDA	Process
GO:0001666	response to hypoxia	17437992.	IGI	Process
GO:0001666	response to hypoxia	9606183.10074486.11792862.19273585.	IMP	Process
GO:0001666	response to hypoxia	11782478.	ISO	Process
GO:0001755	neural crest cell migration	14659802.	IMP	Process
GO:0001837	epithelial to mesenchymal transition	18037992.	IMP	Process
GO:0001892	embryonic placenta development	16287860.	IGI	Process
GO:0001892	embryonic placenta development	16287860.	IMP	Process
GO:0001922	B-1 B cell homeostasis	11854513.	IMP	Process
GO:0001944	vasculature development	18653562.	IGI	Process
GO:0001947	heart looping	14659802.	IMP	Process
GO:0002039	p53 binding	-	ISO	Function
GO:0002052	positive regulation of neuroblast proliferation	17215402.	IGI	Process
GO:0002248	connective tissue replacement involved in inflammatory response wound healing	18037992.	IMP	Process
GO:0003151	outflow tract morphogenesis	9436976.	IMP	Process
GO:0003208	cardiac ventricle morphogenesis	9436976.	IMP	Process
GO:0003677	DNA binding	15456877.	IDA	Function
GO:0003677	DNA binding	9113979.	IGI	Function
GO:0003700	DNA-binding transcription factor activity	15456877.	IDA	Function
GO:0003700	DNA-binding transcription factor activity	11782478.	ISO	Function
GO:0005515	protein binding	8702901.11292862.16777103.17371845.20440072.20609350.21546903.21871655.26245371.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11691837.15016652.15456877.18295594.20440072.21546903.22009797.24030251.24553947.	IDA	Component
GO:0005634	nucleus	-	ISO	Component
GO:0005654	nucleoplasm	-	ISO	Component
GO:0005667	transcription factor complex	-	ISO	Component
GO:0005737	cytoplasm	-	ISO	Component
GO:0005829	cytosol	-	ISO	Component
GO:0006089	lactate metabolic process	15328538.	IMP	Process
GO:0006110	regulation of glycolytic process	17437992.	IGI	Process
GO:0006355	regulation of transcription, DNA-templated	15456877.	IDA	Process
GO:0006355	regulation of transcription, DNA-templated	11782478.	ISO	Process
GO:0006357	regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0006366	transcription by RNA polymerase II	-	ISO	Process
GO:0006879	cellular iron ion homeostasis	16787915.	IMP	Process
GO:0007165	signal transduction	-	ISO	Process
GO:0007595	lactation	12620994.	IMP	Process
GO:0008134	transcription factor binding	-	ISO	Function
GO:0008284	positive regulation of cell proliferation	-	ISO	Process
GO:0008542	visual learning	12972594.	IMP	Process
GO:0010468	regulation of gene expression	18281291.	IMP	Process
GO:0010468	regulation of gene expression	-	ISO	Process
GO:0010508	positive regulation of autophagy	18281291.	IMP	Process
GO:0010573	vascular endothelial growth factor production	-	ISO	Process
GO:0010575	positive regulation of vascular endothelial growth factor production	-	ISO	Process
GO:0010628	positive regulation of gene expression	-	ISO	Process
GO:0010629	negative regulation of gene expression	-	ISO	Process
GO:0010634	positive regulation of epithelial cell migration	18037992.	IMP	Process
GO:0010870	positive regulation of receptor biosynthetic process	-	ISO	Process
GO:0014850	response to muscle activity	15328538.	IMP	Process
GO:0016239	positive regulation of macroautophagy	19273585.	IMP	Process
GO:0016604	nuclear body	-	ISO	Component
GO:0016607	nuclear speck	21546903.	IDA	Component
GO:0019896	axonal transport of mitochondrion	-	ISO	Process
GO:0019899	enzyme binding	-	ISO	Function
GO:0019901	protein kinase binding	-	ISO	Function
GO:0019904	protein domain specific binding	-	ISO	Function
GO:0021502	neural fold elevation formation	10328919.	IMP	Process
GO:0021987	cerebral cortex development	12972594.	IMP	Process
GO:0030154	cell differentiation	16287860.	IGI	Process
GO:0030154	cell differentiation	15073147.	IMP	Process
GO:0030279	negative regulation of ossification	22081627.	IMP	Process
GO:0030502	negative regulation of bone mineralization	17181398.	IMP	Process
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	11691837.	IMP	Process
GO:0031514	motile cilium	11818497.	IDA	Component
GO:0031625	ubiquitin protein ligase binding	-	ISO	Function
GO:0032007	negative regulation of TOR signaling	20808783.	IMP	Process
GO:0032364	oxygen homeostasis	9436976.	IMP	Process
GO:0032364	oxygen homeostasis	-	ISO	Process
GO:0032909	regulation of transforming growth factor beta2 production	-	ISO	Process
GO:0032963	collagen metabolic process	18037992.	IMP	Process
GO:0032991	protein-containing complex	-	ISO	Component
GO:0035035	histone acetyltransferase binding	-	ISO	Function
GO:0035162	embryonic hemopoiesis	16787915.	IMP	Process
GO:0035257	nuclear hormone receptor binding	-	ISO	Function
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	20440072.	IMP	Process
GO:0042127	regulation of cell proliferation	17437992.	IMP	Process
GO:0042541	hemoglobin biosynthetic process	16787915.	IMP	Process
GO:0042593	glucose homeostasis	15328538.17437992.	IMP	Process
GO:0042826	histone deacetylase binding	19071119.	IPI	Function
GO:0043065	positive regulation of apoptotic process	-	ISO	Process
GO:0043066	negative regulation of apoptotic process	17181398.18281291.	IMP	Process
GO:0043066	negative regulation of apoptotic process	-	ISO	Process
GO:0043524	negative regulation of neuron apoptotic process	12972594.	IMP	Process
GO:0043536	positive regulation of blood vessel endothelial cell migration	-	ISO	Process
GO:0043565	sequence-specific DNA binding	9368100.24030251.26245371.	IDA	Function
GO:0043565	sequence-specific DNA binding	-	ISO	Function
GO:0043565	sequence-specific DNA binding	-	ISO	Function
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	12832481.	IMP	Process
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	-	ISO	Process
GO:0044877	protein-containing complex binding	-	ISO	Function
GO:0045648	positive regulation of erythrocyte differentiation	16787915.	IMP	Process
GO:0045722	positive regulation of gluconeogenesis	-	ISO	Process
GO:0045766	positive regulation of angiogenesis	-	ISO	Process
GO:0045893	positive regulation of transcription, DNA-templated	-	ISO	Process
GO:0045906	negative regulation of vasoconstriction	-	ISO	Process
GO:0045926	negative regulation of growth	11691837.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	8702901.24011070.24030251.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	9113979.15766748.	IGI	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	17284606.21856340.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISO	Process
GO:0046716	muscle cell cellular homeostasis	15328538.	IMP	Process
GO:0046886	positive regulation of hormone biosynthetic process	-	ISO	Process
GO:0046982	protein heterodimerization activity	26245371.	IDA	Function
GO:0046982	protein heterodimerization activity	-	ISO	Function
GO:0046983	protein dimerization activity	-	IEA	Function
GO:0048514	blood vessel morphogenesis	9606183.	IMP	Process
GO:0048546	digestive tract morphogenesis	20808783.	IMP	Process
GO:0048593	camera-type eye morphogenesis	22627278.	IGI	Process
GO:0048661	positive regulation of smooth muscle cell proliferation	-	ISO	Process
GO:0050790	regulation of catalytic activity	15328538.	IMP	Process
GO:0051216	cartilage development	11691837.	IMP	Process
GO:0051541	elastin metabolic process	18037992.	IMP	Process
GO:0051879	Hsp90 protein binding	-	ISO	Function
GO:0060574	intestinal epithelial cell maturation	20808783.	IMP	Process
GO:0060992	response to fungicide	-	ISO	Process
GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development	12620994.	IMP	Process
GO:0061072	iris morphogenesis	22627278.	IGI	Process
GO:0061298	retina vasculature development in camera-type eye	21212189.	IMP	Process
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	ISO	Process
GO:0070243	regulation of thymocyte apoptotic process	15456877.	IGI	Process
GO:0070244	negative regulation of thymocyte apoptotic process	15456877.	IMP	Process
GO:0070888	E-box binding	24011070.	IMP	Function
GO:0071456	cellular response to hypoxia	24011070.	IGI	Process
GO:0071456	cellular response to hypoxia	-	ISO	Process
GO:0071542	dopaminergic neuron differentiation	17215402.	IGI	Process
GO:0071542	dopaminergic neuron differentiation	17215402.	IMP	Process
GO:0090575	RNA polymerase II transcription factor complex	-	ISO	Component
GO:0097411	hypoxia-inducible factor-1alpha signaling pathway	8470821.	IDA	Process
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	-	ISO	Process
GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	-	ISO	Process
GO:1903599	positive regulation of autophagy of mitochondrion	18281291.	IMP	Process
GO:1903715	regulation of aerobic respiration	18281291.	IMP	Process
GO:2000378	negative regulation of reactive oxygen species metabolic process	18281291.	IMP	Process
GO:2001054	negative regulation of mesenchymal cell apoptotic process	10328919.	IMP	Process