EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSMUSG00000022191 (Gene tree)
Gene ID: 14000
Gene Symbol: Drosha
Alias: 1110013A17Rik|Etohi2|Rnasen
Full Name: drosha%2C ribonuclease type III
Gene Type: protein_coding
Species: Mus_musculus
Status: confidence
Strand: Plus strand
Length: 110477 bases
Position: chr15:12824815-12935291
Accession: 1261425
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSMUSP00000087762	Ribonuclease_3	PF00636.26	2.8e-42	1	2
ENSMUSP00000087762	Ribonuclease_3	PF00636.26	2.8e-42	2	2
ENSMUSP00000129279	Ribonuclease_3	PF00636.26	2.8e-42	1	2
ENSMUSP00000129279	Ribonuclease_3	PF00636.26	2.8e-42	2	2
ENSMUSP00000087762	dsrm	PF00035.26	2.8e-14	1	1
ENSMUSP00000129279	dsrm	PF00035.26	2.8e-14	1	1
ENSMUSP00000087762	Ribonucleas_3_3	PF14622.6	9.2e-44	1	2
ENSMUSP00000087762	Ribonucleas_3_3	PF14622.6	9.2e-44	2	2
ENSMUSP00000129279	Ribonucleas_3_3	PF14622.6	9.2e-44	1	2
ENSMUSP00000129279	Ribonucleas_3_3	PF14622.6	9.2e-44	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
27452465	The Cardiomyocyte RNA Binding Proteome: Links to Intermediary Metabolism and Heart Disease	IC & HL_1	2016 Jul 21	Liao Y	DOI: 10.1016/j.celrep.2016.06.084

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSMUST00000169061	-	4570	XM_006520021	ENSMUSP00000129279	1373 (aa)	XP_006520084	Q5HZJ0
ENSMUST00000141010	-	588	-	-	- (aa)	-	-
ENSMUST00000150211	-	3248	-	-	- (aa)	-	-
ENSMUST00000147647	-	881	-	-	- (aa)	-	-
ENSMUST00000141706	-	881	-	-	- (aa)	-	-
ENSMUST00000090292	-	4519	-	ENSMUSP00000087762	1373 (aa)	-	Q5HZJ0
ENSMUST00000156594	-	699	-	-	- (aa)	-	-

Gene Model

Click here to download ENSMUSG00000022191's gene model file

Pathways

Pathway ID	Pathway Name	Source
mmu03008	Ribosome biogenesis in eukaryotes	KEGG
mmu05205	Proteoglycans in cancer	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSMUSG00000022191's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSMUSG00000022191	Drosha	100	95.633	ENSG00000113360	DROSHA	99	95.633	Homo_sapiens
ENSMUSG00000022191	Drosha	100	93.387	ENSAMEG00000006000	DROSHA	100	93.314	Ailuropoda_melanoleuca
ENSMUSG00000022191	Drosha	69	91.062	ENSACIG00000019308	drosha	94	90.984	Amphilophus_citrinellus
ENSMUSG00000022191	Drosha	99	78.448	ENSATEG00000021939	drosha	87	78.420	Anabas_testudineus
ENSMUSG00000022191	Drosha	99	84.945	ENSAPLG00000004372	DROSHA	100	85.091	Anas_platyrhynchos
ENSMUSG00000022191	Drosha	100	81.799	ENSACAG00000007970	DROSHA	100	82.086	Anolis_carolinensis
ENSMUSG00000022191	Drosha	100	93.086	ENSANAG00000020506	DROSHA	99	95.950	Aotus_nancymaae
ENSMUSG00000022191	Drosha	97	73.588	ENSACLG00000012227	drosha	88	77.876	Astatotilapia_calliptera
ENSMUSG00000022191	Drosha	99	73.853	ENSAMXG00000005582	drosha	88	79.211	Astyanax_mexicanus
ENSMUSG00000022191	Drosha	100	92.442	ENSBTAG00000017551	DROSHA	100	92.369	Bos_taurus
ENSMUSG00000022191	Drosha	60	36.611	WBGene00009163	drsh-1	76	36.742	Caenorhabditis_elegans
ENSMUSG00000022191	Drosha	100	95.342	ENSCJAG00000018881	DROSHA	98	95.342	Callithrix_jacchus
ENSMUSG00000022191	Drosha	100	93.886	ENSCAFG00020017559	DROSHA	98	98.240	Canis_lupus_dingo
ENSMUSG00000022191	Drosha	99	94.814	ENSCHIG00000022226	DROSHA	99	94.741	Capra_hircus
ENSMUSG00000022191	Drosha	95	96.581	ENSCPOG00000015051	DROSHA	94	93.837	Cavia_porcellus
ENSMUSG00000022191	Drosha	100	95.488	ENSCCAG00000027283	DROSHA	100	98.468	Cebus_capucinus
ENSMUSG00000022191	Drosha	100	95.415	ENSCATG00000016833	DROSHA	100	97.038	Cercocebus_atys
ENSMUSG00000022191	Drosha	100	95.570	ENSCLAG00000013048	DROSHA	100	95.700	Chinchilla_lanigera
ENSMUSG00000022191	Drosha	100	93.304	ENSCSAG00000017202	DROSHA	97	93.304	Chlorocebus_sabaeus
ENSMUSG00000022191	Drosha	73	89.590	ENSCHOG00000011786	DROSHA	78	89.590	Choloepus_hoffmanni
ENSMUSG00000022191	Drosha	99	85.745	ENSCPBG00000000467	DROSHA	100	85.891	Chrysemys_picta_bellii
ENSMUSG00000022191	Drosha	61	58.014	ENSCSAVG00000010638	-	99	58.852	Ciona_savignyi
ENSMUSG00000022191	Drosha	99	95.395	ENSCANG00000035071	DROSHA	100	97.038	Colobus_angolensis_palliatus
ENSMUSG00000022191	Drosha	100	96.213	ENSCGRG00001008885	Drosha	100	96.213	Cricetulus_griseus_chok1gshd
ENSMUSG00000022191	Drosha	100	96.213	ENSCGRG00000006944	Drosha	100	96.213	Cricetulus_griseus_crigri
ENSMUSG00000022191	Drosha	89	87.113	ENSCSEG00000001452	drosha	87	77.904	Cynoglossus_semilaevis
ENSMUSG00000022191	Drosha	84	79.622	ENSCVAG00000004619	drosha	88	79.608	Cyprinodon_variegatus
ENSMUSG00000022191	Drosha	92	80.017	ENSDARG00000055563	drosha	90	79.590	Danio_rerio
ENSMUSG00000022191	Drosha	99	89.912	ENSDNOG00000001537	DROSHA	99	89.912	Dasypus_novemcinctus
ENSMUSG00000022191	Drosha	99	91.581	ENSDORG00000005624	Drosha	99	91.698	Dipodomys_ordii
ENSMUSG00000022191	Drosha	75	52.281	FBgn0026722	drosha	73	54.918	Drosophila_melanogaster
ENSMUSG00000022191	Drosha	89	97.753	ENSETEG00000007814	DROSHA	88	97.753	Echinops_telfairi
ENSMUSG00000022191	Drosha	100	93.595	ENSEASG00005007149	DROSHA	99	93.595	Equus_asinus_asinus
ENSMUSG00000022191	Drosha	100	95.779	ENSECAG00000013578	DROSHA	97	95.779	Equus_caballus
ENSMUSG00000022191	Drosha	79	89.815	ENSEEUG00000006351	DROSHA	78	89.953	Erinaceus_europaeus
ENSMUSG00000022191	Drosha	67	89.384	ENSELUG00000015039	drosha	83	75.504	Esox_lucius
ENSMUSG00000022191	Drosha	100	95.779	ENSFCAG00000000360	DROSHA	99	95.779	Felis_catus
ENSMUSG00000022191	Drosha	99	85.063	ENSFALG00000012843	DROSHA	100	84.829	Ficedula_albicollis
ENSMUSG00000022191	Drosha	100	95.207	ENSFDAG00000018414	DROSHA	100	95.207	Fukomys_damarensis
ENSMUSG00000022191	Drosha	87	62.005	ENSFHEG00000003840	drosha	83	65.505	Fundulus_heteroclitus
ENSMUSG00000022191	Drosha	99	85.007	ENSGALG00000012916	DROSHA	100	85.007	Gallus_gallus
ENSMUSG00000022191	Drosha	84	80.498	ENSGAFG00000016853	drosha	88	79.918	Gambusia_affinis
ENSMUSG00000022191	Drosha	99	85.745	ENSGAGG00000005621	DROSHA	100	85.818	Gopherus_agassizii
ENSMUSG00000022191	Drosha	100	95.633	ENSGGOG00000011006	DROSHA	100	97.140	Gorilla_gorilla
ENSMUSG00000022191	Drosha	94	70.138	ENSHBUG00000015907	drosha	87	78.571	Haplochromis_burtoni
ENSMUSG00000022191	Drosha	100	94.989	ENSHGLG00000018873	DROSHA	99	94.989	Heterocephalus_glaber_female
ENSMUSG00000022191	Drosha	100	94.989	ENSHGLG00100015793	DROSHA	98	94.989	Heterocephalus_glaber_male
ENSMUSG00000022191	Drosha	87	76.778	ENSHCOG00000008454	drosha	95	79.576	Hippocampus_comes
ENSMUSG00000022191	Drosha	71	89.061	ENSIPUG00000021202	drosha	90	75.566	Ictalurus_punctatus
ENSMUSG00000022191	Drosha	75	95.838	ENSSTOG00000016323	DROSHA	100	99.630	Ictidomys_tridecemlineatus
ENSMUSG00000022191	Drosha	100	95.412	ENSJJAG00000019758	Drosha	100	95.412	Jaculus_jaculus
ENSMUSG00000022191	Drosha	90	89.381	ENSLBEG00000006606	drosha	87	76.340	Labrus_bergylta
ENSMUSG00000022191	Drosha	99	80.377	ENSLACG00000005937	DROSHA	99	79.797	Latimeria_chalumnae
ENSMUSG00000022191	Drosha	99	77.077	ENSLOCG00000012852	drosha	87	81.575	Lepisosteus_oculatus
ENSMUSG00000022191	Drosha	99	93.723	ENSLAFG00000013831	DROSHA	100	93.723	Loxodonta_africana
ENSMUSG00000022191	Drosha	100	95.415	ENSMFAG00000003055	DROSHA	99	95.415	Macaca_fascicularis
ENSMUSG00000022191	Drosha	100	93.231	ENSMMUG00000012193	DROSHA	99	98.366	Macaca_mulatta
ENSMUSG00000022191	Drosha	100	95.269	ENSMNEG00000037529	DROSHA	99	95.269	Macaca_nemestrina
ENSMUSG00000022191	Drosha	100	90.400	ENSMLEG00000024167	DROSHA	99	90.400	Mandrillus_leucophaeus
ENSMUSG00000022191	Drosha	98	74.034	ENSMAMG00000012613	drosha	94	89.845	Mastacembelus_armatus
ENSMUSG00000022191	Drosha	97	73.588	ENSMZEG00005019487	drosha	88	77.876	Maylandia_zebra
ENSMUSG00000022191	Drosha	99	85.164	ENSMGAG00000005087	DROSHA	100	85.091	Meleagris_gallopavo
ENSMUSG00000022191	Drosha	100	96.213	ENSMAUG00000002863	Drosha	100	96.213	Mesocricetus_auratus
ENSMUSG00000022191	Drosha	100	93.478	ENSMICG00000002241	DROSHA	100	96.364	Microcebus_murinus
ENSMUSG00000022191	Drosha	99	96.266	ENSMOCG00000015044	Drosha	100	96.266	Microtus_ochrogaster
ENSMUSG00000022191	Drosha	69	87.209	ENSMMOG00000004016	drosha	94	86.943	Mola_mola
ENSMUSG00000022191	Drosha	98	83.916	ENSMODG00000004807	DROSHA	99	83.894	Monodelphis_domestica
ENSMUSG00000022191	Drosha	99	74.034	ENSMALG00000010542	drosha	88	79.221	Monopterus_albus
ENSMUSG00000022191	Drosha	100	99.345	MGP_CAROLIEiJ_G0019687	Drosha	100	99.345	Mus_caroli
ENSMUSG00000022191	Drosha	100	98.835	MGP_PahariEiJ_G0016063	Drosha	100	98.835	Mus_pahari
ENSMUSG00000022191	Drosha	100	99.417	MGP_SPRETEiJ_G0020580	Drosha	100	99.417	Mus_spretus
ENSMUSG00000022191	Drosha	100	95.415	ENSMPUG00000015237	DROSHA	99	95.415	Mustela_putorius_furo
ENSMUSG00000022191	Drosha	100	92.598	ENSMLUG00000002581	DROSHA	99	92.598	Myotis_lucifugus
ENSMUSG00000022191	Drosha	100	90.095	ENSNGAG00000017329	Drosha	100	90.095	Nannospalax_galili
ENSMUSG00000022191	Drosha	71	72.615	ENSNBRG00000001870	drosha	95	73.608	Neolamprologus_brichardi
ENSMUSG00000022191	Drosha	100	87.910	ENSNLEG00000013963	DROSHA	100	96.936	Nomascus_leucogenys
ENSMUSG00000022191	Drosha	78	79.023	ENSMEUG00000002029	DROSHA	82	79.023	Notamacropus_eugenii
ENSMUSG00000022191	Drosha	91	94.828	ENSOPRG00000010845	DROSHA	85	94.828	Ochotona_princeps
ENSMUSG00000022191	Drosha	100	95.280	ENSODEG00000001911	DROSHA	100	95.280	Octodon_degus
ENSMUSG00000022191	Drosha	98	74.945	ENSONIG00000006578	drosha	88	80.213	Oreochromis_niloticus
ENSMUSG00000022191	Drosha	56	80.488	ENSOANG00000015744	-	100	80.488	Ornithorhynchus_anatinus
ENSMUSG00000022191	Drosha	100	91.782	ENSOCUG00000000367	DROSHA	98	91.782	Oryctolagus_cuniculus
ENSMUSG00000022191	Drosha	91	86.166	ENSORLG00000013592	drosha	79	86.583	Oryzias_latipes
ENSMUSG00000022191	Drosha	71	87.907	ENSORLG00020002854	drosha	94	89.326	Oryzias_latipes_hni
ENSMUSG00000022191	Drosha	71	88.889	ENSORLG00015003156	drosha	94	90.363	Oryzias_latipes_hsok
ENSMUSG00000022191	Drosha	84	77.172	ENSOMEG00000001062	drosha	89	77.445	Oryzias_melastigma
ENSMUSG00000022191	Drosha	88	92.675	ENSOGAG00000005424	DROSHA	99	92.675	Otolemur_garnettii
ENSMUSG00000022191	Drosha	100	92.971	ENSPPAG00000037526	DROSHA	100	95.710	Pan_paniscus
ENSMUSG00000022191	Drosha	100	95.779	ENSPPRG00000002687	DROSHA	99	95.779	Panthera_pardus
ENSMUSG00000022191	Drosha	100	95.779	ENSPTIG00000017523	DROSHA	99	95.779	Panthera_tigris_altaica
ENSMUSG00000022191	Drosha	100	95.633	ENSPTRG00000016762	DROSHA	99	95.633	Pan_troglodytes
ENSMUSG00000022191	Drosha	100	93.977	ENSPANG00000003027	DROSHA	99	93.832	Papio_anubis
ENSMUSG00000022191	Drosha	99	75.127	ENSPKIG00000011514	drosha	89	81.026	Paramormyrops_kingsleyae
ENSMUSG00000022191	Drosha	100	95.633	ENSPEMG00000000607	Drosha	100	95.415	Peromyscus_maniculatus_bairdii
ENSMUSG00000022191	Drosha	99	84.721	ENSPCIG00000006010	DROSHA	99	85.083	Phascolarctos_cinereus
ENSMUSG00000022191	Drosha	84	80.463	ENSPREG00000022302	drosha	89	79.722	Poecilia_reticulata
ENSMUSG00000022191	Drosha	100	95.560	ENSPPYG00000015370	DROSHA	99	95.560	Pongo_abelii
ENSMUSG00000022191	Drosha	100	79.913	ENSPCAG00000007190	DROSHA	100	79.840	Procavia_capensis
ENSMUSG00000022191	Drosha	100	92.358	ENSPCOG00000028511	DROSHA	100	96.364	Propithecus_coquereli
ENSMUSG00000022191	Drosha	100	91.412	ENSPVAG00000013167	DROSHA	100	91.339	Pteropus_vampyrus
ENSMUSG00000022191	Drosha	97	73.514	ENSPNYG00000000398	drosha	95	89.267	Pundamilia_nyererei
ENSMUSG00000022191	Drosha	78	92.029	ENSPNAG00000011876	drosha	85	89.181	Pygocentrus_nattereri
ENSMUSG00000022191	Drosha	100	97.888	ENSRNOG00000013451	Drosha	100	97.888	Rattus_norvegicus
ENSMUSG00000022191	Drosha	100	94.109	ENSRBIG00000032786	DROSHA	100	94.545	Rhinopithecus_bieti
ENSMUSG00000022191	Drosha	100	95.488	ENSRROG00000028199	DROSHA	99	95.488	Rhinopithecus_roxellana
ENSMUSG00000022191	Drosha	100	95.342	ENSSBOG00000024008	DROSHA	100	96.834	Saimiri_boliviensis_boliviensis
ENSMUSG00000022191	Drosha	98	83.697	ENSSHAG00000015198	DROSHA	93	96.266	Sarcophilus_harrisii
ENSMUSG00000022191	Drosha	99	71.916	ENSSFOG00015009776	drosha	92	79.585	Scleropages_formosus
ENSMUSG00000022191	Drosha	98	71.194	ENSSMAG00000008069	drosha	88	77.466	Scophthalmus_maximus
ENSMUSG00000022191	Drosha	87	77.586	ENSSDUG00000010944	drosha	95	91.192	Seriola_dumerili
ENSMUSG00000022191	Drosha	87	77.714	ENSSLDG00000025271	drosha	95	91.088	Seriola_lalandi_dorsalis
ENSMUSG00000022191	Drosha	72	74.592	ENSSARG00000004436	-	72	76.357	Sorex_araneus
ENSMUSG00000022191	Drosha	99	80.811	ENSSPUG00000006902	DROSHA	100	80.811	Sphenodon_punctatus
ENSMUSG00000022191	Drosha	100	93.013	ENSSSCG00000016809	DROSHA	100	93.122	Sus_scrofa
ENSMUSG00000022191	Drosha	99	84.446	ENSTGUG00000001955	DROSHA	100	84.218	Taeniopygia_guttata
ENSMUSG00000022191	Drosha	64	89.330	ENSTRUG00000017778	drosha	84	77.212	Takifugu_rubripes
ENSMUSG00000022191	Drosha	100	73.124	ENSTNIG00000008688	drosha	94	90.918	Tetraodon_nigroviridis
ENSMUSG00000022191	Drosha	97	84.823	ENSTBEG00000000537	DROSHA	100	82.353	Tupaia_belangeri
ENSMUSG00000022191	Drosha	100	94.469	ENSTTRG00000004210	DROSHA	100	94.469	Tursiops_truncatus
ENSMUSG00000022191	Drosha	100	93.304	ENSUAMG00000025257	DROSHA	99	93.304	Ursus_americanus
ENSMUSG00000022191	Drosha	100	90.896	ENSUMAG00000014097	DROSHA	100	96.364	Ursus_maritimus
ENSMUSG00000022191	Drosha	81	91.599	ENSVPAG00000011260	DROSHA	100	91.599	Vicugna_pacos
ENSMUSG00000022191	Drosha	100	95.779	ENSVVUG00000022212	DROSHA	99	99.125	Vulpes_vulpes
ENSMUSG00000022191	Drosha	87	79.421	ENSXETG00000016701	drosha	89	78.952	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001530	lipopolysaccharide binding	-	ISO	Function
GO:0003723	RNA binding	-	IEA	Function
GO:0003725	double-stranded RNA binding	21873635.	IBA	Function
GO:0004518	nuclease activity	-	IEA	Function
GO:0004519	endonuclease activity	-	IEA	Function
GO:0004521	endoribonuclease activity	20424607.	IDA	Function
GO:0004525	ribonuclease III activity	21873635.	IBA	Function
GO:0004525	ribonuclease III activity	-	ISO	Function
GO:0005515	protein binding	19632182.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0006396	RNA processing	21873635.	IBA	Process
GO:0010468	regulation of gene expression	22000014.	IMP	Process
GO:0010586	miRNA metabolic process	20424607.	IMP	Process
GO:0010628	positive regulation of gene expression	22053081.	IMP	Process
GO:0014069	postsynaptic density	22897173.	IDA	Component
GO:0016075	rRNA catabolic process	-	IEA	Process
GO:0016787	hydrolase activity	-	IEA	Function
GO:0017151	DEAD/H-box RNA helicase binding	-	ISO	Function
GO:0030422	production of siRNA involved in RNA interference	21873635.	IBA	Process
GO:0031053	primary miRNA processing	21873635.	IBA	Process
GO:0031053	primary miRNA processing	-	ISO	Process
GO:0031054	pre-miRNA processing	21873635.	IBA	Process
GO:0031054	pre-miRNA processing	18604195.	IDA	Process
GO:0042254	ribosome biogenesis	-	IEA	Process
GO:0042803	protein homodimerization activity	-	ISO	Function
GO:0045589	regulation of regulatory T cell differentiation	18725527.	IMP	Process
GO:0046332	SMAD binding	-	ISO	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0050727	regulation of inflammatory response	18725527.	IMP	Process
GO:0050829	defense response to Gram-negative bacterium	-	ISO	Process
GO:0050830	defense response to Gram-positive bacterium	-	ISO	Process
GO:0070412	R-SMAD binding	-	ISO	Function
GO:0070877	microprocessor complex	-	ISO	Component
GO:0070878	primary miRNA binding	-	ISO	Function
GO:2000628	regulation of miRNA metabolic process	22053081.	IMP	Process