EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSMUSG00000024079 (Gene tree)
Gene ID: 19106
Gene Symbol: Eif2ak2
Alias: 2310047A08Rik|4732414G15Rik|IFN- type I-induced and dsRNA-activated kinase|IFN-induced and double-stranded RNA-activated kinase|Pkr|Prkr|Tik|dsRNA-activated kinase|eIF-2 alpha
Full Name: eukaryotic translation initiation factor 2-alpha kinase 2
Gene Type: protein_coding
Species: Mus_musculus
Status: confidence
Strand: Minus strand
Length: 30010 bases
Position: chr17:78852564-78882573
Accession: 1353449
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSMUSP00000024884	dsrm	PF00035.26	2.6e-27	1	2
ENSMUSP00000024884	dsrm	PF00035.26	2.6e-27	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
27281784	Identification of RNA binding Proteins in Macrophages by Interactome Capture	IC & RAW264.7	2016 Jun 8	Liepelt A	DOI: 10.1074/mcp.M115.056564

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSMUST00000024884	-	4313	XM_006523863	ENSMUSP00000024884	515 (aa)	XP_006523926	Q03963
ENSMUST00000171451	-	574	-	-	- (aa)	-	-
ENSMUST00000169940	-	628	-	-	- (aa)	-	-
ENSMUST00000171852	-	704	-	-	- (aa)	-	-

Gene Model

Click here to download ENSMUSG00000024079's gene model file

Pathways

Pathway ID	Pathway Name	Source
mmu04141	Protein processing in endoplasmic reticulum	KEGG
mmu04217	Necroptosis	KEGG
mmu05160	Hepatitis C	KEGG
mmu05162	Measles	KEGG
mmu05164	Influenza A	KEGG
mmu05165	Human papillomavirus infection	KEGG
mmu05167	Kaposi sarcoma-associated herpesvirus infection	KEGG
mmu05168	Herpes simplex virus 1 infection	KEGG
mmu05169	Epstein-Barr virus infection	KEGG
mmu05203	Viral carcinogenesis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSMUSG00000024079's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSMUSG00000024079	Eif2ak2	100	57.866	ENSG00000055332	EIF2AK2	100	59.804	Homo_sapiens
ENSMUSG00000024079	Eif2ak2	96	34.087	ENSAPOG00000010686	-	78	43.945	Acanthochromis_polyacanthus
ENSMUSG00000024079	Eif2ak2	100	50.357	ENSAMEG00000017552	EIF2AK2	100	49.910	Ailuropoda_melanoleuca
ENSMUSG00000024079	Eif2ak2	96	36.771	ENSAOCG00000003388	-	94	36.771	Amphiprion_ocellaris
ENSMUSG00000024079	Eif2ak2	99	33.694	ENSAOCG00000003368	-	99	34.161	Amphiprion_ocellaris
ENSMUSG00000024079	Eif2ak2	96	34.300	ENSAPEG00000023903	-	78	44.674	Amphiprion_percula
ENSMUSG00000024079	Eif2ak2	99	34.161	ENSAPEG00000023919	-	81	41.667	Amphiprion_percula
ENSMUSG00000024079	Eif2ak2	96	37.064	ENSACAG00000008379	EIF2AK2	97	35.846	Anolis_carolinensis
ENSMUSG00000024079	Eif2ak2	99	54.563	ENSANAG00000035319	EIF2AK2	100	54.221	Aotus_nancymaae
ENSMUSG00000024079	Eif2ak2	96	33.214	ENSACLG00000023938	-	97	33.037	Astatotilapia_calliptera
ENSMUSG00000024079	Eif2ak2	98	32.664	ENSACLG00000023699	-	98	32.028	Astatotilapia_calliptera
ENSMUSG00000024079	Eif2ak2	99	54.190	ENSBTAG00000008703	EIF2AK2	99	54.887	Bos_taurus
ENSMUSG00000024079	Eif2ak2	99	56.781	ENSCJAG00000003819	EIF2AK2	99	56.420	Callithrix_jacchus
ENSMUSG00000024079	Eif2ak2	98	53.672	ENSCAFG00000006051	EIF2AK2	98	53.672	Canis_familiaris
ENSMUSG00000024079	Eif2ak2	98	53.672	ENSCAFG00020022842	EIF2AK2	98	53.672	Canis_lupus_dingo
ENSMUSG00000024079	Eif2ak2	99	54.221	ENSCHIG00000016319	EIF2AK2	99	53.537	Capra_hircus
ENSMUSG00000024079	Eif2ak2	99	53.016	ENSTSYG00000013328	EIF2AK2	99	53.989	Carlito_syrichta
ENSMUSG00000024079	Eif2ak2	99	48.654	ENSCAPG00000016388	-	99	48.190	Cavia_aperea
ENSMUSG00000024079	Eif2ak2	99	50.000	ENSCPOG00000012198	EIF2AK2	99	50.000	Cavia_porcellus
ENSMUSG00000024079	Eif2ak2	99	56.848	ENSCCAG00000037822	EIF2AK2	99	56.767	Cebus_capucinus
ENSMUSG00000024079	Eif2ak2	99	54.845	ENSCATG00000036727	EIF2AK2	99	55.027	Cercocebus_atys
ENSMUSG00000024079	Eif2ak2	82	56.979	ENSCLAG00000008409	-	98	56.422	Chinchilla_lanigera
ENSMUSG00000024079	Eif2ak2	100	57.246	ENSCSAG00000012135	EIF2AK2	99	57.246	Chlorocebus_sabaeus
ENSMUSG00000024079	Eif2ak2	72	70.886	ENSCHOG00000004388	-	70	70.886	Choloepus_hoffmanni
ENSMUSG00000024079	Eif2ak2	99	68.242	ENSCGRG00001021739	eIF2aK2	99	70.132	Cricetulus_griseus_chok1gshd
ENSMUSG00000024079	Eif2ak2	82	69.176	ENSCGRG00000015847	Eif2ak2	99	67.117	Cricetulus_griseus_crigri
ENSMUSG00000024079	Eif2ak2	99	52.214	ENSDNOG00000010498	EIF2AK2	99	51.565	Dasypus_novemcinctus
ENSMUSG00000024079	Eif2ak2	99	56.863	ENSDORG00000009488	Eif2ak2	99	56.751	Dipodomys_ordii
ENSMUSG00000024079	Eif2ak2	87	58.088	ENSETEG00000009782	-	88	58.088	Echinops_telfairi
ENSMUSG00000024079	Eif2ak2	99	52.083	ENSEASG00005007360	EIF2AK2	98	52.783	Equus_asinus_asinus
ENSMUSG00000024079	Eif2ak2	100	53.394	ENSECAG00000011726	EIF2AK2	100	52.477	Equus_caballus
ENSMUSG00000024079	Eif2ak2	59	47.869	ENSEEUG00000005539	-	68	62.500	Erinaceus_europaeus
ENSMUSG00000024079	Eif2ak2	99	54.444	ENSFCAG00000006339	EIF2AK2	99	54.444	Felis_catus
ENSMUSG00000024079	Eif2ak2	92	36.723	ENSFALG00000011889	EIF2AK2	90	37.232	Ficedula_albicollis
ENSMUSG00000024079	Eif2ak2	83	56.951	ENSFDAG00000006052	-	99	56.278	Fukomys_damarensis
ENSMUSG00000024079	Eif2ak2	95	35.453	ENSGAFG00000005269	-	95	34.866	Gambusia_affinis
ENSMUSG00000024079	Eif2ak2	95	40.637	ENSGAGG00000002104	EIF2AK2	96	39.744	Gopherus_agassizii
ENSMUSG00000024079	Eif2ak2	100	58.228	ENSGGOG00000005556	EIF2AK2	100	56.781	Gorilla_gorilla
ENSMUSG00000024079	Eif2ak2	99	55.556	ENSHGLG00000013093	EIF2AK2	99	55.370	Heterocephalus_glaber_female
ENSMUSG00000024079	Eif2ak2	99	55.370	ENSHGLG00100005051	EIF2AK2	99	55.185	Heterocephalus_glaber_male
ENSMUSG00000024079	Eif2ak2	99	56.481	ENSSTOG00000013886	EIF2AK2	99	56.983	Ictidomys_tridecemlineatus
ENSMUSG00000024079	Eif2ak2	99	50.290	ENSJJAG00000015000	-	99	50.097	Jaculus_jaculus
ENSMUSG00000024079	Eif2ak2	96	32.759	ENSKMAG00000008407	-	94	33.955	Kryptolebias_marmoratus
ENSMUSG00000024079	Eif2ak2	82	46.975	ENSLOCG00000015909	-	73	46.975	Lepisosteus_oculatus
ENSMUSG00000024079	Eif2ak2	100	56.571	ENSLAFG00000018604	EIF2AK2	100	56.190	Loxodonta_africana
ENSMUSG00000024079	Eif2ak2	98	54.083	ENSMFAG00000030576	EIF2AK2	98	53.748	Macaca_fascicularis
ENSMUSG00000024079	Eif2ak2	99	53.957	ENSMMUG00000037522	EIF2AK2	99	53.623	Macaca_mulatta
ENSMUSG00000024079	Eif2ak2	99	49.067	ENSMNEG00000040090	EIF2AK2	99	48.593	Macaca_nemestrina
ENSMUSG00000024079	Eif2ak2	99	53.986	ENSMLEG00000033494	EIF2AK2	99	53.552	Mandrillus_leucophaeus
ENSMUSG00000024079	Eif2ak2	96	35.616	ENSMZEG00005009747	-	61	41.414	Maylandia_zebra
ENSMUSG00000024079	Eif2ak2	96	35.821	ENSMGAG00000011175	EIF2AK2	90	36.382	Meleagris_gallopavo
ENSMUSG00000024079	Eif2ak2	99	68.665	ENSMAUG00000000309	Eif2ak2	99	68.085	Mesocricetus_auratus
ENSMUSG00000024079	Eif2ak2	99	54.710	ENSMICG00000003317	EIF2AK2	94	53.986	Microcebus_murinus
ENSMUSG00000024079	Eif2ak2	99	49.323	ENSMOCG00000021613	-	96	75.776	Microtus_ochrogaster
ENSMUSG00000024079	Eif2ak2	97	35.065	ENSMMOG00000000659	-	86	33.846	Mola_mola
ENSMUSG00000024079	Eif2ak2	98	46.718	ENSMODG00000015286	-	97	46.139	Monodelphis_domestica
ENSMUSG00000024079	Eif2ak2	100	85.631	MGP_CAROLIEiJ_G0021889	Eif2ak2	100	85.631	Mus_caroli
ENSMUSG00000024079	Eif2ak2	100	88.372	MGP_PahariEiJ_G0020877	Eif2ak2	100	88.372	Mus_pahari
ENSMUSG00000024079	Eif2ak2	100	97.476	MGP_SPRETEiJ_G0022803	Eif2ak2	100	97.476	Mus_spretus
ENSMUSG00000024079	Eif2ak2	92	51.830	ENSMPUG00000009893	EIF2AK2	99	51.823	Mustela_putorius_furo
ENSMUSG00000024079	Eif2ak2	99	49.097	ENSMLUG00000003513	-	99	48.556	Myotis_lucifugus
ENSMUSG00000024079	Eif2ak2	84	45.374	ENSMLUG00000030615	-	99	46.374	Myotis_lucifugus
ENSMUSG00000024079	Eif2ak2	99	62.115	ENSNGAG00000017501	Eif2ak2	99	61.923	Nannospalax_galili
ENSMUSG00000024079	Eif2ak2	97	33.514	ENSNBRG00000019369	-	97	33.333	Neolamprologus_brichardi
ENSMUSG00000024079	Eif2ak2	99	52.190	ENSNLEG00000016201	EIF2AK2	99	52.190	Nomascus_leucogenys
ENSMUSG00000024079	Eif2ak2	87	47.917	ENSOPRG00000008168	-	87	48.214	Ochotona_princeps
ENSMUSG00000024079	Eif2ak2	97	42.883	ENSOANG00000003939	-	96	42.336	Ornithorhynchus_anatinus
ENSMUSG00000024079	Eif2ak2	99	54.430	ENSOCUG00000007223	EIF2AK2	99	55.657	Oryctolagus_cuniculus
ENSMUSG00000024079	Eif2ak2	100	56.172	ENSOGAG00000002562	EIF2AK2	100	56.172	Otolemur_garnettii
ENSMUSG00000024079	Eif2ak2	99	50.450	ENSOARG00000009740	EIF2AK2	99	50.802	Ovis_aries
ENSMUSG00000024079	Eif2ak2	100	57.324	ENSPPAG00000034727	EIF2AK2	100	55.877	Pan_paniscus
ENSMUSG00000024079	Eif2ak2	99	54.244	ENSPPRG00000003287	EIF2AK2	99	53.604	Panthera_pardus
ENSMUSG00000024079	Eif2ak2	99	54.059	ENSPTIG00000018329	EIF2AK2	99	53.889	Panthera_tigris_altaica
ENSMUSG00000024079	Eif2ak2	100	57.324	ENSPTRG00000011834	EIF2AK2	100	55.877	Pan_troglodytes
ENSMUSG00000024079	Eif2ak2	99	54.775	ENSPANG00000004770	EIF2AK2	99	54.348	Papio_anubis
ENSMUSG00000024079	Eif2ak2	97	40.214	ENSPSIG00000018049	EIF2AK2	92	39.394	Pelodiscus_sinensis
ENSMUSG00000024079	Eif2ak2	82	63.830	ENSPEMG00000010269	Eif2ak2	100	63.830	Peromyscus_maniculatus_bairdii
ENSMUSG00000024079	Eif2ak2	97	42.169	ENSPCIG00000010984	-	97	42.463	Phascolarctos_cinereus
ENSMUSG00000024079	Eif2ak2	86	32.671	ENSPLAG00000023907	-	97	31.567	Poecilia_latipinna
ENSMUSG00000024079	Eif2ak2	97	32.075	ENSPREG00000007871	-	97	31.561	Poecilia_reticulata
ENSMUSG00000024079	Eif2ak2	100	52.441	ENSPPYG00000012493	EIF2AK2	100	51.537	Pongo_abelii
ENSMUSG00000024079	Eif2ak2	83	61.864	ENSPCAG00000013068	EIF2AK2	82	61.864	Procavia_capensis
ENSMUSG00000024079	Eif2ak2	99	56.522	ENSPCOG00000014117	EIF2AK2	99	55.616	Propithecus_coquereli
ENSMUSG00000024079	Eif2ak2	100	53.789	ENSPVAG00000013831	EIF2AK2	100	52.311	Pteropus_vampyrus
ENSMUSG00000024079	Eif2ak2	100	76.538	ENSRNOG00000048315	Eif2ak2	100	76.538	Rattus_norvegicus
ENSMUSG00000024079	Eif2ak2	100	56.102	ENSRBIG00000034494	EIF2AK2	100	55.373	Rhinopithecus_bieti
ENSMUSG00000024079	Eif2ak2	100	56.318	ENSRROG00000040152	EIF2AK2	100	56.522	Rhinopithecus_roxellana
ENSMUSG00000024079	Eif2ak2	99	54.745	ENSSBOG00000026743	EIF2AK2	99	54.015	Saimiri_boliviensis_boliviensis
ENSMUSG00000024079	Eif2ak2	96	40.720	ENSSHAG00000001447	-	96	39.962	Sarcophilus_harrisii
ENSMUSG00000024079	Eif2ak2	97	36.691	ENSSFOG00015008993	-	96	36.691	Scleropages_formosus
ENSMUSG00000024079	Eif2ak2	99	35.565	ENSSMAG00000010248	-	99	33.396	Scophthalmus_maximus
ENSMUSG00000024079	Eif2ak2	92	32.574	ENSSPAG00000007673	-	90	32.500	Stegastes_partitus
ENSMUSG00000024079	Eif2ak2	97	32.099	ENSSPAG00000007546	-	97	32.247	Stegastes_partitus
ENSMUSG00000024079	Eif2ak2	100	55.433	ENSSSCG00000008496	-	100	55.433	Sus_scrofa
ENSMUSG00000024079	Eif2ak2	96	34.866	ENSTRUG00000002791	-	97	33.708	Takifugu_rubripes
ENSMUSG00000024079	Eif2ak2	85	36.345	ENSTNIG00000000327	-	100	36.345	Tetraodon_nigroviridis
ENSMUSG00000024079	Eif2ak2	69	60.714	ENSTBEG00000014601	-	65	60.714	Tupaia_belangeri
ENSMUSG00000024079	Eif2ak2	100	54.348	ENSTTRG00000006882	EIF2AK2	100	55.027	Tursiops_truncatus
ENSMUSG00000024079	Eif2ak2	84	53.440	ENSUAMG00000015141	-	97	53.318	Ursus_americanus
ENSMUSG00000024079	Eif2ak2	100	50.906	ENSUMAG00000014765	EIF2AK2	100	50.995	Ursus_maritimus
ENSMUSG00000024079	Eif2ak2	99	54.749	ENSVPAG00000003303	EIF2AK2	99	55.121	Vicugna_pacos
ENSMUSG00000024079	Eif2ak2	99	54.151	ENSVVUG00000018911	EIF2AK2	99	53.019	Vulpes_vulpes
ENSMUSG00000024079	Eif2ak2	89	34.216	ENSXETG00000025302	eif2ak2	97	34.216	Xenopus_tropicalis
ENSMUSG00000024079	Eif2ak2	97	33.989	ENSXCOG00000006974	-	96	33.766	Xiphophorus_couchianus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000166	nucleotide binding	-	IEA	Function
GO:0000186	activation of MAPKK activity	-	ISO	Process
GO:0001819	positive regulation of cytokine production	20038207.	IMP	Process
GO:0002376	immune system process	-	IEA	Process
GO:0003723	RNA binding	-	IEA	Function
GO:0003725	double-stranded RNA binding	21703541.	IDA	Function
GO:0003725	double-stranded RNA binding	21266579.	ISO	Function
GO:0004672	protein kinase activity	21873635.	IBA	Function
GO:0004672	protein kinase activity	7519779.15545996.	IDA	Function
GO:0004672	protein kinase activity	21123651.	IMP	Function
GO:0004672	protein kinase activity	-	ISO	Function
GO:0004674	protein serine/threonine kinase activity	-	IEA	Function
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	21873635.	IBA	Function
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	-	ISO	Function
GO:0004713	protein tyrosine kinase activity	-	IEA	Function
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IEA	Function
GO:0005515	protein binding	7519779.10488071.12882984.18362360.20144759.22801494.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	ISO	Component
GO:0005737	cytoplasm	-	ISO	Component
GO:0005829	cytosol	-	ISO	Component
GO:0006412	translation	7519779.	IDA	Process
GO:0006468	protein phosphorylation	7519779.15542627.	IDA	Process
GO:0006468	protein phosphorylation	-	ISO	Process
GO:0008285	negative regulation of cell proliferation	-	IEA	Process
GO:0009615	response to virus	-	ISO	Process
GO:0009636	response to toxic substance	-	ISO	Process
GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	-	IEA	Process
GO:0016301	kinase activity	-	IEA	Function
GO:0016310	phosphorylation	-	IEA	Process
GO:0016740	transferase activity	-	IEA	Function
GO:0017148	negative regulation of translation	-	ISO	Process
GO:0022626	cytosolic ribosome	21873635.	IBA	Component
GO:0030968	endoplasmic reticulum unfolded protein response	15542627.	IDA	Process
GO:0032496	response to lipopolysaccharide	-	ISO	Process
GO:0032722	positive regulation of chemokine production	20038207.	IMP	Process
GO:0032874	positive regulation of stress-activated MAPK cascade	20038207.	IMP	Process
GO:0033197	response to vitamin E	-	ISO	Process
GO:0033689	negative regulation of osteoblast proliferation	-	ISO	Process
GO:0034198	cellular response to amino acid starvation	-	ISO	Process
GO:0035455	response to interferon-alpha	-	ISO	Process
GO:0042802	identical protein binding	-	ISO	Function
GO:0042981	regulation of apoptotic process	-	IEA	Process
GO:0043065	positive regulation of apoptotic process	-	ISO	Process
GO:0043066	negative regulation of apoptotic process	15542627.	IGI	Process
GO:0045071	negative regulation of viral genome replication	20038207.	IMP	Process
GO:0045071	negative regulation of viral genome replication	-	ISO	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0046777	protein autophosphorylation	7519779.15542627.22801494.	IDA	Process
GO:0046777	protein autophosphorylation	-	ISO	Process
GO:0048471	perinuclear region of cytoplasm	-	ISO	Component
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	ISO	Process
GO:0051607	defense response to virus	-	IEA	Process
GO:1900225	regulation of NLRP3 inflammasome complex assembly	22801494.	IMP	Process
GO:1901224	positive regulation of NIK/NF-kappaB signaling	20038207.	IMP	Process
GO:1901532	regulation of hematopoietic progenitor cell differentiation	23403623.	IMP	Process
GO:1902033	regulation of hematopoietic stem cell proliferation	23403623.	IMP	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	23403623.	IMP	Process