EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSMUSG00000028124 (Gene tree)
Gene ID: 14630
Gene Symbol: Gclm
Alias: Gcmc|Glclr
Full Name: glutamate-cysteine ligase%2C modifier subunit
Gene Type: protein_coding
Species: Mus_musculus
Status: putative
Strand: Plus strand
Length: 25176
Position: chr3: 122245557-122270732
Accession: 104995
RBP type: non-canonical RBP
Summary: -

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
27281784	Identification of RNA binding Proteins in Macrophages by Interactome Capture	IC & RAW264.7	2016 Jun 8	Liepelt A	DOI: 10.1074/mcp.M115.056564

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSMUST00000176761	-	495	-	-	- (aa)	-	-
ENSMUST00000029769	-	5589	-	ENSMUSP00000029769	274 (aa)	-	O09172
ENSMUST00000137540	-	762	-	-	- (aa)	-	-
ENSMUST00000176445	-	877	-	ENSMUSP00000134906	199 (aa)	-	H3BJA3
ENSMUST00000149983	-	1088	-	ENSMUSP00000123683	153 (aa)	-	F6VNW5
ENSMUST00000199699	-	292	-	ENSMUSP00000142381	98 (aa)	-	A0A0G2JDI4
ENSMUST00000178826	-	1002	-	ENSMUSP00000136987	274 (aa)	-	O09172

Gene Model

Click here to download ENSMUSG00000028124's gene model file

Pathways

Pathway ID	Pathway Name	Source
mmu00270	Cysteine and methionine metabolism	KEGG
mmu00480	Glutathione metabolism	KEGG
mmu01100	Metabolic pathways	KEGG
mmu04216	Ferroptosis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSMUSG00000028124's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSMUSG00000028124	Gclm	100	96.350	ENSG00000023909	GCLM	100	96.350	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004357	glutamate-cysteine ligase activity	-	ISO	Function
GO:0004357	glutamate-cysteine ligase activity	-	ISO	Function
GO:0006534	cysteine metabolic process	12384496.	IMP	Process
GO:0006536	glutamate metabolic process	-	ISO	Process
GO:0006749	glutathione metabolic process	12384496.	IMP	Process
GO:0006750	glutathione biosynthetic process	21873635.	IBA	Process
GO:0006750	glutathione biosynthetic process	16081425.	IDA	Process
GO:0006750	glutathione biosynthetic process	-	ISO	Process
GO:0006979	response to oxidative stress	12384496.	IMP	Process
GO:0006979	response to oxidative stress	-	ISO	Process
GO:0008637	apoptotic mitochondrial changes	15288121.	IGI	Process
GO:0017109	glutamate-cysteine ligase complex	21873635.	IBA	Component
GO:0017109	glutamate-cysteine ligase complex	12384496.16081425.	IDA	Component
GO:0017109	glutamate-cysteine ligase complex	-	ISO	Component
GO:0030234	enzyme regulator activity	21873635.	IBA	Function
GO:0035226	glutamate-cysteine ligase catalytic subunit binding	12384496.	IDA	Function
GO:0035226	glutamate-cysteine ligase catalytic subunit binding	-	ISO	Function
GO:0035229	positive regulation of glutamate-cysteine ligase activity	21873635.	IBA	Process
GO:0035229	positive regulation of glutamate-cysteine ligase activity	12384496.15288121.16081425.	IDA	Process
GO:0035229	positive regulation of glutamate-cysteine ligase activity	-	ISO	Process
GO:0042493	response to drug	-	ISO	Process
GO:0043524	negative regulation of neuron apoptotic process	-	ISO	Process
GO:0046982	protein heterodimerization activity	12384496.16081425.	IPI	Function
GO:0046982	protein heterodimerization activity	-	ISO	Function
GO:0050880	regulation of blood vessel size	-	ISO	Process
GO:0051409	response to nitrosative stress	-	ISO	Process
GO:0051900	regulation of mitochondrial depolarization	15288121.	IGI	Process
GO:1990830	cellular response to leukemia inhibitory factor	20439489.	IEP	Process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	15288121.	IGI	Process