EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSMUSG00000031583 (Gene tree)
Gene ID: 22427
Gene Symbol: Wrn
Alias: -
Full Name: Werner syndrome RecQ like helicase
Gene Type: protein_coding
Species: Mus_musculus
Status: putative
Strand: Minus strand
Length: 151144 bases
Position: chr8:33234384-33385527
Accession: 109635
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSMUSP00000147379	HRDC	PF00570.23	6.9e-14	1	1
ENSMUSP00000033990	HRDC	PF00570.23	9.5e-14	1	1
ENSMUSP00000033991	HRDC	PF00570.23	9.5e-14	1	1
ENSMUSP00000147379	DEAD	PF00270.29	1.8e-15	1	1
ENSMUSP00000033990	DEAD	PF00270.29	3.1e-15	1	1
ENSMUSP00000033991	DEAD	PF00270.29	3.1e-15	1	1
ENSMUSP00000033990	DNA_pol_A_exo1	PF01612.20	3.8e-35	1	1
ENSMUSP00000033991	DNA_pol_A_exo1	PF01612.20	3.8e-35	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSMUST00000209293	-	1921	-	-	- (aa)	-	-
ENSMUST00000033991	-	6262	XM_006509091	ENSMUSP00000033991	1401 (aa)	XP_006509154	O09053
ENSMUST00000033990	-	5019	-	ENSMUSP00000033990	1401 (aa)	-	O09053
ENSMUST00000211498	-	4856	-	ENSMUSP00000147379	1158 (aa)	-	A0A1B0GR54

Gene Model

Click here to download ENSMUSG00000031583's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSMUSG00000031583's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSMUSG00000031583	Wrn	100	69.735	ENSG00000165392	WRN	99	70.014	Homo_sapiens
ENSMUSG00000031583	Wrn	97	70.000	ENSAMEG00000000475	-	97	70.000	Ailuropoda_melanoleuca
ENSMUSG00000031583	Wrn	93	55.898	ENSAPLG00000001616	WRN	91	56.349	Anas_platyrhynchos
ENSMUSG00000031583	Wrn	94	51.227	ENSACAG00000003109	WRN	100	51.522	Anolis_carolinensis
ENSMUSG00000031583	Wrn	100	68.134	ENSANAG00000032806	WRN	98	71.526	Aotus_nancymaae
ENSMUSG00000031583	Wrn	94	48.834	ENSAMXG00000010066	wrn	89	48.909	Astyanax_mexicanus
ENSMUSG00000031583	Wrn	99	68.594	ENSBTAG00000021592	WRN	99	68.594	Bos_taurus
ENSMUSG00000031583	Wrn	69	32.795	WBGene00006944	wrn-1	73	32.795	Caenorhabditis_elegans
ENSMUSG00000031583	Wrn	100	70.482	ENSCJAG00000012511	WRN	99	70.551	Callithrix_jacchus
ENSMUSG00000031583	Wrn	100	70.325	ENSCAFG00000006410	WRN	97	70.325	Canis_familiaris
ENSMUSG00000031583	Wrn	100	68.511	ENSCAFG00020001236	WRN	99	68.511	Canis_lupus_dingo
ENSMUSG00000031583	Wrn	99	68.714	ENSCHIG00000014991	WRN	99	68.714	Capra_hircus
ENSMUSG00000031583	Wrn	99	71.266	ENSTSYG00000012689	WRN	99	71.337	Carlito_syrichta
ENSMUSG00000031583	Wrn	90	64.809	ENSCAPG00000016803	WRN	98	65.689	Cavia_aperea
ENSMUSG00000031583	Wrn	99	68.417	ENSCPOG00000002943	WRN	99	68.417	Cavia_porcellus
ENSMUSG00000031583	Wrn	100	71.229	ENSCCAG00000023793	WRN	99	71.229	Cebus_capucinus
ENSMUSG00000031583	Wrn	99	71.510	ENSCATG00000040557	WRN	99	72.754	Cercocebus_atys
ENSMUSG00000031583	Wrn	100	69.815	ENSCLAG00000000817	WRN	99	69.815	Chinchilla_lanigera
ENSMUSG00000031583	Wrn	96	71.095	ENSCSAG00000015810	WRN	99	70.882	Chlorocebus_sabaeus
ENSMUSG00000031583	Wrn	70	86.592	ENSCHOG00000008966	WRN	74	86.592	Choloepus_hoffmanni
ENSMUSG00000031583	Wrn	95	57.618	ENSCPBG00000013421	WRN	90	57.949	Chrysemys_picta_bellii
ENSMUSG00000031583	Wrn	72	40.324	ENSCING00000002232	-	70	40.324	Ciona_intestinalis
ENSMUSG00000031583	Wrn	100	70.182	ENSCANG00000037137	WRN	99	70.182	Colobus_angolensis_palliatus
ENSMUSG00000031583	Wrn	100	83.464	ENSCGRG00001016491	Wrn	100	83.749	Cricetulus_griseus_chok1gshd
ENSMUSG00000031583	Wrn	100	82.399	ENSCGRG00000016821	Wrn	100	82.744	Cricetulus_griseus_crigri
ENSMUSG00000031583	Wrn	94	47.270	ENSDARG00000098211	wrn	90	47.270	Danio_rerio
ENSMUSG00000031583	Wrn	100	64.268	ENSDNOG00000008481	WRN	100	66.499	Dasypus_novemcinctus
ENSMUSG00000031583	Wrn	100	69.247	ENSDORG00000002696	Wrn	100	69.669	Dipodomys_ordii
ENSMUSG00000031583	Wrn	79	81.159	ENSETEG00000019854	WRN	79	81.159	Echinops_telfairi
ENSMUSG00000031583	Wrn	97	67.398	ENSEASG00005016813	WRN	99	77.322	Equus_asinus_asinus
ENSMUSG00000031583	Wrn	100	68.185	ENSECAG00000000110	WRN	99	68.185	Equus_caballus
ENSMUSG00000031583	Wrn	85	64.977	ENSEEUG00000004926	WRN	90	64.977	Erinaceus_europaeus
ENSMUSG00000031583	Wrn	94	46.989	ENSELUG00000017817	wrn	96	50.771	Esox_lucius
ENSMUSG00000031583	Wrn	100	66.224	ENSFCAG00000024759	WRN	99	66.224	Felis_catus
ENSMUSG00000031583	Wrn	100	70.747	ENSFDAG00000008637	WRN	99	70.747	Fukomys_damarensis
ENSMUSG00000031583	Wrn	95	56.062	ENSGALG00000040909	WRN	89	56.356	Gallus_gallus
ENSMUSG00000031583	Wrn	97	57.143	ENSGAGG00000022647	WRN	99	55.123	Gopherus_agassizii
ENSMUSG00000031583	Wrn	100	71.408	ENSGGOG00000022154	WRN	99	71.550	Gorilla_gorilla
ENSMUSG00000031583	Wrn	100	72.191	ENSHGLG00000003638	WRN	100	72.119	Heterocephalus_glaber_female
ENSMUSG00000031583	Wrn	95	47.041	ENSIPUG00000002090	wrn	99	45.334	Ictalurus_punctatus
ENSMUSG00000031583	Wrn	100	71.596	ENSSTOG00000013599	WRN	99	71.596	Ictidomys_tridecemlineatus
ENSMUSG00000031583	Wrn	100	71.225	ENSJJAG00000015655	Wrn	100	71.225	Jaculus_jaculus
ENSMUSG00000031583	Wrn	97	48.895	ENSLACG00000001569	-	93	49.110	Latimeria_chalumnae
ENSMUSG00000031583	Wrn	94	52.024	ENSLOCG00000010792	wrn	93	50.110	Lepisosteus_oculatus
ENSMUSG00000031583	Wrn	100	71.186	ENSLAFG00000004434	WRN	100	71.186	Loxodonta_africana
ENSMUSG00000031583	Wrn	99	71.143	ENSMFAG00000043428	WRN	99	71.500	Macaca_fascicularis
ENSMUSG00000031583	Wrn	100	69.693	ENSMMUG00000022655	WRN	99	70.042	Macaca_mulatta
ENSMUSG00000031583	Wrn	100	70.202	ENSMNEG00000032617	WRN	99	70.272	Macaca_nemestrina
ENSMUSG00000031583	Wrn	99	71.795	ENSMLEG00000038296	WRN	99	71.866	Mandrillus_leucophaeus
ENSMUSG00000031583	Wrn	94	56.522	ENSMGAG00000004960	WRN	88	56.890	Meleagris_gallopavo
ENSMUSG00000031583	Wrn	100	84.034	ENSMAUG00000016235	Wrn	100	84.248	Mesocricetus_auratus
ENSMUSG00000031583	Wrn	100	67.767	ENSMICG00000010630	WRN	99	67.767	Microcebus_murinus
ENSMUSG00000031583	Wrn	100	81.954	ENSMOCG00000013972	Wrn	100	81.954	Microtus_ochrogaster
ENSMUSG00000031583	Wrn	99	56.054	ENSMODG00000018997	WRN	99	56.481	Monodelphis_domestica
ENSMUSG00000031583	Wrn	100	97.502	MGP_CAROLIEiJ_G0030961	Wrn	100	97.502	Mus_caroli
ENSMUSG00000031583	Wrn	100	93.790	MGP_PahariEiJ_G0021430	Wrn	100	93.790	Mus_pahari
ENSMUSG00000031583	Wrn	100	98.858	MGP_SPRETEiJ_G0032079	Wrn	100	98.858	Mus_spretus
ENSMUSG00000031583	Wrn	100	68.772	ENSMPUG00000010201	WRN	99	68.772	Mustela_putorius_furo
ENSMUSG00000031583	Wrn	99	71.041	ENSMLUG00000005863	WRN	99	71.041	Myotis_lucifugus
ENSMUSG00000031583	Wrn	99	77.011	ENSNGAG00000018413	Wrn	99	77.011	Nannospalax_galili
ENSMUSG00000031583	Wrn	100	70.934	ENSNLEG00000012006	WRN	99	71.146	Nomascus_leucogenys
ENSMUSG00000031583	Wrn	74	62.174	ENSMEUG00000008271	-	75	62.174	Notamacropus_eugenii
ENSMUSG00000031583	Wrn	88	59.669	ENSOPRG00000001480	WRN	88	59.669	Ochotona_princeps
ENSMUSG00000031583	Wrn	100	71.408	ENSODEG00000004076	WRN	100	71.408	Octodon_degus
ENSMUSG00000031583	Wrn	97	58.399	ENSOANG00000005952	-	94	59.780	Ornithorhynchus_anatinus
ENSMUSG00000031583	Wrn	100	71.449	ENSOCUG00000012620	WRN	90	71.378	Oryctolagus_cuniculus
ENSMUSG00000031583	Wrn	97	68.973	ENSOGAG00000009600	WRN	100	69.046	Otolemur_garnettii
ENSMUSG00000031583	Wrn	99	69.022	ENSOARG00000000163	WRN	99	69.022	Ovis_aries
ENSMUSG00000031583	Wrn	100	70.860	ENSPPAG00000036871	WRN	99	71.215	Pan_paniscus
ENSMUSG00000031583	Wrn	100	68.799	ENSPPRG00000010928	WRN	99	68.728	Panthera_pardus
ENSMUSG00000031583	Wrn	100	68.657	ENSPTIG00000020609	WRN	99	68.657	Panthera_tigris_altaica
ENSMUSG00000031583	Wrn	100	70.630	ENSPTRG00000020145	WRN	99	70.984	Pan_troglodytes
ENSMUSG00000031583	Wrn	99	70.112	ENSPANG00000018594	WRN	99	70.391	Papio_anubis
ENSMUSG00000031583	Wrn	77	59.735	ENSPKIG00000025497	wrn	99	59.735	Paramormyrops_kingsleyae
ENSMUSG00000031583	Wrn	97	56.866	ENSPSIG00000013411	WRN	92	57.358	Pelodiscus_sinensis
ENSMUSG00000031583	Wrn	99	82.800	ENSPEMG00000020615	Wrn	99	82.800	Peromyscus_maniculatus_bairdii
ENSMUSG00000031583	Wrn	96	56.461	ENSPCIG00000020146	WRN	98	57.122	Phascolarctos_cinereus
ENSMUSG00000031583	Wrn	100	70.153	ENSPPYG00000018494	WRN	99	70.502	Pongo_abelii
ENSMUSG00000031583	Wrn	90	69.914	ENSPCAG00000013763	WRN	88	69.914	Procavia_capensis
ENSMUSG00000031583	Wrn	78	59.869	ENSPCOG00000012938	WRN	96	59.837	Propithecus_coquereli
ENSMUSG00000031583	Wrn	93	68.293	ENSPVAG00000012909	WRN	91	68.293	Pteropus_vampyrus
ENSMUSG00000031583	Wrn	94	48.558	ENSPNAG00000021848	wrn	88	48.708	Pygocentrus_nattereri
ENSMUSG00000031583	Wrn	100	86.652	ENSRNOG00000015440	Wrn	100	86.652	Rattus_norvegicus
ENSMUSG00000031583	Wrn	100	70.584	ENSRBIG00000031825	WRN	100	70.405	Rhinopithecus_bieti
ENSMUSG00000031583	Wrn	100	70.182	ENSRROG00000045381	WRN	99	70.112	Rhinopithecus_roxellana
ENSMUSG00000031583	Wrn	100	70.650	ENSSBOG00000027238	WRN	99	70.650	Saimiri_boliviensis_boliviensis
ENSMUSG00000031583	Wrn	99	56.627	ENSSHAG00000005577	WRN	99	57.255	Sarcophilus_harrisii
ENSMUSG00000031583	Wrn	95	49.481	ENSSFOG00015006123	wrn	95	49.554	Scleropages_formosus
ENSMUSG00000031583	Wrn	73	66.667	ENSSARG00000006157	WRN	87	66.667	Sorex_araneus
ENSMUSG00000031583	Wrn	97	72.153	ENSSSCG00000015840	WRN	99	72.079	Sus_scrofa
ENSMUSG00000031583	Wrn	72	56.736	ENSTGUG00000001765	WRN	100	56.967	Taeniopygia_guttata
ENSMUSG00000031583	Wrn	78	55.774	ENSTBEG00000012702	-	78	55.774	Tupaia_belangeri
ENSMUSG00000031583	Wrn	98	65.654	ENSTTRG00000012302	WRN	99	65.529	Tursiops_truncatus
ENSMUSG00000031583	Wrn	100	67.211	ENSUAMG00000021324	WRN	99	67.306	Ursus_americanus
ENSMUSG00000031583	Wrn	85	67.500	ENSUMAG00000007159	WRN	97	67.500	Ursus_maritimus
ENSMUSG00000031583	Wrn	100	65.269	ENSVPAG00000011004	WRN	99	65.269	Vicugna_pacos
ENSMUSG00000031583	Wrn	100	66.896	ENSVVUG00000019867	WRN	99	66.896	Vulpes_vulpes
ENSMUSG00000031583	Wrn	98	53.443	ENSXETG00000018302	wrn	99	54.996	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000166	nucleotide binding	-	IEA	Function
GO:0000287	magnesium ion binding	21873635.	IBA	Function
GO:0000287	magnesium ion binding	-	ISO	Function
GO:0000400	four-way junction DNA binding	21873635.	IBA	Function
GO:0000400	four-way junction DNA binding	-	ISO	Function
GO:0000403	Y-form DNA binding	21873635.	IBA	Function
GO:0000403	Y-form DNA binding	-	ISO	Function
GO:0000405	bubble DNA binding	21873635.	IBA	Function
GO:0000405	bubble DNA binding	-	ISO	Function
GO:0000723	telomere maintenance	15235603.15367665.	IGI	Process
GO:0000723	telomere maintenance	12707040.	IMP	Process
GO:0000723	telomere maintenance	-	ISO	Process
GO:0000724	double-strand break repair via homologous recombination	21873635.	IBA	Process
GO:0000731	DNA synthesis involved in DNA repair	21873635.	IBA	Process
GO:0000731	DNA synthesis involved in DNA repair	-	ISO	Process
GO:0000781	chromosome, telomeric region	21873635.	IBA	Component
GO:0000781	chromosome, telomeric region	26195664.	IMP	Component
GO:0000781	chromosome, telomeric region	-	ISO	Component
GO:0001302	replicative cell aging	21873635.	IBA	Process
GO:0001302	replicative cell aging	10757812.	IMP	Process
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003677	DNA binding	-	ISO	Function
GO:0003678	DNA helicase activity	-	ISO	Function
GO:0003682	chromatin binding	21873635.	IBA	Function
GO:0003682	chromatin binding	-	ISO	Function
GO:0003824	catalytic activity	-	IEA	Function
GO:0004003	ATP-dependent DNA helicase activity	-	ISO	Function
GO:0004386	helicase activity	-	ISO	Function
GO:0004518	nuclease activity	-	IEA	Function
GO:0004527	exonuclease activity	-	ISO	Function
GO:0005515	protein binding	11301316.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9789047.	IDA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	11420665.	IDA	Component
GO:0005654	nucleoplasm	11420665.	ISO	Component
GO:0005657	replication fork	21873635.	IBA	Component
GO:0005657	replication fork	26195664.	IMP	Component
GO:0005662	DNA replication factor A complex	21873635.	IBA	Component
GO:0005694	chromosome	21873635.	IBA	Component
GO:0005730	nucleolus	11420665.	IDA	Component
GO:0005730	nucleolus	11420665.	ISO	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005813	centrosome	-	ISO	Component
GO:0006139	nucleobase-containing compound metabolic process	-	IEA	Process
GO:0006259	DNA metabolic process	11756244.12707040.	IMP	Process
GO:0006259	DNA metabolic process	-	ISO	Process
GO:0006260	DNA replication	26195664.	IGI	Process
GO:0006260	DNA replication	9789047.26195664.	IMP	Process
GO:0006260	DNA replication	-	ISO	Process
GO:0006281	DNA repair	21873635.	IBA	Process
GO:0006284	base-excision repair	21873635.	IBA	Process
GO:0006284	base-excision repair	-	ISO	Process
GO:0006302	double-strand break repair	-	ISO	Process
GO:0006310	DNA recombination	21873635.	IBA	Process
GO:0006974	cellular response to DNA damage stimulus	-	ISO	Process
GO:0006979	response to oxidative stress	21873635.	IBA	Process
GO:0006979	response to oxidative stress	-	ISO	Process
GO:0007569	cell aging	21873635.	IBA	Process
GO:0007569	cell aging	-	ISO	Process
GO:0008026	ATP-dependent helicase activity	-	IEA	Function
GO:0008152	metabolic process	-	IEA	Process
GO:0008340	determination of adult lifespan	21873635.	IBA	Process
GO:0008408	3'-5' exonuclease activity	21873635.	IBA	Function
GO:0008408	3'-5' exonuclease activity	10871373.	IDA	Function
GO:0008408	3'-5' exonuclease activity	-	ISO	Function
GO:0009267	cellular response to starvation	21873635.	IBA	Process
GO:0009267	cellular response to starvation	11420665.	ISO	Process
GO:0009378	four-way junction helicase activity	21873635.	IBA	Function
GO:0009378	four-way junction helicase activity	-	ISO	Function
GO:0010225	response to UV-C	21873635.	IBA	Process
GO:0010225	response to UV-C	-	ISO	Process
GO:0010259	multicellular organism aging	21873635.	IBA	Process
GO:0010259	multicellular organism aging	15235603.	IGI	Process
GO:0010259	multicellular organism aging	-	ISO	Process
GO:0016607	nuclear speck	-	ISO	Component
GO:0016787	hydrolase activity	-	IEA	Function
GO:0016887	ATPase activity	-	ISO	Function
GO:0030145	manganese ion binding	21873635.	IBA	Function
GO:0030145	manganese ion binding	-	ISO	Function
GO:0031297	replication fork processing	21873635.	IBA	Process
GO:0031297	replication fork processing	-	ISO	Process
GO:0032405	MutLalpha complex binding	-	ISO	Function
GO:0032508	DNA duplex unwinding	21873635.	IBA	Process
GO:0032508	DNA duplex unwinding	-	ISO	Process
GO:0035861	site of double-strand break	21873635.	IBA	Component
GO:0040009	regulation of growth rate	12707040.	IMP	Process
GO:0042803	protein homodimerization activity	21873635.	IBA	Function
GO:0042803	protein homodimerization activity	-	ISO	Function
GO:0042981	regulation of apoptotic process	21873635.	IBA	Process
GO:0042981	regulation of apoptotic process	-	ISO	Process
GO:0043005	neuron projection	-	ISO	Component
GO:0043138	3'-5' DNA helicase activity	-	ISO	Function
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	21873635.	IBA	Function
GO:0044237	cellular metabolic process	-	IEA	Process
GO:0044806	G-quadruplex DNA unwinding	21873635.	IBA	Process
GO:0044806	G-quadruplex DNA unwinding	26195664.	IGI	Process
GO:0044806	G-quadruplex DNA unwinding	26195664.	IMP	Process
GO:0044806	G-quadruplex DNA unwinding	-	ISO	Process
GO:0044877	protein-containing complex binding	21873635.	IBA	Function
GO:0044877	protein-containing complex binding	-	ISO	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0051345	positive regulation of hydrolase activity	21873635.	IBA	Process
GO:0051345	positive regulation of hydrolase activity	-	ISO	Process
GO:0051880	G-quadruplex DNA binding	-	ISO	Function
GO:0061749	forked DNA-dependent helicase activity	21873635.	IBA	Function
GO:0061749	forked DNA-dependent helicase activity	-	ISO	Function
GO:0061820	telomeric D-loop disassembly	21873635.	IBA	Process
GO:0061820	telomeric D-loop disassembly	-	ISO	Process
GO:0061821	telomeric D-loop binding	21873635.	IBA	Function
GO:0061821	telomeric D-loop binding	-	ISO	Function
GO:0070337	3'-flap-structured DNA binding	21873635.	IBA	Function
GO:0070337	3'-flap-structured DNA binding	-	ISO	Function
GO:0071480	cellular response to gamma radiation	21873635.	IBA	Process
GO:0071480	cellular response to gamma radiation	-	ISO	Process
GO:0098530	positive regulation of strand invasion	21873635.	IBA	Process
GO:0098530	positive regulation of strand invasion	-	ISO	Process
GO:1902570	protein localization to nucleolus	11420665.	ISO	Process
GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	21873635.	IBA	Function
GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	-	ISO	Function