EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSMUSG00000049717 (Gene tree)
Gene ID: 319583
Gene Symbol: Lig4
Alias: 5830471N16Rik|DNA ligase IV|tiny
Full Name: ligase IV%2C DNA%2C ATP-dependent
Gene Type: protein_coding
Species: Mus_musculus
Status: putative
Strand: Minus strand
Length: 8638 bases
Position: chr8:9969049-9977686
Accession: 1335098
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSMUSP00000093130	RNA_ligase	PF09414.10	5.7e-09	1	1
ENSMUSP00000130807	RNA_ligase	PF09414.10	5.7e-09	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSMUST00000170033	-	3105	XM_017312854	ENSMUSP00000130807	911 (aa)	XP_017168343	Q8BTF7
ENSMUST00000095476	-	5028	-	ENSMUSP00000093130	911 (aa)	-	Q8BTF7

Gene Model

Click here to download ENSMUSG00000049717's gene model file

Pathways

Pathway ID	Pathway Name	Source
mmu03450	Non-homologous end-joining	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSMUSG00000049717's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSMUSG00000049717	Lig4	100	87.047	ENSG00000174405	LIG4	100	87.047	Homo_sapiens
ENSMUSG00000049717	Lig4	99	64.835	ENSAPOG00000000866	lig4	99	64.945	Acanthochromis_polyacanthus
ENSMUSG00000049717	Lig4	100	83.425	ENSAMEG00000019685	LIG4	99	83.425	Ailuropoda_melanoleuca
ENSMUSG00000049717	Lig4	99	65.457	ENSACIG00000018309	lig4	99	65.567	Amphilophus_citrinellus
ENSMUSG00000049717	Lig4	99	64.505	ENSAOCG00000011768	lig4	99	64.615	Amphiprion_ocellaris
ENSMUSG00000049717	Lig4	99	64.725	ENSAPEG00000017815	lig4	99	64.835	Amphiprion_percula
ENSMUSG00000049717	Lig4	99	65.198	ENSATEG00000005583	lig4	99	65.308	Anabas_testudineus
ENSMUSG00000049717	Lig4	97	73.750	ENSAPLG00000001673	LIG4	99	73.750	Anas_platyrhynchos
ENSMUSG00000049717	Lig4	99	74.640	ENSACAG00000014566	LIG4	99	74.640	Anolis_carolinensis
ENSMUSG00000049717	Lig4	100	86.937	ENSANAG00000012446	LIG4	100	86.937	Aotus_nancymaae
ENSMUSG00000049717	Lig4	99	64.474	ENSACLG00000027051	lig4	99	64.796	Astatotilapia_calliptera
ENSMUSG00000049717	Lig4	99	63.567	ENSAMXG00000008192	lig4	94	63.567	Astyanax_mexicanus
ENSMUSG00000049717	Lig4	100	85.181	ENSBTAG00000015868	LIG4	100	85.181	Bos_taurus
ENSMUSG00000049717	Lig4	100	86.059	ENSCJAG00000014689	LIG4	100	86.059	Callithrix_jacchus
ENSMUSG00000049717	Lig4	100	85.291	ENSCAFG00000006031	LIG4	100	85.291	Canis_familiaris
ENSMUSG00000049717	Lig4	100	85.291	ENSCAFG00020021230	LIG4	100	85.291	Canis_lupus_dingo
ENSMUSG00000049717	Lig4	100	84.632	ENSCHIG00000001019	LIG4	100	84.632	Capra_hircus
ENSMUSG00000049717	Lig4	99	85.825	ENSCAPG00000006284	LIG4	99	85.825	Cavia_aperea
ENSMUSG00000049717	Lig4	100	85.730	ENSCPOG00000014266	LIG4	100	85.730	Cavia_porcellus
ENSMUSG00000049717	Lig4	100	85.950	ENSCCAG00000019971	LIG4	100	85.950	Cebus_capucinus
ENSMUSG00000049717	Lig4	100	86.279	ENSCATG00000021075	LIG4	100	86.279	Cercocebus_atys
ENSMUSG00000049717	Lig4	100	86.718	ENSCLAG00000003376	LIG4	100	86.718	Chinchilla_lanigera
ENSMUSG00000049717	Lig4	100	86.498	ENSCSAG00000000211	LIG4	100	86.498	Chlorocebus_sabaeus
ENSMUSG00000049717	Lig4	99	76.269	ENSCPBG00000023291	LIG4	100	75.817	Chrysemys_picta_bellii
ENSMUSG00000049717	Lig4	69	45.683	ENSCING00000009536	-	97	45.683	Ciona_intestinalis
ENSMUSG00000049717	Lig4	83	45.729	ENSCSAVG00000010336	-	98	45.729	Ciona_savignyi
ENSMUSG00000049717	Lig4	100	86.608	ENSCANG00000005805	LIG4	100	86.608	Colobus_angolensis_palliatus
ENSMUSG00000049717	Lig4	100	92.325	ENSCGRG00001012072	Lig4	100	92.325	Cricetulus_griseus_chok1gshd
ENSMUSG00000049717	Lig4	100	92.325	ENSCGRG00000013417	Lig4	100	92.325	Cricetulus_griseus_crigri
ENSMUSG00000049717	Lig4	97	65.114	ENSCSEG00000013905	lig4	95	65.114	Cynoglossus_semilaevis
ENSMUSG00000049717	Lig4	99	64.784	ENSCVAG00000007896	lig4	99	64.784	Cyprinodon_variegatus
ENSMUSG00000049717	Lig4	99	63.415	ENSDARG00000060620	lig4	98	63.415	Danio_rerio
ENSMUSG00000049717	Lig4	100	84.539	ENSDNOG00000000513	LIG4	100	84.539	Dasypus_novemcinctus
ENSMUSG00000049717	Lig4	100	85.620	ENSDORG00000027303	Lig4	100	85.620	Dipodomys_ordii
ENSMUSG00000049717	Lig4	89	31.548	FBgn0030506	Lig4	91	31.548	Drosophila_melanogaster
ENSMUSG00000049717	Lig4	99	81.042	ENSETEG00000015563	LIG4	100	81.153	Echinops_telfairi
ENSMUSG00000049717	Lig4	99	43.606	ENSEBUG00000014243	lig4	99	43.606	Eptatretus_burgeri
ENSMUSG00000049717	Lig4	100	85.840	ENSEASG00005022073	LIG4	100	85.840	Equus_asinus_asinus
ENSMUSG00000049717	Lig4	100	85.510	ENSECAG00000003257	LIG4	100	85.510	Equus_caballus
ENSMUSG00000049717	Lig4	99	65.491	ENSELUG00000006787	lig4	99	65.821	Esox_lucius
ENSMUSG00000049717	Lig4	100	85.071	ENSFCAG00000031985	LIG4	100	85.071	Felis_catus
ENSMUSG00000049717	Lig4	89	74.416	ENSFALG00000004214	LIG4	98	74.416	Ficedula_albicollis
ENSMUSG00000049717	Lig4	100	85.401	ENSFDAG00000008973	LIG4	100	85.401	Fukomys_damarensis
ENSMUSG00000049717	Lig4	99	63.626	ENSFHEG00000007398	lig4	90	63.626	Fundulus_heteroclitus
ENSMUSG00000049717	Lig4	85	64.212	ENSGMOG00000012843	lig4	99	64.212	Gadus_morhua
ENSMUSG00000049717	Lig4	100	72.926	ENSGALG00000016854	LIG4	100	72.926	Gallus_gallus
ENSMUSG00000049717	Lig4	99	64.365	ENSGAFG00000019779	lig4	95	63.916	Gambusia_affinis
ENSMUSG00000049717	Lig4	99	63.234	ENSGACG00000014135	lig4	99	63.234	Gasterosteus_aculeatus
ENSMUSG00000049717	Lig4	100	86.937	ENSGGOG00000027771	LIG4	100	86.937	Gorilla_gorilla
ENSMUSG00000049717	Lig4	99	64.364	ENSHBUG00000006245	lig4	99	64.686	Haplochromis_burtoni
ENSMUSG00000049717	Lig4	100	85.291	ENSHGLG00000000718	LIG4	100	85.291	Heterocephalus_glaber_female
ENSMUSG00000049717	Lig4	100	85.291	ENSHGLG00100003265	LIG4	100	85.291	Heterocephalus_glaber_male
ENSMUSG00000049717	Lig4	99	64.505	ENSHCOG00000012010	lig4	99	64.505	Hippocampus_comes
ENSMUSG00000049717	Lig4	99	64.945	ENSIPUG00000013748	lig4	99	64.945	Ictalurus_punctatus
ENSMUSG00000049717	Lig4	100	86.169	ENSSTOG00000024303	LIG4	100	86.169	Ictidomys_tridecemlineatus
ENSMUSG00000049717	Lig4	100	86.608	ENSJJAG00000006750	Lig4	100	86.608	Jaculus_jaculus
ENSMUSG00000049717	Lig4	99	64.230	ENSKMAG00000001149	lig4	99	64.230	Kryptolebias_marmoratus
ENSMUSG00000049717	Lig4	91	65.542	ENSLBEG00000014578	lig4	99	65.663	Labrus_bergylta
ENSMUSG00000049717	Lig4	99	71.350	ENSLACG00000003282	LIG4	99	71.350	Latimeria_chalumnae
ENSMUSG00000049717	Lig4	99	70.044	ENSLOCG00000008901	lig4	98	70.044	Lepisosteus_oculatus
ENSMUSG00000049717	Lig4	100	82.804	ENSLAFG00000031152	LIG4	100	82.804	Loxodonta_africana
ENSMUSG00000049717	Lig4	100	86.389	ENSMFAG00000037235	LIG4	100	86.389	Macaca_fascicularis
ENSMUSG00000049717	Lig4	100	86.389	ENSMMUG00000008874	LIG4	100	86.389	Macaca_mulatta
ENSMUSG00000049717	Lig4	100	86.389	ENSMNEG00000023575	LIG4	100	86.389	Macaca_nemestrina
ENSMUSG00000049717	Lig4	100	86.389	ENSMLEG00000026720	LIG4	100	86.389	Mandrillus_leucophaeus
ENSMUSG00000049717	Lig4	99	65.275	ENSMAMG00000008472	lig4	99	65.385	Mastacembelus_armatus
ENSMUSG00000049717	Lig4	99	64.474	ENSMZEG00005001855	lig4	99	64.686	Maylandia_zebra
ENSMUSG00000049717	Lig4	100	72.926	ENSMGAG00000015532	LIG4	100	72.926	Meleagris_gallopavo
ENSMUSG00000049717	Lig4	100	89.352	ENSMOCG00000019000	Lig4	100	89.352	Microtus_ochrogaster
ENSMUSG00000049717	Lig4	99	64.009	ENSMMOG00000004390	lig4	99	64.120	Mola_mola
ENSMUSG00000049717	Lig4	100	80.461	ENSMODG00000025064	LIG4	100	80.921	Monodelphis_domestica
ENSMUSG00000049717	Lig4	99	64.452	ENSMALG00000008555	lig4	99	64.452	Monopterus_albus
ENSMUSG00000049717	Lig4	100	98.024	MGP_CAROLIEiJ_G0030809	Lig4	100	98.024	Mus_caroli
ENSMUSG00000049717	Lig4	100	97.475	MGP_PahariEiJ_G0021270	Lig4	100	97.475	Mus_pahari
ENSMUSG00000049717	Lig4	100	98.573	MGP_SPRETEiJ_G0031917	Lig4	100	98.573	Mus_spretus
ENSMUSG00000049717	Lig4	100	84.083	ENSMPUG00000018675	LIG4	100	84.083	Mustela_putorius_furo
ENSMUSG00000049717	Lig4	100	85.730	ENSMLUG00000001267	LIG4	100	85.730	Myotis_lucifugus
ENSMUSG00000049717	Lig4	100	88.694	ENSNGAG00000013258	Lig4	100	88.694	Nannospalax_galili
ENSMUSG00000049717	Lig4	99	64.693	ENSNBRG00000021252	lig4	99	65.017	Neolamprologus_brichardi
ENSMUSG00000049717	Lig4	100	86.389	ENSNLEG00000007888	LIG4	100	86.389	Nomascus_leucogenys
ENSMUSG00000049717	Lig4	100	84.632	ENSOPRG00000005765	LIG4	100	84.632	Ochotona_princeps
ENSMUSG00000049717	Lig4	100	84.852	ENSODEG00000019683	LIG4	100	84.852	Octodon_degus
ENSMUSG00000049717	Lig4	99	64.583	ENSONIG00000011969	lig4	98	64.796	Oreochromis_niloticus
ENSMUSG00000049717	Lig4	100	86.279	ENSOCUG00000015734	LIG4	100	86.279	Oryctolagus_cuniculus
ENSMUSG00000049717	Lig4	99	63.377	ENSORLG00000004041	lig4	99	63.596	Oryzias_latipes
ENSMUSG00000049717	Lig4	99	63.816	ENSORLG00020019607	lig4	99	64.035	Oryzias_latipes_hni
ENSMUSG00000049717	Lig4	99	63.487	ENSORLG00015017754	lig4	99	63.706	Oryzias_latipes_hsok
ENSMUSG00000049717	Lig4	74	68.491	ENSOMEG00000003459	lig4	98	68.491	Oryzias_melastigma
ENSMUSG00000049717	Lig4	100	85.855	ENSOGAG00000032120	LIG4	99	85.855	Otolemur_garnettii
ENSMUSG00000049717	Lig4	82	86.174	ENSOARG00000005590	LIG4	98	86.174	Ovis_aries
ENSMUSG00000049717	Lig4	100	86.828	ENSPPAG00000032998	LIG4	100	86.828	Pan_paniscus
ENSMUSG00000049717	Lig4	100	85.510	ENSPPRG00000017804	LIG4	100	85.510	Panthera_pardus
ENSMUSG00000049717	Lig4	100	85.510	ENSPTIG00000010051	LIG4	100	85.510	Panthera_tigris_altaica
ENSMUSG00000049717	Lig4	100	86.937	ENSPTRG00000006025	LIG4	100	86.937	Pan_troglodytes
ENSMUSG00000049717	Lig4	100	86.389	ENSPANG00000007562	LIG4	100	86.389	Papio_anubis
ENSMUSG00000049717	Lig4	99	65.423	ENSPKIG00000011645	lig4	98	65.423	Paramormyrops_kingsleyae
ENSMUSG00000049717	Lig4	99	76.070	ENSPSIG00000001504	LIG4	99	76.070	Pelodiscus_sinensis
ENSMUSG00000049717	Lig4	99	61.889	ENSPMGG00000013486	lig4	99	61.690	Periophthalmus_magnuspinnatus
ENSMUSG00000049717	Lig4	100	91.338	ENSPEMG00000000076	Lig4	100	91.338	Peromyscus_maniculatus_bairdii
ENSMUSG00000049717	Lig4	100	81.360	ENSPCIG00000021882	LIG4	100	81.360	Phascolarctos_cinereus
ENSMUSG00000049717	Lig4	99	64.182	ENSPFOG00000000797	lig4	99	63.736	Poecilia_formosa
ENSMUSG00000049717	Lig4	99	64.071	ENSPLAG00000001196	lig4	99	63.626	Poecilia_latipinna
ENSMUSG00000049717	Lig4	99	64.182	ENSPMEG00000021353	lig4	99	63.956	Poecilia_mexicana
ENSMUSG00000049717	Lig4	99	63.737	ENSPREG00000007323	lig4	99	63.516	Poecilia_reticulata
ENSMUSG00000049717	Lig4	100	86.718	ENSPPYG00000005540	LIG4	100	86.718	Pongo_abelii
ENSMUSG00000049717	Lig4	100	85.840	ENSPVAG00000016403	LIG4	100	85.840	Pteropus_vampyrus
ENSMUSG00000049717	Lig4	99	64.474	ENSPNYG00000009660	lig4	99	64.686	Pundamilia_nyererei
ENSMUSG00000049717	Lig4	100	64.145	ENSPNAG00000028056	lig4	100	64.254	Pygocentrus_nattereri
ENSMUSG00000049717	Lig4	100	64.145	ENSPNAG00000028069	LIG4	100	64.254	Pygocentrus_nattereri
ENSMUSG00000049717	Lig4	100	94.182	ENSRNOG00000014605	Lig4	100	94.182	Rattus_norvegicus
ENSMUSG00000049717	Lig4	100	85.291	ENSRBIG00000039962	LIG4	100	85.291	Rhinopithecus_bieti
ENSMUSG00000049717	Lig4	100	86.279	ENSRROG00000006040	LIG4	100	86.279	Rhinopithecus_roxellana
ENSMUSG00000049717	Lig4	100	86.169	ENSSBOG00000019029	LIG4	100	86.169	Saimiri_boliviensis_boliviensis
ENSMUSG00000049717	Lig4	100	78.618	ENSSHAG00000009525	LIG4	100	78.618	Sarcophilus_harrisii
ENSMUSG00000049717	Lig4	100	64.520	ENSSFOG00015012835	lig4	100	64.520	Scleropages_formosus
ENSMUSG00000049717	Lig4	99	62.348	ENSSMAG00000011267	lig4	99	62.348	Scophthalmus_maximus
ENSMUSG00000049717	Lig4	99	65.410	ENSSDUG00000010343	lig4	98	65.410	Seriola_dumerili
ENSMUSG00000049717	Lig4	99	63.787	ENSSLDG00000003239	lig4	99	63.787	Seriola_lalandi_dorsalis
ENSMUSG00000049717	Lig4	100	80.635	ENSSARG00000006573	LIG4	100	80.635	Sorex_araneus
ENSMUSG00000049717	Lig4	93	75.948	ENSSPUG00000002444	LIG4	100	75.948	Sphenodon_punctatus
ENSMUSG00000049717	Lig4	99	64.835	ENSSPAG00000001609	lig4	99	64.945	Stegastes_partitus
ENSMUSG00000049717	Lig4	99	83.828	ENSSSCG00000009540	LIG4	99	83.828	Sus_scrofa
ENSMUSG00000049717	Lig4	99	73.187	ENSTGUG00000010795	LIG4	100	73.187	Taeniopygia_guttata
ENSMUSG00000049717	Lig4	99	64.895	ENSTRUG00000009984	lig4	99	64.895	Takifugu_rubripes
ENSMUSG00000049717	Lig4	99	64.615	ENSTNIG00000010348	lig4	99	64.835	Tetraodon_nigroviridis
ENSMUSG00000049717	Lig4	100	87.157	ENSTBEG00000017741	LIG4	100	87.157	Tupaia_belangeri
ENSMUSG00000049717	Lig4	100	85.950	ENSTTRG00000012660	LIG4	100	85.950	Tursiops_truncatus
ENSMUSG00000049717	Lig4	100	83.644	ENSUAMG00000003773	LIG4	100	83.644	Ursus_americanus
ENSMUSG00000049717	Lig4	99	70.110	ENSXETG00000002654	lig4	99	70.110	Xenopus_tropicalis
ENSMUSG00000049717	Lig4	99	63.960	ENSXCOG00000017401	lig4	99	63.516	Xiphophorus_couchianus
ENSMUSG00000049717	Lig4	99	64.333	ENSXMAG00000015142	lig4	99	63.886	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000012	single strand break repair	-	ISO	Process
GO:0000166	nucleotide binding	-	IEA	Function
GO:0000793	condensed chromosome	-	ISO	Component
GO:0001701	in utero embryonic development	9823897.10911993.16777961.	IMP	Process
GO:0002328	pro-B cell differentiation	9823897.10911993.	IMP	Process
GO:0003677	DNA binding	-	ISO	Function
GO:0003909	DNA ligase activity	-	ISO	Function
GO:0003910	DNA ligase (ATP) activity	15194694.	IDA	Function
GO:0003910	DNA ligase (ATP) activity	-	ISO	Function
GO:0005515	protein binding	20620605.	IPI	Function
GO:0005524	ATP binding	15194694.	IDA	Function
GO:0005524	ATP binding	-	ISO	Function
GO:0005634	nucleus	-	ISO	Component
GO:0005654	nucleoplasm	-	ISO	Component
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	21873635.	IBA	Component
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	15194694.	IDA	Component
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	-	ISO	Component
GO:0006260	DNA replication	-	IEA	Process
GO:0006266	DNA ligation	15194694.	IDA	Process
GO:0006266	DNA ligation	15968270.	IMP	Process
GO:0006266	DNA ligation	-	ISO	Process
GO:0006281	DNA repair	11779495.21390131.	IMP	Process
GO:0006297	nucleotide-excision repair, DNA gap filling	21873635.	IBA	Process
GO:0006297	nucleotide-excision repair, DNA gap filling	-	ISO	Process
GO:0006302	double-strand break repair	12531011.15175260.	IGI	Process
GO:0006302	double-strand break repair	12531011.15175260.17554302.	IMP	Process
GO:0006302	double-strand break repair	-	ISO	Process
GO:0006303	double-strand break repair via nonhomologous end joining	21873635.	IBA	Process
GO:0006303	double-strand break repair via nonhomologous end joining	10823907.12361565.16777961.	IMP	Process
GO:0006303	double-strand break repair via nonhomologous end joining	-	ISO	Process
GO:0006310	DNA recombination	-	IEA	Process
GO:0006974	cellular response to DNA damage stimulus	-	IEA	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007417	central nervous system development	10911993.	IGI	Process
GO:0007417	central nervous system development	9875844.9889105.	IMP	Process
GO:0008022	protein C-terminus binding	-	ISO	Function
GO:0008283	cell proliferation	15175260.17554302.	IMP	Process
GO:0010165	response to X-ray	-	ISO	Process
GO:0010212	response to ionizing radiation	10823907.21390131.	IMP	Process
GO:0010332	response to gamma radiation	9823897.10911993.	IMP	Process
GO:0016874	ligase activity	-	ISO	Function
GO:0032807	DNA ligase IV complex	21873635.	IBA	Component
GO:0032807	DNA ligase IV complex	-	ISO	Component
GO:0033077	T cell differentiation in thymus	9823897.10911993.	IMP	Process
GO:0033151	V(D)J recombination	15194694.	IDA	Process
GO:0033151	V(D)J recombination	10716994.	IMP	Process
GO:0033151	V(D)J recombination	-	ISO	Process
GO:0033152	immunoglobulin V(D)J recombination	21873635.	IBA	Process
GO:0033152	immunoglobulin V(D)J recombination	9823897.	IMP	Process
GO:0033153	T cell receptor V(D)J recombination	10911993.	IMP	Process
GO:0035019	somatic stem cell population maintenance	17554302.	IMP	Process
GO:0036464	cytoplasmic ribonucleoprotein granule	-	ISO	Component
GO:0043524	negative regulation of neuron apoptotic process	10911993.16777961.	IGI	Process
GO:0043524	negative regulation of neuron apoptotic process	9875844.	IMP	Process
GO:0045190	isotype switching	17713479.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048146	positive regulation of fibroblast proliferation	9823897.10911993.	IMP	Process
GO:0050769	positive regulation of neurogenesis	9875844.10716994.16777961.	IMP	Process
GO:0051102	DNA ligation involved in DNA recombination	9823897.	IMP	Process
GO:0051103	DNA ligation involved in DNA repair	9823897.	IMP	Process
GO:0051103	DNA ligation involved in DNA repair	-	ISO	Process
GO:0051276	chromosome organization	15175260.	IGI	Process
GO:0051301	cell division	-	IEA	Process
GO:0051402	neuron apoptotic process	11248063.	IGI	Process
GO:0070419	nonhomologous end joining complex	-	ISO	Component
GO:0071479	cellular response to ionizing radiation	-	ISO	Process
GO:0071897	DNA biosynthetic process	-	IEA	Process
GO:0097680	double-strand break repair via classical nonhomologous end joining	-	ISO	Process
GO:2001252	positive regulation of chromosome organization	-	ISO	Process