EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSMUSG00000059923 (Gene tree)
Gene ID: 14784
Gene Symbol: Grb2
Alias: -
Full Name: growth factor receptor bound protein 2
Gene Type: protein_coding
Species: Mus_musculus
Status: putative
Strand: Minus strand
Length: 64553
Position: chr11: 115644045-115708597
Accession: 95805
RBP type: non-canonical RBP
Summary: -

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
27281784	Identification of RNA binding Proteins in Macrophages by Interactome Capture	IC & RAW264.7	2016 Jun 8	Liepelt A	DOI: 10.1074/mcp.M115.056564

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSMUST00000106499	-	2333	-	ENSMUSP00000102108	176 (aa)	-	Q60631
ENSMUST00000021090	-	2709	-	ENSMUSP00000021090	217 (aa)	-	Q60631
ENSMUST00000135065	-	369	-	ENSMUSP00000117539	71 (aa)	-	B1AT95
ENSMUST00000106495	-	2041	-	ENSMUSP00000102104	203 (aa)	-	B1AT92
ENSMUST00000106497	-	2683	-	ENSMUSP00000102106	217 (aa)	-	Q60631

Gene Model

Click here to download ENSMUSG00000059923's gene model file

Pathways

Pathway ID	Pathway Name	Source
mmu01521	EGFR tyrosine kinase inhibitor resistance	KEGG
mmu01522	Endocrine resistance	KEGG
mmu04010	MAPK signaling pathway	KEGG
mmu04012	ErbB signaling pathway	KEGG
mmu04014	Ras signaling pathway	KEGG
mmu04062	Chemokine signaling pathway	KEGG
mmu04068	FoxO signaling pathway	KEGG
mmu04072	Phospholipase D signaling pathway	KEGG
mmu04150	mTOR signaling pathway	KEGG
mmu04151	PI3K-Akt signaling pathway	KEGG
mmu04380	Osteoclast differentiation	KEGG
mmu04510	Focal adhesion	KEGG
mmu04540	Gap junction	KEGG
mmu04550	Signaling pathways regulating pluripotency of stem cells	KEGG
mmu04630	JAK-STAT signaling pathway	KEGG
mmu04650	Natural killer cell mediated cytotoxicity	KEGG
mmu04660	T cell receptor signaling pathway	KEGG
mmu04662	B cell receptor signaling pathway	KEGG
mmu04664	Fc epsilon RI signaling pathway	KEGG
mmu04714	Thermogenesis	KEGG
mmu04722	Neurotrophin signaling pathway	KEGG
mmu04910	Insulin signaling pathway	KEGG
mmu04912	GnRH signaling pathway	KEGG
mmu04915	Estrogen signaling pathway	KEGG
mmu04917	Prolactin signaling pathway	KEGG
mmu04926	Relaxin signaling pathway	KEGG
mmu05034	Alcoholism	KEGG
mmu05160	Hepatitis C	KEGG
mmu05161	Hepatitis B	KEGG
mmu05163	Human cytomegalovirus infection	KEGG
mmu05165	Human papillomavirus infection	KEGG
mmu05200	Pathways in cancer	KEGG
mmu05203	Viral carcinogenesis	KEGG
mmu05205	Proteoglycans in cancer	KEGG
mmu05206	MicroRNAs in cancer	KEGG
mmu05210	Colorectal cancer	KEGG
mmu05211	Renal cell carcinoma	KEGG
mmu05213	Endometrial cancer	KEGG
mmu05214	Glioma	KEGG
mmu05215	Prostate cancer	KEGG
mmu05220	Chronic myeloid leukemia	KEGG
mmu05221	Acute myeloid leukemia	KEGG
mmu05223	Non-small cell lung cancer	KEGG
mmu05224	Breast cancer	KEGG
mmu05225	Hepatocellular carcinoma	KEGG
mmu05226	Gastric cancer	KEGG
mmu05231	Choline metabolism in cancer	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSMUSG00000059923's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSMUSG00000059923	Grb2	100	100.000	ENSG00000177885	GRB2	100	100.000	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001784	phosphotyrosine residue binding	-	ISO	Function
GO:0005070	SH3/SH2 adaptor activity	7689150.	IDA	Function
GO:0005154	epidermal growth factor receptor binding	-	ISO	Function
GO:0005168	neurotrophin TRKA receptor binding	-	ISO	Function
GO:0005515	protein binding	7518772.7529871.7535773.8479540.8632004.9182757.9569023.10077576.10330178.10373493.10521483.10748054.10871282.10982817.11152963.11445578.11551227.11551923.11571277.11585837.11684012.11711534.11739737.14722116.15102471.15301538.15467741.15569713.15953601.16249387.16339969.16405865.17673906.18273058.19597497.19597498.19805304.19914172.21487392.21930792.22561606.22732588.23452850.24584089.	IPI	Function
GO:0005634	nucleus	-	ISO	Component
GO:0005654	nucleoplasm	-	ISO	Component
GO:0005730	nucleolus	-	ISO	Component
GO:0005737	cytoplasm	15736129.	IDA	Component
GO:0005737	cytoplasm	-	ISO	Component
GO:0005768	endosome	-	ISO	Component
GO:0005794	Golgi apparatus	-	IEA	Component
GO:0005886	plasma membrane	17923684.	IDA	Component
GO:0005911	cell-cell junction	23793062.	IDA	Component
GO:0007265	Ras protein signal transduction	1322798.	TAS	Process
GO:0007568	aging	-	ISO	Process
GO:0008180	COP9 signalosome	22561606.	IDA	Component
GO:0008180	COP9 signalosome	-	ISO	Component
GO:0008286	insulin receptor signaling pathway	-	ISO	Process
GO:0008543	fibroblast growth factor receptor signaling pathway	11585837.	IGI	Process
GO:0012506	vesicle membrane	12147689.	IDA	Component
GO:0016020	membrane	15983387.	IDA	Component
GO:0017124	SH3 domain binding	-	ISO	Function
GO:0019899	enzyme binding	-	ISO	Function
GO:0019901	protein kinase binding	-	ISO	Function
GO:0019903	protein phosphatase binding	20398064.	IPI	Function
GO:0019904	protein domain specific binding	8438166.	IPI	Function
GO:0019904	protein domain specific binding	-	ISO	Function
GO:0030154	cell differentiation	16908534.	IMP	Process
GO:0030838	positive regulation of actin filament polymerization	17923684.	IGI	Process
GO:0031623	receptor internalization	-	ISO	Process
GO:0032991	protein-containing complex	-	ISO	Component
GO:0042770	signal transduction in response to DNA damage	-	ISO	Process
GO:0042802	identical protein binding	-	ISO	Function
GO:0043408	regulation of MAPK cascade	15569713.	IGI	Process
GO:0043560	insulin receptor substrate binding	-	ISO	Function
GO:0046875	ephrin receptor binding	12925710.	IPI	Function
GO:0046875	ephrin receptor binding	-	ISO	Function
GO:0048646	anatomical structure formation involved in morphogenesis	11369229.	IMP	Process
GO:0051219	phosphoprotein binding	-	ISO	Function
GO:0051291	protein heterooligomerization	-	ISO	Process
GO:0060670	branching involved in labyrinthine layer morphogenesis	11369229.	IMP	Process
GO:0070436	Grb2-EGFR complex	-	ISO	Component
GO:0071479	cellular response to ionizing radiation	-	ISO	Process
GO:2000379	positive regulation of reactive oxygen species metabolic process	-	ISO	Process