EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSMUSG00000070544 (Gene tree)
Gene ID: 21969
Gene Symbol: Top1
Alias: D130064I21Rik|Top-1
Full Name: topoisomerase (DNA) I
Gene Type: protein_coding
Species: Mus_musculus
Status: putative
Strand: Plus strand
Length: 76877
Position: chr2: 160645888-160722764
Accession: 98788
RBP type: non-canonical RBP
Summary: -

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
27281784	Identification of RNA binding Proteins in Macrophages by Interactome Capture	IC & RAW264.7	2016 Jun 8	Liepelt A	DOI: 10.1074/mcp.M115.056564

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSMUST00000133262	-	3783	-	-	- (aa)	-	-
ENSMUST00000150039	-	599	-	-	- (aa)	-	-
ENSMUST00000109468	-	3856	-	ENSMUSP00000105094	767 (aa)	-	Q04750
ENSMUST00000164694	-	2172	-	-	- (aa)	-	-
ENSMUST00000129289	-	698	-	-	- (aa)	-	-
ENSMUST00000164510	-	590	-	-	- (aa)	-	-

Gene Model

Click here to download ENSMUSG00000070544's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSMUSG00000070544's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSMUSG00000070544	Top1	100	97.001	ENSG00000198900	TOP1	100	97.001	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000228	nuclear chromosome	-	ISO	Component
GO:0000932	P-body	-	ISO	Component
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISO	Function
GO:0001650	fibrillar center	-	ISO	Component
GO:0001651	dense fibrillar component	-	ISO	Component
GO:0003677	DNA binding	-	ISO	Function
GO:0003682	chromatin binding	-	ISO	Function
GO:0003690	double-stranded DNA binding	-	ISO	Function
GO:0003697	single-stranded DNA binding	-	ISO	Function
GO:0003916	DNA topoisomerase activity	-	IEA	Function
GO:0003917	DNA topoisomerase type I activity	21873635.	IBA	Function
GO:0003917	DNA topoisomerase type I activity	7842491.9094096.16261531.	IDA	Function
GO:0003917	DNA topoisomerase type I activity	-	ISO	Function
GO:0004674	protein serine/threonine kinase activity	-	ISO	Function
GO:0005524	ATP binding	-	ISO	Function
GO:0005634	nucleus	8943335.9094096.16261531.	IDA	Component
GO:0005634	nucleus	-	ISO	Component
GO:0005654	nucleoplasm	-	ISO	Component
GO:0005694	chromosome	-	IEA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	-	ISO	Component
GO:0005737	cytoplasm	16261531.	IDA	Component
GO:0006260	DNA replication	21873635.	IBA	Process
GO:0006260	DNA replication	11756244.	IMP	Process
GO:0006265	DNA topological change	21873635.	IBA	Process
GO:0006265	DNA topological change	7842491.16261531.	IDA	Process
GO:0006265	DNA topological change	-	ISO	Process
GO:0006338	chromatin remodeling	21873635.	IBA	Process
GO:0006338	chromatin remodeling	-	ISO	Process
GO:0007059	chromosome segregation	21873635.	IBA	Process
GO:0009303	rRNA transcription	-	ISO	Process
GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)	-	ISO	Component
GO:0016853	isomerase activity	-	IEA	Function
GO:0018105	peptidyl-serine phosphorylation	-	ISO	Process
GO:0019904	protein domain specific binding	-	ISO	Function
GO:0031298	replication fork protection complex	21873635.	IBA	Component
GO:0031490	chromatin DNA binding	-	ISO	Function
GO:0032922	circadian regulation of gene expression	-	ISO	Process
GO:0032993	protein-DNA complex	-	ISO	Component
GO:0040016	embryonic cleavage	8943335.	IMP	Process
GO:0043204	perikaryon	16261531.	IDA	Component
GO:0044877	protein-containing complex binding	-	ISO	Function
GO:0048511	rhythmic process	-	IEA	Process
GO:0097100	supercoiled DNA binding	-	ISO	Function