EuRBPDB

Description

RBDs

Transcripts

Gene Model

PPI

Orthologs

Description

Ensembl ID: ENSOCUG00000005317 (Gene tree)
Gene ID: 100342289
Gene Symbol: CRACR2A
Alias: -
Full Name: calcium release activated channel regulator 2A
Gene Type: protein_coding
Species: Oryctolagus_cuniculus
Status: putative
Strand: Minus strand
Length: 73591 bases
Position: chr8:29769078-29842668
Accession: 100342289
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSOCUP00000004610	MMR_HSR1	PF01926.23	1.7e-06	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSOCUT00000005315	CRACR2A-201	2178	XM_008259682	ENSOCUP00000004610	726 (aa)	XP_008257906	G1SNN8

Gene Model

Click here to download ENSOCUG00000005317's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSOCUG00000005317's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSOCUG00000005317	CRACR2A	100	82.650	ENSG00000130038	CRACR2A	100	83.607	Homo_sapiens
ENSOCUG00000005317	CRACR2A	90	46.980	ENSAPOG00000013779	cracr2ab	99	47.632	Acanthochromis_polyacanthus
ENSOCUG00000005317	CRACR2A	81	46.597	ENSAPOG00000009642	cracr2b	86	46.597	Acanthochromis_polyacanthus
ENSOCUG00000005317	CRACR2A	70	83.366	ENSAMEG00000005041	-	97	86.826	Ailuropoda_melanoleuca
ENSOCUG00000005317	CRACR2A	94	52.639	ENSACIG00000010099	CRACR2A	94	52.639	Amphilophus_citrinellus
ENSOCUG00000005317	CRACR2A	94	48.119	ENSAOCG00000023189	cracr2ab	97	49.022	Amphiprion_ocellaris
ENSOCUG00000005317	CRACR2A	94	53.770	ENSAOCG00000008147	-	94	53.912	Amphiprion_ocellaris
ENSOCUG00000005317	CRACR2A	83	46.561	ENSAOCG00000019493	cracr2b	87	46.561	Amphiprion_ocellaris
ENSOCUG00000005317	CRACR2A	87	44.595	ENSAPEG00000021843	cracr2b	93	44.595	Amphiprion_percula
ENSOCUG00000005317	CRACR2A	94	53.912	ENSAPEG00000002244	CRACR2A	94	54.054	Amphiprion_percula
ENSOCUG00000005317	CRACR2A	94	45.931	ENSAPEG00000006383	cracr2ab	99	46.879	Amphiprion_percula
ENSOCUG00000005317	CRACR2A	94	53.617	ENSATEG00000017411	CRACR2A	96	53.617	Anabas_testudineus
ENSOCUG00000005317	CRACR2A	83	44.595	ENSATEG00000010344	cracr2b	92	44.595	Anabas_testudineus
ENSOCUG00000005317	CRACR2A	94	44.168	ENSATEG00000018003	cracr2ab	97	48.493	Anabas_testudineus
ENSOCUG00000005317	CRACR2A	94	39.481	ENSACAG00000015413	CRACR2B	95	39.481	Anolis_carolinensis
ENSOCUG00000005317	CRACR2A	100	84.016	ENSANAG00000036979	CRACR2A	100	84.016	Aotus_nancymaae
ENSOCUG00000005317	CRACR2A	80	41.518	ENSACLG00000013916	cracr2b	85	41.518	Astatotilapia_calliptera
ENSOCUG00000005317	CRACR2A	94	52.354	ENSACLG00000007547	CRACR2A	94	52.354	Astatotilapia_calliptera
ENSOCUG00000005317	CRACR2A	94	48.357	ENSACLG00000023670	cracr2ab	97	48.752	Astatotilapia_calliptera
ENSOCUG00000005317	CRACR2A	58	44.934	ENSAMXG00000010368	cracr2ab	99	45.354	Astyanax_mexicanus
ENSOCUG00000005317	CRACR2A	100	79.752	ENSBTAG00000018940	CRACR2A	100	79.752	Bos_taurus
ENSOCUG00000005317	CRACR2A	100	81.831	ENSCJAG00000018917	CRACR2A	100	82.787	Callithrix_jacchus
ENSOCUG00000005317	CRACR2A	100	80.028	ENSCAFG00000015404	CRACR2A	100	80.028	Canis_familiaris
ENSOCUG00000005317	CRACR2A	100	80.028	ENSCAFG00020014835	CRACR2A	100	80.028	Canis_lupus_dingo
ENSOCUG00000005317	CRACR2A	100	80.303	ENSCHIG00000018141	CRACR2A	100	80.303	Capra_hircus
ENSOCUG00000005317	CRACR2A	100	82.967	ENSTSYG00000014194	CRACR2A	100	82.967	Carlito_syrichta
ENSOCUG00000005317	CRACR2A	86	74.522	ENSCAPG00000006188	CRACR2A	100	74.522	Cavia_aperea
ENSOCUG00000005317	CRACR2A	99	79.780	ENSCPOG00000020119	CRACR2A	99	79.780	Cavia_porcellus
ENSOCUG00000005317	CRACR2A	100	82.650	ENSCCAG00000019735	CRACR2A	100	82.650	Cebus_capucinus
ENSOCUG00000005317	CRACR2A	100	83.607	ENSCATG00000040964	CRACR2A	100	84.563	Cercocebus_atys
ENSOCUG00000005317	CRACR2A	100	78.159	ENSCLAG00000013246	CRACR2A	100	78.297	Chinchilla_lanigera
ENSOCUG00000005317	CRACR2A	100	82.721	ENSCSAG00000011199	CRACR2A	100	83.673	Chlorocebus_sabaeus
ENSOCUG00000005317	CRACR2A	76	52.778	ENSCPBG00000007146	CRACR2B	73	52.778	Chrysemys_picta_bellii
ENSOCUG00000005317	CRACR2A	99	64.609	ENSCPBG00000009731	CRACR2A	99	64.609	Chrysemys_picta_bellii
ENSOCUG00000005317	CRACR2A	100	84.131	ENSCANG00000032776	CRACR2A	100	84.131	Colobus_angolensis_palliatus
ENSOCUG00000005317	CRACR2A	100	78.159	ENSCGRG00001008752	-	100	78.159	Cricetulus_griseus_chok1gshd
ENSOCUG00000005317	CRACR2A	100	77.473	ENSCGRG00000015501	-	100	77.473	Cricetulus_griseus_crigri
ENSOCUG00000005317	CRACR2A	90	41.361	ENSCSEG00000008307	cracr2ab	98	45.526	Cynoglossus_semilaevis
ENSOCUG00000005317	CRACR2A	80	44.681	ENSCSEG00000007618	cracr2b	89	42.500	Cynoglossus_semilaevis
ENSOCUG00000005317	CRACR2A	93	49.710	ENSCSEG00000003612	CRACR2A	93	49.710	Cynoglossus_semilaevis
ENSOCUG00000005317	CRACR2A	94	50.354	ENSCVAG00000009954	cracr2ab	97	50.354	Cyprinodon_variegatus
ENSOCUG00000005317	CRACR2A	94	51.931	ENSCVAG00000013782	CRACR2A	97	51.931	Cyprinodon_variegatus
ENSOCUG00000005317	CRACR2A	94	48.043	ENSDARG00000045758	cracr2ab	99	46.316	Danio_rerio
ENSOCUG00000005317	CRACR2A	94	52.806	ENSDARG00000068231	CRACR2A	96	53.094	Danio_rerio
ENSOCUG00000005317	CRACR2A	100	76.495	ENSDNOG00000043722	CRACR2A	99	76.495	Dasypus_novemcinctus
ENSOCUG00000005317	CRACR2A	100	81.181	ENSEASG00005017095	CRACR2A	100	81.181	Equus_asinus_asinus
ENSOCUG00000005317	CRACR2A	100	82.555	ENSECAG00000034127	CRACR2A	100	82.555	Equus_caballus
ENSOCUG00000005317	CRACR2A	83	54.277	ENSELUG00000001781	cracr2ab	73	54.277	Esox_lucius
ENSOCUG00000005317	CRACR2A	94	52.119	ENSELUG00000018918	CRACR2A	94	51.836	Esox_lucius
ENSOCUG00000005317	CRACR2A	100	80.854	ENSFCAG00000015741	CRACR2A	100	80.854	Felis_catus
ENSOCUG00000005317	CRACR2A	96	40.673	ENSFALG00000010481	CRACR2B	96	40.673	Ficedula_albicollis
ENSOCUG00000005317	CRACR2A	97	62.693	ENSFALG00000004782	CRACR2A	99	62.693	Ficedula_albicollis
ENSOCUG00000005317	CRACR2A	100	74.397	ENSFDAG00000013877	CRACR2A	100	75.067	Fukomys_damarensis
ENSOCUG00000005317	CRACR2A	94	47.090	ENSFHEG00000021525	cracr2ab	98	47.619	Fundulus_heteroclitus
ENSOCUG00000005317	CRACR2A	94	46.761	ENSGAFG00000008771	cracr2ab	97	46.761	Gambusia_affinis
ENSOCUG00000005317	CRACR2A	94	52.074	ENSGAFG00000014607	CRACR2A	94	52.074	Gambusia_affinis
ENSOCUG00000005317	CRACR2A	76	45.789	ENSGAFG00000020778	cracr2b	79	45.789	Gambusia_affinis
ENSOCUG00000005317	CRACR2A	99	65.158	ENSGAGG00000002264	CRACR2A	99	65.158	Gopherus_agassizii
ENSOCUG00000005317	CRACR2A	100	82.514	ENSGGOG00000010289	CRACR2A	100	83.470	Gorilla_gorilla
ENSOCUG00000005317	CRACR2A	94	52.354	ENSHBUG00000017137	CRACR2A	94	52.354	Haplochromis_burtoni
ENSOCUG00000005317	CRACR2A	94	48.090	ENSHBUG00000018719	cracr2ab	97	48.485	Haplochromis_burtoni
ENSOCUG00000005317	CRACR2A	100	78.326	ENSHGLG00000003776	CRACR2A	100	78.326	Heterocephalus_glaber_female
ENSOCUG00000005317	CRACR2A	100	78.326	ENSHGLG00100005482	CRACR2A	100	78.326	Heterocephalus_glaber_male
ENSOCUG00000005317	CRACR2A	94	51.636	ENSHCOG00000006842	CRACR2A	95	51.636	Hippocampus_comes
ENSOCUG00000005317	CRACR2A	94	49.856	ENSHCOG00000004942	cracr2ab	97	49.856	Hippocampus_comes
ENSOCUG00000005317	CRACR2A	77	45.408	ENSIPUG00000013598	cracr2b	85	45.408	Ictalurus_punctatus
ENSOCUG00000005317	CRACR2A	94	47.612	ENSIPUG00000017914	cracr2ab	94	47.753	Ictalurus_punctatus
ENSOCUG00000005317	CRACR2A	94	53.683	ENSIPUG00000015191	CRACR2A	94	53.683	Ictalurus_punctatus
ENSOCUG00000005317	CRACR2A	100	82.030	ENSSTOG00000021197	CRACR2A	99	82.030	Ictidomys_tridecemlineatus
ENSOCUG00000005317	CRACR2A	99	71.214	ENSJJAG00000014186	-	99	71.351	Jaculus_jaculus
ENSOCUG00000005317	CRACR2A	94	50.919	ENSKMAG00000021906	CRACR2A	95	50.576	Kryptolebias_marmoratus
ENSOCUG00000005317	CRACR2A	94	48.404	ENSKMAG00000016358	cracr2ab	97	48.404	Kryptolebias_marmoratus
ENSOCUG00000005317	CRACR2A	83	42.009	ENSLBEG00000014261	cracr2b	91	42.009	Labrus_bergylta
ENSOCUG00000005317	CRACR2A	94	53.824	ENSLBEG00000010713	CRACR2A	95	53.824	Labrus_bergylta
ENSOCUG00000005317	CRACR2A	94	48.921	ENSLBEG00000018669	cracr2ab	97	48.921	Labrus_bergylta
ENSOCUG00000005317	CRACR2A	94	38.857	ENSLACG00000009026	-	100	38.857	Latimeria_chalumnae
ENSOCUG00000005317	CRACR2A	94	38.841	ENSLACG00000007778	-	100	38.841	Latimeria_chalumnae
ENSOCUG00000005317	CRACR2A	94	56.205	ENSLOCG00000016848	cracr2ab	96	56.205	Lepisosteus_oculatus
ENSOCUG00000005317	CRACR2A	100	83.470	ENSMFAG00000036067	CRACR2A	100	84.426	Macaca_fascicularis
ENSOCUG00000005317	CRACR2A	100	83.060	ENSMMUG00000023583	CRACR2A	100	84.016	Macaca_mulatta
ENSOCUG00000005317	CRACR2A	100	83.197	ENSMNEG00000031773	CRACR2A	100	84.153	Macaca_nemestrina
ENSOCUG00000005317	CRACR2A	100	83.333	ENSMLEG00000044159	CRACR2A	99	84.290	Mandrillus_leucophaeus
ENSOCUG00000005317	CRACR2A	94	54.261	ENSMAMG00000001270	CRACR2A	95	54.261	Mastacembelus_armatus
ENSOCUG00000005317	CRACR2A	83	56.268	ENSMAMG00000011388	cracr2ab	81	56.268	Mastacembelus_armatus
ENSOCUG00000005317	CRACR2A	81	44.595	ENSMAMG00000005360	cracr2b	90	44.595	Mastacembelus_armatus
ENSOCUG00000005317	CRACR2A	94	48.834	ENSMZEG00005005975	cracr2ab	96	48.834	Maylandia_zebra
ENSOCUG00000005317	CRACR2A	94	52.211	ENSMZEG00005016858	CRACR2A	94	52.211	Maylandia_zebra
ENSOCUG00000005317	CRACR2A	100	77.641	ENSMAUG00000010171	-	100	77.641	Mesocricetus_auratus
ENSOCUG00000005317	CRACR2A	100	82.466	ENSMICG00000012907	CRACR2A	100	82.466	Microcebus_murinus
ENSOCUG00000005317	CRACR2A	99	79.230	ENSMOCG00000016052	-	99	79.230	Microtus_ochrogaster
ENSOCUG00000005317	CRACR2A	94	48.319	ENSMMOG00000001929	cracr2ab	97	48.886	Mola_mola
ENSOCUG00000005317	CRACR2A	94	50.499	ENSMMOG00000019358	CRACR2A	94	50.499	Mola_mola
ENSOCUG00000005317	CRACR2A	94	52.825	ENSMALG00000021818	CRACR2A	95	53.107	Monopterus_albus
ENSOCUG00000005317	CRACR2A	83	44.444	ENSMALG00000006310	cracr2b	92	44.444	Monopterus_albus
ENSOCUG00000005317	CRACR2A	83	54.839	ENSMALG00000012964	cracr2ab	95	47.703	Monopterus_albus
ENSOCUG00000005317	CRACR2A	100	79.670	ENSMUSG00000061414	Cracr2a	100	79.670	Mus_musculus
ENSOCUG00000005317	CRACR2A	100	79.092	ENSMPUG00000009336	CRACR2A	100	79.092	Mustela_putorius_furo
ENSOCUG00000005317	CRACR2A	100	79.863	ENSNGAG00000014625	-	100	79.863	Nannospalax_galili
ENSOCUG00000005317	CRACR2A	94	49.415	ENSNBRG00000005924	cracr2ab	96	49.415	Neolamprologus_brichardi
ENSOCUG00000005317	CRACR2A	74	56.744	ENSNBRG00000015888	CRACR2A	91	56.269	Neolamprologus_brichardi
ENSOCUG00000005317	CRACR2A	100	81.557	ENSNLEG00000003001	CRACR2A	99	82.514	Nomascus_leucogenys
ENSOCUG00000005317	CRACR2A	98	80.447	ENSODEG00000002836	CRACR2A	98	80.447	Octodon_degus
ENSOCUG00000005317	CRACR2A	94	44.850	ENSORLG00000014854	cracr2ab	97	44.850	Oryzias_latipes
ENSOCUG00000005317	CRACR2A	94	52.594	ENSORLG00000025905	CRACR2A	94	53.026	Oryzias_latipes
ENSOCUG00000005317	CRACR2A	94	52.738	ENSORLG00020010617	CRACR2A	94	53.170	Oryzias_latipes_hni
ENSOCUG00000005317	CRACR2A	94	52.161	ENSORLG00015001413	CRACR2A	98	49.712	Oryzias_latipes_hsok
ENSOCUG00000005317	CRACR2A	94	46.490	ENSORLG00015013042	cracr2ab	97	46.490	Oryzias_latipes_hsok
ENSOCUG00000005317	CRACR2A	94	50.144	ENSOMEG00000007213	cracr2ab	97	50.144	Oryzias_melastigma
ENSOCUG00000005317	CRACR2A	96	84.330	ENSOGAG00000001502	CRACR2A	100	84.330	Otolemur_garnettii
ENSOCUG00000005317	CRACR2A	100	79.505	ENSOARG00000010465	CRACR2A	100	79.505	Ovis_aries
ENSOCUG00000005317	CRACR2A	100	82.265	ENSPPAG00000026014	CRACR2A	100	83.220	Pan_paniscus
ENSOCUG00000005317	CRACR2A	100	80.716	ENSPPRG00000006970	CRACR2A	100	80.716	Panthera_pardus
ENSOCUG00000005317	CRACR2A	100	82.265	ENSPTRG00000004545	CRACR2A	100	83.220	Pan_troglodytes
ENSOCUG00000005317	CRACR2A	99	83.241	ENSPANG00000025412	CRACR2A	98	84.211	Papio_anubis
ENSOCUG00000005317	CRACR2A	94	51.185	ENSPKIG00000019679	-	95	51.185	Paramormyrops_kingsleyae
ENSOCUG00000005317	CRACR2A	98	50.691	ENSPKIG00000001449	-	96	51.105	Paramormyrops_kingsleyae
ENSOCUG00000005317	CRACR2A	90	51.061	ENSPMGG00000005501	-	90	51.061	Periophthalmus_magnuspinnatus
ENSOCUG00000005317	CRACR2A	94	51.669	ENSPMGG00000009818	cracr2ab	97	51.965	Periophthalmus_magnuspinnatus
ENSOCUG00000005317	CRACR2A	57	69.734	ENSPCIG00000001087	-	99	69.734	Phascolarctos_cinereus
ENSOCUG00000005317	CRACR2A	93	35.100	ENSPFOG00000010947	cracr2b	81	45.263	Poecilia_formosa
ENSOCUG00000005317	CRACR2A	94	52.237	ENSPFOG00000005266	cracr2ab	99	52.237	Poecilia_formosa
ENSOCUG00000005317	CRACR2A	94	52.790	ENSPLAG00000001077	-	94	52.790	Poecilia_latipinna
ENSOCUG00000005317	CRACR2A	94	50.852	ENSPLAG00000003905	cracr2ab	97	50.852	Poecilia_latipinna
ENSOCUG00000005317	CRACR2A	76	45.263	ENSPLAG00000003773	cracr2b	81	45.263	Poecilia_latipinna
ENSOCUG00000005317	CRACR2A	94	52.933	ENSPMEG00000005485	-	94	52.933	Poecilia_mexicana
ENSOCUG00000005317	CRACR2A	94	51.216	ENSPMEG00000007308	cracr2ab	97	51.429	Poecilia_mexicana
ENSOCUG00000005317	CRACR2A	76	45.789	ENSPMEG00000020754	cracr2b	81	45.789	Poecilia_mexicana
ENSOCUG00000005317	CRACR2A	94	51.965	ENSPREG00000002593	cracr2ab	97	51.965	Poecilia_reticulata
ENSOCUG00000005317	CRACR2A	94	52.586	ENSPREG00000021082	CRACR2A	94	52.586	Poecilia_reticulata
ENSOCUG00000005317	CRACR2A	100	83.014	ENSPCOG00000020329	CRACR2A	100	83.014	Propithecus_coquereli
ENSOCUG00000005317	CRACR2A	94	51.433	ENSPNYG00000020714	CRACR2A	96	51.433	Pundamilia_nyererei
ENSOCUG00000005317	CRACR2A	94	48.028	ENSPNYG00000000606	cracr2ab	97	48.096	Pundamilia_nyererei
ENSOCUG00000005317	CRACR2A	94	48.895	ENSPNAG00000029103	cracr2ab	94	48.895	Pygocentrus_nattereri
ENSOCUG00000005317	CRACR2A	94	54.441	ENSPNAG00000020348	CRACR2A	94	54.441	Pygocentrus_nattereri
ENSOCUG00000005317	CRACR2A	100	83.333	ENSRBIG00000044914	CRACR2A	100	84.153	Rhinopithecus_bieti
ENSOCUG00000005317	CRACR2A	76	85.637	ENSRROG00000028125	CRACR2A	92	85.637	Rhinopithecus_roxellana
ENSOCUG00000005317	CRACR2A	100	82.810	ENSSBOG00000024718	CRACR2A	100	83.765	Saimiri_boliviensis_boliviensis
ENSOCUG00000005317	CRACR2A	94	51.332	ENSSFOG00015008628	-	98	51.685	Scleropages_formosus
ENSOCUG00000005317	CRACR2A	94	53.485	ENSSFOG00015004037	cracr2ab	97	54.339	Scleropages_formosus
ENSOCUG00000005317	CRACR2A	94	52.661	ENSSMAG00000011200	CRACR2A	95	53.738	Scophthalmus_maximus
ENSOCUG00000005317	CRACR2A	82	46.222	ENSSMAG00000013579	cracr2b	89	46.222	Scophthalmus_maximus
ENSOCUG00000005317	CRACR2A	94	47.135	ENSSMAG00000001304	cracr2ab	97	47.854	Scophthalmus_maximus
ENSOCUG00000005317	CRACR2A	83	42.534	ENSSDUG00000013283	cracr2b	92	42.534	Seriola_dumerili
ENSOCUG00000005317	CRACR2A	94	54.391	ENSSDUG00000000911	CRACR2A	95	54.391	Seriola_dumerili
ENSOCUG00000005317	CRACR2A	94	54.816	ENSSLDG00000010742	CRACR2A	95	54.816	Seriola_lalandi_dorsalis
ENSOCUG00000005317	CRACR2A	94	46.884	ENSSLDG00000023518	cracr2ab	94	44.006	Seriola_lalandi_dorsalis
ENSOCUG00000005317	CRACR2A	83	42.793	ENSSLDG00000022995	cracr2b	91	42.793	Seriola_lalandi_dorsalis
ENSOCUG00000005317	CRACR2A	73	50.917	ENSSPUG00000010462	-	57	50.917	Sphenodon_punctatus
ENSOCUG00000005317	CRACR2A	95	60.801	ENSSPUG00000017268	CRACR2A	95	61.056	Sphenodon_punctatus
ENSOCUG00000005317	CRACR2A	94	48.401	ENSSPAG00000022330	cracr2ab	99	46.122	Stegastes_partitus
ENSOCUG00000005317	CRACR2A	94	53.890	ENSSPAG00000012064	CRACR2A	94	53.955	Stegastes_partitus
ENSOCUG00000005317	CRACR2A	99	81.085	ENSSSCG00000000732	CRACR2A	100	83.382	Sus_scrofa
ENSOCUG00000005317	CRACR2A	94	52.305	ENSTRUG00000023284	CRACR2A	97	50.884	Takifugu_rubripes
ENSOCUG00000005317	CRACR2A	100	79.614	ENSUAMG00000021584	CRACR2A	100	79.614	Ursus_americanus
ENSOCUG00000005317	CRACR2A	100	79.339	ENSUMAG00000014780	CRACR2A	100	79.339	Ursus_maritimus
ENSOCUG00000005317	CRACR2A	100	80.441	ENSVVUG00000018097	CRACR2A	100	80.441	Vulpes_vulpes
ENSOCUG00000005317	CRACR2A	94	49.358	ENSXCOG00000007494	CRACR2A	96	49.358	Xiphophorus_couchianus
ENSOCUG00000005317	CRACR2A	90	51.343	ENSXCOG00000013604	cracr2ab	97	51.343	Xiphophorus_couchianus
ENSOCUG00000005317	CRACR2A	94	49.927	ENSXMAG00000011202	cracr2ab	97	49.927	Xiphophorus_maculatus
ENSOCUG00000005317	CRACR2A	94	52.217	ENSXMAG00000021050	CRACR2A	94	52.217	Xiphophorus_maculatus