EuRBPDB

Description

RBDs

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Description

Ensembl ID: ENSODEG00000009254 (Gene tree)
Gene ID: -
Gene Symbol: -
Alias: -
Full Name: -
Gene Type: protein_coding
Species: Octodon_degus
Status: putative
Strand: Plus strand
Length: 1555 bases
Position: chrJH651655.1:5024240-5025794
Accession: -
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSODEP00000012485	RRM_1	PF00076.22	5.2e-20	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSODET00000012654	-	1206	-	ENSODEP00000012485	401 (aa)	-	-

Gene Model

Click here to download ENSODEG00000009254's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSODEG00000009254's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSODEG00000009254	-	100	65.957	ENSODEG00000012729	-	99	64.468

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSODEG00000009254	-	100	70.085	ENSG00000063244	U2AF2	96	82.712	Homo_sapiens
ENSODEG00000009254	-	72	74.277	ENSAPOG00000023155	u2af2a	96	74.277	Acanthochromis_polyacanthus
ENSODEG00000009254	-	83	65.027	ENSAPOG00000002208	-	98	56.277	Acanthochromis_polyacanthus
ENSODEG00000009254	-	82	69.613	ENSAMEG00000003864	U2AF2	100	66.990	Ailuropoda_melanoleuca
ENSODEG00000009254	-	94	58.711	ENSACIG00000014173	-	98	55.338	Amphilophus_citrinellus
ENSODEG00000009254	-	84	73.046	ENSACIG00000005749	u2af2a	100	65.349	Amphilophus_citrinellus
ENSODEG00000009254	-	83	65.301	ENSAOCG00000003595	-	98	56.494	Amphiprion_ocellaris
ENSODEG00000009254	-	99	66.667	ENSAOCG00000015571	u2af2a	98	65.778	Amphiprion_ocellaris
ENSODEG00000009254	-	84	72.776	ENSAPEG00000009376	u2af2a	99	63.158	Amphiprion_percula
ENSODEG00000009254	-	83	65.027	ENSAPEG00000020062	-	96	56.823	Amphiprion_percula
ENSODEG00000009254	-	99	65.451	ENSATEG00000022332	u2af2a	99	63.948	Anabas_testudineus
ENSODEG00000009254	-	83	65.574	ENSATEG00000020577	-	98	56.793	Anabas_testudineus
ENSODEG00000009254	-	100	64.990	ENSACAG00000015489	U2AF2	99	68.026	Anolis_carolinensis
ENSODEG00000009254	-	100	57.235	ENSANAG00000028042	U2AF2	99	55.940	Aotus_nancymaae
ENSODEG00000009254	-	83	65.301	ENSACLG00000020793	-	98	56.494	Astatotilapia_calliptera
ENSODEG00000009254	-	84	73.046	ENSACLG00000022181	u2af2a	100	65.429	Astatotilapia_calliptera
ENSODEG00000009254	-	100	58.996	ENSAMXG00000033347	u2af2a	99	62.313	Astyanax_mexicanus
ENSODEG00000009254	-	99	64.955	ENSAMXG00000039454	u2af2b	98	63.556	Astyanax_mexicanus
ENSODEG00000009254	-	100	69.280	ENSBTAG00000002830	U2AF2	99	69.757	Bos_taurus
ENSODEG00000009254	-	94	46.617	WBGene00006697	uaf-1	97	47.552	Caenorhabditis_elegans
ENSODEG00000009254	-	100	69.492	ENSCJAG00000017128	U2AF2	99	68.008	Callithrix_jacchus
ENSODEG00000009254	-	100	70.085	ENSCAFG00000002551	U2AF2	99	68.590	Canis_familiaris
ENSODEG00000009254	-	93	70.000	ENSCAFG00020015445	U2AF2	97	65.659	Canis_lupus_dingo
ENSODEG00000009254	-	93	60.202	ENSCHIG00000023595	U2AF2	96	58.531	Capra_hircus
ENSODEG00000009254	-	100	69.492	ENSTSYG00000007432	U2AF2	99	68.008	Carlito_syrichta
ENSODEG00000009254	-	92	69.927	ENSCAPG00000008466	U2AF2	100	67.467	Cavia_aperea
ENSODEG00000009254	-	100	70.306	ENSCPOG00000001582	U2AF2	99	68.777	Cavia_porcellus
ENSODEG00000009254	-	100	69.492	ENSCCAG00000023336	U2AF2	99	68.008	Cebus_capucinus
ENSODEG00000009254	-	100	70.085	ENSCATG00000004637	U2AF2	99	68.590	Cercocebus_atys
ENSODEG00000009254	-	100	70.085	ENSCLAG00000000596	U2AF2	99	68.590	Chinchilla_lanigera
ENSODEG00000009254	-	100	70.085	ENSCSAG00000001722	U2AF2	99	68.590	Chlorocebus_sabaeus
ENSODEG00000009254	-	84	73.810	ENSCPBG00000004485	U2AF2	96	82.373	Chrysemys_picta_bellii
ENSODEG00000009254	-	83	57.923	ENSCING00000003455	-	91	51.131	Ciona_intestinalis
ENSODEG00000009254	-	83	57.967	ENSCSAVG00000006813	-	98	50.889	Ciona_savignyi
ENSODEG00000009254	-	89	69.176	ENSCANG00000031002	-	96	67.529	Colobus_angolensis_palliatus
ENSODEG00000009254	-	100	67.024	ENSCANG00000043845	-	99	65.953	Colobus_angolensis_palliatus
ENSODEG00000009254	-	98	63.834	ENSCGRG00001007486	-	98	65.652	Cricetulus_griseus_chok1gshd
ENSODEG00000009254	-	100	69.492	ENSCGRG00001003185	-	99	69.978	Cricetulus_griseus_chok1gshd
ENSODEG00000009254	-	98	63.834	ENSCGRG00000018587	-	98	65.652	Cricetulus_griseus_crigri
ENSODEG00000009254	-	57	82.479	ENSCGRG00000004524	-	75	82.759	Cricetulus_griseus_crigri
ENSODEG00000009254	-	95	51.282	ENSCSEG00000018709	u2af2a	95	51.282	Cynoglossus_semilaevis
ENSODEG00000009254	-	99	56.427	ENSCSEG00000020504	-	93	56.542	Cynoglossus_semilaevis
ENSODEG00000009254	-	99	66.079	ENSCVAG00000001259	u2af2a	99	65.198	Cyprinodon_variegatus
ENSODEG00000009254	-	83	65.301	ENSCVAG00000023307	-	98	56.061	Cyprinodon_variegatus
ENSODEG00000009254	-	84	72.312	ENSDARG00000012505	u2af2a	99	64.286	Danio_rerio
ENSODEG00000009254	-	100	61.311	ENSDARG00000011740	u2af2b	98	69.231	Danio_rerio
ENSODEG00000009254	-	89	69.176	ENSDNOG00000047039	U2AF2	95	67.529	Dasypus_novemcinctus
ENSODEG00000009254	-	100	69.492	ENSDORG00000003250	U2af2	99	68.008	Dipodomys_ordii
ENSODEG00000009254	-	83	59.392	FBgn0005411	U2af50	99	58.380	Drosophila_melanogaster
ENSODEG00000009254	-	82	45.526	FBgn0034834	LS2	96	42.760	Drosophila_melanogaster
ENSODEG00000009254	-	83	49.864	ENSEBUG00000001732	U2AF2	98	44.545	Eptatretus_burgeri
ENSODEG00000009254	-	96	55.896	ENSEBUG00000010917	U2AF2	98	53.468	Eptatretus_burgeri
ENSODEG00000009254	-	94	69.639	ENSEASG00005020708	U2AF2	90	67.396	Equus_asinus_asinus
ENSODEG00000009254	-	100	67.241	ENSECAG00000010110	U2AF2	99	69.978	Equus_caballus
ENSODEG00000009254	-	99	56.277	ENSELUG00000018459	-	98	57.339	Esox_lucius
ENSODEG00000009254	-	100	61.765	ENSELUG00000015850	u2af2a	99	61.765	Esox_lucius
ENSODEG00000009254	-	100	60.426	ENSELUG00000022291	u2af2b	99	61.050	Esox_lucius
ENSODEG00000009254	-	100	69.492	ENSFCAG00000011504	U2AF2	99	68.008	Felis_catus
ENSODEG00000009254	-	92	69.927	ENSFDAG00000011264	U2AF2	99	66.525	Fukomys_damarensis
ENSODEG00000009254	-	99	66.079	ENSFHEG00000016025	u2af2a	99	65.198	Fundulus_heteroclitus
ENSODEG00000009254	-	100	62.338	ENSGMOG00000004535	u2af2a	99	63.755	Gadus_morhua
ENSODEG00000009254	-	98	64.946	ENSGALG00000052748	U2AF2	65	68.062	Gallus_gallus
ENSODEG00000009254	-	99	66.079	ENSGAFG00000013626	u2af2a	87	65.198	Gambusia_affinis
ENSODEG00000009254	-	99	56.264	ENSGAFG00000005628	-	98	56.923	Gambusia_affinis
ENSODEG00000009254	-	100	66.009	ENSGACG00000010632	U2AF2	99	65.132	Gasterosteus_aculeatus
ENSODEG00000009254	-	90	60.244	ENSGACG00000014500	-	99	55.675	Gasterosteus_aculeatus
ENSODEG00000009254	-	72	82.373	ENSGAGG00000011849	U2AF2	96	82.373	Gopherus_agassizii
ENSODEG00000009254	-	63	74.319	ENSGGOG00000036399	-	96	74.319	Gorilla_gorilla
ENSODEG00000009254	-	84	73.046	ENSHBUG00000013935	u2af2a	100	65.349	Haplochromis_burtoni
ENSODEG00000009254	-	83	65.301	ENSHBUG00000017424	-	98	56.494	Haplochromis_burtoni
ENSODEG00000009254	-	100	69.492	ENSHGLG00000005889	U2AF2	99	68.008	Heterocephalus_glaber_female
ENSODEG00000009254	-	92	69.927	ENSHGLG00100004757	U2AF2	100	67.467	Heterocephalus_glaber_male
ENSODEG00000009254	-	100	64.286	ENSHCOG00000019367	u2af2a	99	63.636	Hippocampus_comes
ENSODEG00000009254	-	99	57.812	ENSIPUG00000009844	-	98	56.473	Ictalurus_punctatus
ENSODEG00000009254	-	99	61.588	ENSIPUG00000009077	u2af2	98	63.239	Ictalurus_punctatus
ENSODEG00000009254	-	100	63.043	ENSIPUG00000007717	u2af2a	99	63.043	Ictalurus_punctatus
ENSODEG00000009254	-	100	69.492	ENSSTOG00000019595	U2AF2	99	68.008	Ictidomys_tridecemlineatus
ENSODEG00000009254	-	100	69.492	ENSJJAG00000017705	U2af2	99	68.008	Jaculus_jaculus
ENSODEG00000009254	-	99	65.021	ENSKMAG00000005960	u2af2a	100	64.545	Kryptolebias_marmoratus
ENSODEG00000009254	-	100	65.714	ENSLBEG00000016162	u2af2a	99	64.835	Labrus_bergylta
ENSODEG00000009254	-	83	62.667	ENSLBEG00000005001	-	98	54.486	Labrus_bergylta
ENSODEG00000009254	-	83	74.659	ENSLACG00000001648	U2AF2	90	78.182	Latimeria_chalumnae
ENSODEG00000009254	-	99	56.867	ENSLOCG00000010843	-	98	57.576	Lepisosteus_oculatus
ENSODEG00000009254	-	56	70.980	ENSLOCG00000008050	u2af2b	93	61.043	Lepisosteus_oculatus
ENSODEG00000009254	-	100	61.966	ENSLAFG00000028496	-	99	61.111	Loxodonta_africana
ENSODEG00000009254	-	100	63.750	ENSLAFG00000018056	-	99	68.008	Loxodonta_africana
ENSODEG00000009254	-	100	69.492	ENSMFAG00000038383	U2AF2	99	68.008	Macaca_fascicularis
ENSODEG00000009254	-	100	69.280	ENSMMUG00000004810	U2AF2	99	67.797	Macaca_mulatta
ENSODEG00000009254	-	100	70.085	ENSMNEG00000042096	U2AF2	99	68.590	Macaca_nemestrina
ENSODEG00000009254	-	92	70.617	ENSMLEG00000032219	U2AF2	89	68.352	Mandrillus_leucophaeus
ENSODEG00000009254	-	100	65.076	ENSMAMG00000019817	u2af2a	99	64.208	Mastacembelus_armatus
ENSODEG00000009254	-	83	64.208	ENSMAMG00000020158	-	98	55.195	Mastacembelus_armatus
ENSODEG00000009254	-	83	65.301	ENSMZEG00005023318	-	98	56.494	Maylandia_zebra
ENSODEG00000009254	-	100	66.374	ENSMZEG00005016563	u2af2a	99	65.495	Maylandia_zebra
ENSODEG00000009254	-	92	69.927	ENSMAUG00000008180	U2af2	99	67.097	Mesocricetus_auratus
ENSODEG00000009254	-	100	70.085	ENSMICG00000027681	U2AF2	99	68.590	Microcebus_murinus
ENSODEG00000009254	-	100	66.812	ENSMOCG00000007227	-	99	65.284	Microtus_ochrogaster
ENSODEG00000009254	-	100	69.492	ENSMOCG00000013214	-	99	68.008	Microtus_ochrogaster
ENSODEG00000009254	-	72	79.661	ENSMOCG00000001018	-	96	79.661	Microtus_ochrogaster
ENSODEG00000009254	-	83	60.526	ENSMMOG00000000531	-	98	51.483	Mola_mola
ENSODEG00000009254	-	84	72.507	ENSMMOG00000016600	u2af2a	100	64.896	Mola_mola
ENSODEG00000009254	-	100	66.593	ENSMALG00000009985	u2af2a	99	65.055	Monopterus_albus
ENSODEG00000009254	-	100	70.085	MGP_CAROLIEiJ_G0029150	U2af2	99	68.590	Mus_caroli
ENSODEG00000009254	-	100	70.085	ENSMUSG00000030435	U2af2	96	82.712	Mus_musculus
ENSODEG00000009254	-	100	70.085	MGP_PahariEiJ_G0021017	U2af2	99	68.590	Mus_pahari
ENSODEG00000009254	-	100	70.085	MGP_SPRETEiJ_G0030203	U2af2	99	68.590	Mus_spretus
ENSODEG00000009254	-	100	70.085	ENSMPUG00000007135	U2AF2	99	68.590	Mustela_putorius_furo
ENSODEG00000009254	-	56	80.342	ENSMLUG00000011051	-	97	80.342	Myotis_lucifugus
ENSODEG00000009254	-	100	63.223	ENSNGAG00000020369	U2af2	99	68.008	Nannospalax_galili
ENSODEG00000009254	-	84	73.046	ENSNBRG00000002568	u2af2a	100	65.349	Neolamprologus_brichardi
ENSODEG00000009254	-	83	63.733	ENSNBRG00000011100	-	98	55.556	Neolamprologus_brichardi
ENSODEG00000009254	-	100	59.121	ENSNLEG00000010562	U2AF2	96	82.712	Nomascus_leucogenys
ENSODEG00000009254	-	92	60.546	ENSMEUG00000002346	U2AF2	100	58.811	Notamacropus_eugenii
ENSODEG00000009254	-	83	65.301	ENSONIG00000009682	-	98	56.494	Oreochromis_niloticus
ENSODEG00000009254	-	100	64.468	ENSONIG00000012793	u2af2a	99	62.979	Oreochromis_niloticus
ENSODEG00000009254	-	100	60.625	ENSORLG00000011545	u2af2a	100	63.781	Oryzias_latipes
ENSODEG00000009254	-	100	60.625	ENSORLG00020006941	u2af2a	100	63.781	Oryzias_latipes_hni
ENSODEG00000009254	-	100	60.625	ENSORLG00015012843	u2af2a	99	62.741	Oryzias_latipes_hsok
ENSODEG00000009254	-	100	64.592	ENSOMEG00000011386	u2af2a	100	63.761	Oryzias_melastigma
ENSODEG00000009254	-	100	69.492	ENSOGAG00000007206	-	99	68.008	Otolemur_garnettii
ENSODEG00000009254	-	97	50.351	ENSOGAG00000034729	-	66	63.509	Otolemur_garnettii
ENSODEG00000009254	-	100	62.316	ENSOARG00000001091	U2AF2	99	60.842	Ovis_aries
ENSODEG00000009254	-	100	69.492	ENSPPAG00000039782	U2AF2	99	68.008	Pan_paniscus
ENSODEG00000009254	-	100	69.492	ENSPPRG00000013843	U2AF2	99	68.008	Panthera_pardus
ENSODEG00000009254	-	99	60.907	ENSPTIG00000005489	U2AF2	86	63.171	Panthera_tigris_altaica
ENSODEG00000009254	-	100	69.492	ENSPTRG00000011523	U2AF2	96	82.712	Pan_troglodytes
ENSODEG00000009254	-	100	70.085	ENSPANG00000008459	U2AF2	99	68.590	Papio_anubis
ENSODEG00000009254	-	100	63.404	ENSPKIG00000024346	u2af2b	100	64.760	Paramormyrops_kingsleyae
ENSODEG00000009254	-	99	56.616	ENSPKIG00000014878	-	98	55.748	Paramormyrops_kingsleyae
ENSODEG00000009254	-	93	52.153	ENSPSIG00000008014	U2AF2	100	50.749	Pelodiscus_sinensis
ENSODEG00000009254	-	84	66.755	ENSPMGG00000022980	u2af2a	100	60.268	Periophthalmus_magnuspinnatus
ENSODEG00000009254	-	100	69.492	ENSPEMG00000007378	U2af2	96	82.712	Peromyscus_maniculatus_bairdii
ENSODEG00000009254	-	83	61.995	ENSPMAG00000004097	u2af2a	99	53.947	Petromyzon_marinus
ENSODEG00000009254	-	100	62.810	ENSPCIG00000018013	U2AF2	99	67.585	Phascolarctos_cinereus
ENSODEG00000009254	-	99	65.510	ENSPFOG00000010799	u2af2a	98	64.208	Poecilia_formosa
ENSODEG00000009254	-	83	65.027	ENSPFOG00000006433	-	98	56.923	Poecilia_formosa
ENSODEG00000009254	-	83	65.027	ENSPLAG00000003275	-	97	57.014	Poecilia_latipinna
ENSODEG00000009254	-	99	66.079	ENSPLAG00000014365	u2af2a	99	65.198	Poecilia_latipinna
ENSODEG00000009254	-	99	66.079	ENSPMEG00000002969	u2af2a	99	65.198	Poecilia_mexicana
ENSODEG00000009254	-	83	64.560	ENSPMEG00000003734	-	97	58.182	Poecilia_mexicana
ENSODEG00000009254	-	91	59.850	ENSPREG00000013036	-	97	64.336	Poecilia_reticulata
ENSODEG00000009254	-	99	65.021	ENSPREG00000008739	u2af2a	100	64.773	Poecilia_reticulata
ENSODEG00000009254	-	62	81.467	ENSPPYG00000010429	-	93	67.828	Pongo_abelii
ENSODEG00000009254	-	100	55.672	ENSPCAG00000014399	-	86	67.667	Procavia_capensis
ENSODEG00000009254	-	91	61.809	ENSPCAG00000003709	-	95	61.055	Procavia_capensis
ENSODEG00000009254	-	100	69.492	ENSPCOG00000025870	U2AF2	99	68.008	Propithecus_coquereli
ENSODEG00000009254	-	100	69.280	ENSPVAG00000004540	U2AF2	99	67.797	Pteropus_vampyrus
ENSODEG00000009254	-	83	65.301	ENSPNYG00000011605	-	98	56.494	Pundamilia_nyererei
ENSODEG00000009254	-	84	73.046	ENSPNYG00000001438	u2af2a	100	65.349	Pundamilia_nyererei
ENSODEG00000009254	-	99	56.494	ENSPNAG00000007182	-	98	57.143	Pygocentrus_nattereri
ENSODEG00000009254	-	100	63.913	ENSPNAG00000017620	u2af2a	99	63.913	Pygocentrus_nattereri
ENSODEG00000009254	-	99	65.402	ENSPNAG00000027289	u2af2b	98	64.509	Pygocentrus_nattereri
ENSODEG00000009254	-	100	70.085	ENSRNOG00000015914	U2af2	99	68.590	Rattus_norvegicus
ENSODEG00000009254	-	100	69.280	ENSRBIG00000041018	U2AF2	99	68.008	Rhinopithecus_bieti
ENSODEG00000009254	-	100	68.996	ENSRROG00000031238	-	99	67.467	Rhinopithecus_roxellana
ENSODEG00000009254	-	81	69.041	ENSRROG00000031103	-	100	66.425	Rhinopithecus_roxellana
ENSODEG00000009254	-	100	70.085	ENSSBOG00000023891	U2AF2	99	68.590	Saimiri_boliviensis_boliviensis
ENSODEG00000009254	-	56	52.843	ENSSHAG00000001167	U2AF2	53	72.678	Sarcophilus_harrisii
ENSODEG00000009254	-	99	57.143	ENSSFOG00015003884	-	98	55.628	Scleropages_formosus
ENSODEG00000009254	-	84	72.581	ENSSFOG00015019182	u2af2b	84	70.699	Scleropages_formosus
ENSODEG00000009254	-	99	56.710	ENSSMAG00000013779	-	98	57.143	Scophthalmus_maximus
ENSODEG00000009254	-	100	60.206	ENSSMAG00000012582	u2af2a	99	64.912	Scophthalmus_maximus
ENSODEG00000009254	-	99	66.444	ENSSDUG00000009457	u2af2a	98	65.556	Seriola_dumerili
ENSODEG00000009254	-	83	63.395	ENSSDUG00000021434	-	94	55.098	Seriola_dumerili
ENSODEG00000009254	-	100	65.934	ENSSLDG00000022742	u2af2a	99	65.055	Seriola_lalandi_dorsalis
ENSODEG00000009254	-	83	63.395	ENSSLDG00000016151	-	98	55.098	Seriola_lalandi_dorsalis
ENSODEG00000009254	-	100	64.315	ENSSPUG00000010229	U2AF2	99	66.879	Sphenodon_punctatus
ENSODEG00000009254	-	84	72.776	ENSSPAG00000022519	u2af2a	99	63.812	Stegastes_partitus
ENSODEG00000009254	-	83	65.027	ENSSPAG00000005241	-	98	56.277	Stegastes_partitus
ENSODEG00000009254	-	100	70.085	ENSSSCG00000034815	U2AF2	99	69.978	Sus_scrofa
ENSODEG00000009254	-	84	70.350	ENSTRUG00000005514	u2af2a	98	63.039	Takifugu_rubripes
ENSODEG00000009254	-	94	60.341	ENSTNIG00000011257	-	98	56.044	Tetraodon_nigroviridis
ENSODEG00000009254	-	99	65.161	ENSTNIG00000008106	U2AF2	99	63.656	Tetraodon_nigroviridis
ENSODEG00000009254	-	81	65.123	ENSTBEG00000009104	U2AF2	95	65.110	Tupaia_belangeri
ENSODEG00000009254	-	100	69.492	ENSTTRG00000000987	U2AF2	99	68.008	Tursiops_truncatus
ENSODEG00000009254	-	92	69.927	ENSUAMG00000019883	U2AF2	100	66.374	Ursus_americanus
ENSODEG00000009254	-	92	69.927	ENSUMAG00000024586	U2AF2	96	82.712	Ursus_maritimus
ENSODEG00000009254	-	92	70.617	ENSVVUG00000006956	U2AF2	66	69.545	Vulpes_vulpes
ENSODEG00000009254	-	100	64.482	ENSXETG00000019128	u2af2	99	67.532	Xenopus_tropicalis
ENSODEG00000009254	-	84	72.507	ENSXCOG00000019406	u2af2a	100	64.692	Xiphophorus_couchianus
ENSODEG00000009254	-	99	66.079	ENSXMAG00000011979	u2af2a	99	65.198	Xiphophorus_maculatus
ENSODEG00000009254	-	83	64.208	ENSXMAG00000000768	-	94	55.844	Xiphophorus_maculatus